Are serum cystatin C levels influenced by steroid doses in lupus nephritis patients?

Detalhes bibliográficos
Autor(a) principal: Madureira E Silva, Marcus Vinicius [UNIFESP]
Data de Publicação: 2011
Outros Autores: Moscoso Solorzano, Grace [UNIFESP], Nishida, Sonia Kiyomi [UNIFESP], Mastroianni Kirsztajn, Gianna [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0101-28002011000300006
http://repositorio.unifesp.br/handle/11600/6597
Resumo: INTRODUCTION: Cystatin C is considered a promising test to evaluate glomerular filtration rate, since it has characteristics of an ideal endogenous marker, being similar or even superior to serum creatinine according to some studies. However, it is possible that some factors (as corticotherapy) could have an influence on serum cystatin C levels regardless of the glomerular filtration rate. The aim of this study was to investigate if different doses of glucocorticoid could have an influence on serum cystatin C levels in lupus nephritis patients. METHODS: We evaluated 42 patients with lupus nephritis that performed 109 different blood collections; their mean age was 37.7 ± 13.1 years old, and 88% were female; the mean estimated glomerular filtration rate was of 61.9 ± 20.0 mL/min. Patients were divided according to their glucocorticoid dose in two groups: A - high (pulse therapy with methylprednisolone and prednisone > 0.5 mg/kg/d, n = 14) versus B - low doses (prednisone ≤ 0.5 mg/kg/d, n = 28). Serum creatinine levels were used as parameters for renal function comparison. Cystatin C was determined by an in-house methodology, using Luminex system flow citometry. RESULTS: Considering these groups, cystatin C levels were different only in the second visit (p = 0.106). But, when the serum creatinine levels were considered in the same groups, a marginally significant difference among them (p = 0.070) was observed, which suggested that the difference in cystatin C levels between the groups was caused by their respective glomerular filtration rate. There was not any difference between those groups that received or did not receive pulse therapy. CONCLUSION: Although some previous studies have shown that glucocorticoid has an influence on serum cystatin C levels, we have not observed such interference in the lupus nephritis patients submitted to corticotherapy.
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spelling Are serum cystatin C levels influenced by steroid doses in lupus nephritis patients?Os níveis séricos de cistatina C sofrem influência da dose de corticoide em pacientes com nefrite lúpica?GlucocorticoidsCystatin CCreatinineGlomerular filtration rateLupus nephritisGlicocorticoidesCistatina CCreatininaTaxa de filtração glomerularNefrite lúpicaINTRODUCTION: Cystatin C is considered a promising test to evaluate glomerular filtration rate, since it has characteristics of an ideal endogenous marker, being similar or even superior to serum creatinine according to some studies. However, it is possible that some factors (as corticotherapy) could have an influence on serum cystatin C levels regardless of the glomerular filtration rate. The aim of this study was to investigate if different doses of glucocorticoid could have an influence on serum cystatin C levels in lupus nephritis patients. METHODS: We evaluated 42 patients with lupus nephritis that performed 109 different blood collections; their mean age was 37.7 ± 13.1 years old, and 88% were female; the mean estimated glomerular filtration rate was of 61.9 ± 20.0 mL/min. Patients were divided according to their glucocorticoid dose in two groups: A - high (pulse therapy with methylprednisolone and prednisone > 0.5 mg/kg/d, n = 14) versus B - low doses (prednisone ≤ 0.5 mg/kg/d, n = 28). Serum creatinine levels were used as parameters for renal function comparison. Cystatin C was determined by an in-house methodology, using Luminex system flow citometry. RESULTS: Considering these groups, cystatin C levels were different only in the second visit (p = 0.106). But, when the serum creatinine levels were considered in the same groups, a marginally significant difference among them (p = 0.070) was observed, which suggested that the difference in cystatin C levels between the groups was caused by their respective glomerular filtration rate. There was not any difference between those groups that received or did not receive pulse therapy. CONCLUSION: Although some previous studies have shown that glucocorticoid has an influence on serum cystatin C levels, we have not observed such interference in the lupus nephritis patients submitted to corticotherapy.INTRODUÇÃO: A cistatina C é considerada como um teste promissor para avaliar a taxa de filtração glomerular, pois apresenta características de um marcador endógeno ideal, sendo similar ou até superior à creatinina sérica, segundo alguns estudos. No entanto, é possível que alguns fatores (como corticoterapia) influenciem os níveis séricos da cistatina C, independente da taxa de filtração glomerular. Procurouse investigar se diferentes doses de glicocorticoides afetariam os níveis do marcador em pacientes com nefrite lúpica. MÉTODOS:Foramavaliados42pacientescom nefrite lúpica, submetidos a 109 coletas de sangue diferentes; a idade média deles era de 37,7 ± 13,1 anos, e 88% eram do sexo feminino; a taxa de filtração glomerular estimada média era de 61,9 ± 20,0 mL/min. Os pacientes foram divididos, de acordo com a dose de corticoide, em dois grupos: A - altas (pulsoterapia com metilprednisolona e prednisona > 0,5 mg/kg/dia, n = 14) versus B - baixas doses (prednisona ≤ 0,5 mg/kg/dia, n = 28). Os níveis de creatinina sérica foram usados como parâmetros de comparação em relação à função renal. A cistatina C foi determinadapor metodologia desenvolvida in-house, usando citometria de fluxo na plataforma Luminex. RESULTADOS: Considerando esses dois grupos, os níveis de cistatina C foram diferentes apenas nas amostras da segunda consulta (p = 0,106). Mas, quando considerados os níveis de creatinina sérica nos mesmos grupos, foi observada uma diferença marginalmente significante entre eles (p=0,070), sugerindo que a diferença nos níveis de cistatina C entre os grupos foi causada por suas respectivas taxas de filtração glomerular. Não houve diferença entre os que receberam, ou não, pulsoterapia. CONCLUSÕES: Embora alguns estudos tenham mostrado que os glicorticoides podem influenciar os níveis de cistatina C, não foi observada tal interferência nesta população de pacientes com nefrite lúpica submetidos à corticoterapia.Universidade Federal de São Paulo (UNIFESP)UNIFESP, EPM, São Paulo, BrazilSciELOSociedade Brasileira de NefrologiaUniversidade Federal de São Paulo (UNIFESP)Madureira E Silva, Marcus Vinicius [UNIFESP]Moscoso Solorzano, Grace [UNIFESP]Nishida, Sonia Kiyomi [UNIFESP]Mastroianni Kirsztajn, Gianna [UNIFESP]2015-06-14T13:43:14Z2015-06-14T13:43:14Z2011-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion306-312application/pdfhttp://dx.doi.org/10.1590/S0101-28002011000300006Jornal Brasileiro de Nefrologia. Sociedade Brasileira de Nefrologia, v. 33, n. 3, p. 306-312, 2011.10.1590/S0101-28002011000300006S0101-28002011000300006.pdf0101-2800S0101-28002011000300006http://repositorio.unifesp.br/handle/11600/6597engJornal Brasileiro de Nefrologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T18:22:14Zoai:repositorio.unifesp.br/:11600/6597Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T18:22:14Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Are serum cystatin C levels influenced by steroid doses in lupus nephritis patients?
Os níveis séricos de cistatina C sofrem influência da dose de corticoide em pacientes com nefrite lúpica?
title Are serum cystatin C levels influenced by steroid doses in lupus nephritis patients?
spellingShingle Are serum cystatin C levels influenced by steroid doses in lupus nephritis patients?
Madureira E Silva, Marcus Vinicius [UNIFESP]
Glucocorticoids
Cystatin C
Creatinine
Glomerular filtration rate
Lupus nephritis
Glicocorticoides
Cistatina C
Creatinina
Taxa de filtração glomerular
Nefrite lúpica
title_short Are serum cystatin C levels influenced by steroid doses in lupus nephritis patients?
title_full Are serum cystatin C levels influenced by steroid doses in lupus nephritis patients?
title_fullStr Are serum cystatin C levels influenced by steroid doses in lupus nephritis patients?
title_full_unstemmed Are serum cystatin C levels influenced by steroid doses in lupus nephritis patients?
title_sort Are serum cystatin C levels influenced by steroid doses in lupus nephritis patients?
author Madureira E Silva, Marcus Vinicius [UNIFESP]
author_facet Madureira E Silva, Marcus Vinicius [UNIFESP]
Moscoso Solorzano, Grace [UNIFESP]
Nishida, Sonia Kiyomi [UNIFESP]
Mastroianni Kirsztajn, Gianna [UNIFESP]
author_role author
author2 Moscoso Solorzano, Grace [UNIFESP]
Nishida, Sonia Kiyomi [UNIFESP]
Mastroianni Kirsztajn, Gianna [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Madureira E Silva, Marcus Vinicius [UNIFESP]
Moscoso Solorzano, Grace [UNIFESP]
Nishida, Sonia Kiyomi [UNIFESP]
Mastroianni Kirsztajn, Gianna [UNIFESP]
dc.subject.por.fl_str_mv Glucocorticoids
Cystatin C
Creatinine
Glomerular filtration rate
Lupus nephritis
Glicocorticoides
Cistatina C
Creatinina
Taxa de filtração glomerular
Nefrite lúpica
topic Glucocorticoids
Cystatin C
Creatinine
Glomerular filtration rate
Lupus nephritis
Glicocorticoides
Cistatina C
Creatinina
Taxa de filtração glomerular
Nefrite lúpica
description INTRODUCTION: Cystatin C is considered a promising test to evaluate glomerular filtration rate, since it has characteristics of an ideal endogenous marker, being similar or even superior to serum creatinine according to some studies. However, it is possible that some factors (as corticotherapy) could have an influence on serum cystatin C levels regardless of the glomerular filtration rate. The aim of this study was to investigate if different doses of glucocorticoid could have an influence on serum cystatin C levels in lupus nephritis patients. METHODS: We evaluated 42 patients with lupus nephritis that performed 109 different blood collections; their mean age was 37.7 ± 13.1 years old, and 88% were female; the mean estimated glomerular filtration rate was of 61.9 ± 20.0 mL/min. Patients were divided according to their glucocorticoid dose in two groups: A - high (pulse therapy with methylprednisolone and prednisone > 0.5 mg/kg/d, n = 14) versus B - low doses (prednisone ≤ 0.5 mg/kg/d, n = 28). Serum creatinine levels were used as parameters for renal function comparison. Cystatin C was determined by an in-house methodology, using Luminex system flow citometry. RESULTS: Considering these groups, cystatin C levels were different only in the second visit (p = 0.106). But, when the serum creatinine levels were considered in the same groups, a marginally significant difference among them (p = 0.070) was observed, which suggested that the difference in cystatin C levels between the groups was caused by their respective glomerular filtration rate. There was not any difference between those groups that received or did not receive pulse therapy. CONCLUSION: Although some previous studies have shown that glucocorticoid has an influence on serum cystatin C levels, we have not observed such interference in the lupus nephritis patients submitted to corticotherapy.
publishDate 2011
dc.date.none.fl_str_mv 2011-09-01
2015-06-14T13:43:14Z
2015-06-14T13:43:14Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0101-28002011000300006
Jornal Brasileiro de Nefrologia. Sociedade Brasileira de Nefrologia, v. 33, n. 3, p. 306-312, 2011.
10.1590/S0101-28002011000300006
S0101-28002011000300006.pdf
0101-2800
S0101-28002011000300006
http://repositorio.unifesp.br/handle/11600/6597
url http://dx.doi.org/10.1590/S0101-28002011000300006
http://repositorio.unifesp.br/handle/11600/6597
identifier_str_mv Jornal Brasileiro de Nefrologia. Sociedade Brasileira de Nefrologia, v. 33, n. 3, p. 306-312, 2011.
10.1590/S0101-28002011000300006
S0101-28002011000300006.pdf
0101-2800
S0101-28002011000300006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Jornal Brasileiro de Nefrologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 306-312
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
publisher.none.fl_str_mv Sociedade Brasileira de Nefrologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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