Study of advanced rheumatoid arthritis

• Autor(a) principal: Carvalho, Carolina Da Silva
• Data de Publicação: 2014
• Outros Autores: Andrade, Luiz Eduardo Coelho [UNIFESP], Keusseyan, Silene Peres [UNIFESP], Rangel, João Lucas, Ferreira-strixino, Juliana, Martin, Airton Abrahão, Raniero, Leandro José
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.4322/rbeb.2014.004; http://repositorio.unifesp.br/handle/11600/8251
• topic: FTIR spectroscopy; Human serum; Rheumatoid arthritis; Partial Least Square

INTRODUCTION: Rheumatic diseases are considered public health problems affecting millions of people worldwide resulting in high and rising health-care costs. In this work, Fourier Transform Infrared spectroscopy associated to Partial Least Square regression (PLS) analysis was used to diagnose rheumatoid arthritis (RA) from human serum. METHODS: The sera of 94 individuals were collected, which included 47 from rheumatic patients and 47 from healthy individuals. The results from PLS analysis were compared to standard clinical trials such as anti-citrullinated peptide antibodies, C- Reactive protein, and Rheumatoid factor. RESULTS: For clinical diagnosis, the anti-citrullinated peptide antibodies of second generation proved to be the most specific to diagnosis rheumatoid arthritis even after long periods of drug therapy. CONCLUSIONS: The qualitative PLS analysis has shown higher values of IgM of RA group, but the difference was very small. The RA patients were under medication, which interfered with the IgM concentration.