Clinical management of localized bcg adverse events in children
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1590/S1678-9946201658084 http://repositorio.unifesp.br/handle/11600/49255 |
Resumo: | BCG adverse events (BCG-AE) are rare conditions with no well-established treatment. This study aims to describe clinical characteristics and outcome of localized BCG-AE. Children with BCG-AEs who were treated at the Reference Center for Special Immunobiologicals of the Federal University of Sao Paulo from 2009 to 2011 were included. Patients were followed monthly until 3 months after healing. One hundred and twenty-seven patients with localized BCG-AE were followed: 67 (52.7%) had suppurative lymphadenitis |
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Clinical management of localized bcg adverse events in childrenBcg VaccineAdverse EventTherapeuticsMycobacterium BovisSevere Combined ImmunodeficiencyCalmette-Guerin VaccineComplicationsDiseaseAdenitisBrazilBCG adverse events (BCG-AE) are rare conditions with no well-established treatment. This study aims to describe clinical characteristics and outcome of localized BCG-AE. Children with BCG-AEs who were treated at the Reference Center for Special Immunobiologicals of the Federal University of Sao Paulo from 2009 to 2011 were included. Patients were followed monthly until 3 months after healing. One hundred and twenty-seven patients with localized BCG-AE were followed: 67 (52.7%) had suppurative lymphadenitis30 (23.6%) injection-site abscessfive (3.9%) had enlarged lymph node > 3 cmfour (3.1%) had ulcer > 1 cmand one (0.8%) had a local bacterial infection. Five patients (3.9%) had more than one BCG-AE simultaneously. Fifteen patients (11.8%) had atypical manifestations: seven wart-like lesionsfive BCG reactivationstwo other dermatologic lesions and one with vasomotor phenomenon. Isoniazid was used in 96 patients with typical BCG-AE (85.7%) until lesion resolution which took place 3.1 months later (in median)the healing rate was 90.6%. Patients with atypical manifestations had an individual approach. Regarding the outcome, 105/112 patients with typical AE and 13/15 patients with atypical AE had resolution of BCG-AE. Localized BCG-AE caused by BCG Moreau RJ had positive outcome when treated with a short course of isoniazid. Atypical BCG-AE are not infrequent.Reference Center for Special Immunobiologicals, Division of Pediatric Infectious Diseases, Federal University of São Paulo, São Paulo, SP, BrazilDepartment of Pediatrics, Federal University of São Paulo, São Paulo, SP, BrazilOutpatient Clinic of Recurrent Infections, Faculty of Medicine ABC, Santo André, SP, BrazilReference Center for Special Immunobiologicals, Division of Pediatric Infectious Diseases, Federal University of São Paulo, São Paulo, SP, BrazilDepartment of Pediatrics, Federal University of São Paulo, São Paulo, SP, BrazilWeb of ScienceFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil [11/21754-8]FAPESP: 11/21754-8Ios Press2019-01-21T10:29:31Z2019-01-21T10:29:31Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionUNSP 84http://dx.doi.org/10.1590/S1678-9946201658084Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao paulo, v. 58, p. UNSP 84, 2016.10.1590/S1678-9946201658084S0036-46652016005000266.pdf0036-4665S0036-46652016005000266http://repositorio.unifesp.br/handle/11600/49255WOS:000396241000034engRevista Do Instituto De Medicina Tropical De Sao Pauloinfo:eu-repo/semantics/openAccessMoreira, Thais das Neves Fraga [UNIFESP]de Moraes-Pinto, Maria Isabel [UNIFESP]Costa-Carvalho, Beatriz Tavares [UNIFESP]Grumach, Anete SevciovicWeckx, Lily Yin [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2022-02-07T21:01:43Zoai:repositorio.unifesp.br/:11600/49255Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652022-02-07T21:01:43Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Clinical management of localized bcg adverse events in children |
| title |
Clinical management of localized bcg adverse events in children |
| spellingShingle |
Clinical management of localized bcg adverse events in children Moreira, Thais das Neves Fraga [UNIFESP] Bcg Vaccine Adverse Event Therapeutics Mycobacterium BovisSevere Combined Immunodeficiency Calmette-Guerin Vaccine Complications Disease Adenitis Brazil |
| title_short |
Clinical management of localized bcg adverse events in children |
| title_full |
Clinical management of localized bcg adverse events in children |
| title_fullStr |
Clinical management of localized bcg adverse events in children |
| title_full_unstemmed |
Clinical management of localized bcg adverse events in children |
| title_sort |
Clinical management of localized bcg adverse events in children |
| author |
Moreira, Thais das Neves Fraga [UNIFESP] |
| author_facet |
Moreira, Thais das Neves Fraga [UNIFESP] de Moraes-Pinto, Maria Isabel [UNIFESP] Costa-Carvalho, Beatriz Tavares [UNIFESP] Grumach, Anete Sevciovic Weckx, Lily Yin [UNIFESP] |
| author_role |
author |
| author2 |
de Moraes-Pinto, Maria Isabel [UNIFESP] Costa-Carvalho, Beatriz Tavares [UNIFESP] Grumach, Anete Sevciovic Weckx, Lily Yin [UNIFESP] |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Moreira, Thais das Neves Fraga [UNIFESP] de Moraes-Pinto, Maria Isabel [UNIFESP] Costa-Carvalho, Beatriz Tavares [UNIFESP] Grumach, Anete Sevciovic Weckx, Lily Yin [UNIFESP] |
| dc.subject.por.fl_str_mv |
Bcg Vaccine Adverse Event Therapeutics Mycobacterium BovisSevere Combined Immunodeficiency Calmette-Guerin Vaccine Complications Disease Adenitis Brazil |
| topic |
Bcg Vaccine Adverse Event Therapeutics Mycobacterium BovisSevere Combined Immunodeficiency Calmette-Guerin Vaccine Complications Disease Adenitis Brazil |
| description |
BCG adverse events (BCG-AE) are rare conditions with no well-established treatment. This study aims to describe clinical characteristics and outcome of localized BCG-AE. Children with BCG-AEs who were treated at the Reference Center for Special Immunobiologicals of the Federal University of Sao Paulo from 2009 to 2011 were included. Patients were followed monthly until 3 months after healing. One hundred and twenty-seven patients with localized BCG-AE were followed: 67 (52.7%) had suppurative lymphadenitis |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 2019-01-21T10:29:31Z 2019-01-21T10:29:31Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1678-9946201658084 Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao paulo, v. 58, p. UNSP 84, 2016. 10.1590/S1678-9946201658084 S0036-46652016005000266.pdf 0036-4665 S0036-46652016005000266 http://repositorio.unifesp.br/handle/11600/49255 WOS:000396241000034 |
| url |
http://dx.doi.org/10.1590/S1678-9946201658084 http://repositorio.unifesp.br/handle/11600/49255 |
| identifier_str_mv |
Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao paulo, v. 58, p. UNSP 84, 2016. 10.1590/S1678-9946201658084 S0036-46652016005000266.pdf 0036-4665 S0036-46652016005000266 WOS:000396241000034 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Revista Do Instituto De Medicina Tropical De Sao Paulo |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
UNSP 84 |
| dc.publisher.none.fl_str_mv |
Ios Press |
| publisher.none.fl_str_mv |
Ios Press |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
| institution |
UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1814268370040651776 |