Wound-healing and benzodiazepines: does sleep play a role in this relationship?

Detalhes bibliográficos
Autor(a) principal: Egydio, Flavia [UNIFESP]
Data de Publicação: 2012
Outros Autores: Pires, Gabriel Natan [UNIFESP], Tufik, Sergio [UNIFESP], Andersen, Monica Levy [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://repositorio.unifesp.br/handle/11600/7193
http://dx.doi.org/10.6061/clinics/2012(07)20
Resumo: Patients who have suffered burns frequently experience psychological consequences, among which anxiety disorders are prominent. Benzodiazepines are commonly administered to treat these symptoms. The effects of benzodiazepines on healing may not be direct but rather are modulated by alterations of the sleep architecture. This hypothesis is supported by studies that demonstrate the effects of benzodiazepines on the immune system and the inflammatory profile under both normal sleep conditions and during sleep deprivation, particularly rapid eye movement sleep deprivation.
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spelling Egydio, Flavia [UNIFESP]Pires, Gabriel Natan [UNIFESP]Tufik, Sergio [UNIFESP]Andersen, Monica Levy [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:44:49Z2015-06-14T13:44:49Z2012-07-01Clinics. Faculdade de Medicina / USP, v. 67, n. 7, p. 827-830, 2012.1807-5932http://repositorio.unifesp.br/handle/11600/7193http://dx.doi.org/10.6061/clinics/2012(07)20S1807-59322012000700020.pdfS1807-5932201200070002010.6061/clinics/2012(07)20WOS:000307723100020Patients who have suffered burns frequently experience psychological consequences, among which anxiety disorders are prominent. Benzodiazepines are commonly administered to treat these symptoms. The effects of benzodiazepines on healing may not be direct but rather are modulated by alterations of the sleep architecture. This hypothesis is supported by studies that demonstrate the effects of benzodiazepines on the immune system and the inflammatory profile under both normal sleep conditions and during sleep deprivation, particularly rapid eye movement sleep deprivation.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Associacao Fundo de Incentivo a Pesquisa (AFIP)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo-FAPESP (CEPID)Universidade Federal de São Paulo (UNIFESP) Departamento de PsicobiologiaUNIFESP, Depto. de Psicobiologia2011/14462-0 e 2010/14768-098/14303-3SciELO827-830engFaculdade de Medicina / USPClinicsBenzodiazepinesSleep DeprivationWound HealingBurnsImmune SystemWound-healing and benzodiazepines: does sleep play a role in this relationship?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS1807-59322012000700020.pdfapplication/pdf169751${dspace.ui.url}/bitstream/11600/7193/1/S1807-59322012000700020.pdf5336cd3338a42d5a50801ea6a427cf31MD51open accessTEXTS1807-59322012000700020.pdf.txtS1807-59322012000700020.pdf.txtExtracted texttext/plain22214${dspace.ui.url}/bitstream/11600/7193/2/S1807-59322012000700020.pdf.txtf2d0623509f8caa7ad549bfe3c606467MD52open access11600/71932021-10-05 21:18:09.946open accessoai:repositorio.unifesp.br:11600/7193Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-10-06T00:18:09Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Wound-healing and benzodiazepines: does sleep play a role in this relationship?
title Wound-healing and benzodiazepines: does sleep play a role in this relationship?
spellingShingle Wound-healing and benzodiazepines: does sleep play a role in this relationship?
Egydio, Flavia [UNIFESP]
Benzodiazepines
Sleep Deprivation
Wound Healing
Burns
Immune System
title_short Wound-healing and benzodiazepines: does sleep play a role in this relationship?
title_full Wound-healing and benzodiazepines: does sleep play a role in this relationship?
title_fullStr Wound-healing and benzodiazepines: does sleep play a role in this relationship?
title_full_unstemmed Wound-healing and benzodiazepines: does sleep play a role in this relationship?
title_sort Wound-healing and benzodiazepines: does sleep play a role in this relationship?
author Egydio, Flavia [UNIFESP]
author_facet Egydio, Flavia [UNIFESP]
Pires, Gabriel Natan [UNIFESP]
Tufik, Sergio [UNIFESP]
Andersen, Monica Levy [UNIFESP]
author_role author
author2 Pires, Gabriel Natan [UNIFESP]
Tufik, Sergio [UNIFESP]
Andersen, Monica Levy [UNIFESP]
author2_role author
author
author
dc.contributor.institution.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Egydio, Flavia [UNIFESP]
Pires, Gabriel Natan [UNIFESP]
Tufik, Sergio [UNIFESP]
Andersen, Monica Levy [UNIFESP]
dc.subject.eng.fl_str_mv Benzodiazepines
Sleep Deprivation
Wound Healing
Burns
Immune System
topic Benzodiazepines
Sleep Deprivation
Wound Healing
Burns
Immune System
description Patients who have suffered burns frequently experience psychological consequences, among which anxiety disorders are prominent. Benzodiazepines are commonly administered to treat these symptoms. The effects of benzodiazepines on healing may not be direct but rather are modulated by alterations of the sleep architecture. This hypothesis is supported by studies that demonstrate the effects of benzodiazepines on the immune system and the inflammatory profile under both normal sleep conditions and during sleep deprivation, particularly rapid eye movement sleep deprivation.
publishDate 2012
dc.date.issued.fl_str_mv 2012-07-01
dc.date.accessioned.fl_str_mv 2015-06-14T13:44:49Z
dc.date.available.fl_str_mv 2015-06-14T13:44:49Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Clinics. Faculdade de Medicina / USP, v. 67, n. 7, p. 827-830, 2012.
dc.identifier.uri.fl_str_mv http://repositorio.unifesp.br/handle/11600/7193
http://dx.doi.org/10.6061/clinics/2012(07)20
dc.identifier.issn.none.fl_str_mv 1807-5932
dc.identifier.file.none.fl_str_mv S1807-59322012000700020.pdf
dc.identifier.scielo.none.fl_str_mv S1807-59322012000700020
dc.identifier.doi.none.fl_str_mv 10.6061/clinics/2012(07)20
dc.identifier.wos.none.fl_str_mv WOS:000307723100020
identifier_str_mv Clinics. Faculdade de Medicina / USP, v. 67, n. 7, p. 827-830, 2012.
1807-5932
S1807-59322012000700020.pdf
S1807-59322012000700020
10.6061/clinics/2012(07)20
WOS:000307723100020
url http://repositorio.unifesp.br/handle/11600/7193
http://dx.doi.org/10.6061/clinics/2012(07)20
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Clinics
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 827-830
dc.publisher.none.fl_str_mv Faculdade de Medicina / USP
publisher.none.fl_str_mv Faculdade de Medicina / USP
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
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