Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica

Detalhes bibliográficos
Autor(a) principal: Marcucci, Marcelo
Data de Publicação: 2009
Outros Autores: Abdala, Nitamar [UNIFESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0100-39842009000300005
http://repositorio.unifesp.br/handle/11600/5080
Resumo: OBJECTIVE: To evaluate metabolite concentration in the masseter of patients with systemic sclerosis, by analyzing creatine, choline, lipid and lactate levels, and correlating them with the presence of mandibular osteolysis. MATERIALS AND METHODS: The sample included 25 individuals, 15 of them with diagnosis of systemic sclerosis, divided into two groups according to the presence (group I) or absence (group II) of osteolysis, and 10 healthy individuals (group III, control). All of them were submitted to proton magnetic resonance spectroscopy with PRESS sequence and 3D acquisition. RESULTS: Metabolite analysis showed that the creatine and lipid levels were the same for the three groups. Patients in group I presented higher levels of choline when compared with group III. On the other hand, lower lactate levels were observed in groups I and II when compared with the healthy individuals. Creatine/lipid and choline/lactate ratios were the same in the three groups. CONCLUSION: Lower lactate levels were observed in the patients with systemic sclerosis (groups I and II). Choline levels were increased in the patients with mandibular osteolysis (group I). Creatine/choline, lipid/lactate and choline/lipid ratios were different among the three groups. Further studies are necessary to understand the role played by the masseter in the development of mandibular osteolysis.
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spelling Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmicaProton spectroscopy study of the masseter in patients with systemic sclerosisMasseterSystemic sclerosisProton spectroscopyMasseterEsclerose sistêmicaEspectroscopia de prótonOBJECTIVE: To evaluate metabolite concentration in the masseter of patients with systemic sclerosis, by analyzing creatine, choline, lipid and lactate levels, and correlating them with the presence of mandibular osteolysis. MATERIALS AND METHODS: The sample included 25 individuals, 15 of them with diagnosis of systemic sclerosis, divided into two groups according to the presence (group I) or absence (group II) of osteolysis, and 10 healthy individuals (group III, control). All of them were submitted to proton magnetic resonance spectroscopy with PRESS sequence and 3D acquisition. RESULTS: Metabolite analysis showed that the creatine and lipid levels were the same for the three groups. Patients in group I presented higher levels of choline when compared with group III. On the other hand, lower lactate levels were observed in groups I and II when compared with the healthy individuals. Creatine/lipid and choline/lactate ratios were the same in the three groups. CONCLUSION: Lower lactate levels were observed in the patients with systemic sclerosis (groups I and II). Choline levels were increased in the patients with mandibular osteolysis (group I). Creatine/choline, lipid/lactate and choline/lipid ratios were different among the three groups. Further studies are necessary to understand the role played by the masseter in the development of mandibular osteolysis.OBJETIVO: Avaliar a concentração de metabólitos no masseter em portadores de esclerose sistêmica, analisando os índices de creatina, colina, lipídio e lactato, e relacionar com a presença de osteólise mandibular. MATERIAIS E MÉTODOS: Foram selecionados 25 pacientes, sendo 15 com diagnóstico de esclerose sistêmica e agrupados de acordo com a presença (grupo I) ou ausência (grupo II) de osteólise, e 10 indivíduos normais (grupo III, controle). Todos foram submetidos a exame de espectroscopia de próton por ressonância magnética, com técnica PRESS e aquisição tridimensional. RESULTADOS: O estudo dos metabólitos dos três grupos apresentou os mesmos valores absolutos de creatina e lipídio. Os pacientes do grupo I apresentaram maior quantidade de colina em relação aos do grupo III. Já os indivíduos dos grupos I e II apresentaram menor quantidade de lactato em relação aos indivíduos normais. Os índices creatina/lipídio e colina/lactato foram os mesmos em todos os grupos. CONCLUSÃO: Observamos menor quantidade de lactato nos pacientes com esclerose sistêmica (grupos I e II). A colina está aumentada nos pacientes com osteólise mandibular (grupo I). Os índices creatina/colina, creatina/lactato, lipídio/lactato e colina/lipídio foram diferentes entre os grupos estudados. Mais estudos são necessários para a compreensão da participação do masseter no desenvolvimento da osteólise mandibular.Hospital Heliópolis Serviço de Estomatologia e Cirurgia Buco Maxilo FaciaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Diagnóstico por ImagemUNIFESP, EPM, Depto. de Diagnóstico por ImagemSciELOColégio Brasileiro de Radiologia e Diagnóstico por ImagemHospital Heliópolis Serviço de Estomatologia e Cirurgia Buco Maxilo FaciaUniversidade Federal de São Paulo (UNIFESP)Marcucci, MarceloAbdala, Nitamar [UNIFESP]2015-06-14T13:39:14Z2015-06-14T13:39:14Z2009-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion145-150application/pdfhttp://dx.doi.org/10.1590/S0100-39842009000300005Radiologia Brasileira. Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, v. 42, n. 3, p. 145-150, 2009.10.1590/S0100-39842009000300005S0100-39842009000300005.pdf0100-3984S0100-39842009000300005http://repositorio.unifesp.br/handle/11600/5080porRadiologia Brasileirainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-28T17:47:37Zoai:repositorio.unifesp.br/:11600/5080Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-28T17:47:37Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica
Proton spectroscopy study of the masseter in patients with systemic sclerosis
title Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica
spellingShingle Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica
Marcucci, Marcelo
Masseter
Systemic sclerosis
Proton spectroscopy
Masseter
Esclerose sistêmica
Espectroscopia de próton
title_short Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica
title_full Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica
title_fullStr Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica
title_full_unstemmed Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica
title_sort Análise do masseter, por espectroscopia de próton, em pacientes com esclerose sistêmica
author Marcucci, Marcelo
author_facet Marcucci, Marcelo
Abdala, Nitamar [UNIFESP]
author_role author
author2 Abdala, Nitamar [UNIFESP]
author2_role author
dc.contributor.none.fl_str_mv Hospital Heliópolis Serviço de Estomatologia e Cirurgia Buco Maxilo Facia
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Marcucci, Marcelo
Abdala, Nitamar [UNIFESP]
dc.subject.por.fl_str_mv Masseter
Systemic sclerosis
Proton spectroscopy
Masseter
Esclerose sistêmica
Espectroscopia de próton
topic Masseter
Systemic sclerosis
Proton spectroscopy
Masseter
Esclerose sistêmica
Espectroscopia de próton
description OBJECTIVE: To evaluate metabolite concentration in the masseter of patients with systemic sclerosis, by analyzing creatine, choline, lipid and lactate levels, and correlating them with the presence of mandibular osteolysis. MATERIALS AND METHODS: The sample included 25 individuals, 15 of them with diagnosis of systemic sclerosis, divided into two groups according to the presence (group I) or absence (group II) of osteolysis, and 10 healthy individuals (group III, control). All of them were submitted to proton magnetic resonance spectroscopy with PRESS sequence and 3D acquisition. RESULTS: Metabolite analysis showed that the creatine and lipid levels were the same for the three groups. Patients in group I presented higher levels of choline when compared with group III. On the other hand, lower lactate levels were observed in groups I and II when compared with the healthy individuals. Creatine/lipid and choline/lactate ratios were the same in the three groups. CONCLUSION: Lower lactate levels were observed in the patients with systemic sclerosis (groups I and II). Choline levels were increased in the patients with mandibular osteolysis (group I). Creatine/choline, lipid/lactate and choline/lipid ratios were different among the three groups. Further studies are necessary to understand the role played by the masseter in the development of mandibular osteolysis.
publishDate 2009
dc.date.none.fl_str_mv 2009-06-01
2015-06-14T13:39:14Z
2015-06-14T13:39:14Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0100-39842009000300005
Radiologia Brasileira. Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, v. 42, n. 3, p. 145-150, 2009.
10.1590/S0100-39842009000300005
S0100-39842009000300005.pdf
0100-3984
S0100-39842009000300005
http://repositorio.unifesp.br/handle/11600/5080
url http://dx.doi.org/10.1590/S0100-39842009000300005
http://repositorio.unifesp.br/handle/11600/5080
identifier_str_mv Radiologia Brasileira. Colégio Brasileiro de Radiologia e Diagnóstico por Imagem, v. 42, n. 3, p. 145-150, 2009.
10.1590/S0100-39842009000300005
S0100-39842009000300005.pdf
0100-3984
S0100-39842009000300005
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Radiologia Brasileira
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 145-150
application/pdf
dc.publisher.none.fl_str_mv Colégio Brasileiro de Radiologia e Diagnóstico por Imagem
publisher.none.fl_str_mv Colégio Brasileiro de Radiologia e Diagnóstico por Imagem
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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