Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects?
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1016/j.pbb.2011.05.009 http://repositorio.unifesp.br/handle/11600/33974 |
Resumo: | The habitual consumption of marine fish is largely associated to human mental health. Fish oil is particularly rich in n-3 polyunsaturated fatty acids that are known to play a role. in several neuronal and cognitive functions. in parallel, the orange-pinkish carotenoid astaxanthin (ASTA) is found in salmon and displays important antioxidant and anti-inflammatory properties. Many neuronal dysfunctions and anomalous psychotic behavior (such as anxiety, depression, etc.) have been strongly related to the higher sensitivity of cathecolaminergic brain regions to oxidative stress. Thus, the aim of this work was to study the combined effect of ASTA and fish oil on the redox status in plasma and in the monoaminergic-rich anterior forebrain region of Wistar rats with possible correlations with the anxiolytic behavior. Upon fish oil supplementation, the downregulation of superoxide dismutase and catalase activities combined to increased free iron content resulted in higher levels of lipid and protein oxidation in the anterior forebrain of animals. Such harmful oxidative modifications were hindered by concomitant supplementation with ASTA despite ASIA-related antioxidant protection was mainly observed in plasma. Although it is clear that ASTA properly crosses the brain-blood barrier, our data also address a possible indirect role of ASTA in restoring basal oxidative conditions in anterior forebrain of animals: by improving GSH-based antioxidant capacity of plasma. Preliminary anxiolytic tests performed in the elevated plus maze are in alignment with our biochemical observations. (C) 2011 Elsevier Inc. All rights reserved. |
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Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects?AstaxanthinOmega-3AnxietyFish oilAntioxidantBrainCarotenoidElevated plus mazeThe habitual consumption of marine fish is largely associated to human mental health. Fish oil is particularly rich in n-3 polyunsaturated fatty acids that are known to play a role. in several neuronal and cognitive functions. in parallel, the orange-pinkish carotenoid astaxanthin (ASTA) is found in salmon and displays important antioxidant and anti-inflammatory properties. Many neuronal dysfunctions and anomalous psychotic behavior (such as anxiety, depression, etc.) have been strongly related to the higher sensitivity of cathecolaminergic brain regions to oxidative stress. Thus, the aim of this work was to study the combined effect of ASTA and fish oil on the redox status in plasma and in the monoaminergic-rich anterior forebrain region of Wistar rats with possible correlations with the anxiolytic behavior. Upon fish oil supplementation, the downregulation of superoxide dismutase and catalase activities combined to increased free iron content resulted in higher levels of lipid and protein oxidation in the anterior forebrain of animals. Such harmful oxidative modifications were hindered by concomitant supplementation with ASTA despite ASIA-related antioxidant protection was mainly observed in plasma. Although it is clear that ASTA properly crosses the brain-blood barrier, our data also address a possible indirect role of ASTA in restoring basal oxidative conditions in anterior forebrain of animals: by improving GSH-based antioxidant capacity of plasma. Preliminary anxiolytic tests performed in the elevated plus maze are in alignment with our biochemical observations. (C) 2011 Elsevier Inc. All rights reserved.Univ Cruzeiro Sul, CBS, Postgrad Program, BR-08060070 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, BrazilUniv Cruzeiro Sul, Inst Phys Act & Sport Sci, Postgrad Program, BR-01506000 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, BR-04023062 São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)International Foundation for ScienceUniversidade Cruzeiro do SulAssociacao Fundo de Incentivo a Psicofarmacologia (AFIP)Departamento de Psicobiologia, UNIFESPFAPESP: 2007/03334-6FAPESP: 2009/12342-8FAPESP: 2002/09405-9International Foundation for Science: F/3816-1Elsevier B.V.Univ Cruzeiro SulUniversidade Federal de São Paulo (UNIFESP)Mattei, Rita [UNIFESP]Polotow, Tatiana GeraldoVardaris, Cristina VasconcellosGuerra, Beatriz AlvesLeite, Jose Roberto [UNIFESP]Otton, RosemariBarros, Marcelo Paes de2016-01-24T14:17:07Z2016-01-24T14:17:07Z2011-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion349-355application/pdfhttp://dx.doi.org/10.1016/j.pbb.2011.05.009Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 99, n. 3, p. 349-355, 2011.10.1016/j.pbb.2011.05.009WOS000293371100009.pdf0091-3057http://repositorio.unifesp.br/handle/11600/33974WOS:000293371100009engPharmacology Biochemistry and Behaviorinfo:eu-repo/semantics/openAccesshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-08T07:43:53Zoai:repositorio.unifesp.br/:11600/33974Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-08T07:43:53Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects? |
title |
Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects? |
spellingShingle |
Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects? Mattei, Rita [UNIFESP] Astaxanthin Omega-3 Anxiety Fish oil Antioxidant Brain Carotenoid Elevated plus maze |
title_short |
Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects? |
title_full |
Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects? |
title_fullStr |
Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects? |
title_full_unstemmed |
Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects? |
title_sort |
Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects? |
author |
Mattei, Rita [UNIFESP] |
author_facet |
Mattei, Rita [UNIFESP] Polotow, Tatiana Geraldo Vardaris, Cristina Vasconcellos Guerra, Beatriz Alves Leite, Jose Roberto [UNIFESP] Otton, Rosemari Barros, Marcelo Paes de |
author_role |
author |
author2 |
Polotow, Tatiana Geraldo Vardaris, Cristina Vasconcellos Guerra, Beatriz Alves Leite, Jose Roberto [UNIFESP] Otton, Rosemari Barros, Marcelo Paes de |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Univ Cruzeiro Sul Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Mattei, Rita [UNIFESP] Polotow, Tatiana Geraldo Vardaris, Cristina Vasconcellos Guerra, Beatriz Alves Leite, Jose Roberto [UNIFESP] Otton, Rosemari Barros, Marcelo Paes de |
dc.subject.por.fl_str_mv |
Astaxanthin Omega-3 Anxiety Fish oil Antioxidant Brain Carotenoid Elevated plus maze |
topic |
Astaxanthin Omega-3 Anxiety Fish oil Antioxidant Brain Carotenoid Elevated plus maze |
description |
The habitual consumption of marine fish is largely associated to human mental health. Fish oil is particularly rich in n-3 polyunsaturated fatty acids that are known to play a role. in several neuronal and cognitive functions. in parallel, the orange-pinkish carotenoid astaxanthin (ASTA) is found in salmon and displays important antioxidant and anti-inflammatory properties. Many neuronal dysfunctions and anomalous psychotic behavior (such as anxiety, depression, etc.) have been strongly related to the higher sensitivity of cathecolaminergic brain regions to oxidative stress. Thus, the aim of this work was to study the combined effect of ASTA and fish oil on the redox status in plasma and in the monoaminergic-rich anterior forebrain region of Wistar rats with possible correlations with the anxiolytic behavior. Upon fish oil supplementation, the downregulation of superoxide dismutase and catalase activities combined to increased free iron content resulted in higher levels of lipid and protein oxidation in the anterior forebrain of animals. Such harmful oxidative modifications were hindered by concomitant supplementation with ASTA despite ASIA-related antioxidant protection was mainly observed in plasma. Although it is clear that ASTA properly crosses the brain-blood barrier, our data also address a possible indirect role of ASTA in restoring basal oxidative conditions in anterior forebrain of animals: by improving GSH-based antioxidant capacity of plasma. Preliminary anxiolytic tests performed in the elevated plus maze are in alignment with our biochemical observations. (C) 2011 Elsevier Inc. All rights reserved. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-09-01 2016-01-24T14:17:07Z 2016-01-24T14:17:07Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.pbb.2011.05.009 Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 99, n. 3, p. 349-355, 2011. 10.1016/j.pbb.2011.05.009 WOS000293371100009.pdf 0091-3057 http://repositorio.unifesp.br/handle/11600/33974 WOS:000293371100009 |
url |
http://dx.doi.org/10.1016/j.pbb.2011.05.009 http://repositorio.unifesp.br/handle/11600/33974 |
identifier_str_mv |
Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 99, n. 3, p. 349-355, 2011. 10.1016/j.pbb.2011.05.009 WOS000293371100009.pdf 0091-3057 WOS:000293371100009 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pharmacology Biochemistry and Behavior |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
dc.format.none.fl_str_mv |
349-355 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268408215109632 |