Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile

Detalhes bibliográficos
Autor(a) principal: Silva, Narjara Pereira da
Data de Publicação: 2013
Outros Autores: Suano de Souza, Fabiola Isabel, Pendezza, Aline Ifanger, Affonso Fonseca, Fernando Luiz, Hix, Sonia, Oliveira, Allan Chiaratti [UNIFESP], Sarni, Roseli Oselka Saccardo [UNIFESP], D'Almeida, Vania [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/0013000017p68
DOI: 10.1016/j.nut.2012.05.015
Texto Completo: http://dx.doi.org/10.1016/j.nut.2012.05.015
http://repositorio.unifesp.br/handle/11600/35653
Resumo: Objective: To evaluate homocysteine and total cysteine levels in prepubertal children and to determine the association between these levels and obesity, increased waist circumference, glucose levels, and lipid profile alterations.Methods: Using a cross-sectional study, 677 prepubertal students 6 to 11 y old were assessed. the weight, height, and waist circumference of the students were measured. Laboratory analyses included triacylglycerols, total cholesterol and its fractions, glucose, vitamin B12, folate, homocysteine, and cysteine. Chi-square tests and logistic regression (forward-stepwise) were used for statistical analysis; the significance level was set at 5%.Results: the median age of the students was 8.9 y (6.5-11.5), and the prevalences of overweight and obesity were 90 in 677 (13.3%) and 81 in 677 (12.0%). respectively. An increase in waist circumference was observed in 180 of 677 children (26.6%). Inadequate levels of low-density lipoprotein cholesterol, triacylglycerols, and high-density lipoprotein cholesterol were found in 95 (14.0%), 129 (19.1%), and 179 (26.4%) of the 677 students, respectively. the median homocysteine and total cysteine plasma levels were 5.6 mu mol/L (0.1-11.7) and 365.7 mu mol/L (191.5-589.2), respectively. A multivariate analysis showed that children with a waist circumference above the 90th percentile (7.3 mu mol/L) were 2.4 times (95% confidence interval 1.4-4.0) more likely to have increased homocysteine levels and that children with increased waist circumferences and those with high low-density lipoprotein cholesterol levels were 2.7 (95% confidence interval 1.6-4.6) and 2.1 (95% confidence interval 1.1-4.0) times more likely, respectively, to have total cysteine levels above the 90th percentile (445.0 mu mol/L).Conclusion: the association of abdominal obesity in prepuberty with levels of homocysteine and cysteine found in this study of a prepubertal population could be an early and independent predictor of cardiovascular risk. (C) 2013 Elsevier Inc. All rights reserved.
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spelling Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profileHomocysteineCysteineWaist circumferenceObesityChildrenObjective: To evaluate homocysteine and total cysteine levels in prepubertal children and to determine the association between these levels and obesity, increased waist circumference, glucose levels, and lipid profile alterations.Methods: Using a cross-sectional study, 677 prepubertal students 6 to 11 y old were assessed. the weight, height, and waist circumference of the students were measured. Laboratory analyses included triacylglycerols, total cholesterol and its fractions, glucose, vitamin B12, folate, homocysteine, and cysteine. Chi-square tests and logistic regression (forward-stepwise) were used for statistical analysis; the significance level was set at 5%.Results: the median age of the students was 8.9 y (6.5-11.5), and the prevalences of overweight and obesity were 90 in 677 (13.3%) and 81 in 677 (12.0%). respectively. An increase in waist circumference was observed in 180 of 677 children (26.6%). Inadequate levels of low-density lipoprotein cholesterol, triacylglycerols, and high-density lipoprotein cholesterol were found in 95 (14.0%), 129 (19.1%), and 179 (26.4%) of the 677 students, respectively. the median homocysteine and total cysteine plasma levels were 5.6 mu mol/L (0.1-11.7) and 365.7 mu mol/L (191.5-589.2), respectively. A multivariate analysis showed that children with a waist circumference above the 90th percentile (7.3 mu mol/L) were 2.4 times (95% confidence interval 1.4-4.0) more likely to have increased homocysteine levels and that children with increased waist circumferences and those with high low-density lipoprotein cholesterol levels were 2.7 (95% confidence interval 1.6-4.6) and 2.1 (95% confidence interval 1.1-4.0) times more likely, respectively, to have total cysteine levels above the 90th percentile (445.0 mu mol/L).Conclusion: the association of abdominal obesity in prepuberty with levels of homocysteine and cysteine found in this study of a prepubertal population could be an early and independent predictor of cardiovascular risk. (C) 2013 Elsevier Inc. All rights reserved.Fac Med ABC, Dept Pediat, São Paulo, BrazilFac Med ABC, Curso Ciencias Farmaceut, São Paulo, BrazilFac Med ABC, Disciplina Bioquim, São Paulo, BrazilUniversidade Federal de São Paulo, Lab Erros Inatos Metab, São Paulo, BrazilUniversidade Federal de São Paulo, Lab Erros Inatos Metab, São Paulo, BrazilWeb of ScienceElsevier B.V.Universidade Federal de São Paulo (UNIFESP)Fac Med ABCSilva, Narjara Pereira daSuano de Souza, Fabiola IsabelPendezza, Aline IfangerAffonso Fonseca, Fernando LuizHix, SoniaOliveira, Allan Chiaratti [UNIFESP]Sarni, Roseli Oselka Saccardo [UNIFESP]D'Almeida, Vania [UNIFESP]2016-01-24T14:30:49Z2016-01-24T14:30:49Z2013-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion166-171http://dx.doi.org/10.1016/j.nut.2012.05.015Nutrition. New York: Elsevier B.V., v. 29, n. 1, p. 166-171, 2013.10.1016/j.nut.2012.05.0150899-9007http://repositorio.unifesp.br/handle/11600/35653WOS:000313138200027ark:/48912/0013000017p68engNutritioninfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-10-10T10:29:58Zoai:repositorio.unifesp.br/:11600/35653Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T21:02:10.207860Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile
title Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile
spellingShingle Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile
Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile
Silva, Narjara Pereira da
Homocysteine
Cysteine
Waist circumference
Obesity
Children
Silva, Narjara Pereira da
Homocysteine
Cysteine
Waist circumference
Obesity
Children
title_short Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile
title_full Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile
title_fullStr Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile
Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile
title_full_unstemmed Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile
Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile
title_sort Homocysteine and cysteine levels in prepubertal children: Association with waist circumference and lipid profile
author Silva, Narjara Pereira da
author_facet Silva, Narjara Pereira da
Silva, Narjara Pereira da
Suano de Souza, Fabiola Isabel
Pendezza, Aline Ifanger
Affonso Fonseca, Fernando Luiz
Hix, Sonia
Oliveira, Allan Chiaratti [UNIFESP]
Sarni, Roseli Oselka Saccardo [UNIFESP]
D'Almeida, Vania [UNIFESP]
Suano de Souza, Fabiola Isabel
Pendezza, Aline Ifanger
Affonso Fonseca, Fernando Luiz
Hix, Sonia
Oliveira, Allan Chiaratti [UNIFESP]
Sarni, Roseli Oselka Saccardo [UNIFESP]
D'Almeida, Vania [UNIFESP]
author_role author
author2 Suano de Souza, Fabiola Isabel
Pendezza, Aline Ifanger
Affonso Fonseca, Fernando Luiz
Hix, Sonia
Oliveira, Allan Chiaratti [UNIFESP]
Sarni, Roseli Oselka Saccardo [UNIFESP]
D'Almeida, Vania [UNIFESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Fac Med ABC
dc.contributor.author.fl_str_mv Silva, Narjara Pereira da
Suano de Souza, Fabiola Isabel
Pendezza, Aline Ifanger
Affonso Fonseca, Fernando Luiz
Hix, Sonia
Oliveira, Allan Chiaratti [UNIFESP]
Sarni, Roseli Oselka Saccardo [UNIFESP]
D'Almeida, Vania [UNIFESP]
dc.subject.por.fl_str_mv Homocysteine
Cysteine
Waist circumference
Obesity
Children
topic Homocysteine
Cysteine
Waist circumference
Obesity
Children
description Objective: To evaluate homocysteine and total cysteine levels in prepubertal children and to determine the association between these levels and obesity, increased waist circumference, glucose levels, and lipid profile alterations.Methods: Using a cross-sectional study, 677 prepubertal students 6 to 11 y old were assessed. the weight, height, and waist circumference of the students were measured. Laboratory analyses included triacylglycerols, total cholesterol and its fractions, glucose, vitamin B12, folate, homocysteine, and cysteine. Chi-square tests and logistic regression (forward-stepwise) were used for statistical analysis; the significance level was set at 5%.Results: the median age of the students was 8.9 y (6.5-11.5), and the prevalences of overweight and obesity were 90 in 677 (13.3%) and 81 in 677 (12.0%). respectively. An increase in waist circumference was observed in 180 of 677 children (26.6%). Inadequate levels of low-density lipoprotein cholesterol, triacylglycerols, and high-density lipoprotein cholesterol were found in 95 (14.0%), 129 (19.1%), and 179 (26.4%) of the 677 students, respectively. the median homocysteine and total cysteine plasma levels were 5.6 mu mol/L (0.1-11.7) and 365.7 mu mol/L (191.5-589.2), respectively. A multivariate analysis showed that children with a waist circumference above the 90th percentile (7.3 mu mol/L) were 2.4 times (95% confidence interval 1.4-4.0) more likely to have increased homocysteine levels and that children with increased waist circumferences and those with high low-density lipoprotein cholesterol levels were 2.7 (95% confidence interval 1.6-4.6) and 2.1 (95% confidence interval 1.1-4.0) times more likely, respectively, to have total cysteine levels above the 90th percentile (445.0 mu mol/L).Conclusion: the association of abdominal obesity in prepuberty with levels of homocysteine and cysteine found in this study of a prepubertal population could be an early and independent predictor of cardiovascular risk. (C) 2013 Elsevier Inc. All rights reserved.
publishDate 2013
dc.date.none.fl_str_mv 2013-01-01
2016-01-24T14:30:49Z
2016-01-24T14:30:49Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.nut.2012.05.015
Nutrition. New York: Elsevier B.V., v. 29, n. 1, p. 166-171, 2013.
10.1016/j.nut.2012.05.015
0899-9007
http://repositorio.unifesp.br/handle/11600/35653
WOS:000313138200027
dc.identifier.dark.fl_str_mv ark:/48912/0013000017p68
url http://dx.doi.org/10.1016/j.nut.2012.05.015
http://repositorio.unifesp.br/handle/11600/35653
identifier_str_mv Nutrition. New York: Elsevier B.V., v. 29, n. 1, p. 166-171, 2013.
10.1016/j.nut.2012.05.015
0899-9007
WOS:000313138200027
ark:/48912/0013000017p68
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Nutrition
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
eu_rights_str_mv openAccess
rights_invalid_str_mv http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.format.none.fl_str_mv 166-171
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1822251971076161536
dc.identifier.doi.none.fl_str_mv 10.1016/j.nut.2012.05.015