Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects?

Detalhes bibliográficos
Autor(a) principal: Mattei, Rita [UNIFESP]
Data de Publicação: 2011
Outros Autores: Polotow, Tatiana Geraldo, Vardaris, Cristina Vasconcellos, Guerra, Beatriz Alves, Leite, Jose Roberto [UNIFESP], Otton, Rosemari, Barros, Marcelo Paes de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1016/j.pbb.2011.05.009
http://repositorio.unifesp.br/handle/11600/33974
Resumo: The habitual consumption of marine fish is largely associated to human mental health. Fish oil is particularly rich in n-3 polyunsaturated fatty acids that are known to play a role. in several neuronal and cognitive functions. in parallel, the orange-pinkish carotenoid astaxanthin (ASTA) is found in salmon and displays important antioxidant and anti-inflammatory properties. Many neuronal dysfunctions and anomalous psychotic behavior (such as anxiety, depression, etc.) have been strongly related to the higher sensitivity of cathecolaminergic brain regions to oxidative stress. Thus, the aim of this work was to study the combined effect of ASTA and fish oil on the redox status in plasma and in the monoaminergic-rich anterior forebrain region of Wistar rats with possible correlations with the anxiolytic behavior. Upon fish oil supplementation, the downregulation of superoxide dismutase and catalase activities combined to increased free iron content resulted in higher levels of lipid and protein oxidation in the anterior forebrain of animals. Such harmful oxidative modifications were hindered by concomitant supplementation with ASTA despite ASIA-related antioxidant protection was mainly observed in plasma. Although it is clear that ASTA properly crosses the brain-blood barrier, our data also address a possible indirect role of ASTA in restoring basal oxidative conditions in anterior forebrain of animals: by improving GSH-based antioxidant capacity of plasma. Preliminary anxiolytic tests performed in the elevated plus maze are in alignment with our biochemical observations. (C) 2011 Elsevier Inc. All rights reserved.
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spelling Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects?AstaxanthinOmega-3AnxietyFish oilAntioxidantBrainCarotenoidElevated plus mazeThe habitual consumption of marine fish is largely associated to human mental health. Fish oil is particularly rich in n-3 polyunsaturated fatty acids that are known to play a role. in several neuronal and cognitive functions. in parallel, the orange-pinkish carotenoid astaxanthin (ASTA) is found in salmon and displays important antioxidant and anti-inflammatory properties. Many neuronal dysfunctions and anomalous psychotic behavior (such as anxiety, depression, etc.) have been strongly related to the higher sensitivity of cathecolaminergic brain regions to oxidative stress. Thus, the aim of this work was to study the combined effect of ASTA and fish oil on the redox status in plasma and in the monoaminergic-rich anterior forebrain region of Wistar rats with possible correlations with the anxiolytic behavior. Upon fish oil supplementation, the downregulation of superoxide dismutase and catalase activities combined to increased free iron content resulted in higher levels of lipid and protein oxidation in the anterior forebrain of animals. Such harmful oxidative modifications were hindered by concomitant supplementation with ASTA despite ASIA-related antioxidant protection was mainly observed in plasma. Although it is clear that ASTA properly crosses the brain-blood barrier, our data also address a possible indirect role of ASTA in restoring basal oxidative conditions in anterior forebrain of animals: by improving GSH-based antioxidant capacity of plasma. Preliminary anxiolytic tests performed in the elevated plus maze are in alignment with our biochemical observations. (C) 2011 Elsevier Inc. All rights reserved.Univ Cruzeiro Sul, CBS, Postgrad Program, BR-08060070 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, BrazilUniv Cruzeiro Sul, Inst Phys Act & Sport Sci, Postgrad Program, BR-01506000 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)International Foundation for ScienceUniversidade Cruzeiro do SulAssociacao Fundo de Incentivo a Psicofarmacologia (AFIP)Departamento de Psicobiologia, UNIFESPFAPESP: 2007/03334-6FAPESP: 2009/12342-8FAPESP: 2002/09405-9International Foundation for Science: F/3816-1Elsevier B.V.Univ Cruzeiro SulUniversidade Federal de São Paulo (UNIFESP)Mattei, Rita [UNIFESP]Polotow, Tatiana GeraldoVardaris, Cristina VasconcellosGuerra, Beatriz AlvesLeite, Jose Roberto [UNIFESP]Otton, RosemariBarros, Marcelo Paes de2016-01-24T14:17:07Z2016-01-24T14:17:07Z2011-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion349-355application/pdfhttp://dx.doi.org/10.1016/j.pbb.2011.05.009Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 99, n. 3, p. 349-355, 2011.10.1016/j.pbb.2011.05.009WOS000293371100009.pdf0091-3057http://repositorio.unifesp.br/handle/11600/33974WOS:000293371100009engPharmacology Biochemistry and Behaviorinfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-08T07:43:53Zoai:repositorio.unifesp.br/:11600/33974Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-08T07:43:53Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects?
title Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects?
spellingShingle Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects?
Mattei, Rita [UNIFESP]
Astaxanthin
Omega-3
Anxiety
Fish oil
Antioxidant
Brain
Carotenoid
Elevated plus maze
title_short Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects?
title_full Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects?
title_fullStr Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects?
title_full_unstemmed Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects?
title_sort Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects?
author Mattei, Rita [UNIFESP]
author_facet Mattei, Rita [UNIFESP]
Polotow, Tatiana Geraldo
Vardaris, Cristina Vasconcellos
Guerra, Beatriz Alves
Leite, Jose Roberto [UNIFESP]
Otton, Rosemari
Barros, Marcelo Paes de
author_role author
author2 Polotow, Tatiana Geraldo
Vardaris, Cristina Vasconcellos
Guerra, Beatriz Alves
Leite, Jose Roberto [UNIFESP]
Otton, Rosemari
Barros, Marcelo Paes de
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Univ Cruzeiro Sul
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Mattei, Rita [UNIFESP]
Polotow, Tatiana Geraldo
Vardaris, Cristina Vasconcellos
Guerra, Beatriz Alves
Leite, Jose Roberto [UNIFESP]
Otton, Rosemari
Barros, Marcelo Paes de
dc.subject.por.fl_str_mv Astaxanthin
Omega-3
Anxiety
Fish oil
Antioxidant
Brain
Carotenoid
Elevated plus maze
topic Astaxanthin
Omega-3
Anxiety
Fish oil
Antioxidant
Brain
Carotenoid
Elevated plus maze
description The habitual consumption of marine fish is largely associated to human mental health. Fish oil is particularly rich in n-3 polyunsaturated fatty acids that are known to play a role. in several neuronal and cognitive functions. in parallel, the orange-pinkish carotenoid astaxanthin (ASTA) is found in salmon and displays important antioxidant and anti-inflammatory properties. Many neuronal dysfunctions and anomalous psychotic behavior (such as anxiety, depression, etc.) have been strongly related to the higher sensitivity of cathecolaminergic brain regions to oxidative stress. Thus, the aim of this work was to study the combined effect of ASTA and fish oil on the redox status in plasma and in the monoaminergic-rich anterior forebrain region of Wistar rats with possible correlations with the anxiolytic behavior. Upon fish oil supplementation, the downregulation of superoxide dismutase and catalase activities combined to increased free iron content resulted in higher levels of lipid and protein oxidation in the anterior forebrain of animals. Such harmful oxidative modifications were hindered by concomitant supplementation with ASTA despite ASIA-related antioxidant protection was mainly observed in plasma. Although it is clear that ASTA properly crosses the brain-blood barrier, our data also address a possible indirect role of ASTA in restoring basal oxidative conditions in anterior forebrain of animals: by improving GSH-based antioxidant capacity of plasma. Preliminary anxiolytic tests performed in the elevated plus maze are in alignment with our biochemical observations. (C) 2011 Elsevier Inc. All rights reserved.
publishDate 2011
dc.date.none.fl_str_mv 2011-09-01
2016-01-24T14:17:07Z
2016-01-24T14:17:07Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.pbb.2011.05.009
Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 99, n. 3, p. 349-355, 2011.
10.1016/j.pbb.2011.05.009
WOS000293371100009.pdf
0091-3057
http://repositorio.unifesp.br/handle/11600/33974
WOS:000293371100009
url http://dx.doi.org/10.1016/j.pbb.2011.05.009
http://repositorio.unifesp.br/handle/11600/33974
identifier_str_mv Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 99, n. 3, p. 349-355, 2011.
10.1016/j.pbb.2011.05.009
WOS000293371100009.pdf
0091-3057
WOS:000293371100009
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pharmacology Biochemistry and Behavior
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
eu_rights_str_mv openAccess
rights_invalid_str_mv http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.format.none.fl_str_mv 349-355
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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