Infliximab, methotrexate and their combination for the treatment of rheumatoid arthritis: a systematic review and meta-analysis

• Autor(a) principal: Costa, Juliana de Oliveira
• Data de Publicação: 2015
• Outros Autores: Lemos, Livia Lovato Pires de, Machado, Marina Amaral de Ávila, Almeida, Alessandra Maciel, Kakehasi, Adriana Maria, Araújo, Vania de Eloisa [UNIFESP], Cherchiglia, Mariangela Leal, Andrade, Eli Iola Gurgel, Acúrcio, Francisco de Assis
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1016/j.rbr.2014.10.009; http://repositorio.unifesp.br/handle/11600/38788
• topic: Infliximab; Systematic review; Meta-analysis; Rheumatoid arthritis; Efficacy

We performed a systematic review to evaluate the efficacy and safety of infliximab + methotrexate (IFX + MTX) regimens versus MTX alone or in combination with other disease-modifying anti-rheumatic drugs (DMARDs). We searched through major databases, the grey literature and did a manual search. Two independent reviewers conducted the selection, data extraction and analysis of the quality of the studies. Meta-analysis was conducted using Review Manager (R) 5.1 software. Nine trials were included. the mean modified Jadad score was 4.4, but only one study showed low risk of bias. IFX + MTX regimen presented better responses in clinical outcomes of ACR and DA528 by up to 54 weeks, and of radiographic progression by up to 104 weeks. Withdrawals due to lack of efficacy was lower in the IFX + MTX group. No significant difference in adverse events was observed. the IFX + MTX combination is more effective than treatment with MTX alone or DMARDs combination. This regimen presented good tolerability in patients previously treated with DMARDs, not treated with MTX or with insufficient responses to MTX. the efficacy of IFX + MTX is noted primarily during initial periods of treatment. High doses of IFX were as effective as the standard dose, but with possible higher risk of serious infections. Therefore, we advise clinicians to use the standard dose of IFX 3 mg/kg every 8 weeks. (C) 2013 Elsevier Editora Ltda. All rights reserved.