Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica
Autor(a) principal: | |
---|---|
Data de Publicação: | 2009 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0100-39842009000300005 http://repositorio.unifesp.br/handle/11600/5080 |
Resumo: | OBJECTIVE: To evaluate metabolite concentration in the masseter of patients with systemic sclerosis, by analyzing creatine, choline, lipid and lactate levels, and correlating them with the presence of mandibular osteolysis. MATERIALS AND METHODS: The sample included 25 individuals, 15 of them with diagnosis of systemic sclerosis, divided into two groups according to the presence (group I) or absence (group II) of osteolysis, and 10 healthy individuals (group III, control). All of them were submitted to proton magnetic resonance spectroscopy with PRESS sequence and 3D acquisition. RESULTS: Metabolite analysis showed that the creatine and lipid levels were the same for the three groups. Patients in group I presented higher levels of choline when compared with group III. On the other hand, lower lactate levels were observed in groups I and II when compared with the healthy individuals. Creatine/lipid and choline/lactate ratios were the same in the three groups. CONCLUSION: Lower lactate levels were observed in the patients with systemic sclerosis (groups I and II). Choline levels were increased in the patients with mandibular osteolysis (group I). Creatine/choline, lipid/lactate and choline/lipid ratios were different among the three groups. Further studies are necessary to understand the role played by the masseter in the development of mandibular osteolysis. |
id |
UFSP_087a14f226725987c46dc0b833119795 |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br/:11600/5080 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmicaProton spectroscopy study of the masseter in patients with systemic sclerosisMasseterSystemic sclerosisProton spectroscopyMasseterEsclerose sistêmicaEspectroscopia de prótonOBJECTIVE: To evaluate metabolite concentration in the masseter of patients with systemic sclerosis, by analyzing creatine, choline, lipid and lactate levels, and correlating them with the presence of mandibular osteolysis. MATERIALS AND METHODS: The sample included 25 individuals, 15 of them with diagnosis of systemic sclerosis, divided into two groups according to the presence (group I) or absence (group II) of osteolysis, and 10 healthy individuals (group III, control). All of them were submitted to proton magnetic resonance spectroscopy with PRESS sequence and 3D acquisition. RESULTS: Metabolite analysis showed that the creatine and lipid levels were the same for the three groups. Patients in group I presented higher levels of choline when compared with group III. On the other hand, lower lactate levels were observed in groups I and II when compared with the healthy individuals. Creatine/lipid and choline/lactate ratios were the same in the three groups. CONCLUSION: Lower lactate levels were observed in the patients with systemic sclerosis (groups I and II). Choline levels were increased in the patients with mandibular osteolysis (group I). Creatine/choline, lipid/lactate and choline/lipid ratios were different among the three groups. Further studies are necessary to understand the role played by the masseter in the development of mandibular osteolysis.OBJETIVO: Avaliar a concentração de metabólitos no masseter em portadores de esclerose sistêmica, analisando os índices de creatina, colina, lipídio e lactato, e relacionar com a presença de osteólise mandibular. MATERIAIS E MÉTODOS: Foram selecionados 25 pacientes, sendo 15 com diagnóstico de esclerose sistêmica e agrupados de acordo com a presença (grupo I) ou ausência (grupo II) de osteólise, e 10 indivíduos normais (grupo III, controle). Todos foram submetidos a exame de espectroscopia de próton por ressonância magnética, com técnica PRESS e aquisição tridimensional. RESULTADOS: O estudo dos metabólitos dos três grupos apresentou os mesmos valores absolutos de creatina e lipídio. Os pacientes do grupo I apresentaram maior quantidade de colina em relação aos do grupo III. Já os indivíduos dos grupos I e II apresentaram menor quantidade de lactato em relação aos indivíduos normais. Os índices creatina/lipídio e colina/lactato foram os mesmos em todos os grupos. CONCLUSÃO: Observamos menor quantidade de lactato nos pacientes com esclerose sistêmica (grupos I e II). A colina está aumentada nos pacientes com osteólise mandibular (grupo I). Os índices creatina/colina, creatina/lactato, lipídio/lactato e colina/lipídio foram diferentes entre os grupos estudados. Mais estudos são necessários para a compreensão da participação do masseter no desenvolvimento da osteólise mandibular.Hospital Heliópolis Serviço de Estomatologia e Cirurgia Buco Maxilo FaciaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Diagnóstico por ImagemUNIFESP, EPM, Depto. de Diagnóstico por ImagemSciELOColégio Brasileiro de Radiologia e Diagnóstico por ImagemHospital Heliópolis Serviço de Estomatologia e Cirurgia Buco Maxilo FaciaUniversidade Federal de São Paulo (UNIFESP)Marcucci, MarceloAbdala, Nitamar [UNIFESP]2015-06-14T13:39:14Z2015-06-14T13:39:14Z2009-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion145-150application/pdfhttp://dx.doi.org/10.1590/S0100-39842009000300005Radiologia Brasileira. Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, v. 42, n. 3, p. 145-150, 2009.10.1590/S0100-39842009000300005S0100-39842009000300005.pdf0100-3984S0100-39842009000300005http://repositorio.unifesp.br/handle/11600/5080porRadiologia Brasileirainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T17:47:37Zoai:repositorio.unifesp.br/:11600/5080Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-28T17:47:37Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica Proton spectroscopy study of the masseter in patients with systemic sclerosis |
title |
Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica |
spellingShingle |
Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica Marcucci, Marcelo Masseter Systemic sclerosis Proton spectroscopy Masseter Esclerose sistêmica Espectroscopia de próton |
title_short |
Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica |
title_full |
Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica |
title_fullStr |
Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica |
title_full_unstemmed |
Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica |
title_sort |
Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica |
author |
Marcucci, Marcelo |
author_facet |
Marcucci, Marcelo Abdala, Nitamar [UNIFESP] |
author_role |
author |
author2 |
Abdala, Nitamar [UNIFESP] |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Hospital Heliópolis Serviço de Estomatologia e Cirurgia Buco Maxilo Facia Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Marcucci, Marcelo Abdala, Nitamar [UNIFESP] |
dc.subject.por.fl_str_mv |
Masseter Systemic sclerosis Proton spectroscopy Masseter Esclerose sistêmica Espectroscopia de próton |
topic |
Masseter Systemic sclerosis Proton spectroscopy Masseter Esclerose sistêmica Espectroscopia de próton |
description |
OBJECTIVE: To evaluate metabolite concentration in the masseter of patients with systemic sclerosis, by analyzing creatine, choline, lipid and lactate levels, and correlating them with the presence of mandibular osteolysis. MATERIALS AND METHODS: The sample included 25 individuals, 15 of them with diagnosis of systemic sclerosis, divided into two groups according to the presence (group I) or absence (group II) of osteolysis, and 10 healthy individuals (group III, control). All of them were submitted to proton magnetic resonance spectroscopy with PRESS sequence and 3D acquisition. RESULTS: Metabolite analysis showed that the creatine and lipid levels were the same for the three groups. Patients in group I presented higher levels of choline when compared with group III. On the other hand, lower lactate levels were observed in groups I and II when compared with the healthy individuals. Creatine/lipid and choline/lactate ratios were the same in the three groups. CONCLUSION: Lower lactate levels were observed in the patients with systemic sclerosis (groups I and II). Choline levels were increased in the patients with mandibular osteolysis (group I). Creatine/choline, lipid/lactate and choline/lipid ratios were different among the three groups. Further studies are necessary to understand the role played by the masseter in the development of mandibular osteolysis. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-06-01 2015-06-14T13:39:14Z 2015-06-14T13:39:14Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0100-39842009000300005 Radiologia Brasileira. Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, v. 42, n. 3, p. 145-150, 2009. 10.1590/S0100-39842009000300005 S0100-39842009000300005.pdf 0100-3984 S0100-39842009000300005 http://repositorio.unifesp.br/handle/11600/5080 |
url |
http://dx.doi.org/10.1590/S0100-39842009000300005 http://repositorio.unifesp.br/handle/11600/5080 |
identifier_str_mv |
Radiologia Brasileira. Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, v. 42, n. 3, p. 145-150, 2009. 10.1590/S0100-39842009000300005 S0100-39842009000300005.pdf 0100-3984 S0100-39842009000300005 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Radiologia Brasileira |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
145-150 application/pdf |
dc.publisher.none.fl_str_mv |
Colégio Brasileiro de Radiologia e Diagnóstico por Imagem |
publisher.none.fl_str_mv |
Colégio Brasileiro de Radiologia e Diagnóstico por Imagem |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268325193056256 |