Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
dARK ID: | ark:/48912/0013000017p68 |
DOI: | 10.1016/j.nut.2012.05.015 |
Texto Completo: | http://dx.doi.org/10.1016/j.nut.2012.05.015 http://repositorio.unifesp.br/handle/11600/35653 |
Resumo: | Objective: To evaluate homocysteine and total cysteine levels in prepubertal children and to determine the association between these levels and obesity, increased waist circumference, glucose levels, and lipid profile alterations.Methods: Using a cross-sectional study, 677 prepubertal students 6 to 11 y old were assessed. the weight, height, and waist circumference of the students were measured. Laboratory analyses included triacylglycerols, total cholesterol and its fractions, glucose, vitamin B12, folate, homocysteine, and cysteine. Chi-square tests and logistic regression (forward-stepwise) were used for statistical analysis; the significance level was set at 5%.Results: the median age of the students was 8.9 y (6.5-11.5), and the prevalences of overweight and obesity were 90 in 677 (13.3%) and 81 in 677 (12.0%). respectively. An increase in waist circumference was observed in 180 of 677 children (26.6%). Inadequate levels of low-density lipoprotein cholesterol, triacylglycerols, and high-density lipoprotein cholesterol were found in 95 (14.0%), 129 (19.1%), and 179 (26.4%) of the 677 students, respectively. the median homocysteine and total cysteine plasma levels were 5.6 mu mol/L (0.1-11.7) and 365.7 mu mol/L (191.5-589.2), respectively. A multivariate analysis showed that children with a waist circumference above the 90th percentile (7.3 mu mol/L) were 2.4 times (95% confidence interval 1.4-4.0) more likely to have increased homocysteine levels and that children with increased waist circumferences and those with high low-density lipoprotein cholesterol levels were 2.7 (95% confidence interval 1.6-4.6) and 2.1 (95% confidence interval 1.1-4.0) times more likely, respectively, to have total cysteine levels above the 90th percentile (445.0 mu mol/L).Conclusion: the association of abdominal obesity in prepuberty with levels of homocysteine and cysteine found in this study of a prepubertal population could be an early and independent predictor of cardiovascular risk. (C) 2013 Elsevier Inc. All rights reserved. |
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Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profileHomocysteineCysteineWaist circumferenceObesityChildrenObjective: To evaluate homocysteine and total cysteine levels in prepubertal children and to determine the association between these levels and obesity, increased waist circumference, glucose levels, and lipid profile alterations.Methods: Using a cross-sectional study, 677 prepubertal students 6 to 11 y old were assessed. the weight, height, and waist circumference of the students were measured. Laboratory analyses included triacylglycerols, total cholesterol and its fractions, glucose, vitamin B12, folate, homocysteine, and cysteine. Chi-square tests and logistic regression (forward-stepwise) were used for statistical analysis; the significance level was set at 5%.Results: the median age of the students was 8.9 y (6.5-11.5), and the prevalences of overweight and obesity were 90 in 677 (13.3%) and 81 in 677 (12.0%). respectively. An increase in waist circumference was observed in 180 of 677 children (26.6%). Inadequate levels of low-density lipoprotein cholesterol, triacylglycerols, and high-density lipoprotein cholesterol were found in 95 (14.0%), 129 (19.1%), and 179 (26.4%) of the 677 students, respectively. the median homocysteine and total cysteine plasma levels were 5.6 mu mol/L (0.1-11.7) and 365.7 mu mol/L (191.5-589.2), respectively. A multivariate analysis showed that children with a waist circumference above the 90th percentile (7.3 mu mol/L) were 2.4 times (95% confidence interval 1.4-4.0) more likely to have increased homocysteine levels and that children with increased waist circumferences and those with high low-density lipoprotein cholesterol levels were 2.7 (95% confidence interval 1.6-4.6) and 2.1 (95% confidence interval 1.1-4.0) times more likely, respectively, to have total cysteine levels above the 90th percentile (445.0 mu mol/L).Conclusion: the association of abdominal obesity in prepuberty with levels of homocysteine and cysteine found in this study of a prepubertal population could be an early and independent predictor of cardiovascular risk. (C) 2013 Elsevier Inc. All rights reserved.Fac Med ABC, Dept Pediat, São Paulo, BrazilFac Med ABC, Curso Ciencias Farmaceut, São Paulo, BrazilFac Med ABC, Disciplina Bioquim, São Paulo, BrazilUniversidade Federal de São Paulo, Lab Erros Inatos Metab, São Paulo, BrazilUniversidade Federal de São Paulo, Lab Erros Inatos Metab, São Paulo, BrazilWeb of ScienceElsevier B.V.Universidade Federal de São Paulo (UNIFESP)Fac Med ABCSilva, Narjara Pereira daSuano de Souza, Fabiola IsabelPendezza, Aline IfangerAffonso Fonseca, Fernando LuizHix, SoniaOliveira, Allan Chiaratti [UNIFESP]Sarni, Roseli Oselka Saccardo [UNIFESP]D'Almeida, Vania [UNIFESP]2016-01-24T14:30:49Z2016-01-24T14:30:49Z2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion166-171http://dx.doi.org/10.1016/j.nut.2012.05.015Nutrition. New York: Elsevier B.V., v. 29, n. 1, p. 166-171, 2013.10.1016/j.nut.2012.05.0150899-9007http://repositorio.unifesp.br/handle/11600/35653WOS:000313138200027ark:/48912/0013000017p68engNutritioninfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-10-10T10:29:58Zoai:repositorio.unifesp.br/:11600/35653Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T21:02:10.207860Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile |
title |
Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile |
spellingShingle |
Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile Silva, Narjara Pereira da Homocysteine Cysteine Waist circumference Obesity Children Silva, Narjara Pereira da Homocysteine Cysteine Waist circumference Obesity Children |
title_short |
Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile |
title_full |
Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile |
title_fullStr |
Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile |
title_full_unstemmed |
Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile |
title_sort |
Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile |
author |
Silva, Narjara Pereira da |
author_facet |
Silva, Narjara Pereira da Silva, Narjara Pereira da Suano de Souza, Fabiola Isabel Pendezza, Aline Ifanger Affonso Fonseca, Fernando Luiz Hix, Sonia Oliveira, Allan Chiaratti [UNIFESP] Sarni, Roseli Oselka Saccardo [UNIFESP] D'Almeida, Vania [UNIFESP] Suano de Souza, Fabiola Isabel Pendezza, Aline Ifanger Affonso Fonseca, Fernando Luiz Hix, Sonia Oliveira, Allan Chiaratti [UNIFESP] Sarni, Roseli Oselka Saccardo [UNIFESP] D'Almeida, Vania [UNIFESP] |
author_role |
author |
author2 |
Suano de Souza, Fabiola Isabel Pendezza, Aline Ifanger Affonso Fonseca, Fernando Luiz Hix, Sonia Oliveira, Allan Chiaratti [UNIFESP] Sarni, Roseli Oselka Saccardo [UNIFESP] D'Almeida, Vania [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Fac Med ABC |
dc.contributor.author.fl_str_mv |
Silva, Narjara Pereira da Suano de Souza, Fabiola Isabel Pendezza, Aline Ifanger Affonso Fonseca, Fernando Luiz Hix, Sonia Oliveira, Allan Chiaratti [UNIFESP] Sarni, Roseli Oselka Saccardo [UNIFESP] D'Almeida, Vania [UNIFESP] |
dc.subject.por.fl_str_mv |
Homocysteine Cysteine Waist circumference Obesity Children |
topic |
Homocysteine Cysteine Waist circumference Obesity Children |
description |
Objective: To evaluate homocysteine and total cysteine levels in prepubertal children and to determine the association between these levels and obesity, increased waist circumference, glucose levels, and lipid profile alterations.Methods: Using a cross-sectional study, 677 prepubertal students 6 to 11 y old were assessed. the weight, height, and waist circumference of the students were measured. Laboratory analyses included triacylglycerols, total cholesterol and its fractions, glucose, vitamin B12, folate, homocysteine, and cysteine. Chi-square tests and logistic regression (forward-stepwise) were used for statistical analysis; the significance level was set at 5%.Results: the median age of the students was 8.9 y (6.5-11.5), and the prevalences of overweight and obesity were 90 in 677 (13.3%) and 81 in 677 (12.0%). respectively. An increase in waist circumference was observed in 180 of 677 children (26.6%). Inadequate levels of low-density lipoprotein cholesterol, triacylglycerols, and high-density lipoprotein cholesterol were found in 95 (14.0%), 129 (19.1%), and 179 (26.4%) of the 677 students, respectively. the median homocysteine and total cysteine plasma levels were 5.6 mu mol/L (0.1-11.7) and 365.7 mu mol/L (191.5-589.2), respectively. A multivariate analysis showed that children with a waist circumference above the 90th percentile (7.3 mu mol/L) were 2.4 times (95% confidence interval 1.4-4.0) more likely to have increased homocysteine levels and that children with increased waist circumferences and those with high low-density lipoprotein cholesterol levels were 2.7 (95% confidence interval 1.6-4.6) and 2.1 (95% confidence interval 1.1-4.0) times more likely, respectively, to have total cysteine levels above the 90th percentile (445.0 mu mol/L).Conclusion: the association of abdominal obesity in prepuberty with levels of homocysteine and cysteine found in this study of a prepubertal population could be an early and independent predictor of cardiovascular risk. (C) 2013 Elsevier Inc. All rights reserved. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-01 2016-01-24T14:30:49Z 2016-01-24T14:30:49Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.nut.2012.05.015 Nutrition. New York: Elsevier B.V., v. 29, n. 1, p. 166-171, 2013. 10.1016/j.nut.2012.05.015 0899-9007 http://repositorio.unifesp.br/handle/11600/35653 WOS:000313138200027 |
dc.identifier.dark.fl_str_mv |
ark:/48912/0013000017p68 |
url |
http://dx.doi.org/10.1016/j.nut.2012.05.015 http://repositorio.unifesp.br/handle/11600/35653 |
identifier_str_mv |
Nutrition. New York: Elsevier B.V., v. 29, n. 1, p. 166-171, 2013. 10.1016/j.nut.2012.05.015 0899-9007 WOS:000313138200027 ark:/48912/0013000017p68 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Nutrition |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
dc.format.none.fl_str_mv |
166-171 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1822251971076161536 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.nut.2012.05.015 |