Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/37461 http://dx.doi.org/10.1111/j.2047-2927.2013.00168.x |
Resumo: | Nicotine is largely consumed as a component of cigarettes. It induces apoptosis, interferes with endocrine function by changing the sex hormones secretion and leads to male infertility. Testosterone is produced from cholesterol by Leydig cells (LC), with the participation of testicular macrophages (MO). Thus, to investigate whether nicotine administration to pregnant and lactating rats changes cholesterol and sexual hormone levels and LC and MO populations of offspring, female rats received nicotine (2mg/kg/day) through osmotic minipumps from the first day of pregnancy up to the end of weaning. At 1, 30, 60 and 90days post-partum (dpp) the plasma cholesterol and testosterone levels were obtained, as well as the biometric, histopathological and stereological testicular parameters. Nicotine reduced the body weight, cholesterol levels and lipid droplet number in foetal LC at 1dpp. the number of apoptotic LC did not change in the offspring of nicotine group at any age studied. No alterations in the numerical densities of MO and LC occurred at 60 and 90dpp. Hypertrophy of mature LC and increase in cholesterol and testosterone levels were noted at 90dpp. in conclusion, nicotine when administered to rats throughout pregnancy and lactation induces morphofunctional alterations of foetal and mature LC and affects cholesterol and testosterone levels. |
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Paccola, Camila Cicconi [UNIFESP]Neves, F. M. O. [UNIFESP]Cipriano, I. [UNIFESP]Stumpp, Taiza [UNIFESP]Miraglia, Sandra Maria [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:35:20Z2016-01-24T14:35:20Z2014-03-01Andrology. Hoboken: Wiley-Blackwell, v. 2, n. 2, p. 175-185, 2014.2047-2919http://repositorio.unifesp.br/handle/11600/37461http://dx.doi.org/10.1111/j.2047-2927.2013.00168.x10.1111/j.2047-2927.2013.00168.xWOS:000331696100004Nicotine is largely consumed as a component of cigarettes. It induces apoptosis, interferes with endocrine function by changing the sex hormones secretion and leads to male infertility. Testosterone is produced from cholesterol by Leydig cells (LC), with the participation of testicular macrophages (MO). Thus, to investigate whether nicotine administration to pregnant and lactating rats changes cholesterol and sexual hormone levels and LC and MO populations of offspring, female rats received nicotine (2mg/kg/day) through osmotic minipumps from the first day of pregnancy up to the end of weaning. At 1, 30, 60 and 90days post-partum (dpp) the plasma cholesterol and testosterone levels were obtained, as well as the biometric, histopathological and stereological testicular parameters. Nicotine reduced the body weight, cholesterol levels and lipid droplet number in foetal LC at 1dpp. the number of apoptotic LC did not change in the offspring of nicotine group at any age studied. No alterations in the numerical densities of MO and LC occurred at 60 and 90dpp. Hypertrophy of mature LC and increase in cholesterol and testosterone levels were noted at 90dpp. in conclusion, nicotine when administered to rats throughout pregnancy and lactation induces morphofunctional alterations of foetal and mature LC and affects cholesterol and testosterone levels.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal de São Paulo, Dept Morphol & Genet, Dev Biol Lab, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Morphol & Genet, Dev Biol Lab, São Paulo, BrazilFAPESP: 2009/07855-6Web of Science175-185engWiley-BlackwellAndrologyhttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlinfo:eu-repo/semantics/openAccessLeydig cellnicotinerattestistesticular macrophageEffects of prenatal and lactation nicotine exposure on rat testicular interstitial tissueinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/374612022-06-01 15:08:50.603metadata only accessoai:repositorio.unifesp.br:11600/37461Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-06-01T18:08:50Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue |
title |
Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue |
spellingShingle |
Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue Paccola, Camila Cicconi [UNIFESP] Leydig cell nicotine rat testis testicular macrophage |
title_short |
Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue |
title_full |
Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue |
title_fullStr |
Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue |
title_full_unstemmed |
Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue |
title_sort |
Effects of prenatal and lactation nicotine exposure on rat testicular interstitial tissue |
author |
Paccola, Camila Cicconi [UNIFESP] |
author_facet |
Paccola, Camila Cicconi [UNIFESP] Neves, F. M. O. [UNIFESP] Cipriano, I. [UNIFESP] Stumpp, Taiza [UNIFESP] Miraglia, Sandra Maria [UNIFESP] |
author_role |
author |
author2 |
Neves, F. M. O. [UNIFESP] Cipriano, I. [UNIFESP] Stumpp, Taiza [UNIFESP] Miraglia, Sandra Maria [UNIFESP] |
author2_role |
author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Paccola, Camila Cicconi [UNIFESP] Neves, F. M. O. [UNIFESP] Cipriano, I. [UNIFESP] Stumpp, Taiza [UNIFESP] Miraglia, Sandra Maria [UNIFESP] |
dc.subject.eng.fl_str_mv |
Leydig cell nicotine rat testis testicular macrophage |
topic |
Leydig cell nicotine rat testis testicular macrophage |
description |
Nicotine is largely consumed as a component of cigarettes. It induces apoptosis, interferes with endocrine function by changing the sex hormones secretion and leads to male infertility. Testosterone is produced from cholesterol by Leydig cells (LC), with the participation of testicular macrophages (MO). Thus, to investigate whether nicotine administration to pregnant and lactating rats changes cholesterol and sexual hormone levels and LC and MO populations of offspring, female rats received nicotine (2mg/kg/day) through osmotic minipumps from the first day of pregnancy up to the end of weaning. At 1, 30, 60 and 90days post-partum (dpp) the plasma cholesterol and testosterone levels were obtained, as well as the biometric, histopathological and stereological testicular parameters. Nicotine reduced the body weight, cholesterol levels and lipid droplet number in foetal LC at 1dpp. the number of apoptotic LC did not change in the offspring of nicotine group at any age studied. No alterations in the numerical densities of MO and LC occurred at 60 and 90dpp. Hypertrophy of mature LC and increase in cholesterol and testosterone levels were noted at 90dpp. in conclusion, nicotine when administered to rats throughout pregnancy and lactation induces morphofunctional alterations of foetal and mature LC and affects cholesterol and testosterone levels. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-03-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:35:20Z |
dc.date.available.fl_str_mv |
2016-01-24T14:35:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Andrology. Hoboken: Wiley-Blackwell, v. 2, n. 2, p. 175-185, 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/37461 http://dx.doi.org/10.1111/j.2047-2927.2013.00168.x |
dc.identifier.issn.none.fl_str_mv |
2047-2919 |
dc.identifier.doi.none.fl_str_mv |
10.1111/j.2047-2927.2013.00168.x |
dc.identifier.wos.none.fl_str_mv |
WOS:000331696100004 |
identifier_str_mv |
Andrology. Hoboken: Wiley-Blackwell, v. 2, n. 2, p. 175-185, 2014. 2047-2919 10.1111/j.2047-2927.2013.00168.x WOS:000331696100004 |
url |
http://repositorio.unifesp.br/handle/11600/37461 http://dx.doi.org/10.1111/j.2047-2927.2013.00168.x |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Andrology |
dc.rights.driver.fl_str_mv |
http://olabout.wiley.com/WileyCDA/Section/id-406071.html info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://olabout.wiley.com/WileyCDA/Section/id-406071.html |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
175-185 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764124615081984 |