Medical treatment of cardiac arrhythmias in Chagas'heart disease

Detalhes bibliográficos
Autor(a) principal: De Paola, Angelo Amato Vincenzo [UNIFESP]
Data de Publicação: 1995
Outros Autores: Gondin, Fernando Antonio Aquino [UNIFESP], Hara, Vanderlei [UNIFESP], Mendonça, Alayde [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1516-31801995000200018
http://repositorio.unifesp.br/handle/11600/372
Resumo: There are no controlled clinical trials evaluating drug therapy in patients with ventricular arrhythmias and chronic chagasic cardiomyopathy. Empirical treatment with disopyramide (400-1,000mg/d), phenytoin (4-6mg/d), mexiletine (600-1,200mg/d), propafenone (900mg/d), amiodarone ( loading: 1,000mg/d, 10-14 days; maintenance 200-600mg/d), and sotalol (320mg/d) had efficacy and tolerance ranging from 18% to 90% with heterogeneous criteria for efficacy definition. Further studies with homogenous criteria are required to determine which is the most appropriate drug therapy for patients with chronic chagasic cardiomyopathy and ventricular arrhythmias.
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spelling Medical treatment of cardiac arrhythmias in Chagas'heart diseaseChronic chagasic cardiomyopathyCardiac arrhythmiaAntiarrhythmic drugsThere are no controlled clinical trials evaluating drug therapy in patients with ventricular arrhythmias and chronic chagasic cardiomyopathy. Empirical treatment with disopyramide (400-1,000mg/d), phenytoin (4-6mg/d), mexiletine (600-1,200mg/d), propafenone (900mg/d), amiodarone ( loading: 1,000mg/d, 10-14 days; maintenance 200-600mg/d), and sotalol (320mg/d) had efficacy and tolerance ranging from 18% to 90% with heterogeneous criteria for efficacy definition. Further studies with homogenous criteria are required to determine which is the most appropriate drug therapy for patients with chronic chagasic cardiomyopathy and ventricular arrhythmias.Apesar da grande importância da cardiopatia chagásica em nosso meio, não existem estudos clínicos controlados que avaliem adequadamente as opções terapêuticas nessa patologia. Foram testadas disopiramida (400-1.000 mg/dia), difenil hidantoína (4-6 mg/kg/dia), mexiletine (600-1.200 mg/d), propafenona (900 mg/d), amiodarona (impregnação: 1.000 mg/dia/ 10-14 dias; manutenção: 200-600 mg/d) e sotalol (320 mg/dia) com níveis de eficácia e tolerância variando de 18 a 90% dependendo das definições empregadas. Estudos comparativos controlados poderão esclarecer futuramente as melhores estratégias farmacológicas para o tratamento dessa entidade nosológica.Escola Paulista de Medicina Clinical Cardiac ElectrophysiologyUNIFESP, EPM, Clinical Cardiac ElectrophysiologySciELOAssociação Paulista de Medicina - APMUniversidade Federal de São Paulo (UNIFESP)De Paola, Angelo Amato Vincenzo [UNIFESP]Gondin, Fernando Antonio Aquino [UNIFESP]Hara, Vanderlei [UNIFESP]Mendonça, Alayde [UNIFESP]2015-06-14T13:24:28Z2015-06-14T13:24:28Z1995-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion858-861application/pdfhttp://dx.doi.org/10.1590/S1516-31801995000200018São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 113, n. 2, p. 858-861, 1995.10.1590/S1516-31801995000200018S1516-31801995000200018.pdf1516-3180S1516-31801995000200018http://repositorio.unifesp.br/handle/11600/372engSão Paulo Medical Journalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T00:34:33Zoai:repositorio.unifesp.br/:11600/372Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-30T00:34:33Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Medical treatment of cardiac arrhythmias in Chagas'heart disease
title Medical treatment of cardiac arrhythmias in Chagas'heart disease
spellingShingle Medical treatment of cardiac arrhythmias in Chagas'heart disease
De Paola, Angelo Amato Vincenzo [UNIFESP]
Chronic chagasic cardiomyopathy
Cardiac arrhythmia
Antiarrhythmic drugs
title_short Medical treatment of cardiac arrhythmias in Chagas'heart disease
title_full Medical treatment of cardiac arrhythmias in Chagas'heart disease
title_fullStr Medical treatment of cardiac arrhythmias in Chagas'heart disease
title_full_unstemmed Medical treatment of cardiac arrhythmias in Chagas'heart disease
title_sort Medical treatment of cardiac arrhythmias in Chagas'heart disease
author De Paola, Angelo Amato Vincenzo [UNIFESP]
author_facet De Paola, Angelo Amato Vincenzo [UNIFESP]
Gondin, Fernando Antonio Aquino [UNIFESP]
Hara, Vanderlei [UNIFESP]
Mendonça, Alayde [UNIFESP]
author_role author
author2 Gondin, Fernando Antonio Aquino [UNIFESP]
Hara, Vanderlei [UNIFESP]
Mendonça, Alayde [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv De Paola, Angelo Amato Vincenzo [UNIFESP]
Gondin, Fernando Antonio Aquino [UNIFESP]
Hara, Vanderlei [UNIFESP]
Mendonça, Alayde [UNIFESP]
dc.subject.por.fl_str_mv Chronic chagasic cardiomyopathy
Cardiac arrhythmia
Antiarrhythmic drugs
topic Chronic chagasic cardiomyopathy
Cardiac arrhythmia
Antiarrhythmic drugs
description There are no controlled clinical trials evaluating drug therapy in patients with ventricular arrhythmias and chronic chagasic cardiomyopathy. Empirical treatment with disopyramide (400-1,000mg/d), phenytoin (4-6mg/d), mexiletine (600-1,200mg/d), propafenone (900mg/d), amiodarone ( loading: 1,000mg/d, 10-14 days; maintenance 200-600mg/d), and sotalol (320mg/d) had efficacy and tolerance ranging from 18% to 90% with heterogeneous criteria for efficacy definition. Further studies with homogenous criteria are required to determine which is the most appropriate drug therapy for patients with chronic chagasic cardiomyopathy and ventricular arrhythmias.
publishDate 1995
dc.date.none.fl_str_mv 1995-04-01
2015-06-14T13:24:28Z
2015-06-14T13:24:28Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1516-31801995000200018
São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 113, n. 2, p. 858-861, 1995.
10.1590/S1516-31801995000200018
S1516-31801995000200018.pdf
1516-3180
S1516-31801995000200018
http://repositorio.unifesp.br/handle/11600/372
url http://dx.doi.org/10.1590/S1516-31801995000200018
http://repositorio.unifesp.br/handle/11600/372
identifier_str_mv São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 113, n. 2, p. 858-861, 1995.
10.1590/S1516-31801995000200018
S1516-31801995000200018.pdf
1516-3180
S1516-31801995000200018
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv São Paulo Medical Journal
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 858-861
application/pdf
dc.publisher.none.fl_str_mv Associação Paulista de Medicina - APM
publisher.none.fl_str_mv Associação Paulista de Medicina - APM
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268394015293440

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