Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1016/j.rmed.2004.10.009 http://repositorio.unifesp.br/handle/11600/28120 |
Resumo: | Objectives: To determine the efficacy of oral theophylline compared with placebo in people with stable chronic obstructive pulmonary disease (COPD).Methods: Systematic review of randomized-controlled trials comparing oral Theophylline; with placebo for a minimum of 7 days in people with stable COPD.Results: Twenty randomized-controlled trials were included in this review. the Meta-analysis; following outcomes showed significant improvement with theophylline compared with placebo: FEV, and FVC both improved with theophylline (weighted mean difference [WMD] 0.10 L; 95% confidence interval [95% CI] 0.04-0.16 and WMD 0.21 L; 95% CI 0.10-0.32, respectively). VO2 max also improved with theophylline (WMD 195.27mL/ min; 95% Cl 112.71-277.83), as did PaO2 and PaCO2 (WMD 3.18mmHg;,95% Cl 1.23-5.13 and WMD -2.36mmHg; 95% Cl -3.52 to -1.21, respectively). Patients preferred theophylline over placebo (relative risk 2.27; 95% Cl 1.26-4.11). Theophylline increased the risk of nausea compared with placebo (RR 7.67; 95% Cl 1.47-39.94).Conclusion: This review has shown that theophylline still has a role in the management of stable COPD, and is preferred by patients over placebo. However, the benefits of theophylline in stable COPD have to be weighed against the risk of adverse effects. (C) 2004 Elsevier B.V. All rights reserved. |
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Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysisCOPDoraltheophyllinesystematic reviewmeta-analysiscochraneObjectives: To determine the efficacy of oral theophylline compared with placebo in people with stable chronic obstructive pulmonary disease (COPD).Methods: Systematic review of randomized-controlled trials comparing oral Theophylline; with placebo for a minimum of 7 days in people with stable COPD.Results: Twenty randomized-controlled trials were included in this review. the Meta-analysis; following outcomes showed significant improvement with theophylline compared with placebo: FEV, and FVC both improved with theophylline (weighted mean difference [WMD] 0.10 L; 95% confidence interval [95% CI] 0.04-0.16 and WMD 0.21 L; 95% CI 0.10-0.32, respectively). VO2 max also improved with theophylline (WMD 195.27mL/ min; 95% Cl 112.71-277.83), as did PaO2 and PaCO2 (WMD 3.18mmHg;,95% Cl 1.23-5.13 and WMD -2.36mmHg; 95% Cl -3.52 to -1.21, respectively). Patients preferred theophylline over placebo (relative risk 2.27; 95% Cl 1.26-4.11). Theophylline increased the risk of nausea compared with placebo (RR 7.67; 95% Cl 1.47-39.94).Conclusion: This review has shown that theophylline still has a role in the management of stable COPD, and is preferred by patients over placebo. However, the benefits of theophylline in stable COPD have to be weighed against the risk of adverse effects. (C) 2004 Elsevier B.V. All rights reserved.Natl Collaborating Ctr Womens & Childrens Hlth, London, EnglandUniversidade Federal de São Paulo, Div Resp, São Paulo, BrazilEmergency Med Div, São Paulo, BrazilFed Univ Alagoas, Vasc Dis Div, São Paulo, BrazilUNIFESP, Div Resp, Pulm Rehabil Ctr, São Paulo, BrazilUniv Toronto, W Pk Healthcare Ctr, Toronto, ON, CanadaUniv Laval, Hop Laval, Ctr Pneumol, Inst Cardiol & Pneumol, Laval, PQ, CanadaUniversidade Federal de São Paulo, Div Internal Med, São Paulo, BrazilUniversidade Federal de São Paulo, Div Resp, São Paulo, BrazilUNIFESP, Div Resp, Pulm Rehabil Ctr, São Paulo, BrazilUniversidade Federal de São Paulo, Div Internal Med, São Paulo, BrazilWeb of ScienceW B Saunders Co LtdNatl Collaborating Ctr Womens & Childrens HlthUniversidade Federal de São Paulo (UNIFESP)Emergency Med DivFed Univ AlagoasUniv TorontoUniv LavalRam, Felix SFJardim, José RobertoAtallah, Álvaro Nagib [UNIFESP]Castro, Aldemar Araujo [UNIFESP]Mazzini, Renato Coimbra [UNIFESP]Goldstein, RogerLacasse, YvesCendon Filha, Sônia Perez [UNIFESP]2016-01-24T12:37:36Z2016-01-24T12:37:36Z2005-02-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion135-144application/pdfhttp://dx.doi.org/10.1016/j.rmed.2004.10.009Respiratory Medicine. London: W B Saunders Co Ltd, v. 99, n. 2, p. 135-144, 2005.10.1016/j.rmed.2004.10.009WOS000226879600001.pdf0954-6111http://repositorio.unifesp.br/handle/11600/28120WOS:000226879600001engRespiratory Medicineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T16:31:18Zoai:repositorio.unifesp.br/:11600/28120Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-30T16:31:18Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis |
title |
Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis |
spellingShingle |
Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis Ram, Felix SF COPD oral theophylline systematic review meta-analysis cochrane |
title_short |
Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis |
title_full |
Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis |
title_fullStr |
Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis |
title_full_unstemmed |
Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis |
title_sort |
Efficacy of theophylline in people with stable chronic obstructive pulmonary disease: a systematic review and meta-analysis |
author |
Ram, Felix SF |
author_facet |
Ram, Felix SF Jardim, José Roberto Atallah, Álvaro Nagib [UNIFESP] Castro, Aldemar Araujo [UNIFESP] Mazzini, Renato Coimbra [UNIFESP] Goldstein, Roger Lacasse, Yves Cendon Filha, Sônia Perez [UNIFESP] |
author_role |
author |
author2 |
Jardim, José Roberto Atallah, Álvaro Nagib [UNIFESP] Castro, Aldemar Araujo [UNIFESP] Mazzini, Renato Coimbra [UNIFESP] Goldstein, Roger Lacasse, Yves Cendon Filha, Sônia Perez [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Natl Collaborating Ctr Womens & Childrens Hlth Universidade Federal de São Paulo (UNIFESP) Emergency Med Div Fed Univ Alagoas Univ Toronto Univ Laval |
dc.contributor.author.fl_str_mv |
Ram, Felix SF Jardim, José Roberto Atallah, Álvaro Nagib [UNIFESP] Castro, Aldemar Araujo [UNIFESP] Mazzini, Renato Coimbra [UNIFESP] Goldstein, Roger Lacasse, Yves Cendon Filha, Sônia Perez [UNIFESP] |
dc.subject.por.fl_str_mv |
COPD oral theophylline systematic review meta-analysis cochrane |
topic |
COPD oral theophylline systematic review meta-analysis cochrane |
description |
Objectives: To determine the efficacy of oral theophylline compared with placebo in people with stable chronic obstructive pulmonary disease (COPD).Methods: Systematic review of randomized-controlled trials comparing oral Theophylline; with placebo for a minimum of 7 days in people with stable COPD.Results: Twenty randomized-controlled trials were included in this review. the Meta-analysis; following outcomes showed significant improvement with theophylline compared with placebo: FEV, and FVC both improved with theophylline (weighted mean difference [WMD] 0.10 L; 95% confidence interval [95% CI] 0.04-0.16 and WMD 0.21 L; 95% CI 0.10-0.32, respectively). VO2 max also improved with theophylline (WMD 195.27mL/ min; 95% Cl 112.71-277.83), as did PaO2 and PaCO2 (WMD 3.18mmHg;,95% Cl 1.23-5.13 and WMD -2.36mmHg; 95% Cl -3.52 to -1.21, respectively). Patients preferred theophylline over placebo (relative risk 2.27; 95% Cl 1.26-4.11). Theophylline increased the risk of nausea compared with placebo (RR 7.67; 95% Cl 1.47-39.94).Conclusion: This review has shown that theophylline still has a role in the management of stable COPD, and is preferred by patients over placebo. However, the benefits of theophylline in stable COPD have to be weighed against the risk of adverse effects. (C) 2004 Elsevier B.V. All rights reserved. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-02-01 2016-01-24T12:37:36Z 2016-01-24T12:37:36Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.rmed.2004.10.009 Respiratory Medicine. London: W B Saunders Co Ltd, v. 99, n. 2, p. 135-144, 2005. 10.1016/j.rmed.2004.10.009 WOS000226879600001.pdf 0954-6111 http://repositorio.unifesp.br/handle/11600/28120 WOS:000226879600001 |
url |
http://dx.doi.org/10.1016/j.rmed.2004.10.009 http://repositorio.unifesp.br/handle/11600/28120 |
identifier_str_mv |
Respiratory Medicine. London: W B Saunders Co Ltd, v. 99, n. 2, p. 135-144, 2005. 10.1016/j.rmed.2004.10.009 WOS000226879600001.pdf 0954-6111 WOS:000226879600001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Respiratory Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
135-144 application/pdf |
dc.publisher.none.fl_str_mv |
W B Saunders Co Ltd |
publisher.none.fl_str_mv |
W B Saunders Co Ltd |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1814268360361246720 |