Epidemiology and molecular analysis of herpes simplex keratitis requiring primary penetrating keratoplasty
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/27951 http://dx.doi.org/10.1136/bjo.2003.040162 |
Resumo: | Aims: To determine whether herpes simplex keratitis (HSK) has declined as an indication for penetrating keratoplasty (PKP) at the University of California San Francisco (UCSF) over the past 30 years.Methods: Records of the Hogan Eye Pathology Laboratory were reviewed to determine the incidence of PKP performed for HSK from 1972 through 2001. Archived corneal tissue with the diagnosis of HSK was evaluated for herpes simplex virus (HSV) DNA by polymerase chain reaction (PCR) based assays.Results: the number of corneal buttons submitted with the clinical diagnosis of HSK decreased from 1972 to 2001, while the overall number of PKPs performed did not. the percentage of corneal buttons with a clinical diagnosis of HSK that contained detectable HSV DNA did not change over the course of the study period.Conclusion: HSK declined as an indication for PKP from 1972 to 2001 at UCSF. It is unlikely that this decline was the result of improved diagnostic accuracy since detection of HSV DNA in corneal buttons with a clinical diagnosis of HSK was similar at the beginning and end of the study period. |
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Branco, Bruno C. [UNIFESP]Gaudio, P. A.Margolis, T. P.Univ Calif San FranciscoUniversidade Federal de São Paulo (UNIFESP)Yale Univ2016-01-24T12:37:23Z2016-01-24T12:37:23Z2004-10-01British Journal of Ophthalmology. London: B M J Publishing Group, v. 88, n. 10, p. 1285-1288, 2004.0007-1161http://repositorio.unifesp.br/handle/11600/27951http://dx.doi.org/10.1136/bjo.2003.04016210.1136/bjo.2003.040162WOS:000223951100015Aims: To determine whether herpes simplex keratitis (HSK) has declined as an indication for penetrating keratoplasty (PKP) at the University of California San Francisco (UCSF) over the past 30 years.Methods: Records of the Hogan Eye Pathology Laboratory were reviewed to determine the incidence of PKP performed for HSK from 1972 through 2001. Archived corneal tissue with the diagnosis of HSK was evaluated for herpes simplex virus (HSV) DNA by polymerase chain reaction (PCR) based assays.Results: the number of corneal buttons submitted with the clinical diagnosis of HSK decreased from 1972 to 2001, while the overall number of PKPs performed did not. the percentage of corneal buttons with a clinical diagnosis of HSK that contained detectable HSV DNA did not change over the course of the study period.Conclusion: HSK declined as an indication for PKP from 1972 to 2001 at UCSF. It is unlikely that this decline was the result of improved diagnostic accuracy since detection of HSV DNA in corneal buttons with a clinical diagnosis of HSK was similar at the beginning and end of the study period.Univ Calif San Francisco, Francis I Proctor Fdn, San Francisco, CA 94143 USAUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, BrazilYale Univ, Sch Med, Dept Ophthalmol, New Haven, CT USAUniv Calif San Francisco, Dept Ophthalmol, San Francisco, CA 94143 USAUniversidade Federal de São Paulo, Dept Ophthalmol, São Paulo, BrazilWeb of Science1285-1288engB M J Publishing GroupBritish Journal of OphthalmologyEpidemiology and molecular analysis of herpes simplex keratitis requiring primary penetrating keratoplastyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/279512022-06-02 09:20:35.109metadata only accessoai:repositorio.unifesp.br:11600/27951Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-06-02T12:20:35Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Epidemiology and molecular analysis of herpes simplex keratitis requiring primary penetrating keratoplasty |
title |
Epidemiology and molecular analysis of herpes simplex keratitis requiring primary penetrating keratoplasty |
spellingShingle |
Epidemiology and molecular analysis of herpes simplex keratitis requiring primary penetrating keratoplasty Branco, Bruno C. [UNIFESP] |
title_short |
Epidemiology and molecular analysis of herpes simplex keratitis requiring primary penetrating keratoplasty |
title_full |
Epidemiology and molecular analysis of herpes simplex keratitis requiring primary penetrating keratoplasty |
title_fullStr |
Epidemiology and molecular analysis of herpes simplex keratitis requiring primary penetrating keratoplasty |
title_full_unstemmed |
Epidemiology and molecular analysis of herpes simplex keratitis requiring primary penetrating keratoplasty |
title_sort |
Epidemiology and molecular analysis of herpes simplex keratitis requiring primary penetrating keratoplasty |
author |
Branco, Bruno C. [UNIFESP] |
author_facet |
Branco, Bruno C. [UNIFESP] Gaudio, P. A. Margolis, T. P. |
author_role |
author |
author2 |
Gaudio, P. A. Margolis, T. P. |
author2_role |
author author |
dc.contributor.institution.none.fl_str_mv |
Univ Calif San Francisco Universidade Federal de São Paulo (UNIFESP) Yale Univ |
dc.contributor.author.fl_str_mv |
Branco, Bruno C. [UNIFESP] Gaudio, P. A. Margolis, T. P. |
description |
Aims: To determine whether herpes simplex keratitis (HSK) has declined as an indication for penetrating keratoplasty (PKP) at the University of California San Francisco (UCSF) over the past 30 years.Methods: Records of the Hogan Eye Pathology Laboratory were reviewed to determine the incidence of PKP performed for HSK from 1972 through 2001. Archived corneal tissue with the diagnosis of HSK was evaluated for herpes simplex virus (HSV) DNA by polymerase chain reaction (PCR) based assays.Results: the number of corneal buttons submitted with the clinical diagnosis of HSK decreased from 1972 to 2001, while the overall number of PKPs performed did not. the percentage of corneal buttons with a clinical diagnosis of HSK that contained detectable HSV DNA did not change over the course of the study period.Conclusion: HSK declined as an indication for PKP from 1972 to 2001 at UCSF. It is unlikely that this decline was the result of improved diagnostic accuracy since detection of HSV DNA in corneal buttons with a clinical diagnosis of HSK was similar at the beginning and end of the study period. |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004-10-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:37:23Z |
dc.date.available.fl_str_mv |
2016-01-24T12:37:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
British Journal of Ophthalmology. London: B M J Publishing Group, v. 88, n. 10, p. 1285-1288, 2004. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/27951 http://dx.doi.org/10.1136/bjo.2003.040162 |
dc.identifier.issn.none.fl_str_mv |
0007-1161 |
dc.identifier.doi.none.fl_str_mv |
10.1136/bjo.2003.040162 |
dc.identifier.wos.none.fl_str_mv |
WOS:000223951100015 |
identifier_str_mv |
British Journal of Ophthalmology. London: B M J Publishing Group, v. 88, n. 10, p. 1285-1288, 2004. 0007-1161 10.1136/bjo.2003.040162 WOS:000223951100015 |
url |
http://repositorio.unifesp.br/handle/11600/27951 http://dx.doi.org/10.1136/bjo.2003.040162 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
British Journal of Ophthalmology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1285-1288 |
dc.publisher.none.fl_str_mv |
B M J Publishing Group |
publisher.none.fl_str_mv |
B M J Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764133548949504 |