Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis

Detalhes bibliográficos
Autor(a) principal: Ram, Felix SF
Data de Publicação: 2005
Outros Autores: Jardim, José Roberto, Atallah, Álvaro Nagib [UNIFESP], Castro, Aldemar Araujo [UNIFESP], Mazzini, Renato Coimbra [UNIFESP], Goldstein, Roger, Lacasse, Yves, Cendon Filha, Sônia Perez [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1016/j.rmed.2004.10.009
http://repositorio.unifesp.br/handle/11600/28120
Resumo: Objectives: To determine the efficacy of oral theophylline compared with placebo in people with stable chronic obstructive pulmonary disease (COPD).Methods: Systematic review of randomized-controlled trials comparing oral Theophylline; with placebo for a minimum of 7 days in people with stable COPD.Results: Twenty randomized-controlled trials were included in this review. the Meta-analysis; following outcomes showed significant improvement with theophylline compared with placebo: FEV, and FVC both improved with theophylline (weighted mean difference [WMD] 0.10 L; 95% confidence interval [95% CI] 0.04-0.16 and WMD 0.21 L; 95% CI 0.10-0.32, respectively). VO2 max also improved with theophylline (WMD 195.27mL/ min; 95% Cl 112.71-277.83), as did PaO2 and PaCO2 (WMD 3.18mmHg;,95% Cl 1.23-5.13 and WMD -2.36mmHg; 95% Cl -3.52 to -1.21, respectively). Patients preferred theophylline over placebo (relative risk 2.27; 95% Cl 1.26-4.11). Theophylline increased the risk of nausea compared with placebo (RR 7.67; 95% Cl 1.47-39.94).Conclusion: This review has shown that theophylline still has a role in the management of stable COPD, and is preferred by patients over placebo. However, the benefits of theophylline in stable COPD have to be weighed against the risk of adverse effects. (C) 2004 Elsevier B.V. All rights reserved.
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spelling Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysisCOPDoraltheophyllinesystematic reviewmeta-analysiscochraneObjectives: To determine the efficacy of oral theophylline compared with placebo in people with stable chronic obstructive pulmonary disease (COPD).Methods: Systematic review of randomized-controlled trials comparing oral Theophylline; with placebo for a minimum of 7 days in people with stable COPD.Results: Twenty randomized-controlled trials were included in this review. the Meta-analysis; following outcomes showed significant improvement with theophylline compared with placebo: FEV, and FVC both improved with theophylline (weighted mean difference [WMD] 0.10 L; 95% confidence interval [95% CI] 0.04-0.16 and WMD 0.21 L; 95% CI 0.10-0.32, respectively). VO2 max also improved with theophylline (WMD 195.27mL/ min; 95% Cl 112.71-277.83), as did PaO2 and PaCO2 (WMD 3.18mmHg;,95% Cl 1.23-5.13 and WMD -2.36mmHg; 95% Cl -3.52 to -1.21, respectively). Patients preferred theophylline over placebo (relative risk 2.27; 95% Cl 1.26-4.11). Theophylline increased the risk of nausea compared with placebo (RR 7.67; 95% Cl 1.47-39.94).Conclusion: This review has shown that theophylline still has a role in the management of stable COPD, and is preferred by patients over placebo. However, the benefits of theophylline in stable COPD have to be weighed against the risk of adverse effects. (C) 2004 Elsevier B.V. All rights reserved.Natl Collaborating Ctr Womens & Childrens Hlth, London, EnglandUniversidade Federal de São Paulo, Div Resp, São Paulo, BrazilEmergency Med Div, São Paulo, BrazilFed Univ Alagoas, Vasc Dis Div, São Paulo, BrazilUNIFESP, Div Resp, Pulm Rehabil Ctr, São Paulo, BrazilUniv Toronto, W Pk Healthcare Ctr, Toronto, ON, CanadaUniv Laval, Hop Laval, Ctr Pneumol, Inst Cardiol & Pneumol, Laval, PQ, CanadaUniversidade Federal de São Paulo, Div Internal Med, São Paulo, BrazilUniversidade Federal de São Paulo, Div Resp, São Paulo, BrazilUNIFESP, Div Resp, Pulm Rehabil Ctr, São Paulo, BrazilUniversidade Federal de São Paulo, Div Internal Med, São Paulo, BrazilWeb of ScienceW B Saunders Co LtdNatl Collaborating Ctr Womens & Childrens HlthUniversidade Federal de São Paulo (UNIFESP)Emergency Med DivFed Univ AlagoasUniv TorontoUniv LavalRam, Felix SFJardim, José RobertoAtallah, Álvaro Nagib [UNIFESP]Castro, Aldemar Araujo [UNIFESP]Mazzini, Renato Coimbra [UNIFESP]Goldstein, RogerLacasse, YvesCendon Filha, Sônia Perez [UNIFESP]2016-01-24T12:37:36Z2016-01-24T12:37:36Z2005-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion135-144application/pdfhttp://dx.doi.org/10.1016/j.rmed.2004.10.009Respiratory Medicine. London: W B Saunders Co Ltd, v. 99, n. 2, p. 135-144, 2005.10.1016/j.rmed.2004.10.009WOS000226879600001.pdf0954-6111http://repositorio.unifesp.br/handle/11600/28120WOS:000226879600001engRespiratory Medicineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T16:31:18Zoai:repositorio.unifesp.br/:11600/28120Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-30T16:31:18Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis
title Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis
spellingShingle Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis
Ram, Felix SF
COPD
oral
theophylline
systematic review
meta-analysis
cochrane
title_short Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis
title_full Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis
title_fullStr Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis
title_full_unstemmed Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis
title_sort Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis
author Ram, Felix SF
author_facet Ram, Felix SF
Jardim, José Roberto
Atallah, Álvaro Nagib [UNIFESP]
Castro, Aldemar Araujo [UNIFESP]
Mazzini, Renato Coimbra [UNIFESP]
Goldstein, Roger
Lacasse, Yves
Cendon Filha, Sônia Perez [UNIFESP]
author_role author
author2 Jardim, José Roberto
Atallah, Álvaro Nagib [UNIFESP]
Castro, Aldemar Araujo [UNIFESP]
Mazzini, Renato Coimbra [UNIFESP]
Goldstein, Roger
Lacasse, Yves
Cendon Filha, Sônia Perez [UNIFESP]
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Natl Collaborating Ctr Womens & Childrens Hlth
Universidade Federal de São Paulo (UNIFESP)
Emergency Med Div
Fed Univ Alagoas
Univ Toronto
Univ Laval
dc.contributor.author.fl_str_mv Ram, Felix SF
Jardim, José Roberto
Atallah, Álvaro Nagib [UNIFESP]
Castro, Aldemar Araujo [UNIFESP]
Mazzini, Renato Coimbra [UNIFESP]
Goldstein, Roger
Lacasse, Yves
Cendon Filha, Sônia Perez [UNIFESP]
dc.subject.por.fl_str_mv COPD
oral
theophylline
systematic review
meta-analysis
cochrane
topic COPD
oral
theophylline
systematic review
meta-analysis
cochrane
description Objectives: To determine the efficacy of oral theophylline compared with placebo in people with stable chronic obstructive pulmonary disease (COPD).Methods: Systematic review of randomized-controlled trials comparing oral Theophylline; with placebo for a minimum of 7 days in people with stable COPD.Results: Twenty randomized-controlled trials were included in this review. the Meta-analysis; following outcomes showed significant improvement with theophylline compared with placebo: FEV, and FVC both improved with theophylline (weighted mean difference [WMD] 0.10 L; 95% confidence interval [95% CI] 0.04-0.16 and WMD 0.21 L; 95% CI 0.10-0.32, respectively). VO2 max also improved with theophylline (WMD 195.27mL/ min; 95% Cl 112.71-277.83), as did PaO2 and PaCO2 (WMD 3.18mmHg;,95% Cl 1.23-5.13 and WMD -2.36mmHg; 95% Cl -3.52 to -1.21, respectively). Patients preferred theophylline over placebo (relative risk 2.27; 95% Cl 1.26-4.11). Theophylline increased the risk of nausea compared with placebo (RR 7.67; 95% Cl 1.47-39.94).Conclusion: This review has shown that theophylline still has a role in the management of stable COPD, and is preferred by patients over placebo. However, the benefits of theophylline in stable COPD have to be weighed against the risk of adverse effects. (C) 2004 Elsevier B.V. All rights reserved.
publishDate 2005
dc.date.none.fl_str_mv 2005-02-01
2016-01-24T12:37:36Z
2016-01-24T12:37:36Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.rmed.2004.10.009
Respiratory Medicine. London: W B Saunders Co Ltd, v. 99, n. 2, p. 135-144, 2005.
10.1016/j.rmed.2004.10.009
WOS000226879600001.pdf
0954-6111
http://repositorio.unifesp.br/handle/11600/28120
WOS:000226879600001
url http://dx.doi.org/10.1016/j.rmed.2004.10.009
http://repositorio.unifesp.br/handle/11600/28120
identifier_str_mv Respiratory Medicine. London: W B Saunders Co Ltd, v. 99, n. 2, p. 135-144, 2005.
10.1016/j.rmed.2004.10.009
WOS000226879600001.pdf
0954-6111
WOS:000226879600001
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Respiratory Medicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 135-144
application/pdf
dc.publisher.none.fl_str_mv W B Saunders Co Ltd
publisher.none.fl_str_mv W B Saunders Co Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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