Ablation of the ability to control the right-to-left cardiac shunt does not affect oxygen uptake, specific dynamic action or growth in the rattlesnake Crotalus durissus
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/36247 http://dx.doi.org/10.1242/jeb.083840 |
Resumo: | The morphologically undivided ventricle of the heart in non-crocodilian reptiles permits the mixing of oxygen-rich blood returning from the lungs and oxygen-poor blood from the systemic circulation. A possible functional significance for this intra-cardiac shunt has been debated for almost a century. Unilateral left vagotomy rendered the single effective pulmonary artery of the South American rattlesnake, Crotalus durissus, unable to adjust the magnitude of blood flow to the lung. the higher constant perfusion of the lung circulation and the incapability of adjusting the right-left shunt in left-denervated snakes persisted over time, providing a unique model for investigation of the long-term consequences of cardiac shunting in a squamate. Oxygen uptake recorded at rest and during spontaneous and forced activity was not affected by removing control of the cardiac shunt. Furthermore, metabolic rate and energetic balance during the post-prandial metabolic increment, plus the food conversion efficiency and growth rate, were all similarly unaffected. These results show that control of cardiac shunting is not associated with a clear functional advantage in adjusting metabolic rate, effectiveness of digestion or growth rates. |
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Leite, Cleo A. C. [UNIFESP]Taylor, Edwin W.Wang, TobiasAbe, Augusto S.Andrade, Denis O. V. deUniversidade Federal de São Paulo (UNIFESP)Univ BirminghamUniversidade de São Paulo (USP)Aarhus Univ2016-01-24T14:31:38Z2016-01-24T14:31:38Z2013-05-01Journal of Experimental Biology. Cambridge: Company of Biologists Ltd, v. 216, n. 10, p. 1881-1889, 2013.0022-0949http://repositorio.unifesp.br/handle/11600/36247http://dx.doi.org/10.1242/jeb.083840WOS000318483600021.pdf10.1242/jeb.083840WOS:000318483600021The morphologically undivided ventricle of the heart in non-crocodilian reptiles permits the mixing of oxygen-rich blood returning from the lungs and oxygen-poor blood from the systemic circulation. A possible functional significance for this intra-cardiac shunt has been debated for almost a century. Unilateral left vagotomy rendered the single effective pulmonary artery of the South American rattlesnake, Crotalus durissus, unable to adjust the magnitude of blood flow to the lung. the higher constant perfusion of the lung circulation and the incapability of adjusting the right-left shunt in left-denervated snakes persisted over time, providing a unique model for investigation of the long-term consequences of cardiac shunting in a squamate. Oxygen uptake recorded at rest and during spontaneous and forced activity was not affected by removing control of the cardiac shunt. Furthermore, metabolic rate and energetic balance during the post-prandial metabolic increment, plus the food conversion efficiency and growth rate, were all similarly unaffected. These results show that control of cardiac shunting is not associated with a clear functional advantage in adjusting metabolic rate, effectiveness of digestion or growth rates.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Danish Research CouncilFed Univ São Paulo UNIFESP, Dept Biol, BR-09972270 Diadema, SP, BrazilUniv Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, EnglandState Univ São Paulo UNESP, Dept Zool, BR-13506900 Rio Claro, SP, BrazilAarhus Univ, Dept Biosci, DK-8000 Aarhus C, DenmarkFed Univ São Paulo UNIFESP, Dept Biol, BR-09972270 Diadema, SP, BrazilWeb of Science1881-1889engCompany of Biologists LtdJournal of Experimental Biologycardiac shuntvagotomyrattlesnakeCrotalusoxygen uptakeheartAblation of the ability to control the right-to-left cardiac shunt does not affect oxygen uptake, specific dynamic action or growth in the rattlesnake Crotalus durissusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000318483600021.pdfapplication/pdf1656056${dspace.ui.url}/bitstream/11600/36247/1/WOS000318483600021.pdfb97a5b93bc14cdd84cafcb56825eddb9MD51open accessTEXTWOS000318483600021.pdf.txtWOS000318483600021.pdf.txtExtracted texttext/plain54473${dspace.ui.url}/bitstream/11600/36247/9/WOS000318483600021.pdf.txt50e30c75c21385acd082868c0e160539MD59open accessTHUMBNAILWOS000318483600021.pdf.jpgWOS000318483600021.pdf.jpgIM Thumbnailimage/jpeg8541${dspace.ui.url}/bitstream/11600/36247/11/WOS000318483600021.pdf.jpg462ba9299f0981ea759acf7870d200e4MD511open access11600/362472023-06-05 19:24:39.118open accessoai:repositorio.unifesp.br:11600/36247Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:24:39Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Ablation of the ability to control the right-to-left cardiac shunt does not affect oxygen uptake, specific dynamic action or growth in the rattlesnake Crotalus durissus |
title |
Ablation of the ability to control the right-to-left cardiac shunt does not affect oxygen uptake, specific dynamic action or growth in the rattlesnake Crotalus durissus |
spellingShingle |
Ablation of the ability to control the right-to-left cardiac shunt does not affect oxygen uptake, specific dynamic action or growth in the rattlesnake Crotalus durissus Leite, Cleo A. C. [UNIFESP] cardiac shunt vagotomy rattlesnake Crotalus oxygen uptake heart |
title_short |
Ablation of the ability to control the right-to-left cardiac shunt does not affect oxygen uptake, specific dynamic action or growth in the rattlesnake Crotalus durissus |
title_full |
Ablation of the ability to control the right-to-left cardiac shunt does not affect oxygen uptake, specific dynamic action or growth in the rattlesnake Crotalus durissus |
title_fullStr |
Ablation of the ability to control the right-to-left cardiac shunt does not affect oxygen uptake, specific dynamic action or growth in the rattlesnake Crotalus durissus |
title_full_unstemmed |
Ablation of the ability to control the right-to-left cardiac shunt does not affect oxygen uptake, specific dynamic action or growth in the rattlesnake Crotalus durissus |
title_sort |
Ablation of the ability to control the right-to-left cardiac shunt does not affect oxygen uptake, specific dynamic action or growth in the rattlesnake Crotalus durissus |
author |
Leite, Cleo A. C. [UNIFESP] |
author_facet |
Leite, Cleo A. C. [UNIFESP] Taylor, Edwin W. Wang, Tobias Abe, Augusto S. Andrade, Denis O. V. de |
author_role |
author |
author2 |
Taylor, Edwin W. Wang, Tobias Abe, Augusto S. Andrade, Denis O. V. de |
author2_role |
author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Univ Birmingham Universidade de São Paulo (USP) Aarhus Univ |
dc.contributor.author.fl_str_mv |
Leite, Cleo A. C. [UNIFESP] Taylor, Edwin W. Wang, Tobias Abe, Augusto S. Andrade, Denis O. V. de |
dc.subject.eng.fl_str_mv |
cardiac shunt vagotomy rattlesnake Crotalus oxygen uptake heart |
topic |
cardiac shunt vagotomy rattlesnake Crotalus oxygen uptake heart |
description |
The morphologically undivided ventricle of the heart in non-crocodilian reptiles permits the mixing of oxygen-rich blood returning from the lungs and oxygen-poor blood from the systemic circulation. A possible functional significance for this intra-cardiac shunt has been debated for almost a century. Unilateral left vagotomy rendered the single effective pulmonary artery of the South American rattlesnake, Crotalus durissus, unable to adjust the magnitude of blood flow to the lung. the higher constant perfusion of the lung circulation and the incapability of adjusting the right-left shunt in left-denervated snakes persisted over time, providing a unique model for investigation of the long-term consequences of cardiac shunting in a squamate. Oxygen uptake recorded at rest and during spontaneous and forced activity was not affected by removing control of the cardiac shunt. Furthermore, metabolic rate and energetic balance during the post-prandial metabolic increment, plus the food conversion efficiency and growth rate, were all similarly unaffected. These results show that control of cardiac shunting is not associated with a clear functional advantage in adjusting metabolic rate, effectiveness of digestion or growth rates. |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-05-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T14:31:38Z |
dc.date.available.fl_str_mv |
2016-01-24T14:31:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Journal of Experimental Biology. Cambridge: Company of Biologists Ltd, v. 216, n. 10, p. 1881-1889, 2013. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/36247 http://dx.doi.org/10.1242/jeb.083840 |
dc.identifier.issn.none.fl_str_mv |
0022-0949 |
dc.identifier.file.none.fl_str_mv |
WOS000318483600021.pdf |
dc.identifier.doi.none.fl_str_mv |
10.1242/jeb.083840 |
dc.identifier.wos.none.fl_str_mv |
WOS:000318483600021 |
identifier_str_mv |
Journal of Experimental Biology. Cambridge: Company of Biologists Ltd, v. 216, n. 10, p. 1881-1889, 2013. 0022-0949 WOS000318483600021.pdf 10.1242/jeb.083840 WOS:000318483600021 |
url |
http://repositorio.unifesp.br/handle/11600/36247 http://dx.doi.org/10.1242/jeb.083840 |
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eng |
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Journal of Experimental Biology |
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1881-1889 |
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Company of Biologists Ltd |
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Company of Biologists Ltd |
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