A membrana de látex como implante para correção de defeitos musculares em cães e coelhos
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Manancial - Repositório Digital da UFSM |
Texto Completo: | http://repositorio.ufsm.br/handle/1/10127 |
Resumo: | This dissertation presents an implant model of natural latex to be used on partial canine diaphragm replacement. The implant could be used in cases of diaphragmatic hernias, or significant loss of the diaphragm integrity disabling its reconstitution. For such, seven different membranes had been tested, six of them had been produced experimentally and one is a commercial model in use, for several applications. Firstly, the biocompatibility was evaluated in rabbits. Membranes were implanted between the cutaneous and the oblique abdominal sternum muscles by the means of a surgical procedure and the reactions of hipersensibility and rejection were evaluated. Mechanical traction tests were performed in control membranes to measure deformation and resistance. Results pointed that the membranes are incompatible, and not able to substitute muscular sheath in rabbits. New tests were made in dogs. The membranes were regrouped and three of then were tested in a similar way, in abdomen straight muscle. Two membranes were selected, for use in the canine diaphragm, and being tested in front a control group, without membrane. A rectangular defect (4 cm in length and 3 cm in width) was created in the diaphragm muscle, which was substituted, in groups 1 and 2, by the implantation of the corresponding latex membrane. The animals were evaluated radiographically, by blood count, video-surgery, and histopathology study. The results showed that the membrane made of natural latex, vulcanizants mixture and formic acid, were efficient in the correction of the diaphragm defect, promoting repair and local neovascularization, capable to keep the respiratory function and movements of the diaphragm without causing rejection during the evaluated period. |
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A membrana de látex como implante para correção de defeitos musculares em cães e coelhosLatex membrane used like implant to correct muscles defects in dogs and rabbitsMembrana de látexBiocompatibilidadeDiafragmaCoelhosCãesLatex membraneBiocompatibilityDiaphragmRabbitsDogsCNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIAThis dissertation presents an implant model of natural latex to be used on partial canine diaphragm replacement. The implant could be used in cases of diaphragmatic hernias, or significant loss of the diaphragm integrity disabling its reconstitution. For such, seven different membranes had been tested, six of them had been produced experimentally and one is a commercial model in use, for several applications. Firstly, the biocompatibility was evaluated in rabbits. Membranes were implanted between the cutaneous and the oblique abdominal sternum muscles by the means of a surgical procedure and the reactions of hipersensibility and rejection were evaluated. Mechanical traction tests were performed in control membranes to measure deformation and resistance. Results pointed that the membranes are incompatible, and not able to substitute muscular sheath in rabbits. New tests were made in dogs. The membranes were regrouped and three of then were tested in a similar way, in abdomen straight muscle. Two membranes were selected, for use in the canine diaphragm, and being tested in front a control group, without membrane. A rectangular defect (4 cm in length and 3 cm in width) was created in the diaphragm muscle, which was substituted, in groups 1 and 2, by the implantation of the corresponding latex membrane. The animals were evaluated radiographically, by blood count, video-surgery, and histopathology study. The results showed that the membrane made of natural latex, vulcanizants mixture and formic acid, were efficient in the correction of the diaphragm defect, promoting repair and local neovascularization, capable to keep the respiratory function and movements of the diaphragm without causing rejection during the evaluated period.Esta dissertação apresenta um modelo de implante à base de látex natural para a substituição parcial de diafragma canino. Este poderá ser utilizado em casos de hérnias diafragmáticas, ou situações em que haja perda da integridade do diafragma, impossibilitando sua reconstituição. Para tal, foram testadas sete diferentes membranas, das quais seis foram produzidas experimentalmente e um modelo comercial em uso no mercado, para diferentes fins. Foram realizados testes de resistência para verificar a deformação e elasticidade das membranas. A biocompatibilidade foi avaliada primeiramente em coelhos, nos quais as membranas foram fixadas através de procedimento cirúrgico na bainha do músculo oblíquo externo do abdome e avaliadas quanto a reações de hipersensibilidade e rejeição. Os resultados contra-indicam o uso destas em coelhos. Novos testes foram realizados em cães. As membranas foram reagrupadas e três delas testadas de maneira semelhante, no músculo reto do abdome verificando-se biocompatibilidade com essa espécie. Foram selecionadas duas membranas para a utilização no diafragma canino, sendo testadas frente a um grupo controle, sem membrana. Foi criado um defeito retangular no músculo diafragma, com 4 cm de comprimento e 3 cm de largura, que no grupo 1 e 2 foi substituído pelo implante de membrana de látex correspondente. A avaliação foi feita através de análise do hemograma, por estudo radiográfico, por vídeocirurgia e estudo histopatológico. Pode-se inferir dos resultados que a membrana constituída de: látex natural, mistura vulcanizante e ácido fórmico, foi eficiente na correção do defeito no diafragma canino, promovendo a reparação tecidual e neovascularização local, capaz de manter a função do diafragma e movimentos respiratórios sem causar rejeição durante o período de avaliação.Universidade Federal de Santa MariaBRMedicina VeterináriaUFSMPrograma de Pós-Graduação em Medicina VeterináriaRaiser, Alceu Gasparhttp://lattes.cnpq.br/5375404372156000Graça, Dominguita Luhershttp://lattes.cnpq.br/7761878749916936Morais, Ewerton Nuneshttp://lattes.cnpq.br/4349069759138178Zimmermann, Marina2007-02-272007-02-272007-01-17info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfapplication/pdfZIMMERMANN, Marina. Latex membrane used like implant to correct muscles defects in dogs and rabbits. 2007. 52 f. Dissertação (Mestrado em Medicina Veterinária) - Universidade Federal de Santa Maria, Santa Maria, 2007.http://repositorio.ufsm.br/handle/1/10127porinfo:eu-repo/semantics/openAccessreponame:Manancial - Repositório Digital da UFSMinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM2023-03-06T13:28:06Zoai:repositorio.ufsm.br:1/10127Biblioteca Digital de Teses e Dissertaçõeshttps://repositorio.ufsm.br/ONGhttps://repositorio.ufsm.br/oai/requestatendimento.sib@ufsm.br||tedebc@gmail.comopendoar:2023-03-06T13:28:06Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM)false |
dc.title.none.fl_str_mv |
A membrana de látex como implante para correção de defeitos musculares em cães e coelhos Latex membrane used like implant to correct muscles defects in dogs and rabbits |
title |
A membrana de látex como implante para correção de defeitos musculares em cães e coelhos |
spellingShingle |
A membrana de látex como implante para correção de defeitos musculares em cães e coelhos Zimmermann, Marina Membrana de látex Biocompatibilidade Diafragma Coelhos Cães Latex membrane Biocompatibility Diaphragm Rabbits Dogs CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
title_short |
A membrana de látex como implante para correção de defeitos musculares em cães e coelhos |
title_full |
A membrana de látex como implante para correção de defeitos musculares em cães e coelhos |
title_fullStr |
A membrana de látex como implante para correção de defeitos musculares em cães e coelhos |
title_full_unstemmed |
A membrana de látex como implante para correção de defeitos musculares em cães e coelhos |
title_sort |
A membrana de látex como implante para correção de defeitos musculares em cães e coelhos |
author |
Zimmermann, Marina |
author_facet |
Zimmermann, Marina |
author_role |
author |
dc.contributor.none.fl_str_mv |
Raiser, Alceu Gaspar http://lattes.cnpq.br/5375404372156000 Graça, Dominguita Luhers http://lattes.cnpq.br/7761878749916936 Morais, Ewerton Nunes http://lattes.cnpq.br/4349069759138178 |
dc.contributor.author.fl_str_mv |
Zimmermann, Marina |
dc.subject.por.fl_str_mv |
Membrana de látex Biocompatibilidade Diafragma Coelhos Cães Latex membrane Biocompatibility Diaphragm Rabbits Dogs CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
topic |
Membrana de látex Biocompatibilidade Diafragma Coelhos Cães Latex membrane Biocompatibility Diaphragm Rabbits Dogs CNPQ::CIENCIAS AGRARIAS::MEDICINA VETERINARIA |
description |
This dissertation presents an implant model of natural latex to be used on partial canine diaphragm replacement. The implant could be used in cases of diaphragmatic hernias, or significant loss of the diaphragm integrity disabling its reconstitution. For such, seven different membranes had been tested, six of them had been produced experimentally and one is a commercial model in use, for several applications. Firstly, the biocompatibility was evaluated in rabbits. Membranes were implanted between the cutaneous and the oblique abdominal sternum muscles by the means of a surgical procedure and the reactions of hipersensibility and rejection were evaluated. Mechanical traction tests were performed in control membranes to measure deformation and resistance. Results pointed that the membranes are incompatible, and not able to substitute muscular sheath in rabbits. New tests were made in dogs. The membranes were regrouped and three of then were tested in a similar way, in abdomen straight muscle. Two membranes were selected, for use in the canine diaphragm, and being tested in front a control group, without membrane. A rectangular defect (4 cm in length and 3 cm in width) was created in the diaphragm muscle, which was substituted, in groups 1 and 2, by the implantation of the corresponding latex membrane. The animals were evaluated radiographically, by blood count, video-surgery, and histopathology study. The results showed that the membrane made of natural latex, vulcanizants mixture and formic acid, were efficient in the correction of the diaphragm defect, promoting repair and local neovascularization, capable to keep the respiratory function and movements of the diaphragm without causing rejection during the evaluated period. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-02-27 2007-02-27 2007-01-17 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
ZIMMERMANN, Marina. Latex membrane used like implant to correct muscles defects in dogs and rabbits. 2007. 52 f. Dissertação (Mestrado em Medicina Veterinária) - Universidade Federal de Santa Maria, Santa Maria, 2007. http://repositorio.ufsm.br/handle/1/10127 |
identifier_str_mv |
ZIMMERMANN, Marina. Latex membrane used like implant to correct muscles defects in dogs and rabbits. 2007. 52 f. Dissertação (Mestrado em Medicina Veterinária) - Universidade Federal de Santa Maria, Santa Maria, 2007. |
url |
http://repositorio.ufsm.br/handle/1/10127 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Universidade Federal de Santa Maria BR Medicina Veterinária UFSM Programa de Pós-Graduação em Medicina Veterinária |
publisher.none.fl_str_mv |
Universidade Federal de Santa Maria BR Medicina Veterinária UFSM Programa de Pós-Graduação em Medicina Veterinária |
dc.source.none.fl_str_mv |
reponame:Manancial - Repositório Digital da UFSM instname:Universidade Federal de Santa Maria (UFSM) instacron:UFSM |
instname_str |
Universidade Federal de Santa Maria (UFSM) |
instacron_str |
UFSM |
institution |
UFSM |
reponame_str |
Manancial - Repositório Digital da UFSM |
collection |
Manancial - Repositório Digital da UFSM |
repository.name.fl_str_mv |
Manancial - Repositório Digital da UFSM - Universidade Federal de Santa Maria (UFSM) |
repository.mail.fl_str_mv |
atendimento.sib@ufsm.br||tedebc@gmail.com |
_version_ |
1805922121210134528 |