Correlation between heart rate variability and pulmonary function adjusted by confounding factors in healthy adults
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/57928 https://dx.doi.org/10.1590/1414-431X20154435 |
Resumo: | The autonomic nervous system maintains homeostasis, which is the state of balance in the body. That balance can be determined simply and noninvasively by evaluating heart rate variability (HRV). However, independently of autonomic control of the heart, HRV can be influenced by other factors, such as respiratory parameters. Little is known about the relationship between HRV and spirometric indices. In this study, our objective was to determine whether HRV correlates with spirometric indices in adults without cardiopulmonary disease, considering the main confounders (e.g., smoking and physical inactivity). In a sample of 119 asymptomatic adults (age 20-80 years), we evaluated forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1). We evaluated resting HRV indices within a 5-min window in the middle of a 10-min recording period, thereafter analyzing time and frequency domains. To evaluate daily physical activity, we instructed participants to use a triaxial accelerometer for 7 days. Physical inactivity was defined as <150 min/week of moderate to intense physical activity. We found that FVC and FEV1, respectively, correlated significantly with the following aspects of the RR interval: standard deviation of the RR intervals (r= 0.31 and 0.35), low-frequency component (r= 0.38 and 0.40), and Poincare plot SD2 (r= 0.34 and 0.36). Multivariate regression analysis, adjusted for age, sex, smoking, physical inactivity, and cardiovascular risk, identified the SD2 and dyslipidemia as independent predictors of FVC and FEV1 (R-2= 0.125 and 0.180, respectively, for both). We conclude that pulmonary function is influenced by autonomic control of cardiovascular function, independently of the main confounders. |
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Bianchim, Mayara Silveira [UNIFESP]Sperandio, Evandro Fornias [UNIFESP]Martinhao, Graciana Santos [UNIFESP]Matheus, Agatha Caveda [UNIFESP]Lauria, Vinicius Tonon [UNIFESP]Silva, Rodrigo Pereira da [UNIFESP]Spadari, Regina Celia [UNIFESP]Gagliardi, Antonio Ricardo de ToledoArantes, Rodolfo LeiteRomiti, MarcelloDourado, Victor Zuniga [UNIFESP]2020-08-21T17:00:18Z2020-08-21T17:00:18Z2016Brazilian Journal of Medical and Biological Research. Sao Paulo, v. 49, n. 3, p. -, 2016.0100-879Xhttps://repositorio.unifesp.br/handle/11600/57928https://dx.doi.org/10.1590/1414-431X20154435S0100-879X2016000300702-en.pdfS0100-879X201600030070210.1590/1414-431X20154435WOS:000370521400001The autonomic nervous system maintains homeostasis, which is the state of balance in the body. That balance can be determined simply and noninvasively by evaluating heart rate variability (HRV). However, independently of autonomic control of the heart, HRV can be influenced by other factors, such as respiratory parameters. Little is known about the relationship between HRV and spirometric indices. In this study, our objective was to determine whether HRV correlates with spirometric indices in adults without cardiopulmonary disease, considering the main confounders (e.g., smoking and physical inactivity). In a sample of 119 asymptomatic adults (age 20-80 years), we evaluated forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1). We evaluated resting HRV indices within a 5-min window in the middle of a 10-min recording period, thereafter analyzing time and frequency domains. To evaluate daily physical activity, we instructed participants to use a triaxial accelerometer for 7 days. Physical inactivity was defined as <150 min/week of moderate to intense physical activity. We found that FVC and FEV1, respectively, correlated significantly with the following aspects of the RR interval: standard deviation of the RR intervals (r= 0.31 and 0.35), low-frequency component (r= 0.38 and 0.40), and Poincare plot SD2 (r= 0.34 and 0.36). Multivariate regression analysis, adjusted for age, sex, smoking, physical inactivity, and cardiovascular risk, identified the SD2 and dyslipidemia as independent predictors of FVC and FEV1 (R-2= 0.125 and 0.180, respectively, for both). We conclude that pulmonary function is influenced by autonomic control of cardiovascular function, independently of the main confounders.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Fed Sao Paulo, Dept Ciencias Movimento Humano, Lab Epidemiol & Movimento Humano, Santos, SP, BrazilUniv Fed Sao Paulo, Dept Biociencias, Santos, SP, BrazilAngioCorpore Inst Med Cardiovasc, Santos, SP, BrazilUniv Fed Sao Paulo, Dept Ciencias Movimento Humano, Lab Epidemiol & Movimento Humano, Santos, SP, BrazilUniv Fed Sao Paulo, Dept Biociencias, Santos, SP, BrazilFAPESP: 2011/07282-6Web of Science-engAssoc Bras Divulg CientificaBrazilian Journal of Medical and Biological ResearchAutonomic nervous systemSpirometrySmokingCorrelation between heart rate variability and pulmonary function adjusted by confounding factors in healthy adultsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSao Paulo493info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2016000300702-en.pdfapplication/pdf86066${dspace.ui.url}/bitstream/11600/57928/1/S0100-879X2016000300702-en.pdfd6e02ba482c5323ebd0f749720750c40MD51open accessTEXTS0100-879X2016000300702-en.pdf.txtS0100-879X2016000300702-en.pdf.txtExtracted texttext/plain36066${dspace.ui.url}/bitstream/11600/57928/5/S0100-879X2016000300702-en.pdf.txtdd5b98bb656e8c86fe34bbff7fe3691fMD55open accessTHUMBNAILS0100-879X2016000300702-en.pdf.jpgS0100-879X2016000300702-en.pdf.jpgIM Thumbnailimage/jpeg6690${dspace.ui.url}/bitstream/11600/57928/7/S0100-879X2016000300702-en.pdf.jpga1f7d0abb0cfa46d8a50b248b5beb3e4MD57open access11600/579282023-06-05 19:13:20.133open accessoai:repositorio.unifesp.br:11600/57928Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:13:20Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Correlation between heart rate variability and pulmonary function adjusted by confounding factors in healthy adults |
title |
Correlation between heart rate variability and pulmonary function adjusted by confounding factors in healthy adults |
spellingShingle |
Correlation between heart rate variability and pulmonary function adjusted by confounding factors in healthy adults Bianchim, Mayara Silveira [UNIFESP] Autonomic nervous system Spirometry Smoking |
title_short |
Correlation between heart rate variability and pulmonary function adjusted by confounding factors in healthy adults |
title_full |
Correlation between heart rate variability and pulmonary function adjusted by confounding factors in healthy adults |
title_fullStr |
Correlation between heart rate variability and pulmonary function adjusted by confounding factors in healthy adults |
title_full_unstemmed |
Correlation between heart rate variability and pulmonary function adjusted by confounding factors in healthy adults |
title_sort |
Correlation between heart rate variability and pulmonary function adjusted by confounding factors in healthy adults |
author |
Bianchim, Mayara Silveira [UNIFESP] |
author_facet |
Bianchim, Mayara Silveira [UNIFESP] Sperandio, Evandro Fornias [UNIFESP] Martinhao, Graciana Santos [UNIFESP] Matheus, Agatha Caveda [UNIFESP] Lauria, Vinicius Tonon [UNIFESP] Silva, Rodrigo Pereira da [UNIFESP] Spadari, Regina Celia [UNIFESP] Gagliardi, Antonio Ricardo de Toledo Arantes, Rodolfo Leite Romiti, Marcello Dourado, Victor Zuniga [UNIFESP] |
author_role |
author |
author2 |
Sperandio, Evandro Fornias [UNIFESP] Martinhao, Graciana Santos [UNIFESP] Matheus, Agatha Caveda [UNIFESP] Lauria, Vinicius Tonon [UNIFESP] Silva, Rodrigo Pereira da [UNIFESP] Spadari, Regina Celia [UNIFESP] Gagliardi, Antonio Ricardo de Toledo Arantes, Rodolfo Leite Romiti, Marcello Dourado, Victor Zuniga [UNIFESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Bianchim, Mayara Silveira [UNIFESP] Sperandio, Evandro Fornias [UNIFESP] Martinhao, Graciana Santos [UNIFESP] Matheus, Agatha Caveda [UNIFESP] Lauria, Vinicius Tonon [UNIFESP] Silva, Rodrigo Pereira da [UNIFESP] Spadari, Regina Celia [UNIFESP] Gagliardi, Antonio Ricardo de Toledo Arantes, Rodolfo Leite Romiti, Marcello Dourado, Victor Zuniga [UNIFESP] |
dc.subject.eng.fl_str_mv |
Autonomic nervous system Spirometry Smoking |
topic |
Autonomic nervous system Spirometry Smoking |
description |
The autonomic nervous system maintains homeostasis, which is the state of balance in the body. That balance can be determined simply and noninvasively by evaluating heart rate variability (HRV). However, independently of autonomic control of the heart, HRV can be influenced by other factors, such as respiratory parameters. Little is known about the relationship between HRV and spirometric indices. In this study, our objective was to determine whether HRV correlates with spirometric indices in adults without cardiopulmonary disease, considering the main confounders (e.g., smoking and physical inactivity). In a sample of 119 asymptomatic adults (age 20-80 years), we evaluated forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1). We evaluated resting HRV indices within a 5-min window in the middle of a 10-min recording period, thereafter analyzing time and frequency domains. To evaluate daily physical activity, we instructed participants to use a triaxial accelerometer for 7 days. Physical inactivity was defined as <150 min/week of moderate to intense physical activity. We found that FVC and FEV1, respectively, correlated significantly with the following aspects of the RR interval: standard deviation of the RR intervals (r= 0.31 and 0.35), low-frequency component (r= 0.38 and 0.40), and Poincare plot SD2 (r= 0.34 and 0.36). Multivariate regression analysis, adjusted for age, sex, smoking, physical inactivity, and cardiovascular risk, identified the SD2 and dyslipidemia as independent predictors of FVC and FEV1 (R-2= 0.125 and 0.180, respectively, for both). We conclude that pulmonary function is influenced by autonomic control of cardiovascular function, independently of the main confounders. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2020-08-21T17:00:18Z |
dc.date.available.fl_str_mv |
2020-08-21T17:00:18Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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Brazilian Journal of Medical and Biological Research. Sao Paulo, v. 49, n. 3, p. -, 2016. |
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https://repositorio.unifesp.br/handle/11600/57928 https://dx.doi.org/10.1590/1414-431X20154435 |
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0100-879X |
dc.identifier.file.none.fl_str_mv |
S0100-879X2016000300702-en.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2016000300702 |
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10.1590/1414-431X20154435 |
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WOS:000370521400001 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Sao Paulo, v. 49, n. 3, p. -, 2016. 0100-879X S0100-879X2016000300702-en.pdf S0100-879X2016000300702 10.1590/1414-431X20154435 WOS:000370521400001 |
url |
https://repositorio.unifesp.br/handle/11600/57928 https://dx.doi.org/10.1590/1414-431X20154435 |
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