Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus

Detalhes bibliográficos
Autor(a) principal: Goncalves, Sarah Santos [UNIFESP]
Data de Publicação: 2016
Outros Autores: Remondi Souza, Ana Carolina [UNIFESP], Chowdhary, Anuradha, Meis, Jacques F., Colombo, Arnaldo Lopes [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1111/myc.12469
https://repositorio.unifesp.br/handle/11600/57733
Resumo: The significant increase in the use of antifungal agents, both for the treatment of candidiasis and invasive aspergillosis and as azole fungicides in agricultural crop protection has resulted in the emergence of resistant clinical isolates, particularly to triazoles and echinocandins. Notably, among isolates that were primarily sensitive to fluconazole such as Candida parapsilosis and Candida tropicalis have witnessed an emerging resistance development. Also for echinocandins, the occurrence of Candida isolates with lower susceptibility to these drugs has been reported, which is possibly due to its broad clinical use. Triazole resistance among Aspergillus fumigatus and other Aspergillus species is commonly found in European and Asian countries. Specific mutations are associated with azole resistance in A. fumigatus and these mutations are now reported globally from six continents. Therefore, we highlight the need to conduct antifungal resistance surveillance studies using clinical isolates of Candida and Aspergillus in different geographical regions and monitoring of the infection rates in distinct population groups for early detection of resistance to these drugs and implementation of efficient policies for infection control and treatment.
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spelling Epidemiology and molecular mechanisms of antifungal resistance in Candida and AspergillusAntifungal resistanceCandida sppAspergillus sppazolesechinocandinsamphotericin BThe significant increase in the use of antifungal agents, both for the treatment of candidiasis and invasive aspergillosis and as azole fungicides in agricultural crop protection has resulted in the emergence of resistant clinical isolates, particularly to triazoles and echinocandins. Notably, among isolates that were primarily sensitive to fluconazole such as Candida parapsilosis and Candida tropicalis have witnessed an emerging resistance development. Also for echinocandins, the occurrence of Candida isolates with lower susceptibility to these drugs has been reported, which is possibly due to its broad clinical use. Triazole resistance among Aspergillus fumigatus and other Aspergillus species is commonly found in European and Asian countries. Specific mutations are associated with azole resistance in A. fumigatus and these mutations are now reported globally from six continents. Therefore, we highlight the need to conduct antifungal resistance surveillance studies using clinical isolates of Candida and Aspergillus in different geographical regions and monitoring of the infection rates in distinct population groups for early detection of resistance to these drugs and implementation of efficient policies for infection control and treatment.Univ Fed Sao Paulo, Lab Especial Micol, Disciplina Infectol, Escola Paulista Med, BR-04039032 Sao Paulo, SP, BrazilUniv Delhi, Vallabhbhai Patel Chest Inst, Dept Med Mycol, Delhi 110007, IndiaCanisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, NetherlandsRadboud Univ Nijmegen, Dept Med Microbiol, NL-6525 ED Nijmegen, NetherlandsUniv Fed Sao Paulo, Lab Especial Micol, Disciplina Infectol, Escola Paulista Med, BR-04039032 Sao Paulo, SP, BrazilWeb of ScienceFundação de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), BrazilFAPESP: 2012/04767-1FAPESP: 2012/04769-4CNPq: 308011/2010-4CAPES: PNPD 23038.007393/2011-11FAPESP : 2012/04769-4Wiley-Blackwell2020-08-21T16:59:39Z2020-08-21T16:59:39Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion198-219application/pdfhttp://dx.doi.org/10.1111/myc.12469Mycoses. Hoboken, v. 59, n. 4, p. 198-219, 2016.10.1111/myc.12469WOS000372295900001.pdf0933-7407https://repositorio.unifesp.br/handle/11600/57733WOS:000372295900001engMycosesHobokeninfo:eu-repo/semantics/openAccessGoncalves, Sarah Santos [UNIFESP]Remondi Souza, Ana Carolina [UNIFESP]Chowdhary, AnuradhaMeis, Jacques F.Colombo, Arnaldo Lopes [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-01T10:53:33Zoai:repositorio.unifesp.br/:11600/57733Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-01T10:53:33Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus
title Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus
spellingShingle Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus
Goncalves, Sarah Santos [UNIFESP]
Antifungal resistance
Candida spp
Aspergillus spp
azoles
echinocandins
amphotericin B
title_short Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus
title_full Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus
title_fullStr Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus
title_full_unstemmed Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus
title_sort Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus
author Goncalves, Sarah Santos [UNIFESP]
author_facet Goncalves, Sarah Santos [UNIFESP]
Remondi Souza, Ana Carolina [UNIFESP]
Chowdhary, Anuradha
Meis, Jacques F.
Colombo, Arnaldo Lopes [UNIFESP]
author_role author
author2 Remondi Souza, Ana Carolina [UNIFESP]
Chowdhary, Anuradha
Meis, Jacques F.
Colombo, Arnaldo Lopes [UNIFESP]
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Goncalves, Sarah Santos [UNIFESP]
Remondi Souza, Ana Carolina [UNIFESP]
Chowdhary, Anuradha
Meis, Jacques F.
Colombo, Arnaldo Lopes [UNIFESP]
dc.subject.por.fl_str_mv Antifungal resistance
Candida spp
Aspergillus spp
azoles
echinocandins
amphotericin B
topic Antifungal resistance
Candida spp
Aspergillus spp
azoles
echinocandins
amphotericin B
description The significant increase in the use of antifungal agents, both for the treatment of candidiasis and invasive aspergillosis and as azole fungicides in agricultural crop protection has resulted in the emergence of resistant clinical isolates, particularly to triazoles and echinocandins. Notably, among isolates that were primarily sensitive to fluconazole such as Candida parapsilosis and Candida tropicalis have witnessed an emerging resistance development. Also for echinocandins, the occurrence of Candida isolates with lower susceptibility to these drugs has been reported, which is possibly due to its broad clinical use. Triazole resistance among Aspergillus fumigatus and other Aspergillus species is commonly found in European and Asian countries. Specific mutations are associated with azole resistance in A. fumigatus and these mutations are now reported globally from six continents. Therefore, we highlight the need to conduct antifungal resistance surveillance studies using clinical isolates of Candida and Aspergillus in different geographical regions and monitoring of the infection rates in distinct population groups for early detection of resistance to these drugs and implementation of efficient policies for infection control and treatment.
publishDate 2016
dc.date.none.fl_str_mv 2016
2020-08-21T16:59:39Z
2020-08-21T16:59:39Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/myc.12469
Mycoses. Hoboken, v. 59, n. 4, p. 198-219, 2016.
10.1111/myc.12469
WOS000372295900001.pdf
0933-7407
https://repositorio.unifesp.br/handle/11600/57733
WOS:000372295900001
url http://dx.doi.org/10.1111/myc.12469
https://repositorio.unifesp.br/handle/11600/57733
identifier_str_mv Mycoses. Hoboken, v. 59, n. 4, p. 198-219, 2016.
10.1111/myc.12469
WOS000372295900001.pdf
0933-7407
WOS:000372295900001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mycoses
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 198-219
application/pdf
dc.coverage.none.fl_str_mv Hoboken
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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