Adolescent mice are more vulnerable than adults to single injection-induced behavioral sensitization to amphetamine
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/33569 http://dx.doi.org/10.1016/j.pbb.2011.01.013 |
Resumo: | Drug-induced behavioral sensitization in rodents has enhanced our understanding of why drugs acquire increasing motivational and incentive value. Compared to adults, human adolescents have accelerated dependence courses with shorter times from first exposure to dependence. We compared adolescent and adult mice in their ability to develop behavioral sensitization to amphetamine following a single injection. Adult (90-day-old) and adolescent (45-day-old) male Swiss mice received an acute intraperitoneal injection of saline or amphetamine (1.0. 2.0 or 4.0 mg/kg). Seven days later, half of the mice from the saline group received a second injection of saline. the remaining animals were challenged with 2.0 mg/kg amphetamine. Following all of the injections, mice were placed in activity chambers and locomotion was quantified for 45 min. the magnitude of both the acute and sensitized locomotor stimulatory effect of amphetamine was higher in the adolescent mice. Previous experience with the test environment inhibited the acute amphetamine stimulation in both adolescent and adult mice, but facilitated the detection of elevated spontaneous locomotion in adolescent animals. These results support the notion that the adolescent period is associated with an increased risk for development of drug abuse. Additionally, they indicate a complex interaction between the environmental novelty, adolescence and amphetamine. (C) 2011 Elsevier Inc. All rights reserved. |
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Kameda, Sonia Regina [UNIFESP]Fukushiro, Daniela Fukue [UNIFESP]Trombin, Thaís Fernanda [UNIFESP]Procopio-Souza, Roberta [UNIFESP]Patti, Camilla de Lima [UNIFESP]Hollais, André Willian [UNIFESP]Calzavara, Mariana Bendlin [UNIFESP]Abílio, Vanessa Costhek [UNIFESP]Ribeiro, Rosana de Alencar [UNIFESP]Tufik, Sergio [UNIFESP]D'Almeida, Vânia [UNIFESP]Frussa Filho, Roberto [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T14:06:19Z2016-01-24T14:06:19Z2011-04-01Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 98, n. 2, p. 320-324, 2011.0091-3057http://repositorio.unifesp.br/handle/11600/33569http://dx.doi.org/10.1016/j.pbb.2011.01.013WOS000289396300024.pdf10.1016/j.pbb.2011.01.013WOS:000289396300024Drug-induced behavioral sensitization in rodents has enhanced our understanding of why drugs acquire increasing motivational and incentive value. Compared to adults, human adolescents have accelerated dependence courses with shorter times from first exposure to dependence. We compared adolescent and adult mice in their ability to develop behavioral sensitization to amphetamine following a single injection. Adult (90-day-old) and adolescent (45-day-old) male Swiss mice received an acute intraperitoneal injection of saline or amphetamine (1.0. 2.0 or 4.0 mg/kg). Seven days later, half of the mice from the saline group received a second injection of saline. the remaining animals were challenged with 2.0 mg/kg amphetamine. Following all of the injections, mice were placed in activity chambers and locomotion was quantified for 45 min. the magnitude of both the acute and sensitized locomotor stimulatory effect of amphetamine was higher in the adolescent mice. Previous experience with the test environment inhibited the acute amphetamine stimulation in both adolescent and adult mice, but facilitated the detection of elevated spontaneous locomotion in adolescent animals. These results support the notion that the adolescent period is associated with an increased risk for development of drug abuse. Additionally, they indicate a complex interaction between the environmental novelty, adolescence and amphetamine. (C) 2011 Elsevier Inc. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundo de Apoio ao Docente e Aluno (FADA)Associacao Fundo de Pesquisa em Psicobiologia (AFIP)Universidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pediat, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biosci, BR-11060001 Santos, SP, BrazilUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psychobiol, BR-04024002 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pediat, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biosci, BR-11060001 Santos, SP, BrazilWeb of Science320-324engElsevier B.V.Pharmacology Biochemistry and Behaviorhttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policyinfo:eu-repo/semantics/openAccessAdolescentAdultAmphetamineBehavioral sensitizationLocomotionMiceAdolescent mice are more vulnerable than adults to single injection-induced behavioral sensitization to amphetamineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000289396300024.pdfapplication/pdf265484${dspace.ui.url}/bitstream/11600/33569/1/WOS000289396300024.pdf49cbbdc48f1c5bd62eedb1cca1949412MD51open accessTEXTWOS000289396300024.pdf.txtWOS000289396300024.pdf.txtExtracted texttext/plain39452${dspace.ui.url}/bitstream/11600/33569/6/WOS000289396300024.pdf.txt565b3ec93f759fa20510fa2f94048c2aMD56open accessTHUMBNAILWOS000289396300024.pdf.jpgWOS000289396300024.pdf.jpgIM Thumbnailimage/jpeg8375${dspace.ui.url}/bitstream/11600/33569/8/WOS000289396300024.pdf.jpg9d849aa0abf4a2737285fa2975a73a6bMD58open access11600/335692023-06-05 19:12:33.128open accessoai:repositorio.unifesp.br:11600/33569Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:12:33Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Adolescent mice are more vulnerable than adults to single injection-induced behavioral sensitization to amphetamine |
title |
Adolescent mice are more vulnerable than adults to single injection-induced behavioral sensitization to amphetamine |
spellingShingle |
Adolescent mice are more vulnerable than adults to single injection-induced behavioral sensitization to amphetamine Kameda, Sonia Regina [UNIFESP] Adolescent Adult Amphetamine Behavioral sensitization Locomotion Mice |
title_short |
Adolescent mice are more vulnerable than adults to single injection-induced behavioral sensitization to amphetamine |
title_full |
Adolescent mice are more vulnerable than adults to single injection-induced behavioral sensitization to amphetamine |
title_fullStr |
Adolescent mice are more vulnerable than adults to single injection-induced behavioral sensitization to amphetamine |
title_full_unstemmed |
Adolescent mice are more vulnerable than adults to single injection-induced behavioral sensitization to amphetamine |
title_sort |
Adolescent mice are more vulnerable than adults to single injection-induced behavioral sensitization to amphetamine |
author |
Kameda, Sonia Regina [UNIFESP] |
author_facet |
Kameda, Sonia Regina [UNIFESP] Fukushiro, Daniela Fukue [UNIFESP] Trombin, Thaís Fernanda [UNIFESP] Procopio-Souza, Roberta [UNIFESP] Patti, Camilla de Lima [UNIFESP] Hollais, André Willian [UNIFESP] Calzavara, Mariana Bendlin [UNIFESP] Abílio, Vanessa Costhek [UNIFESP] Ribeiro, Rosana de Alencar [UNIFESP] Tufik, Sergio [UNIFESP] D'Almeida, Vânia [UNIFESP] Frussa Filho, Roberto [UNIFESP] |
author_role |
author |
author2 |
Fukushiro, Daniela Fukue [UNIFESP] Trombin, Thaís Fernanda [UNIFESP] Procopio-Souza, Roberta [UNIFESP] Patti, Camilla de Lima [UNIFESP] Hollais, André Willian [UNIFESP] Calzavara, Mariana Bendlin [UNIFESP] Abílio, Vanessa Costhek [UNIFESP] Ribeiro, Rosana de Alencar [UNIFESP] Tufik, Sergio [UNIFESP] D'Almeida, Vânia [UNIFESP] Frussa Filho, Roberto [UNIFESP] |
author2_role |
author author author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Kameda, Sonia Regina [UNIFESP] Fukushiro, Daniela Fukue [UNIFESP] Trombin, Thaís Fernanda [UNIFESP] Procopio-Souza, Roberta [UNIFESP] Patti, Camilla de Lima [UNIFESP] Hollais, André Willian [UNIFESP] Calzavara, Mariana Bendlin [UNIFESP] Abílio, Vanessa Costhek [UNIFESP] Ribeiro, Rosana de Alencar [UNIFESP] Tufik, Sergio [UNIFESP] D'Almeida, Vânia [UNIFESP] Frussa Filho, Roberto [UNIFESP] |
dc.subject.eng.fl_str_mv |
Adolescent Adult Amphetamine Behavioral sensitization Locomotion Mice |
topic |
Adolescent Adult Amphetamine Behavioral sensitization Locomotion Mice |
description |
Drug-induced behavioral sensitization in rodents has enhanced our understanding of why drugs acquire increasing motivational and incentive value. Compared to adults, human adolescents have accelerated dependence courses with shorter times from first exposure to dependence. We compared adolescent and adult mice in their ability to develop behavioral sensitization to amphetamine following a single injection. Adult (90-day-old) and adolescent (45-day-old) male Swiss mice received an acute intraperitoneal injection of saline or amphetamine (1.0. 2.0 or 4.0 mg/kg). Seven days later, half of the mice from the saline group received a second injection of saline. the remaining animals were challenged with 2.0 mg/kg amphetamine. Following all of the injections, mice were placed in activity chambers and locomotion was quantified for 45 min. the magnitude of both the acute and sensitized locomotor stimulatory effect of amphetamine was higher in the adolescent mice. Previous experience with the test environment inhibited the acute amphetamine stimulation in both adolescent and adult mice, but facilitated the detection of elevated spontaneous locomotion in adolescent animals. These results support the notion that the adolescent period is associated with an increased risk for development of drug abuse. Additionally, they indicate a complex interaction between the environmental novelty, adolescence and amphetamine. (C) 2011 Elsevier Inc. All rights reserved. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-04-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:06:19Z |
dc.date.available.fl_str_mv |
2016-01-24T14:06:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 98, n. 2, p. 320-324, 2011. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/33569 http://dx.doi.org/10.1016/j.pbb.2011.01.013 |
dc.identifier.issn.none.fl_str_mv |
0091-3057 |
dc.identifier.file.none.fl_str_mv |
WOS000289396300024.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.pbb.2011.01.013 |
dc.identifier.wos.none.fl_str_mv |
WOS:000289396300024 |
identifier_str_mv |
Pharmacology Biochemistry and Behavior. Oxford: Pergamon-Elsevier B.V., v. 98, n. 2, p. 320-324, 2011. 0091-3057 WOS000289396300024.pdf 10.1016/j.pbb.2011.01.013 WOS:000289396300024 |
url |
http://repositorio.unifesp.br/handle/11600/33569 http://dx.doi.org/10.1016/j.pbb.2011.01.013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Pharmacology Biochemistry and Behavior |
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http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
320-324 |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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Repositório Institucional da UNIFESP |
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