False-positive galactomannan platelia Aspergillus test results for patients receiving piperacillin-tazobactam

• Autor(a) principal: Viscoli, Claudio
• Data de Publicação: 2004
• Outros Autores: Machetti, Marco, Cappellano, Paola [UNIFESP], Bucci, Barbara, Bruzzi, Paolo, Van Lint, Maria Teresa, Bacigalupo, Andrea
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1086/382224; http://repositorio.unifesp.br/handle/11600/27676

At the bone marrow transplantation center of the San Martino Hospital ( Genoa), we observed an increase in the rate of patients with positive Platelia Aspergillus (PA; Bio-Rad) test results, from 10% ( 38 of 386 patients) in the period from January 1999 through January 2003 to 36% ( 21 of 59 patients) in the period from February 2003 through May 2003. Positivity was significantly (P < .001) associated with the administration of piperacillin-tazobactam (PT) (17 [74%] of 23 patients who received PT had positive results vs. 4 [11%] of 36 who did not receive PT). Multivariate analysis found administration of PT (&chi;2 = 34.7; P < .001) and underlying disease (chi(2) = 21.14; P < .001) to be associated with PA positivity. of 15 PT batches tested, 12 had positive PA test results.