Can intraoperative electrocorticography patterns predict surgical outcome in patients with temporal lobe epilepsy secondary to unilateral mesial temporal sclerosis?
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1016/j.seizure.2006.06.009 http://repositorio.unifesp.br/handle/11600/29162 |
Resumo: | Introduction: Intraoperative electrocorticography (ECoG) can be performed in cases of temporal lobe epilepsy due to hippocampal sclerosis (TLE-HS). However, its significance and correlation with surgical outcome are still controversial.Objectives: To analyze the electrophysiological characteristics of temporal lobe structures during ECoG of patients with TLE-HS, with emphasis on the comparison between pre- and post-resection recordings and surgical outcome.Patients and methods: Seventeen patients with refractory TLE-HS submitted to corticoamigdalohipocampectomy were included in the study. Clinical variables included age at the onset, duration of epilepsy and seizure outcome. the postoperative follow-up ranged from 24 to 36 months. According to outcome subjects were divided in two subgroups: (A) individuals free of seizures (Engel 1A), and (B) individuals not-free of seizures (Engel 1B-IV). Four patterns of ECoG findings were identified: isolated discharges; high frequency spikes (HFS); continuous discharges; combination of isolated discharges and HFS. According to predominant topography ECoG was classified as mediobasal, lateral (or neocortical), mediobasal and lateral.Results: the progressive removal of the temporal pole and the hippocampus was associated with significant decrease of neocortical spikes. No correlation between clinical variables and seizure outcome was observed. Patients who only had isolated spikes on intraoperative ECoG presented a statistical trend for excellent surgical control. Patients who presented temporal pole blurring on MRI also had better post-surgical seizure outcome.Conclusions: This study showed that out of diverse clinical and laboratory variables, only isolated discharges on intraoperative ECoG and temporal pole blurring on MRI predicted excellent post-surgicat seizure outcome. However, other studies with larger number of patients are stilt necessary to confirm these findings. (C) 2006 British Epilepsy Association. Published by Elsevier B.V. All rights reserved. |
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Can intraoperative electrocorticography patterns predict surgical outcome in patients with temporal lobe epilepsy secondary to unilateral mesial temporal sclerosis?electrocorticographytemporal lobe epilepsyhippocampus sclerosisIntroduction: Intraoperative electrocorticography (ECoG) can be performed in cases of temporal lobe epilepsy due to hippocampal sclerosis (TLE-HS). However, its significance and correlation with surgical outcome are still controversial.Objectives: To analyze the electrophysiological characteristics of temporal lobe structures during ECoG of patients with TLE-HS, with emphasis on the comparison between pre- and post-resection recordings and surgical outcome.Patients and methods: Seventeen patients with refractory TLE-HS submitted to corticoamigdalohipocampectomy were included in the study. Clinical variables included age at the onset, duration of epilepsy and seizure outcome. the postoperative follow-up ranged from 24 to 36 months. According to outcome subjects were divided in two subgroups: (A) individuals free of seizures (Engel 1A), and (B) individuals not-free of seizures (Engel 1B-IV). Four patterns of ECoG findings were identified: isolated discharges; high frequency spikes (HFS); continuous discharges; combination of isolated discharges and HFS. According to predominant topography ECoG was classified as mediobasal, lateral (or neocortical), mediobasal and lateral.Results: the progressive removal of the temporal pole and the hippocampus was associated with significant decrease of neocortical spikes. No correlation between clinical variables and seizure outcome was observed. Patients who only had isolated spikes on intraoperative ECoG presented a statistical trend for excellent surgical control. Patients who presented temporal pole blurring on MRI also had better post-surgical seizure outcome.Conclusions: This study showed that out of diverse clinical and laboratory variables, only isolated discharges on intraoperative ECoG and temporal pole blurring on MRI predicted excellent post-surgicat seizure outcome. However, other studies with larger number of patients are stilt necessary to confirm these findings. (C) 2006 British Epilepsy Association. Published by Elsevier B.V. All rights reserved.Universidade Federal de São Paulo, Dept Neurol & Neurosurg, Div Neurol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Radiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, Div Neurosurg, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Anesthesiol, São Paulo, BrazilUniv São Paulo, Ribeirao Preto Med Sch, Dept Surg, Div Neurosurg, São Paulo, BrazilUniv São Paulo, Ribeirao Preto Med Sch, Dept Neurol Psychiat & Clin Psychol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, Div Neurol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Radiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Neurol & Neurosurg, Div Neurosurg, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Anesthesiol, São Paulo, BrazilWeb of ScienceW B Saunders Co LtdUniversidade Federal de São Paulo (UNIFESP)Universidade de São Paulo (USP)Oliveira, Pedro A. L.Garzon, Eliana [UNIFESP]Caboclo, Luís Otávio Sales Ferreira [UNIFESP]Sousa, Patricia da Silva [UNIFESP]Carrete Junior, Henrique [UNIFESP]Centeno, Ricardo Silva [UNIFESP]Costa, José Maria P.Machado, Helio RubensYacubian, Elza Márcia Targas [UNIFESP]Bianchin, Marino MuxfeldtSakamoto, Américo Ceiki [UNIFESP]2016-01-24T12:41:29Z2016-01-24T12:41:29Z2006-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion541-551application/pdfhttp://dx.doi.org/10.1016/j.seizure.2006.06.009Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 15, n. 7, p. 541-551, 2006.10.1016/j.seizure.2006.06.009WOS000240864700010.pdf1059-1311http://repositorio.unifesp.br/handle/11600/29162WOS:000240864700010engSeizure-european Journal of Epilepsyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-31T03:58:31Zoai:repositorio.unifesp.br/:11600/29162Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-31T03:58:31Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Can intraoperative electrocorticography patterns predict surgical outcome in patients with temporal lobe epilepsy secondary to unilateral mesial temporal sclerosis? |
title |
Can intraoperative electrocorticography patterns predict surgical outcome in patients with temporal lobe epilepsy secondary to unilateral mesial temporal sclerosis? |
spellingShingle |
Can intraoperative electrocorticography patterns predict surgical outcome in patients with temporal lobe epilepsy secondary to unilateral mesial temporal sclerosis? Oliveira, Pedro A. L. electrocorticography temporal lobe epilepsy hippocampus sclerosis |
title_short |
Can intraoperative electrocorticography patterns predict surgical outcome in patients with temporal lobe epilepsy secondary to unilateral mesial temporal sclerosis? |
title_full |
Can intraoperative electrocorticography patterns predict surgical outcome in patients with temporal lobe epilepsy secondary to unilateral mesial temporal sclerosis? |
title_fullStr |
Can intraoperative electrocorticography patterns predict surgical outcome in patients with temporal lobe epilepsy secondary to unilateral mesial temporal sclerosis? |
title_full_unstemmed |
Can intraoperative electrocorticography patterns predict surgical outcome in patients with temporal lobe epilepsy secondary to unilateral mesial temporal sclerosis? |
title_sort |
Can intraoperative electrocorticography patterns predict surgical outcome in patients with temporal lobe epilepsy secondary to unilateral mesial temporal sclerosis? |
author |
Oliveira, Pedro A. L. |
author_facet |
Oliveira, Pedro A. L. Garzon, Eliana [UNIFESP] Caboclo, Luís Otávio Sales Ferreira [UNIFESP] Sousa, Patricia da Silva [UNIFESP] Carrete Junior, Henrique [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Costa, José Maria P. Machado, Helio Rubens Yacubian, Elza Márcia Targas [UNIFESP] Bianchin, Marino Muxfeldt Sakamoto, Américo Ceiki [UNIFESP] |
author_role |
author |
author2 |
Garzon, Eliana [UNIFESP] Caboclo, Luís Otávio Sales Ferreira [UNIFESP] Sousa, Patricia da Silva [UNIFESP] Carrete Junior, Henrique [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Costa, José Maria P. Machado, Helio Rubens Yacubian, Elza Márcia Targas [UNIFESP] Bianchin, Marino Muxfeldt Sakamoto, Américo Ceiki [UNIFESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Oliveira, Pedro A. L. Garzon, Eliana [UNIFESP] Caboclo, Luís Otávio Sales Ferreira [UNIFESP] Sousa, Patricia da Silva [UNIFESP] Carrete Junior, Henrique [UNIFESP] Centeno, Ricardo Silva [UNIFESP] Costa, José Maria P. Machado, Helio Rubens Yacubian, Elza Márcia Targas [UNIFESP] Bianchin, Marino Muxfeldt Sakamoto, Américo Ceiki [UNIFESP] |
dc.subject.por.fl_str_mv |
electrocorticography temporal lobe epilepsy hippocampus sclerosis |
topic |
electrocorticography temporal lobe epilepsy hippocampus sclerosis |
description |
Introduction: Intraoperative electrocorticography (ECoG) can be performed in cases of temporal lobe epilepsy due to hippocampal sclerosis (TLE-HS). However, its significance and correlation with surgical outcome are still controversial.Objectives: To analyze the electrophysiological characteristics of temporal lobe structures during ECoG of patients with TLE-HS, with emphasis on the comparison between pre- and post-resection recordings and surgical outcome.Patients and methods: Seventeen patients with refractory TLE-HS submitted to corticoamigdalohipocampectomy were included in the study. Clinical variables included age at the onset, duration of epilepsy and seizure outcome. the postoperative follow-up ranged from 24 to 36 months. According to outcome subjects were divided in two subgroups: (A) individuals free of seizures (Engel 1A), and (B) individuals not-free of seizures (Engel 1B-IV). Four patterns of ECoG findings were identified: isolated discharges; high frequency spikes (HFS); continuous discharges; combination of isolated discharges and HFS. According to predominant topography ECoG was classified as mediobasal, lateral (or neocortical), mediobasal and lateral.Results: the progressive removal of the temporal pole and the hippocampus was associated with significant decrease of neocortical spikes. No correlation between clinical variables and seizure outcome was observed. Patients who only had isolated spikes on intraoperative ECoG presented a statistical trend for excellent surgical control. Patients who presented temporal pole blurring on MRI also had better post-surgical seizure outcome.Conclusions: This study showed that out of diverse clinical and laboratory variables, only isolated discharges on intraoperative ECoG and temporal pole blurring on MRI predicted excellent post-surgicat seizure outcome. However, other studies with larger number of patients are stilt necessary to confirm these findings. (C) 2006 British Epilepsy Association. Published by Elsevier B.V. All rights reserved. |
publishDate |
2006 |
dc.date.none.fl_str_mv |
2006-10-01 2016-01-24T12:41:29Z 2016-01-24T12:41:29Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.seizure.2006.06.009 Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 15, n. 7, p. 541-551, 2006. 10.1016/j.seizure.2006.06.009 WOS000240864700010.pdf 1059-1311 http://repositorio.unifesp.br/handle/11600/29162 WOS:000240864700010 |
url |
http://dx.doi.org/10.1016/j.seizure.2006.06.009 http://repositorio.unifesp.br/handle/11600/29162 |
identifier_str_mv |
Seizure-european Journal of Epilepsy. London: W B Saunders Co Ltd, v. 15, n. 7, p. 541-551, 2006. 10.1016/j.seizure.2006.06.009 WOS000240864700010.pdf 1059-1311 WOS:000240864700010 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Seizure-european Journal of Epilepsy |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
541-551 application/pdf |
dc.publisher.none.fl_str_mv |
W B Saunders Co Ltd |
publisher.none.fl_str_mv |
W B Saunders Co Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268437692678144 |