A prospective study showing an excellent response of patients with low-risk differentiated thyroid cancer who did not undergo radioiodine remnant ablation after total thyroidectomy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| dARK ID: | ark:/48912/001300001073x |
| Texto Completo: | https://doi.org/10.1159/000442048 http://repositorio.unifesp.br/handle/11600/49445 |
Resumo: | Objectives: To prospectively evaluate the outcome of patients with low-risk papillary thyroid carcinoma treated with total thyroidectomy (TT) who did not undergo radioiodine remnant ablation (RRA). Study Design: We prospectively followed up 57 patients |
| id |
UFSP_0d6d143f08fd9267a8c3354985c3f6e5 |
|---|---|
| oai_identifier_str |
oai:repositorio.unifesp.br/:11600/49445 |
| network_acronym_str |
UFSP |
| network_name_str |
Repositório Institucional da UNIFESP |
| repository_id_str |
3465 |
| spelling |
A prospective study showing an excellent response of patients with low-risk differentiated thyroid cancer who did not undergo radioiodine remnant ablation after total thyroidectomyLow-Risk Thyroid CarcinomaThyroglobulinThyroglobulin Temporal TrendRadioiodine Remnant AblationNeck UltrasoundLong-Term ImpactRadioactive IodineIncreasing IncidenceTherapyPapillaryAssociationSurveillanceRecurrenceAdjuvantUpdateObjectives: To prospectively evaluate the outcome of patients with low-risk papillary thyroid carcinoma treated with total thyroidectomy (TT) who did not undergo radioiodine remnant ablation (RRA). Study Design: We prospectively followed up 57 patients3 months after TT, thyroglobulin (Tg) assessment and neck ultrasonography (US) were performed while patients were taking L-T-4, presenting suppressed TSH. Six months after TT, patients underwent stimulated Tg testing and whole-body scan (WBS) after recombinant TSH (rhTSH). Then, 18 months after TT, the patients were evaluated by neck US and Tg under TSH between 0.5 and 2.0 mIU/ml. Two years after TT, we performed another rhTSH assessment, measuring Tg and making a WBS. The patients were then annually monitored with neck US and Tg measurement under TSH between 0.5 and 2.0 mIU/l for 36-84 months. Results: Neck US of all patients, 3 months after TT, presented no evidence of abnormal residual tissues or metastatic lymph nodes (negative neck US)at this time, the mean Tg level was 0.42 ng/ml. Six months after surgery, after rhTSH, the mean thyroid bed uptake was 1.82%, and Tg levels ranged from 0.10 to 22.30 ng/ml (mean, 2.89 ng/ml). The patients were followed up without any sign of recurrence (negative neck US and stable or decreasing Tg levels). During the ongoing follow-up, the Tg trend was stable or decreasing, independently of the initial suppressed or stimulated Tg level, or WBS uptake. Conclusions: In patients with low-risk differentiated thyroid cancer, who were operated by TT and who did not undergo RRA, an excellent response to treatment may be confirmed by annual neck US and Tg trend. (C) 2015 European Thyroid Association Published by S. Karger AG, BaselThyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São PauloThyroid Diseases Center, Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, BrazilThyroid Diseases Center and Laboratory of Molecular and Translational Endocrinology, Division of Endocrinology, Department of Medicine, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Pedro de Toledo 669,11th Floor, BR-04039032 Sao Paulo, SP, Brazil.Web of ScienceBrazilian Ministry of Health [25000.168513/2008-11]Brazilian Ministry of Health: 25000.168513/2008-11Future Sci Ltd2019-01-21T10:29:52Z2019-01-21T10:29:52Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion44-49https://doi.org/10.1159/000442048European Thyroid Journal. Basel, v. 5, n. 1, p. 44-49, 2016.10.1159/0004420482235-0640http://repositorio.unifesp.br/handle/11600/49445WOS:000381685300007ark:/48912/001300001073xengEuropean Thyroid Journalinfo:eu-repo/semantics/openAccessJanovsky, Carolina Castro Porto Silva [UNIFESP]Maciel, Rui M. B. [UNIFESP]Camacho, Cleber P. [UNIFESP]Padovani, Rosalia P. [UNIFESP]Nakabashi, Claudia C. [UNIFESP]Yang, Ji H. [UNIFESP]Malouf, Eduardo Z. [UNIFESP]Ikejiri, Elza S. [UNIFESP]Mamone, M. Conceicao O. C. [UNIFESP]Wagner, JairoAndreoni, Danielle M. [UNIFESP]Biscolla, Rosa Paula M. [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2022-02-09T10:54:42Zoai:repositorio.unifesp.br/:11600/49445Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:46:51.009458Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
A prospective study showing an excellent response of patients with low-risk differentiated thyroid cancer who did not undergo radioiodine remnant ablation after total thyroidectomy |
| title |
A prospective study showing an excellent response of patients with low-risk differentiated thyroid cancer who did not undergo radioiodine remnant ablation after total thyroidectomy |
| spellingShingle |
A prospective study showing an excellent response of patients with low-risk differentiated thyroid cancer who did not undergo radioiodine remnant ablation after total thyroidectomy Janovsky, Carolina Castro Porto Silva [UNIFESP] Low-Risk Thyroid Carcinoma Thyroglobulin Thyroglobulin Temporal Trend Radioiodine Remnant Ablation Neck UltrasoundLong-Term Impact Radioactive Iodine Increasing Incidence Therapy Papillary Association Surveillance Recurrence Adjuvant Update |
| title_short |
A prospective study showing an excellent response of patients with low-risk differentiated thyroid cancer who did not undergo radioiodine remnant ablation after total thyroidectomy |
| title_full |
A prospective study showing an excellent response of patients with low-risk differentiated thyroid cancer who did not undergo radioiodine remnant ablation after total thyroidectomy |
| title_fullStr |
A prospective study showing an excellent response of patients with low-risk differentiated thyroid cancer who did not undergo radioiodine remnant ablation after total thyroidectomy |
| title_full_unstemmed |
A prospective study showing an excellent response of patients with low-risk differentiated thyroid cancer who did not undergo radioiodine remnant ablation after total thyroidectomy |
| title_sort |
A prospective study showing an excellent response of patients with low-risk differentiated thyroid cancer who did not undergo radioiodine remnant ablation after total thyroidectomy |
| author |
Janovsky, Carolina Castro Porto Silva [UNIFESP] |
| author_facet |
Janovsky, Carolina Castro Porto Silva [UNIFESP] Maciel, Rui M. B. [UNIFESP] Camacho, Cleber P. [UNIFESP] Padovani, Rosalia P. [UNIFESP] Nakabashi, Claudia C. [UNIFESP] Yang, Ji H. [UNIFESP] Malouf, Eduardo Z. [UNIFESP] Ikejiri, Elza S. [UNIFESP] Mamone, M. Conceicao O. C. [UNIFESP] Wagner, Jairo Andreoni, Danielle M. [UNIFESP] Biscolla, Rosa Paula M. [UNIFESP] |
| author_role |
author |
| author2 |
Maciel, Rui M. B. [UNIFESP] Camacho, Cleber P. [UNIFESP] Padovani, Rosalia P. [UNIFESP] Nakabashi, Claudia C. [UNIFESP] Yang, Ji H. [UNIFESP] Malouf, Eduardo Z. [UNIFESP] Ikejiri, Elza S. [UNIFESP] Mamone, M. Conceicao O. C. [UNIFESP] Wagner, Jairo Andreoni, Danielle M. [UNIFESP] Biscolla, Rosa Paula M. [UNIFESP] |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Janovsky, Carolina Castro Porto Silva [UNIFESP] Maciel, Rui M. B. [UNIFESP] Camacho, Cleber P. [UNIFESP] Padovani, Rosalia P. [UNIFESP] Nakabashi, Claudia C. [UNIFESP] Yang, Ji H. [UNIFESP] Malouf, Eduardo Z. [UNIFESP] Ikejiri, Elza S. [UNIFESP] Mamone, M. Conceicao O. C. [UNIFESP] Wagner, Jairo Andreoni, Danielle M. [UNIFESP] Biscolla, Rosa Paula M. [UNIFESP] |
| dc.subject.por.fl_str_mv |
Low-Risk Thyroid Carcinoma Thyroglobulin Thyroglobulin Temporal Trend Radioiodine Remnant Ablation Neck UltrasoundLong-Term Impact Radioactive Iodine Increasing Incidence Therapy Papillary Association Surveillance Recurrence Adjuvant Update |
| topic |
Low-Risk Thyroid Carcinoma Thyroglobulin Thyroglobulin Temporal Trend Radioiodine Remnant Ablation Neck UltrasoundLong-Term Impact Radioactive Iodine Increasing Incidence Therapy Papillary Association Surveillance Recurrence Adjuvant Update |
| description |
Objectives: To prospectively evaluate the outcome of patients with low-risk papillary thyroid carcinoma treated with total thyroidectomy (TT) who did not undergo radioiodine remnant ablation (RRA). Study Design: We prospectively followed up 57 patients |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 2019-01-21T10:29:52Z 2019-01-21T10:29:52Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://doi.org/10.1159/000442048 European Thyroid Journal. Basel, v. 5, n. 1, p. 44-49, 2016. 10.1159/000442048 2235-0640 http://repositorio.unifesp.br/handle/11600/49445 WOS:000381685300007 |
| dc.identifier.dark.fl_str_mv |
ark:/48912/001300001073x |
| url |
https://doi.org/10.1159/000442048 http://repositorio.unifesp.br/handle/11600/49445 |
| identifier_str_mv |
European Thyroid Journal. Basel, v. 5, n. 1, p. 44-49, 2016. 10.1159/000442048 2235-0640 WOS:000381685300007 ark:/48912/001300001073x |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
European Thyroid Journal |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
44-49 |
| dc.publisher.none.fl_str_mv |
Future Sci Ltd |
| publisher.none.fl_str_mv |
Future Sci Ltd |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
| institution |
UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
| collection |
Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
| repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
| _version_ |
1818602543491579904 |