Small leucine-rich proteoglycans (SLRPs) in the endometrium of polycystic ovary syndrome women: a pilot study

• Autor(a) principal: Simoes, Ricardo Santos
• Data de Publicação: 2017
• Outros Autores: Soares-, Jose Maria, Jr., Simoes, Manuel J., Nader, Helena B.Bruna Linzmeyer, Baracat, Maria Candida P., Maciel, Gustavo Arantes R., Serafini, Paulo C., Azziz, Ricardo, Baracat, Edmund C.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1186/s13048-017-0349-9; http://repositorio.unifesp.br/handle/11600/51396
• topic: Polycystic ovary syndrome; Endometrium; Small leucine-rich proteoglycans; Proliferative phase

Background: Small leucine-rich proteoglycans (SLRPs) play an important role in tissue homeostasis and cell proliferation since these proteoglycans sequester multiple growth factors. However, the content of SLRPs in the endometrium of polycystic ovary syndrome (PCOS) women is unknown. Our purpose was to test the hypothesis that excessive endometrial proliferation in PCOS may be partly related to abnormalities in SLRPs. Methods: In a cross section study a total of 20 endometrial samples were collected from 10 patients with PCOS and 10 ovulatory women during their proliferative (pre-ovulatory) phase. The study subjects were matched for age, body mass index and race. The age range was 20 to 35 years. All volunteers were evaluated in reproductive endocrinology clinic, Gynecology Division, Clinics Hospital, University of Sao Paulo Medical School Profile and concentration of small leucine-rich proteoglycans (decorin, lumican, fibromodulin and biglycan) were determined by immunohistochemical testing and Western blotting. Results: Decorin and lumican demonstrated higher immunoreactivity and relative expression in the endometrium of women with PCOS compared to that of women with regular menstrual cycles. Conclusion: Our data suggests that the endometrium of PCOS women demonstrate a greater content of SLRP than controls