Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S1677-55382011000500005 http://repositorio.unifesp.br/handle/11600/33991 |
Resumo: | Purpose: Neuroendocrine carcinomas (NEC) of the prostate are rare, with only a few series hitherto reported. the objective of this study was to assess in a single institution the clinical and morphologic characteristics of neuroendocrine carcinomas diagnosed in needle core biopsies.Materials and Methods: the current study analyses seven cases diagnosed in needle biopsies at a large tertiary regional cancer center from Northeastern Brazil. Two pathologists reviewed specimens retrospectively, and demographic and morphologic characteristics were compared to 458 acinar tumors diagnosed in the same period.Results: There were five small cell carcinomas and two low-grade neuroendocrine carcinomas (carcinoid). NEC were associated with an acinar component in 5/7 cases and the Gleason score of the acinar component was always > 6. the number of cores involved in prostates with NEC was greater (65% compared to 24% of acinar tumors, p < 0.05). the mean PSA at diagnosis was 417.7 (range 5.7-1593, SD 218.3), compared to 100.5 (p = 0.1) of acinar tumors (range 0.3-8545, SD 22.7). Prostates harboring NEC were bigger (p < 0.001, mean volume 240 mL vs. 53 mL of acinar tumors). Treatment of NEC included palliative surgery, chemotherapy, and hormonal therapy.Conclusions: NEC of the prostate is rare and often associated with a high-grade acinar component. Prostates with NEC tend to be larger and involve a greater number of cores than acinar tumors. PSA at diagnosis does not seem to predict the presence of NE tumors in needle biopsy. |
id |
UFSP_01c32de63be2a6a442d1c9c559f78a95 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br/:11600/33991 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer centerprostateneoplasmscarcinoid tumorneuroendocrine tumortreatment outcomePurpose: Neuroendocrine carcinomas (NEC) of the prostate are rare, with only a few series hitherto reported. the objective of this study was to assess in a single institution the clinical and morphologic characteristics of neuroendocrine carcinomas diagnosed in needle core biopsies.Materials and Methods: the current study analyses seven cases diagnosed in needle biopsies at a large tertiary regional cancer center from Northeastern Brazil. Two pathologists reviewed specimens retrospectively, and demographic and morphologic characteristics were compared to 458 acinar tumors diagnosed in the same period.Results: There were five small cell carcinomas and two low-grade neuroendocrine carcinomas (carcinoid). NEC were associated with an acinar component in 5/7 cases and the Gleason score of the acinar component was always > 6. the number of cores involved in prostates with NEC was greater (65% compared to 24% of acinar tumors, p < 0.05). the mean PSA at diagnosis was 417.7 (range 5.7-1593, SD 218.3), compared to 100.5 (p = 0.1) of acinar tumors (range 0.3-8545, SD 22.7). Prostates harboring NEC were bigger (p < 0.001, mean volume 240 mL vs. 53 mL of acinar tumors). Treatment of NEC included palliative surgery, chemotherapy, and hormonal therapy.Conclusions: NEC of the prostate is rare and often associated with a high-grade acinar component. Prostates with NEC tend to be larger and involve a greater number of cores than acinar tumors. PSA at diagnosis does not seem to predict the presence of NE tumors in needle biopsy.Hosp Canc, Inst Canc Ceara, BR-60430230 Fortaleza, Ceara, BrazilEscola Paulista Med, BR-04023 São Paulo, BrazilEscola Paulista Med, BR-04023 São Paulo, BrazilWeb of ScienceBrazilian Soc UrolHosp CancUniversidade Federal de São Paulo (UNIFESP)Lima, M. V. A.Nogueira, C.Oliveira, J. A. A.Muniz Neto, F. J.Franco, M. [UNIFESP]Tavora, Fabio Rocha Fernandes [UNIFESP]2016-01-24T14:17:08Z2016-01-24T14:17:08Z2011-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion598-604http://dx.doi.org/10.1590/S1677-55382011000500005International Braz J Urol. Rio de Janeiro: Brazilian Soc Urol, v. 37, n. 5, p. 598-604, 2011.10.1590/S1677-553820110005000051677-5538S1677-55382011000500005http://repositorio.unifesp.br/handle/11600/33991WOS:000299854100005engInternational Braz J Urolinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2022-11-03T10:40:48Zoai:repositorio.unifesp.br/:11600/33991Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652022-11-03T10:40:48Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center |
title |
Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center |
spellingShingle |
Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center Lima, M. V. A. prostate neoplasms carcinoid tumor neuroendocrine tumor treatment outcome |
title_short |
Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center |
title_full |
Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center |
title_fullStr |
Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center |
title_full_unstemmed |
Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center |
title_sort |
Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center |
author |
Lima, M. V. A. |
author_facet |
Lima, M. V. A. Nogueira, C. Oliveira, J. A. A. Muniz Neto, F. J. Franco, M. [UNIFESP] Tavora, Fabio Rocha Fernandes [UNIFESP] |
author_role |
author |
author2 |
Nogueira, C. Oliveira, J. A. A. Muniz Neto, F. J. Franco, M. [UNIFESP] Tavora, Fabio Rocha Fernandes [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Hosp Canc Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Lima, M. V. A. Nogueira, C. Oliveira, J. A. A. Muniz Neto, F. J. Franco, M. [UNIFESP] Tavora, Fabio Rocha Fernandes [UNIFESP] |
dc.subject.por.fl_str_mv |
prostate neoplasms carcinoid tumor neuroendocrine tumor treatment outcome |
topic |
prostate neoplasms carcinoid tumor neuroendocrine tumor treatment outcome |
description |
Purpose: Neuroendocrine carcinomas (NEC) of the prostate are rare, with only a few series hitherto reported. the objective of this study was to assess in a single institution the clinical and morphologic characteristics of neuroendocrine carcinomas diagnosed in needle core biopsies.Materials and Methods: the current study analyses seven cases diagnosed in needle biopsies at a large tertiary regional cancer center from Northeastern Brazil. Two pathologists reviewed specimens retrospectively, and demographic and morphologic characteristics were compared to 458 acinar tumors diagnosed in the same period.Results: There were five small cell carcinomas and two low-grade neuroendocrine carcinomas (carcinoid). NEC were associated with an acinar component in 5/7 cases and the Gleason score of the acinar component was always > 6. the number of cores involved in prostates with NEC was greater (65% compared to 24% of acinar tumors, p < 0.05). the mean PSA at diagnosis was 417.7 (range 5.7-1593, SD 218.3), compared to 100.5 (p = 0.1) of acinar tumors (range 0.3-8545, SD 22.7). Prostates harboring NEC were bigger (p < 0.001, mean volume 240 mL vs. 53 mL of acinar tumors). Treatment of NEC included palliative surgery, chemotherapy, and hormonal therapy.Conclusions: NEC of the prostate is rare and often associated with a high-grade acinar component. Prostates with NEC tend to be larger and involve a greater number of cores than acinar tumors. PSA at diagnosis does not seem to predict the presence of NE tumors in needle biopsy. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-09-01 2016-01-24T14:17:08Z 2016-01-24T14:17:08Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1677-55382011000500005 International Braz J Urol. Rio de Janeiro: Brazilian Soc Urol, v. 37, n. 5, p. 598-604, 2011. 10.1590/S1677-55382011000500005 1677-5538 S1677-55382011000500005 http://repositorio.unifesp.br/handle/11600/33991 WOS:000299854100005 |
url |
http://dx.doi.org/10.1590/S1677-55382011000500005 http://repositorio.unifesp.br/handle/11600/33991 |
identifier_str_mv |
International Braz J Urol. Rio de Janeiro: Brazilian Soc Urol, v. 37, n. 5, p. 598-604, 2011. 10.1590/S1677-55382011000500005 1677-5538 S1677-55382011000500005 WOS:000299854100005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Braz J Urol |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
598-604 |
dc.publisher.none.fl_str_mv |
Brazilian Soc Urol |
publisher.none.fl_str_mv |
Brazilian Soc Urol |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268314590904320 |