Efeito do D-alfa-Tocoferol sobre a função renal de ratos hipertensos

• Autor(a) principal: Pletiskaitz, Thaís Maria da Fonseca [UNIFESP]
• Data de Publicação: 2006
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://repositorio.unifesp.br/handle/11600/9369
• topic: Hipertensão; Lesão Renal; D-alfa-tocoferol; Rim/ Fisiologia

Objectives: Evaluate whether or not D-alpha-Tocopherol has a protective effect on renal morphology and function in hypertensive rats. Methods: Wistar Kyoto rats (control) or SHR (hypertensive), male, 2 month old, were distributed in 4 experimental groups: C – control treated with mineral oil; CT – control treated with D-alpha-Tocopherol (CT); H – hypertensive treated with mineral oil; and HT – hypertensive treated with D-alpha-Tocopherol. CT e HT rats received D-alpha- Tocopherol (36mg/kg) in every other day, for 60 days. The arterial blood pressure was measured each 15 days. Kidney morphology and function were studied when the animals completed 4 months old. Results: In HT rats the blood pressure was smaller than in H rats but was increased in comparison to C rats. H rats presented lower values of GFR and RPF than C. Hypertensive rats treated with D-alpha- Tocopherol showed values of GFR and RPF similar to the control values. The urinary flow, the excreted amount of sodium and the excreted amount of potassium in H rats was smaller than in C rats but in HT these parameters were similar to C. In rats H the renal vascular resistance was increased in comparison to rats C. Hypertensive rats treated with D-alpha-Tocopherol showed values of renal vascular resistance similar to the control values. Morphological analysis showed that hypertensive rats presented glomerular hypertrophy and enlarged interlobular artery’s wall. Conclusions: The D-alpha-Tocopherol treatment prevented glomerular and vascular hypertrophy. It also caused a decrease in arterial blood pressure and increased the excreted amount of sodium and potassium. The D-alpha-Tocopherol treatment improved renal and vascular function. These results suggest that D-alpha-Tocopherol has a beneficial effect on renal morphology and function of hypertensive rats.