En Face Doppler Optical Coherence Tomography Measurement of Total Retinal Blood Flow in Diabetic Retinopathy and Diabetic Macular Edema

• Autor(a) principal: Lee, ByungKun
• Data de Publicação: 2017
• Outros Autores: Novais, Eduardo A. [UNIFESP], Waheed, Nadia K., Adhi, Mehreen, de Carlo, Talisa E., Cole, Emily D., Moult, Eric M., Choi, WooJhon, Lane, Mark, Baumal, Caroline R., Duker, Jay S., Fujimoto, James G.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1001/jamaophthalmol.2016.5774; https://repositorio.unifesp.br/handle/11600/55013

IMPORTANCE Alterations in ocular blood flow play an important role in the pathogenesis and progression of diabetic retinopathy (DR). However, the measurement of retinal blood flow in clinical studies has been challenging. En face Doppler optical coherence tomography (OCT) provides an effectivemethod for measuring total retinal blood flow (TRBF) in the clinic. OBJECTIVE To investigate TRBF in eyes with DR of varying severity, with or without diabetic macular edema (DME), using en face Doppler OCT. DESIGN, SETTING, AND PARTICIPANTS Thiswas a cross-sectional study conducted from May 23, 2014, to January 11, 2016, which analyzed 41 eyes with DR from 31 diabetic patients, 20 eyes without DR from 11 diabetic patients, and 16 eyes from 12 healthy age-matched controls, all at the New England Eye Center in Boston, Massachusetts. MAIN OUTCOMES AND MEASURES Participantswere imaged with a high-speed, swept-source OCT prototype at 1050-nm wavelength using repeated en face Doppler OCT raster scans, comprising 600 x 80 axial scans and covering a 1.5 x 2-mm(2) area centered at the optic disc. The TRBF was automatically calculated using custom Matlab software. RESULTS This study included 41 eyes with DR from 31 diabetic patients (mean [SD] age, 62.8 [13.4] years