Placental transfer of Haemophilus influenzae type b antibodies in malnourished pregnant women
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/4207 http://dx.doi.org/10.1590/S1413-86702008000100011 |
Resumo: | This study evaluated the vaccination response to Haemophilus influenzae type b (Hib) in malnourished pregnant women (MN), cord blood (CB) and in infants at two and six months of age for comparison with a control group (C). Twenty-eight malnourished pregnant women and 29 pregnant controls were immunized with conjugated Act-HIB® in the third trimester of pregnancy. Blood samples were collected from all before the immunization, during labor (post immunization), and from CB. All infants were immunized with Hib vaccine according to normal vaccine schedule and sera were collected at two and six months of age. Antibody levels to polyribosylribitol phosphate (PRP) were similar for both groups. Preimmunization: MN 1.94 µg/mL, C 1.68 µg/mL; post-vaccination: MN 18.53 µg/mL and C 17.55 µg/mL; in CB from MN 14.46 µg/mL and from C 17.04 µg/mL. Infants from MN and C mothers presented respectively at two months: 5.18 µg/mL and 8.60 µg/mL and at six months: MN 3.42 µg/mL and C 2.18 µg/mL. Antibody levels were similar in both groups studied (p = 0.485), however the vertical transmission rate was 14% lower in the MN pregnant group. Levels of antibodies > 0.15 µg/mL were found in all newborns from the MN pregnant group. Pregnant MN presented an immunological response to Hib vaccine similar to group C, however, vertical transmission rate of antibodies to PRP in the MN pregnant group was 14% lower than that in C, suggesting a less efficient passage of antibodies within this group. |
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Cavalcante, Rejane Silva [UNIFESP]Kopelman, Benjamin Israel [UNIFESP]Costa-Carvalho, Beatriz Tavares [UNIFESP]University State of Pará Department of Integrated HealthUniversidade Federal de São Paulo (UNIFESP)2015-06-14T13:38:22Z2015-06-14T13:38:22Z2008-02-01Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 12, n. 1, p. 47-51, 2008.1413-8670http://repositorio.unifesp.br/handle/11600/4207http://dx.doi.org/10.1590/S1413-86702008000100011S1413-86702008000100011.pdfS1413-8670200800010001110.1590/S1413-86702008000100011WOS:000257126000011This study evaluated the vaccination response to Haemophilus influenzae type b (Hib) in malnourished pregnant women (MN), cord blood (CB) and in infants at two and six months of age for comparison with a control group (C). Twenty-eight malnourished pregnant women and 29 pregnant controls were immunized with conjugated Act-HIB® in the third trimester of pregnancy. Blood samples were collected from all before the immunization, during labor (post immunization), and from CB. All infants were immunized with Hib vaccine according to normal vaccine schedule and sera were collected at two and six months of age. Antibody levels to polyribosylribitol phosphate (PRP) were similar for both groups. Preimmunization: MN 1.94 µg/mL, C 1.68 µg/mL; post-vaccination: MN 18.53 µg/mL and C 17.55 µg/mL; in CB from MN 14.46 µg/mL and from C 17.04 µg/mL. Infants from MN and C mothers presented respectively at two months: 5.18 µg/mL and 8.60 µg/mL and at six months: MN 3.42 µg/mL and C 2.18 µg/mL. Antibody levels were similar in both groups studied (p = 0.485), however the vertical transmission rate was 14% lower in the MN pregnant group. Levels of antibodies > 0.15 µg/mL were found in all newborns from the MN pregnant group. Pregnant MN presented an immunological response to Hib vaccine similar to group C, however, vertical transmission rate of antibodies to PRP in the MN pregnant group was 14% lower than that in C, suggesting a less efficient passage of antibodies within this group.University State of Pará Department of Integrated HealthFederal University of São Paulo Medical School of São Paulo Department of PediatricsUNIFESP, Medical School of São Paulo Department of PediatricsSciELO47-51engBrazilian Society of Infectious DiseasesBrazilian Journal of Infectious DiseasesPregnant womenmalnourishedHaemophilus influenzae type bpassive immunizationvaccineantibodiesimmunoglobulin GPlacental transfer of Haemophilus influenzae type b antibodies in malnourished pregnant womeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS1413-86702008000100011.pdfapplication/pdf140115${dspace.ui.url}/bitstream/11600/4207/1/S1413-86702008000100011.pdfacf16c7742c184fab2b28e3cae9a4758MD51open accessTEXTS1413-86702008000100011.pdf.txtS1413-86702008000100011.pdf.txtExtracted texttext/plain23753${dspace.ui.url}/bitstream/11600/4207/21/S1413-86702008000100011.pdf.txtb468c284c4463e4fa8df6c8e9d477517MD521open accessTHUMBNAILS1413-86702008000100011.pdf.jpgS1413-86702008000100011.pdf.jpgIM Thumbnailimage/jpeg6751${dspace.ui.url}/bitstream/11600/4207/23/S1413-86702008000100011.pdf.jpgf4b24f2c70c741d4c951fde8a4ffad06MD523open access11600/42072023-06-05 19:35:00.503open accessoai:repositorio.unifesp.br:11600/4207Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:35Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Placental transfer of Haemophilus influenzae type b antibodies in malnourished pregnant women |
title |
Placental transfer of Haemophilus influenzae type b antibodies in malnourished pregnant women |
spellingShingle |
Placental transfer of Haemophilus influenzae type b antibodies in malnourished pregnant women Cavalcante, Rejane Silva [UNIFESP] Pregnant women malnourished Haemophilus influenzae type b passive immunization vaccine antibodies immunoglobulin G |
title_short |
Placental transfer of Haemophilus influenzae type b antibodies in malnourished pregnant women |
title_full |
Placental transfer of Haemophilus influenzae type b antibodies in malnourished pregnant women |
title_fullStr |
Placental transfer of Haemophilus influenzae type b antibodies in malnourished pregnant women |
title_full_unstemmed |
Placental transfer of Haemophilus influenzae type b antibodies in malnourished pregnant women |
title_sort |
Placental transfer of Haemophilus influenzae type b antibodies in malnourished pregnant women |
author |
Cavalcante, Rejane Silva [UNIFESP] |
author_facet |
Cavalcante, Rejane Silva [UNIFESP] Kopelman, Benjamin Israel [UNIFESP] Costa-Carvalho, Beatriz Tavares [UNIFESP] |
author_role |
author |
author2 |
Kopelman, Benjamin Israel [UNIFESP] Costa-Carvalho, Beatriz Tavares [UNIFESP] |
author2_role |
author author |
dc.contributor.institution.none.fl_str_mv |
University State of Pará Department of Integrated Health Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Cavalcante, Rejane Silva [UNIFESP] Kopelman, Benjamin Israel [UNIFESP] Costa-Carvalho, Beatriz Tavares [UNIFESP] |
dc.subject.eng.fl_str_mv |
Pregnant women malnourished Haemophilus influenzae type b passive immunization vaccine antibodies immunoglobulin G |
topic |
Pregnant women malnourished Haemophilus influenzae type b passive immunization vaccine antibodies immunoglobulin G |
description |
This study evaluated the vaccination response to Haemophilus influenzae type b (Hib) in malnourished pregnant women (MN), cord blood (CB) and in infants at two and six months of age for comparison with a control group (C). Twenty-eight malnourished pregnant women and 29 pregnant controls were immunized with conjugated Act-HIB® in the third trimester of pregnancy. Blood samples were collected from all before the immunization, during labor (post immunization), and from CB. All infants were immunized with Hib vaccine according to normal vaccine schedule and sera were collected at two and six months of age. Antibody levels to polyribosylribitol phosphate (PRP) were similar for both groups. Preimmunization: MN 1.94 µg/mL, C 1.68 µg/mL; post-vaccination: MN 18.53 µg/mL and C 17.55 µg/mL; in CB from MN 14.46 µg/mL and from C 17.04 µg/mL. Infants from MN and C mothers presented respectively at two months: 5.18 µg/mL and 8.60 µg/mL and at six months: MN 3.42 µg/mL and C 2.18 µg/mL. Antibody levels were similar in both groups studied (p = 0.485), however the vertical transmission rate was 14% lower in the MN pregnant group. Levels of antibodies > 0.15 µg/mL were found in all newborns from the MN pregnant group. Pregnant MN presented an immunological response to Hib vaccine similar to group C, however, vertical transmission rate of antibodies to PRP in the MN pregnant group was 14% lower than that in C, suggesting a less efficient passage of antibodies within this group. |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008-02-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:38:22Z |
dc.date.available.fl_str_mv |
2015-06-14T13:38:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 12, n. 1, p. 47-51, 2008. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/4207 http://dx.doi.org/10.1590/S1413-86702008000100011 |
dc.identifier.issn.none.fl_str_mv |
1413-8670 |
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S1413-86702008000100011.pdf |
dc.identifier.scielo.none.fl_str_mv |
S1413-86702008000100011 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S1413-86702008000100011 |
dc.identifier.wos.none.fl_str_mv |
WOS:000257126000011 |
identifier_str_mv |
Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 12, n. 1, p. 47-51, 2008. 1413-8670 S1413-86702008000100011.pdf S1413-86702008000100011 10.1590/S1413-86702008000100011 WOS:000257126000011 |
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http://repositorio.unifesp.br/handle/11600/4207 http://dx.doi.org/10.1590/S1413-86702008000100011 |
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eng |
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Brazilian Journal of Infectious Diseases |
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openAccess |
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47-51 |
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Brazilian Society of Infectious Diseases |
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Brazilian Society of Infectious Diseases |
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