Bronchodilator response in wheezing infants assessed by the raised volume rapid thoracic compression technique

Detalhes bibliográficos
Autor(a) principal: Lanza, Fernanda Cordoba [UNIFESP]
Data de Publicação: 2016
Outros Autores: Wandalsen, Gustavo Falbo [UNIFESP], Dos Santos, Amelia Miyashiro [UNIFESP], Solé, Dirceu [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1016/j.rmed.2016.08.013
https://repositorio.unifesp.br/handle/11600/57000
Resumo: Background: Bronchodilator response (BDR) analyzed by the raised volume rapid thoracic compression (RVRTC) in wheezing infants is not yet well described, although bronchodilators (BD) are routine in the treatment of this population. Objective: To evaluate BDR by RVRTC technique in infants with recurrent wheezing and compare to control group. Method: Cross sectional study, 45 infants, age 56 weeks (38-67 weeks). Two groups: wheezing group (WG: history of recurrent wheezing) and control group (CG). RVRTC was evaluated, FVC, FEV0.5, FEF50, FEF75, FEF85, FEF25-75 were measured. Salbutamol was delivered to infants and RVRTC evaluated again. BDR was determined by the increase greater than two standard deviation from the mean change in the CG. Results: In WG (n = 32) lung function was worse than in CG (n = 13): FEV0.5: 0.0(-0.9-0.9z score) vs 0.8(0.2-1.4z score)
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spelling Bronchodilator response in wheezing infants assessed by the raised volume rapid thoracic compression techniqueLung functionWheezingInfantsBronchodilatorBackground: Bronchodilator response (BDR) analyzed by the raised volume rapid thoracic compression (RVRTC) in wheezing infants is not yet well described, although bronchodilators (BD) are routine in the treatment of this population. Objective: To evaluate BDR by RVRTC technique in infants with recurrent wheezing and compare to control group. Method: Cross sectional study, 45 infants, age 56 weeks (38-67 weeks). Two groups: wheezing group (WG: history of recurrent wheezing) and control group (CG). RVRTC was evaluated, FVC, FEV0.5, FEF50, FEF75, FEF85, FEF25-75 were measured. Salbutamol was delivered to infants and RVRTC evaluated again. BDR was determined by the increase greater than two standard deviation from the mean change in the CG. Results: In WG (n = 32) lung function was worse than in CG (n = 13): FEV0.5: 0.0(-0.9-0.9z score) vs 0.8(0.2-1.4z score)FEF50: 0.2(-0.3-1.1z score) vs 0.9(0.5-1.4z score)and FEF25-75: 0.2(-0.5-1.1z score) vs 1.1(0.6-1.6z score), respectively, p < 0.05. Both groups had similar increase after BD. In WG 11 patients (34%) were responder and these had worse lung function compared to nonresponder (n = 21) (p < 0.05). The increase in lung function after BD in responder was higher than in nonresponder: FEV0.5: 6.5(2.1-7.1%) vs -0.5(-2.5-0.7%), FEF50: 5.1(2.7-11.7%) vs 0.4(-1.1-2.8%), FEF75: 20.7(4.7-23.6%) vs -1.3(-6.4-3.9%), FEF25-75: 9.9(3.8-16.4%) vs 0.0(-1.5-1.0%), respectively, p < 0.05. Conclusion: 34% WG showed BDR measured by the RVRTC. The best variables to detect BDR were FEF75, FEF25-75 and FEV0.5. Patients with worse lung function showed better response to BD. (C) 2016 Elsevier Ltd. All rights reserved.Fed Univ Sao Paulo UNIFESP, Dept Pediat, Discipline Allergy Clin Immunol & Rheumatol, Otonis St 725, BR-04025002 Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Pediat, Neonatal Div Med, Marselhesa St 630, BR-04020060 Sao Paulo, SP, BrazilDiscipline of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Universidade Federal de São Paulo (UNIFESP), Sao Paulo, SP, Otonis St 725, 04025-002, BrazilNeonatal Division of Medicine – Department of Pediatrics – Universidade Federal de São Paulo (UNIFESP), Sao Paulo, SP, Marselhesa St 630, 04020-060, BrazilWeb of ScienceW B Saunders Co Ltd2020-07-31T12:47:41Z2020-07-31T12:47:41Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion29-34http://dx.doi.org/10.1016/j.rmed.2016.08.013Respiratory Medicine. London, v. 119, p. 29-34, 2016.10.1016/j.rmed.2016.08.0130954-6111https://repositorio.unifesp.br/handle/11600/57000WOS:000385321200006engRespiratory MedicineLondoninfo:eu-repo/semantics/openAccessLanza, Fernanda Cordoba [UNIFESP]Wandalsen, Gustavo Falbo [UNIFESP]Dos Santos, Amelia Miyashiro [UNIFESP]Solé, Dirceu [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2022-02-07T20:58:45Zoai:repositorio.unifesp.br/:11600/57000Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652022-02-07T20:58:45Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Bronchodilator response in wheezing infants assessed by the raised volume rapid thoracic compression technique
title Bronchodilator response in wheezing infants assessed by the raised volume rapid thoracic compression technique
spellingShingle Bronchodilator response in wheezing infants assessed by the raised volume rapid thoracic compression technique
Lanza, Fernanda Cordoba [UNIFESP]
Lung function
Wheezing
Infants
Bronchodilator
title_short Bronchodilator response in wheezing infants assessed by the raised volume rapid thoracic compression technique
title_full Bronchodilator response in wheezing infants assessed by the raised volume rapid thoracic compression technique
title_fullStr Bronchodilator response in wheezing infants assessed by the raised volume rapid thoracic compression technique
title_full_unstemmed Bronchodilator response in wheezing infants assessed by the raised volume rapid thoracic compression technique
title_sort Bronchodilator response in wheezing infants assessed by the raised volume rapid thoracic compression technique
author Lanza, Fernanda Cordoba [UNIFESP]
author_facet Lanza, Fernanda Cordoba [UNIFESP]
Wandalsen, Gustavo Falbo [UNIFESP]
Dos Santos, Amelia Miyashiro [UNIFESP]
Solé, Dirceu [UNIFESP]
author_role author
author2 Wandalsen, Gustavo Falbo [UNIFESP]
Dos Santos, Amelia Miyashiro [UNIFESP]
Solé, Dirceu [UNIFESP]
author2_role author
author
author
dc.contributor.author.fl_str_mv Lanza, Fernanda Cordoba [UNIFESP]
Wandalsen, Gustavo Falbo [UNIFESP]
Dos Santos, Amelia Miyashiro [UNIFESP]
Solé, Dirceu [UNIFESP]
dc.subject.por.fl_str_mv Lung function
Wheezing
Infants
Bronchodilator
topic Lung function
Wheezing
Infants
Bronchodilator
description Background: Bronchodilator response (BDR) analyzed by the raised volume rapid thoracic compression (RVRTC) in wheezing infants is not yet well described, although bronchodilators (BD) are routine in the treatment of this population. Objective: To evaluate BDR by RVRTC technique in infants with recurrent wheezing and compare to control group. Method: Cross sectional study, 45 infants, age 56 weeks (38-67 weeks). Two groups: wheezing group (WG: history of recurrent wheezing) and control group (CG). RVRTC was evaluated, FVC, FEV0.5, FEF50, FEF75, FEF85, FEF25-75 were measured. Salbutamol was delivered to infants and RVRTC evaluated again. BDR was determined by the increase greater than two standard deviation from the mean change in the CG. Results: In WG (n = 32) lung function was worse than in CG (n = 13): FEV0.5: 0.0(-0.9-0.9z score) vs 0.8(0.2-1.4z score)
publishDate 2016
dc.date.none.fl_str_mv 2016
2020-07-31T12:47:41Z
2020-07-31T12:47:41Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.rmed.2016.08.013
Respiratory Medicine. London, v. 119, p. 29-34, 2016.
10.1016/j.rmed.2016.08.013
0954-6111
https://repositorio.unifesp.br/handle/11600/57000
WOS:000385321200006
url http://dx.doi.org/10.1016/j.rmed.2016.08.013
https://repositorio.unifesp.br/handle/11600/57000
identifier_str_mv Respiratory Medicine. London, v. 119, p. 29-34, 2016.
10.1016/j.rmed.2016.08.013
0954-6111
WOS:000385321200006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Respiratory Medicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 29-34
dc.coverage.none.fl_str_mv London
dc.publisher.none.fl_str_mv W B Saunders Co Ltd
publisher.none.fl_str_mv W B Saunders Co Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268269347995648

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