Microbiota benefits after inulin and partially hydrolized guar gum supplementation - a randomized clinical trial in constipated women
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/34397 https://scielo.isciii.es/pdf/nh/v27n1/14_original_03.pdf |
Resumo: | Introduction: Prebiotics positively affect gut microbiota composition, thus improving gut function. These properties may be useful for the treatment of constipation.Objectives: This study assessed the tolerance and effectiveness of a prebiotic inulin/partially hydrolyzed guar gum mixture (I-PHGG) for the treatment of constipation in females, as well as its influence on the composition of intestinal microbiota and production of short chain fatty acids.Methods: Our study enrolled 60 constipated female health worker volunteers. Participants reported less than 3 bowel movements per week. Volunteers were randomized to treatment with prebiotic or placebo. Treatment consisted of 3 weeks supplementation with 15 g/d I-PHGG (fiber group) or maltodextrin (placebo group). Abdominal discomfort, flatulence, stool consistency, and bowel movements were evaluated by a recorded daily questionnaire and a weekly interview. Changes in fecal bacterial population and short chain fatty acids were assessed by real-time PCR and gas chromatography, respectively.Results: There was an increased frequency of weekly bowel movements and patient satisfaction in both the fiber and placebo groups with no significant differences. Total Clostridium sp significantly decreased in the fiber group (p = 0.046) and increased in the placebo group (p = 0.047). There were no changes in fecal short chain fatty acid profile.Conclusions: Consumption of I-PHGG produced clinical results comparable to placebo in constipated females, but had additional protective effects on gut rnicrobiota by decreasing the amount of pathological bacteria of the Clostridium genera. |
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Waitzberg, Dan LinetzkyPereira, Claudia Cristina Alves [UNIFESP]Logullo, Luciana da Costa EduardoJacintho, Thiago ManzoniAlmeida, Danielle Fontes deSilva, Maria de Lourdes Teixeira daTorrinhas, Raquel Susana Matos de MirandaUniversidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)GANEP Nutr Humana2016-01-24T14:17:39Z2016-01-24T14:17:39Z2012-01-01Nutricion Hospitalaria. Madrid: Aula Medica Ediciones, v. 27, n. 1, p. 123-129, 2012.0212-1611https://repositorio.unifesp.br/handle/11600/34397https://scielo.isciii.es/pdf/nh/v27n1/14_original_03.pdfWOS000300036300014.pdf10.3305/nh.2012.27.1.5445WOS:000300036300014Introduction: Prebiotics positively affect gut microbiota composition, thus improving gut function. These properties may be useful for the treatment of constipation.Objectives: This study assessed the tolerance and effectiveness of a prebiotic inulin/partially hydrolyzed guar gum mixture (I-PHGG) for the treatment of constipation in females, as well as its influence on the composition of intestinal microbiota and production of short chain fatty acids.Methods: Our study enrolled 60 constipated female health worker volunteers. Participants reported less than 3 bowel movements per week. Volunteers were randomized to treatment with prebiotic or placebo. Treatment consisted of 3 weeks supplementation with 15 g/d I-PHGG (fiber group) or maltodextrin (placebo group). Abdominal discomfort, flatulence, stool consistency, and bowel movements were evaluated by a recorded daily questionnaire and a weekly interview. Changes in fecal bacterial population and short chain fatty acids were assessed by real-time PCR and gas chromatography, respectively.Results: There was an increased frequency of weekly bowel movements and patient satisfaction in both the fiber and placebo groups with no significant differences. Total Clostridium sp significantly decreased in the fiber group (p = 0.046) and increased in the placebo group (p = 0.047). There were no changes in fecal short chain fatty acid profile.Conclusions: Consumption of I-PHGG produced clinical results comparable to placebo in constipated females, but had additional protective effects on gut rnicrobiota by decreasing the amount of pathological bacteria of the Clostridium genera.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ São Paulo, Fac Med, Sch Med, Dept Gastroenterol,Surg Gastroenterol Discipline, BR-01246903 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biociences, Santos, BrazilGANEP Nutr Humana, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biosciences, Santos, BrazilFAPESP: 07/58600-2Web of Science123-129engAula Medica EdicionesNutricion HospitalariaGuar gumInulinGut microbiotaShort-chain fatty acidsConstipationMicrobiota benefits after inulin and partially hydrolized guar gum supplementation - a randomized clinical trial in constipated womenBeneficios en la microbiota intestinal después de la suplementación con inulina y la goma guar parcialmente hidrolizada: un ensayo clínico aleatorizado en mujeres con estreñimientoinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000300036300014.pdfapplication/pdf102687${dspace.ui.url}/bitstream/11600/34397/1/WOS000300036300014.pdf8c7c2b91a78381f2141382e10aeb27c2MD51open accessTEXTWOS000300036300014.pdf.txtWOS000300036300014.pdf.txtExtracted texttext/plain31993${dspace.ui.url}/bitstream/11600/34397/6/WOS000300036300014.pdf.txtd4aa5dc2bf6bafe482679d96d5afa550MD56open accessTHUMBNAILWOS000300036300014.pdf.jpgWOS000300036300014.pdf.jpgIM Thumbnailimage/jpeg6252${dspace.ui.url}/bitstream/11600/34397/8/WOS000300036300014.pdf.jpgabfc41aa00f0482852316c97e34d52bfMD58open access11600/343972023-06-05 19:06:58.982open accessoai:repositorio.unifesp.br:11600/34397Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:06:58Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Microbiota benefits after inulin and partially hydrolized guar gum supplementation - a randomized clinical trial in constipated women |
dc.title.alternative.es.fl_str_mv |
Beneficios en la microbiota intestinal después de la suplementación con inulina y la goma guar parcialmente hidrolizada: un ensayo clínico aleatorizado en mujeres con estreñimiento |
title |
Microbiota benefits after inulin and partially hydrolized guar gum supplementation - a randomized clinical trial in constipated women |
spellingShingle |
Microbiota benefits after inulin and partially hydrolized guar gum supplementation - a randomized clinical trial in constipated women Waitzberg, Dan Linetzky Guar gum Inulin Gut microbiota Short-chain fatty acids Constipation |
title_short |
Microbiota benefits after inulin and partially hydrolized guar gum supplementation - a randomized clinical trial in constipated women |
title_full |
Microbiota benefits after inulin and partially hydrolized guar gum supplementation - a randomized clinical trial in constipated women |
title_fullStr |
Microbiota benefits after inulin and partially hydrolized guar gum supplementation - a randomized clinical trial in constipated women |
title_full_unstemmed |
Microbiota benefits after inulin and partially hydrolized guar gum supplementation - a randomized clinical trial in constipated women |
title_sort |
Microbiota benefits after inulin and partially hydrolized guar gum supplementation - a randomized clinical trial in constipated women |
author |
Waitzberg, Dan Linetzky |
author_facet |
Waitzberg, Dan Linetzky Pereira, Claudia Cristina Alves [UNIFESP] Logullo, Luciana da Costa Eduardo Jacintho, Thiago Manzoni Almeida, Danielle Fontes de Silva, Maria de Lourdes Teixeira da Torrinhas, Raquel Susana Matos de Miranda |
author_role |
author |
author2 |
Pereira, Claudia Cristina Alves [UNIFESP] Logullo, Luciana da Costa Eduardo Jacintho, Thiago Manzoni Almeida, Danielle Fontes de Silva, Maria de Lourdes Teixeira da Torrinhas, Raquel Susana Matos de Miranda |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) GANEP Nutr Humana |
dc.contributor.author.fl_str_mv |
Waitzberg, Dan Linetzky Pereira, Claudia Cristina Alves [UNIFESP] Logullo, Luciana da Costa Eduardo Jacintho, Thiago Manzoni Almeida, Danielle Fontes de Silva, Maria de Lourdes Teixeira da Torrinhas, Raquel Susana Matos de Miranda |
dc.subject.eng.fl_str_mv |
Guar gum Inulin Gut microbiota Short-chain fatty acids Constipation |
topic |
Guar gum Inulin Gut microbiota Short-chain fatty acids Constipation |
description |
Introduction: Prebiotics positively affect gut microbiota composition, thus improving gut function. These properties may be useful for the treatment of constipation.Objectives: This study assessed the tolerance and effectiveness of a prebiotic inulin/partially hydrolyzed guar gum mixture (I-PHGG) for the treatment of constipation in females, as well as its influence on the composition of intestinal microbiota and production of short chain fatty acids.Methods: Our study enrolled 60 constipated female health worker volunteers. Participants reported less than 3 bowel movements per week. Volunteers were randomized to treatment with prebiotic or placebo. Treatment consisted of 3 weeks supplementation with 15 g/d I-PHGG (fiber group) or maltodextrin (placebo group). Abdominal discomfort, flatulence, stool consistency, and bowel movements were evaluated by a recorded daily questionnaire and a weekly interview. Changes in fecal bacterial population and short chain fatty acids were assessed by real-time PCR and gas chromatography, respectively.Results: There was an increased frequency of weekly bowel movements and patient satisfaction in both the fiber and placebo groups with no significant differences. Total Clostridium sp significantly decreased in the fiber group (p = 0.046) and increased in the placebo group (p = 0.047). There were no changes in fecal short chain fatty acid profile.Conclusions: Consumption of I-PHGG produced clinical results comparable to placebo in constipated females, but had additional protective effects on gut rnicrobiota by decreasing the amount of pathological bacteria of the Clostridium genera. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:17:39Z |
dc.date.available.fl_str_mv |
2016-01-24T14:17:39Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Nutricion Hospitalaria. Madrid: Aula Medica Ediciones, v. 27, n. 1, p. 123-129, 2012. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/34397 https://scielo.isciii.es/pdf/nh/v27n1/14_original_03.pdf |
dc.identifier.issn.none.fl_str_mv |
0212-1611 |
dc.identifier.file.none.fl_str_mv |
WOS000300036300014.pdf |
dc.identifier.doi.none.fl_str_mv |
10.3305/nh.2012.27.1.5445 |
dc.identifier.wos.none.fl_str_mv |
WOS:000300036300014 |
identifier_str_mv |
Nutricion Hospitalaria. Madrid: Aula Medica Ediciones, v. 27, n. 1, p. 123-129, 2012. 0212-1611 WOS000300036300014.pdf 10.3305/nh.2012.27.1.5445 WOS:000300036300014 |
url |
https://repositorio.unifesp.br/handle/11600/34397 https://scielo.isciii.es/pdf/nh/v27n1/14_original_03.pdf |
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eng |
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openAccess |
dc.format.none.fl_str_mv |
123-129 |
dc.publisher.none.fl_str_mv |
Aula Medica Ediciones |
publisher.none.fl_str_mv |
Aula Medica Ediciones |
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