Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1111/myc.12469 https://repositorio.unifesp.br/handle/11600/57733 |
Resumo: | The significant increase in the use of antifungal agents, both for the treatment of candidiasis and invasive aspergillosis and as azole fungicides in agricultural crop protection has resulted in the emergence of resistant clinical isolates, particularly to triazoles and echinocandins. Notably, among isolates that were primarily sensitive to fluconazole such as Candida parapsilosis and Candida tropicalis have witnessed an emerging resistance development. Also for echinocandins, the occurrence of Candida isolates with lower susceptibility to these drugs has been reported, which is possibly due to its broad clinical use. Triazole resistance among Aspergillus fumigatus and other Aspergillus species is commonly found in European and Asian countries. Specific mutations are associated with azole resistance in A. fumigatus and these mutations are now reported globally from six continents. Therefore, we highlight the need to conduct antifungal resistance surveillance studies using clinical isolates of Candida and Aspergillus in different geographical regions and monitoring of the infection rates in distinct population groups for early detection of resistance to these drugs and implementation of efficient policies for infection control and treatment. |
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Epidemiology and molecular mechanisms of antifungal resistance in Candida and AspergillusAntifungal resistanceCandida sppAspergillus sppazolesechinocandinsamphotericin BThe significant increase in the use of antifungal agents, both for the treatment of candidiasis and invasive aspergillosis and as azole fungicides in agricultural crop protection has resulted in the emergence of resistant clinical isolates, particularly to triazoles and echinocandins. Notably, among isolates that were primarily sensitive to fluconazole such as Candida parapsilosis and Candida tropicalis have witnessed an emerging resistance development. Also for echinocandins, the occurrence of Candida isolates with lower susceptibility to these drugs has been reported, which is possibly due to its broad clinical use. Triazole resistance among Aspergillus fumigatus and other Aspergillus species is commonly found in European and Asian countries. Specific mutations are associated with azole resistance in A. fumigatus and these mutations are now reported globally from six continents. Therefore, we highlight the need to conduct antifungal resistance surveillance studies using clinical isolates of Candida and Aspergillus in different geographical regions and monitoring of the infection rates in distinct population groups for early detection of resistance to these drugs and implementation of efficient policies for infection control and treatment.Univ Fed Sao Paulo, Lab Especial Micol, Disciplina Infectol, Escola Paulista Med, BR-04039032 Sao Paulo, SP, BrazilUniv Delhi, Vallabhbhai Patel Chest Inst, Dept Med Mycol, Delhi 110007, IndiaCanisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, NetherlandsRadboud Univ Nijmegen, Dept Med Microbiol, NL-6525 ED Nijmegen, NetherlandsUniv Fed Sao Paulo, Lab Especial Micol, Disciplina Infectol, Escola Paulista Med, BR-04039032 Sao Paulo, SP, BrazilWeb of ScienceFundação de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES), BrazilFAPESP: 2012/04767-1FAPESP: 2012/04769-4CNPq: 308011/2010-4CAPES: PNPD 23038.007393/2011-11FAPESP : 2012/04769-4Wiley-Blackwell2020-08-21T16:59:39Z2020-08-21T16:59:39Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion198-219application/pdfhttp://dx.doi.org/10.1111/myc.12469Mycoses. Hoboken, v. 59, n. 4, p. 198-219, 2016.10.1111/myc.12469WOS000372295900001.pdf0933-7407https://repositorio.unifesp.br/handle/11600/57733WOS:000372295900001engMycosesHobokeninfo:eu-repo/semantics/openAccessGoncalves, Sarah Santos [UNIFESP]Remondi Souza, Ana Carolina [UNIFESP]Chowdhary, AnuradhaMeis, Jacques F.Colombo, Arnaldo Lopes [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-01T10:53:33Zoai:repositorio.unifesp.br/:11600/57733Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-01T10:53:33Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus |
title |
Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus |
spellingShingle |
Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus Goncalves, Sarah Santos [UNIFESP] Antifungal resistance Candida spp Aspergillus spp azoles echinocandins amphotericin B |
title_short |
Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus |
title_full |
Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus |
title_fullStr |
Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus |
title_full_unstemmed |
Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus |
title_sort |
Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus |
author |
Goncalves, Sarah Santos [UNIFESP] |
author_facet |
Goncalves, Sarah Santos [UNIFESP] Remondi Souza, Ana Carolina [UNIFESP] Chowdhary, Anuradha Meis, Jacques F. Colombo, Arnaldo Lopes [UNIFESP] |
author_role |
author |
author2 |
Remondi Souza, Ana Carolina [UNIFESP] Chowdhary, Anuradha Meis, Jacques F. Colombo, Arnaldo Lopes [UNIFESP] |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Goncalves, Sarah Santos [UNIFESP] Remondi Souza, Ana Carolina [UNIFESP] Chowdhary, Anuradha Meis, Jacques F. Colombo, Arnaldo Lopes [UNIFESP] |
dc.subject.por.fl_str_mv |
Antifungal resistance Candida spp Aspergillus spp azoles echinocandins amphotericin B |
topic |
Antifungal resistance Candida spp Aspergillus spp azoles echinocandins amphotericin B |
description |
The significant increase in the use of antifungal agents, both for the treatment of candidiasis and invasive aspergillosis and as azole fungicides in agricultural crop protection has resulted in the emergence of resistant clinical isolates, particularly to triazoles and echinocandins. Notably, among isolates that were primarily sensitive to fluconazole such as Candida parapsilosis and Candida tropicalis have witnessed an emerging resistance development. Also for echinocandins, the occurrence of Candida isolates with lower susceptibility to these drugs has been reported, which is possibly due to its broad clinical use. Triazole resistance among Aspergillus fumigatus and other Aspergillus species is commonly found in European and Asian countries. Specific mutations are associated with azole resistance in A. fumigatus and these mutations are now reported globally from six continents. Therefore, we highlight the need to conduct antifungal resistance surveillance studies using clinical isolates of Candida and Aspergillus in different geographical regions and monitoring of the infection rates in distinct population groups for early detection of resistance to these drugs and implementation of efficient policies for infection control and treatment. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 2020-08-21T16:59:39Z 2020-08-21T16:59:39Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/myc.12469 Mycoses. Hoboken, v. 59, n. 4, p. 198-219, 2016. 10.1111/myc.12469 WOS000372295900001.pdf 0933-7407 https://repositorio.unifesp.br/handle/11600/57733 WOS:000372295900001 |
url |
http://dx.doi.org/10.1111/myc.12469 https://repositorio.unifesp.br/handle/11600/57733 |
identifier_str_mv |
Mycoses. Hoboken, v. 59, n. 4, p. 198-219, 2016. 10.1111/myc.12469 WOS000372295900001.pdf 0933-7407 WOS:000372295900001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mycoses |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
198-219 application/pdf |
dc.coverage.none.fl_str_mv |
Hoboken |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268447049121792 |