Deficiência da glicose-6-fosfato desidrogenase com infecções de repetição: relato de caso

• Autor(a) principal: Rosa-Borges, Abertina
• Data de Publicação: 2001
• Outros Autores: Sampaio, Márcia G., Condino-Neto, Antônio, Barreto, Orlando C.o., Nudelman, Victor [UNIFESP], Carneiro-Sampaio, Magda Maria Sales, Nogueira, Susie A., Abreu, Thalita F. de, Rehder, Jussara, Costa-Carvalho, Beatriz Tavares [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0021-75572001000400017; http://repositorio.unifesp.br/handle/11600/1223
• topic: glucosephosphate dehydrogenase deficiency; immunodeficiency syndromes; chronic granulomatous disease; neutrophilis; congenital hemolytic anemia; deficiência de glucosefosfato desidrogenase; síndromes de deficiência imunológica; neutrófilos; doenças granulomatosa crônica; anemia hemolítica congênita

OBJECTIVE: To report a case of rare neutrophil functional disorder with clinical and laboratory findings similar to those of chronic granulomatous disease. METHODS: Patient with extremely reduced level of glucose-6-phosphate dehydrogenase and recurrent infections that improved after continuous use of cotrimoxazole. The patient presented leukocytes with defective respiratory burst, similar to what occurs in chronic granulomatous disease. COMMENTS: The diagnosis of glucose-6-phosphate dehydrogenase deficiency in neutrophils should be considered in any patient with hemolytic anemia whose level of G6PD is extremely low or in any patient that presents recurrent infections as differential diagnosis of chronic granulomatous disease.