Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center

Detalhes bibliográficos
Autor(a) principal: Lima, M. V. A.
Data de Publicação: 2011
Outros Autores: Nogueira, C., Oliveira, J. A. A., Muniz Neto, F. J., Franco, M. [UNIFESP], Tavora, Fabio Rocha Fernandes [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1677-55382011000500005
http://repositorio.unifesp.br/handle/11600/33991
Resumo: Purpose: Neuroendocrine carcinomas (NEC) of the prostate are rare, with only a few series hitherto reported. the objective of this study was to assess in a single institution the clinical and morphologic characteristics of neuroendocrine carcinomas diagnosed in needle core biopsies.Materials and Methods: the current study analyses seven cases diagnosed in needle biopsies at a large tertiary regional cancer center from Northeastern Brazil. Two pathologists reviewed specimens retrospectively, and demographic and morphologic characteristics were compared to 458 acinar tumors diagnosed in the same period.Results: There were five small cell carcinomas and two low-grade neuroendocrine carcinomas (carcinoid). NEC were associated with an acinar component in 5/7 cases and the Gleason score of the acinar component was always > 6. the number of cores involved in prostates with NEC was greater (65% compared to 24% of acinar tumors, p < 0.05). the mean PSA at diagnosis was 417.7 (range 5.7-1593, SD 218.3), compared to 100.5 (p = 0.1) of acinar tumors (range 0.3-8545, SD 22.7). Prostates harboring NEC were bigger (p < 0.001, mean volume 240 mL vs. 53 mL of acinar tumors). Treatment of NEC included palliative surgery, chemotherapy, and hormonal therapy.Conclusions: NEC of the prostate is rare and often associated with a high-grade acinar component. Prostates with NEC tend to be larger and involve a greater number of cores than acinar tumors. PSA at diagnosis does not seem to predict the presence of NE tumors in needle biopsy.
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spelling Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer centerprostateneoplasmscarcinoid tumorneuroendocrine tumortreatment outcomePurpose: Neuroendocrine carcinomas (NEC) of the prostate are rare, with only a few series hitherto reported. the objective of this study was to assess in a single institution the clinical and morphologic characteristics of neuroendocrine carcinomas diagnosed in needle core biopsies.Materials and Methods: the current study analyses seven cases diagnosed in needle biopsies at a large tertiary regional cancer center from Northeastern Brazil. Two pathologists reviewed specimens retrospectively, and demographic and morphologic characteristics were compared to 458 acinar tumors diagnosed in the same period.Results: There were five small cell carcinomas and two low-grade neuroendocrine carcinomas (carcinoid). NEC were associated with an acinar component in 5/7 cases and the Gleason score of the acinar component was always > 6. the number of cores involved in prostates with NEC was greater (65% compared to 24% of acinar tumors, p < 0.05). the mean PSA at diagnosis was 417.7 (range 5.7-1593, SD 218.3), compared to 100.5 (p = 0.1) of acinar tumors (range 0.3-8545, SD 22.7). Prostates harboring NEC were bigger (p < 0.001, mean volume 240 mL vs. 53 mL of acinar tumors). Treatment of NEC included palliative surgery, chemotherapy, and hormonal therapy.Conclusions: NEC of the prostate is rare and often associated with a high-grade acinar component. Prostates with NEC tend to be larger and involve a greater number of cores than acinar tumors. PSA at diagnosis does not seem to predict the presence of NE tumors in needle biopsy.Hosp Canc, Inst Canc Ceara, BR-60430230 Fortaleza, Ceara, BrazilEscola Paulista Med, BR-04023 São Paulo, BrazilEscola Paulista Med, BR-04023 São Paulo, BrazilWeb of ScienceBrazilian Soc UrolHosp CancUniversidade Federal de São Paulo (UNIFESP)Lima, M. V. A.Nogueira, C.Oliveira, J. A. A.Muniz Neto, F. J.Franco, M. [UNIFESP]Tavora, Fabio Rocha Fernandes [UNIFESP]2016-01-24T14:17:08Z2016-01-24T14:17:08Z2011-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion598-604http://dx.doi.org/10.1590/S1677-55382011000500005International Braz J Urol. Rio de Janeiro: Brazilian Soc Urol, v. 37, n. 5, p. 598-604, 2011.10.1590/S1677-553820110005000051677-5538S1677-55382011000500005http://repositorio.unifesp.br/handle/11600/33991WOS:000299854100005engInternational Braz J Urolinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2022-11-03T10:40:48Zoai:repositorio.unifesp.br/:11600/33991Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652022-11-03T10:40:48Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center
title Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center
spellingShingle Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center
Lima, M. V. A.
prostate
neoplasms
carcinoid tumor
neuroendocrine tumor
treatment outcome
title_short Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center
title_full Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center
title_fullStr Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center
title_full_unstemmed Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center
title_sort Prostatic carcinomas with neuroendocrine differentiation diagnosed in needle biopsies, a morphologic study of 7 cases among 465 sequential biopsies in a tertiary cancer center
author Lima, M. V. A.
author_facet Lima, M. V. A.
Nogueira, C.
Oliveira, J. A. A.
Muniz Neto, F. J.
Franco, M. [UNIFESP]
Tavora, Fabio Rocha Fernandes [UNIFESP]
author_role author
author2 Nogueira, C.
Oliveira, J. A. A.
Muniz Neto, F. J.
Franco, M. [UNIFESP]
Tavora, Fabio Rocha Fernandes [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Hosp Canc
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Lima, M. V. A.
Nogueira, C.
Oliveira, J. A. A.
Muniz Neto, F. J.
Franco, M. [UNIFESP]
Tavora, Fabio Rocha Fernandes [UNIFESP]
dc.subject.por.fl_str_mv prostate
neoplasms
carcinoid tumor
neuroendocrine tumor
treatment outcome
topic prostate
neoplasms
carcinoid tumor
neuroendocrine tumor
treatment outcome
description Purpose: Neuroendocrine carcinomas (NEC) of the prostate are rare, with only a few series hitherto reported. the objective of this study was to assess in a single institution the clinical and morphologic characteristics of neuroendocrine carcinomas diagnosed in needle core biopsies.Materials and Methods: the current study analyses seven cases diagnosed in needle biopsies at a large tertiary regional cancer center from Northeastern Brazil. Two pathologists reviewed specimens retrospectively, and demographic and morphologic characteristics were compared to 458 acinar tumors diagnosed in the same period.Results: There were five small cell carcinomas and two low-grade neuroendocrine carcinomas (carcinoid). NEC were associated with an acinar component in 5/7 cases and the Gleason score of the acinar component was always > 6. the number of cores involved in prostates with NEC was greater (65% compared to 24% of acinar tumors, p < 0.05). the mean PSA at diagnosis was 417.7 (range 5.7-1593, SD 218.3), compared to 100.5 (p = 0.1) of acinar tumors (range 0.3-8545, SD 22.7). Prostates harboring NEC were bigger (p < 0.001, mean volume 240 mL vs. 53 mL of acinar tumors). Treatment of NEC included palliative surgery, chemotherapy, and hormonal therapy.Conclusions: NEC of the prostate is rare and often associated with a high-grade acinar component. Prostates with NEC tend to be larger and involve a greater number of cores than acinar tumors. PSA at diagnosis does not seem to predict the presence of NE tumors in needle biopsy.
publishDate 2011
dc.date.none.fl_str_mv 2011-09-01
2016-01-24T14:17:08Z
2016-01-24T14:17:08Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1677-55382011000500005
International Braz J Urol. Rio de Janeiro: Brazilian Soc Urol, v. 37, n. 5, p. 598-604, 2011.
10.1590/S1677-55382011000500005
1677-5538
S1677-55382011000500005
http://repositorio.unifesp.br/handle/11600/33991
WOS:000299854100005
url http://dx.doi.org/10.1590/S1677-55382011000500005
http://repositorio.unifesp.br/handle/11600/33991
identifier_str_mv International Braz J Urol. Rio de Janeiro: Brazilian Soc Urol, v. 37, n. 5, p. 598-604, 2011.
10.1590/S1677-55382011000500005
1677-5538
S1677-55382011000500005
WOS:000299854100005
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv International Braz J Urol
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 598-604
dc.publisher.none.fl_str_mv Brazilian Soc Urol
publisher.none.fl_str_mv Brazilian Soc Urol
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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