Associação entre a evolução da disfunção orgânica e as concentrações de citocinas na fase inicial do choque séptico
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNIFESP |
dARK ID: | ark:/48912/001300000mpcx |
Texto Completo: | http://dx.doi.org/10.1590/S0103-507X2011000400006 http://repositorio.unifesp.br/handle/11600/6740 |
Resumo: | OBJECTIVE: To investigate the correlation of organ dysfunction and its progression with inflammatory response during the early phases of septic shock by assessing baseline cytokine concentrations. METHODS: This study included patients over 18 years old with septic shock within the first 48 hours after the onset of organ dysfunction. Interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10) and C-reactive protein levels were assessed at inclusion and after 24 hours, and the differences between these values were calculated. The progression of organ dysfunction was assessed using the Sequential Organ Failure Assessment (SOFA) score upon admission and 24 hours later for a delta-SOFA determination and were categorized as either worsened or improved. The results were expressed as means + standard deviation or median (25-75% percentiles). Values with descriptive p values of 0.05 or less were considered significant. RESULTS: Overall, we included 41 patients with median SOFA scores of 8.0 (6.5-10.0) upon admission (T0) and 8.0 (6.0-10.0) 24 hours later (T1). Worsened, improved or unchanged SOFA scores were observed in 11 (Group 1), 17 (Group 2) and 13 (Group 3) patients, respectively. For Group 1, the baseline IL-6, IL-8 and IL-10 values were higher, and a significant increase of IL-8 levels was found after 24 hours. The change in the SOFA score after 24 hours was significantly, although weakly, correlated with baseline IL-6 and IL-8 concentrations. CONCLUSIONS: Higher baseline IL-6, IL-8 and IL-10 levels are associated with unfavorable organ dysfunction outcomes. Increased IL-8 levels within the first 24 hours are correlated with a worsening dysfunction. |
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Associação entre a evolução da disfunção orgânica e as concentrações de citocinas na fase inicial do choque sépticoAssociation between organ dysfunction and cytokine concentrations during the early phases of septic shockShock, septicMultiple organ failureetiologySystemic inflammatory response syndromeCytokinesChoque sépticoInsuficiência de múltiplos órgãosetiologiaSíndrome de resposta inflamatória sistêmicaCitocinasOBJECTIVE: To investigate the correlation of organ dysfunction and its progression with inflammatory response during the early phases of septic shock by assessing baseline cytokine concentrations. METHODS: This study included patients over 18 years old with septic shock within the first 48 hours after the onset of organ dysfunction. Interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10) and C-reactive protein levels were assessed at inclusion and after 24 hours, and the differences between these values were calculated. The progression of organ dysfunction was assessed using the Sequential Organ Failure Assessment (SOFA) score upon admission and 24 hours later for a delta-SOFA determination and were categorized as either worsened or improved. The results were expressed as means + standard deviation or median (25-75% percentiles). Values with descriptive p values of 0.05 or less were considered significant. RESULTS: Overall, we included 41 patients with median SOFA scores of 8.0 (6.5-10.0) upon admission (T0) and 8.0 (6.0-10.0) 24 hours later (T1). Worsened, improved or unchanged SOFA scores were observed in 11 (Group 1), 17 (Group 2) and 13 (Group 3) patients, respectively. For Group 1, the baseline IL-6, IL-8 and IL-10 values were higher, and a significant increase of IL-8 levels was found after 24 hours. The change in the SOFA score after 24 hours was significantly, although weakly, correlated with baseline IL-6 and IL-8 concentrations. CONCLUSIONS: Higher baseline IL-6, IL-8 and IL-10 levels are associated with unfavorable organ dysfunction outcomes. Increased IL-8 levels within the first 24 hours are correlated with a worsening dysfunction.OBJETIVO: Analisar o comportamento das disfunções orgânicas e sua correlação com a resposta inflamatória, avaliada pelas concentrações basais de citocinas e pela evolução dessas concentrações, na fase precoce do choque séptico. MÉTODOS: Foram avaliados pacientes com idade acima de 18 anos e diagnóstico de choque séptico com menos de 48 horas de início das disfunções orgânicas. Foram mensuradas interleucina 6 (IL-6), interleucina 8 (IL-8), interleucina 10 (IL-10) e proteina C reativa na inclusão e após 24 horas, sendo calculado o delta desses valores. A evolução das disfunções orgânicas foi avaliada através do escore Sequential Organ Failure Assessment (SOFA) na admissão e após 24 horas para determinação do delta SOFA, posteriormente categorizado como piora ou melhora. Os resultados foram expressos como média ± desvio padrão ou mediana (percentil 25%-75%). Consideraram-se significativos resultados com valor descritivo de p menor que 0,05. RESULTADOS: Foram incluídos 41 pacientes com mediana do SOFA de 8,0(6,5 -10,0) e 8,0(6,0-10,0) na admissão (T0) e após 24 horas (T1). Piora, melhora ou ausência de alteração do SOFA foram encontradas respectivamente em 11 (Grupo 1), 17 (Grupo 2) e 13 pacientes (Grupo 3). No grupo 1 os valores basais de IL-6, IL-8 e IL-10 foram mais elevados. No Grupo 1 houve aumento significativo de IL-8 após 24 horas. A variação do SOFA após 24 horas mostrou correlação significativa, embora fraca, com as concentrações basais de IL-6 e IL-8. CONCLUSÃO: As concentrações basais mais elevadas de IL-6, IL-8 e IL-10 associam-se a evolução desfavorável da disfunção orgânica. A elevação das concentrações de IL-8 nas primeiras 24 horas mostrou-se correlacionada a piora dessa disfunção.Universidade Federal de São Paulo (UNIFESP)Universidade de São PauloUNIFESPSciELOAssociação de Medicina Intensiva Brasileira - AMIBUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Machado, Flávia Ribeiro [UNIFESP]Sanches, Luciana Coelho [UNIFESP]Azevedo, Luciano Cesar Pontes [UNIFESP]Brunialti, Milena Karina Coló [UNIFESP]Lourenco, Dayse Maria [UNIFESP]Noguti, Maria Aparecida Eiko [UNIFESP]Salomão, Reinaldo [UNIFESP]2015-06-14T13:43:24Z2015-06-14T13:43:24Z2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion426-433application/pdfhttp://dx.doi.org/10.1590/S0103-507X2011000400006Revista Brasileira de Terapia Intensiva. Associação de Medicina Intensiva Brasileira - AMIB, v. 23, n. 4, p. 426-433, 2011.10.1590/S0103-507X2011000400006S0103-507X2011000400006.pdf0103-507XS0103-507X2011000400006http://repositorio.unifesp.br/handle/11600/6740ark:/48912/001300000mpcxporRevista Brasileira de Terapia Intensivainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T21:06:59Zoai:repositorio.unifesp.br/:11600/6740Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:25:40.528298Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Associação entre a evolução da disfunção orgânica e as concentrações de citocinas na fase inicial do choque séptico Association between organ dysfunction and cytokine concentrations during the early phases of septic shock |
title |
Associação entre a evolução da disfunção orgânica e as concentrações de citocinas na fase inicial do choque séptico |
spellingShingle |
Associação entre a evolução da disfunção orgânica e as concentrações de citocinas na fase inicial do choque séptico Machado, Flávia Ribeiro [UNIFESP] Shock, septic Multiple organ failure etiology Systemic inflammatory response syndrome Cytokines Choque séptico Insuficiência de múltiplos órgãos etiologia Síndrome de resposta inflamatória sistêmica Citocinas |
title_short |
Associação entre a evolução da disfunção orgânica e as concentrações de citocinas na fase inicial do choque séptico |
title_full |
Associação entre a evolução da disfunção orgânica e as concentrações de citocinas na fase inicial do choque séptico |
title_fullStr |
Associação entre a evolução da disfunção orgânica e as concentrações de citocinas na fase inicial do choque séptico |
title_full_unstemmed |
Associação entre a evolução da disfunção orgânica e as concentrações de citocinas na fase inicial do choque séptico |
title_sort |
Associação entre a evolução da disfunção orgânica e as concentrações de citocinas na fase inicial do choque séptico |
author |
Machado, Flávia Ribeiro [UNIFESP] |
author_facet |
Machado, Flávia Ribeiro [UNIFESP] Sanches, Luciana Coelho [UNIFESP] Azevedo, Luciano Cesar Pontes [UNIFESP] Brunialti, Milena Karina Coló [UNIFESP] Lourenco, Dayse Maria [UNIFESP] Noguti, Maria Aparecida Eiko [UNIFESP] Salomão, Reinaldo [UNIFESP] |
author_role |
author |
author2 |
Sanches, Luciana Coelho [UNIFESP] Azevedo, Luciano Cesar Pontes [UNIFESP] Brunialti, Milena Karina Coló [UNIFESP] Lourenco, Dayse Maria [UNIFESP] Noguti, Maria Aparecida Eiko [UNIFESP] Salomão, Reinaldo [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Machado, Flávia Ribeiro [UNIFESP] Sanches, Luciana Coelho [UNIFESP] Azevedo, Luciano Cesar Pontes [UNIFESP] Brunialti, Milena Karina Coló [UNIFESP] Lourenco, Dayse Maria [UNIFESP] Noguti, Maria Aparecida Eiko [UNIFESP] Salomão, Reinaldo [UNIFESP] |
dc.subject.por.fl_str_mv |
Shock, septic Multiple organ failure etiology Systemic inflammatory response syndrome Cytokines Choque séptico Insuficiência de múltiplos órgãos etiologia Síndrome de resposta inflamatória sistêmica Citocinas |
topic |
Shock, septic Multiple organ failure etiology Systemic inflammatory response syndrome Cytokines Choque séptico Insuficiência de múltiplos órgãos etiologia Síndrome de resposta inflamatória sistêmica Citocinas |
description |
OBJECTIVE: To investigate the correlation of organ dysfunction and its progression with inflammatory response during the early phases of septic shock by assessing baseline cytokine concentrations. METHODS: This study included patients over 18 years old with septic shock within the first 48 hours after the onset of organ dysfunction. Interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10) and C-reactive protein levels were assessed at inclusion and after 24 hours, and the differences between these values were calculated. The progression of organ dysfunction was assessed using the Sequential Organ Failure Assessment (SOFA) score upon admission and 24 hours later for a delta-SOFA determination and were categorized as either worsened or improved. The results were expressed as means + standard deviation or median (25-75% percentiles). Values with descriptive p values of 0.05 or less were considered significant. RESULTS: Overall, we included 41 patients with median SOFA scores of 8.0 (6.5-10.0) upon admission (T0) and 8.0 (6.0-10.0) 24 hours later (T1). Worsened, improved or unchanged SOFA scores were observed in 11 (Group 1), 17 (Group 2) and 13 (Group 3) patients, respectively. For Group 1, the baseline IL-6, IL-8 and IL-10 values were higher, and a significant increase of IL-8 levels was found after 24 hours. The change in the SOFA score after 24 hours was significantly, although weakly, correlated with baseline IL-6 and IL-8 concentrations. CONCLUSIONS: Higher baseline IL-6, IL-8 and IL-10 levels are associated with unfavorable organ dysfunction outcomes. Increased IL-8 levels within the first 24 hours are correlated with a worsening dysfunction. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-01 2015-06-14T13:43:24Z 2015-06-14T13:43:24Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0103-507X2011000400006 Revista Brasileira de Terapia Intensiva. Associação de Medicina Intensiva Brasileira - AMIB, v. 23, n. 4, p. 426-433, 2011. 10.1590/S0103-507X2011000400006 S0103-507X2011000400006.pdf 0103-507X S0103-507X2011000400006 http://repositorio.unifesp.br/handle/11600/6740 |
dc.identifier.dark.fl_str_mv |
ark:/48912/001300000mpcx |
url |
http://dx.doi.org/10.1590/S0103-507X2011000400006 http://repositorio.unifesp.br/handle/11600/6740 |
identifier_str_mv |
Revista Brasileira de Terapia Intensiva. Associação de Medicina Intensiva Brasileira - AMIB, v. 23, n. 4, p. 426-433, 2011. 10.1590/S0103-507X2011000400006 S0103-507X2011000400006.pdf 0103-507X S0103-507X2011000400006 ark:/48912/001300000mpcx |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Revista Brasileira de Terapia Intensiva |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
426-433 application/pdf |
dc.publisher.none.fl_str_mv |
Associação de Medicina Intensiva Brasileira - AMIB |
publisher.none.fl_str_mv |
Associação de Medicina Intensiva Brasileira - AMIB |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1818602485272543232 |