Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/35423 http://dx.doi.org/10.1016/j.seizure.2012.07.008 |
Resumo: | Purpose: We analyzed the association of granule cell dispersion (GCD) with memory performance, clinical data and surgical outcome in a series of patients with mesial temporal lobe epilepsy (MILE) and mesial temporal sclerosis (MTS).Method: Hippocampal specimens from 54 patients with MTLE (27 patients with right MILE and 27 with left MTLE) and unilateral MTS, who were separated into CCD and no-GCD groups and thirteen controls were studied. Quantitative neuropathological evaluation was performed using hippocampal sections stained with NeuN. Patients' neuropsychological measures, clinical data, type of MTS and surgical outcome were reviewed.Results: CCD occurred in 28 (51.9%) patients. No correlation between GCD and MTS pattern, clinical data or surgical outcome was found. the presence of GCD was correlated with worse visuospatial memory performance in right MTLE, but not with memory performance in left MTLE.Conclusion: GCD may be related to memory impairment in right MTLE-MTS patients. However, the role of GCD in memory function is not precisely defined. (c) 2012 British Epilepsy Association. Published by Elsevier B.V. All rights reserved. |
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Neves, Rafael Scarpa da Costa [UNIFESP]Tudesco, Ivanda de Souza Silva [UNIFESP]Jardim, Anaclara Prada [UNIFESP]Caboclo, Luís Otávio Sales Ferreira [UNIFESP]Lancellotti, Carmen Lucia PenteadoFerrari-Marinho, TaissaHamad, Ana Paula Andrade [UNIFESP]Marinho, Murilo Martinez [UNIFESP]Centeno, Ricardo Silva [UNIFESP]Cavalheiro, Esper Abrão [UNIFESP]Scorza, Carla Alessandra [UNIFESP]Yacubian, Elza Márcia Targas [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Santa Casa São PauloAFIP2016-01-24T14:27:54Z2016-01-24T14:27:54Z2012-11-01Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 21, n. 9, p. 685-690, 2012.1059-1311http://repositorio.unifesp.br/handle/11600/35423http://dx.doi.org/10.1016/j.seizure.2012.07.008WOS000309442300004.pdf10.1016/j.seizure.2012.07.008WOS:000309442300004Purpose: We analyzed the association of granule cell dispersion (GCD) with memory performance, clinical data and surgical outcome in a series of patients with mesial temporal lobe epilepsy (MILE) and mesial temporal sclerosis (MTS).Method: Hippocampal specimens from 54 patients with MTLE (27 patients with right MILE and 27 with left MTLE) and unilateral MTS, who were separated into CCD and no-GCD groups and thirteen controls were studied. Quantitative neuropathological evaluation was performed using hippocampal sections stained with NeuN. Patients' neuropsychological measures, clinical data, type of MTS and surgical outcome were reviewed.Results: CCD occurred in 28 (51.9%) patients. No correlation between GCD and MTS pattern, clinical data or surgical outcome was found. the presence of GCD was correlated with worse visuospatial memory performance in right MTLE, but not with memory performance in left MTLE.Conclusion: GCD may be related to memory impairment in right MTLE-MTS patients. However, the role of GCD in memory function is not precisely defined. (c) 2012 British Epilepsy Association. Published by Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Instituto Nacional de Neurociencia Translacional (INNT), BrazilUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, Escola Paulista Med, Unidade Pesquisa & Tratamento Epilepsias, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, Escola Paulista Med, BR-04024002 São Paulo, BrazilSanta Casa São Paulo, Dept Pathol, São Paulo, BrazilAFIP, Dept Pathol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Neurol & Neurosci, Escola Paulista Med, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, Escola Paulista Med, Unidade Pesquisa & Tratamento Epilepsias, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, Escola Paulista Med, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Neurol & Neurosci, Escola Paulista Med, BR-04024002 São Paulo, BrazilWeb of Science685-690engW B Saunders Co LtdSeizure-european Journal of EpilepsyMesial temporal lobe epilepsyMenial temporal sclerosisDentate gyrosGranule cell dispersionMemoryGranule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000309442300004.pdfapplication/pdf427446${dspace.ui.url}/bitstream/11600/35423/1/WOS000309442300004.pdf762aa45ac5f75401d9a6828057bbb074MD51open accessTEXTWOS000309442300004.pdf.txtWOS000309442300004.pdf.txtExtracted texttext/plain34873${dspace.ui.url}/bitstream/11600/35423/2/WOS000309442300004.pdf.txt5e3300b7b706626f3f9da932dc78e333MD52open access11600/354232022-11-03 10:40:51.542open accessoai:repositorio.unifesp.br:11600/35423Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-11-03T13:40:51Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy |
title |
Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy |
spellingShingle |
Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy Neves, Rafael Scarpa da Costa [UNIFESP] Mesial temporal lobe epilepsy Menial temporal sclerosis Dentate gyros Granule cell dispersion Memory |
title_short |
Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy |
title_full |
Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy |
title_fullStr |
Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy |
title_full_unstemmed |
Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy |
title_sort |
Granule cell dispersion is associated with memory impairment in right mesial temporal lobe epilepsy |
author |
Neves, Rafael Scarpa da Costa [UNIFESP] |
author_facet |
Neves, Rafael Scarpa da Costa [UNIFESP] Tudesco, Ivanda de Souza Silva [UNIFESP] Jardim, Anaclara Prada [UNIFESP] Caboclo, Luís Otávio Sales Ferreira [UNIFESP] Lancellotti, Carmen Lucia Penteado Ferrari-Marinho, Taissa Hamad, Ana Paula Andrade [UNIFESP] Marinho, Murilo Martinez [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] Scorza, Carla Alessandra [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] |
author_role |
author |
author2 |
Tudesco, Ivanda de Souza Silva [UNIFESP] Jardim, Anaclara Prada [UNIFESP] Caboclo, Luís Otávio Sales Ferreira [UNIFESP] Lancellotti, Carmen Lucia Penteado Ferrari-Marinho, Taissa Hamad, Ana Paula Andrade [UNIFESP] Marinho, Murilo Martinez [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] Scorza, Carla Alessandra [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] |
author2_role |
author author author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Santa Casa São Paulo AFIP |
dc.contributor.author.fl_str_mv |
Neves, Rafael Scarpa da Costa [UNIFESP] Tudesco, Ivanda de Souza Silva [UNIFESP] Jardim, Anaclara Prada [UNIFESP] Caboclo, Luís Otávio Sales Ferreira [UNIFESP] Lancellotti, Carmen Lucia Penteado Ferrari-Marinho, Taissa Hamad, Ana Paula Andrade [UNIFESP] Marinho, Murilo Martinez [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Cavalheiro, Esper Abrão [UNIFESP] Scorza, Carla Alessandra [UNIFESP] Yacubian, Elza Márcia Targas [UNIFESP] |
dc.subject.eng.fl_str_mv |
Mesial temporal lobe epilepsy Menial temporal sclerosis Dentate gyros Granule cell dispersion Memory |
topic |
Mesial temporal lobe epilepsy Menial temporal sclerosis Dentate gyros Granule cell dispersion Memory |
description |
Purpose: We analyzed the association of granule cell dispersion (GCD) with memory performance, clinical data and surgical outcome in a series of patients with mesial temporal lobe epilepsy (MILE) and mesial temporal sclerosis (MTS).Method: Hippocampal specimens from 54 patients with MTLE (27 patients with right MILE and 27 with left MTLE) and unilateral MTS, who were separated into CCD and no-GCD groups and thirteen controls were studied. Quantitative neuropathological evaluation was performed using hippocampal sections stained with NeuN. Patients' neuropsychological measures, clinical data, type of MTS and surgical outcome were reviewed.Results: CCD occurred in 28 (51.9%) patients. No correlation between GCD and MTS pattern, clinical data or surgical outcome was found. the presence of GCD was correlated with worse visuospatial memory performance in right MTLE, but not with memory performance in left MTLE.Conclusion: GCD may be related to memory impairment in right MTLE-MTS patients. However, the role of GCD in memory function is not precisely defined. (c) 2012 British Epilepsy Association. Published by Elsevier B.V. All rights reserved. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-11-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:27:54Z |
dc.date.available.fl_str_mv |
2016-01-24T14:27:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 21, n. 9, p. 685-690, 2012. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/35423 http://dx.doi.org/10.1016/j.seizure.2012.07.008 |
dc.identifier.issn.none.fl_str_mv |
1059-1311 |
dc.identifier.file.none.fl_str_mv |
WOS000309442300004.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.seizure.2012.07.008 |
dc.identifier.wos.none.fl_str_mv |
WOS:000309442300004 |
identifier_str_mv |
Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 21, n. 9, p. 685-690, 2012. 1059-1311 WOS000309442300004.pdf 10.1016/j.seizure.2012.07.008 WOS:000309442300004 |
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http://repositorio.unifesp.br/handle/11600/35423 http://dx.doi.org/10.1016/j.seizure.2012.07.008 |
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eng |
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openAccess |
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685-690 |
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W B Saunders Co Ltd |
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W B Saunders Co Ltd |
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