Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/29221 http://dx.doi.org/10.1152/ajpregu.00186.2006 |
Resumo: | Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus. Am J Physiol Regul Integr Comp Physiol 291: R1527-R1532, 2006. First published June 29, 2006; doi: 10.1152/ajpregu.00186.2006.-Sleep is hypothesized to play a restorative role on immune system. in addition, disturbed sleep is thought to impair host defense mechanisms. Chronic sleep deprivation is a common occurrence in modern society and has been observed in a number of chronic inflammatory conditions, such as systemic lupus erythematosus (SLE). New Zealand Black/New Zealand White (NZB/NZW) F-1 mice develop an autoimmune disease that strongly resembles SLE in humans, exhibiting high titers of antinuclear antibodies associated with the development of rapidly progressive and lethal glomerulonephritis. On the basis of this evidence, the present study examined the onset and progress of lupus in as-yet healthy female mice submitted to sleep deprivation. Sleep deprivation was accomplished by two 96-h periods in the multiple-platform method when mice were 10 wk old, and they were observed until 28 wk of age. Blood samples were collected from the orbital plexus fortnightly to evaluate serum antinuclear antibodies and anti-double-stranded DNA. Proteinuria and longevity as well as body weight were also assessed. the results indicated that mice submitted to sleep deprivation exhibited an earlier onset of the disease, as reflected by the increased number of antinuclear antibodies. However, no statistical difference was found in the other parameters analyzed. According to these results, sleep deprivation could be considered as a risk factor for the onset but not for the evolution of the disease. |
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Palma, Beatriz DuarteGabriel, AlexandreColugnati, Fernando A. B.Tufik, Sergio [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T12:41:33Z2016-01-24T12:41:33Z2006-11-01American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 291, n. 5, p. R1527-R1532, 2006.0363-6119http://repositorio.unifesp.br/handle/11600/29221http://dx.doi.org/10.1152/ajpregu.00186.200610.1152/ajpregu.00186.2006WOS:000241106400040Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus. Am J Physiol Regul Integr Comp Physiol 291: R1527-R1532, 2006. First published June 29, 2006; doi: 10.1152/ajpregu.00186.2006.-Sleep is hypothesized to play a restorative role on immune system. in addition, disturbed sleep is thought to impair host defense mechanisms. Chronic sleep deprivation is a common occurrence in modern society and has been observed in a number of chronic inflammatory conditions, such as systemic lupus erythematosus (SLE). New Zealand Black/New Zealand White (NZB/NZW) F-1 mice develop an autoimmune disease that strongly resembles SLE in humans, exhibiting high titers of antinuclear antibodies associated with the development of rapidly progressive and lethal glomerulonephritis. On the basis of this evidence, the present study examined the onset and progress of lupus in as-yet healthy female mice submitted to sleep deprivation. Sleep deprivation was accomplished by two 96-h periods in the multiple-platform method when mice were 10 wk old, and they were observed until 28 wk of age. Blood samples were collected from the orbital plexus fortnightly to evaluate serum antinuclear antibodies and anti-double-stranded DNA. Proteinuria and longevity as well as body weight were also assessed. the results indicated that mice submitted to sleep deprivation exhibited an earlier onset of the disease, as reflected by the increased number of antinuclear antibodies. However, no statistical difference was found in the other parameters analyzed. According to these results, sleep deprivation could be considered as a risk factor for the onset but not for the evolution of the disease.Universidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Lab Med Invest, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Lab Med Invest, BR-04023062 São Paulo, BrazilWeb of ScienceR1527-R1532engAmer Physiological SocAmerican Journal of Physiology-regulatory Integrative and Comparative PhysiologysleepNew Zealand Black/New Zealand White F-1 miceantinuclear antibodyEffects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/292212022-07-08 10:54:15.799metadata only accessoai:repositorio.unifesp.br:11600/29221Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:21:35.600759Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus |
title |
Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus |
spellingShingle |
Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus Palma, Beatriz Duarte sleep New Zealand Black/New Zealand White F-1 mice antinuclear antibody |
title_short |
Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus |
title_full |
Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus |
title_fullStr |
Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus |
title_full_unstemmed |
Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus |
title_sort |
Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus |
author |
Palma, Beatriz Duarte |
author_facet |
Palma, Beatriz Duarte Gabriel, Alexandre Colugnati, Fernando A. B. Tufik, Sergio [UNIFESP] |
author_role |
author |
author2 |
Gabriel, Alexandre Colugnati, Fernando A. B. Tufik, Sergio [UNIFESP] |
author2_role |
author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Palma, Beatriz Duarte Gabriel, Alexandre Colugnati, Fernando A. B. Tufik, Sergio [UNIFESP] |
dc.subject.eng.fl_str_mv |
sleep New Zealand Black/New Zealand White F-1 mice antinuclear antibody |
topic |
sleep New Zealand Black/New Zealand White F-1 mice antinuclear antibody |
description |
Effects of sleep deprivation on the development of autoimmune disease in an experimental model of systemic lupus erythematosus. Am J Physiol Regul Integr Comp Physiol 291: R1527-R1532, 2006. First published June 29, 2006; doi: 10.1152/ajpregu.00186.2006.-Sleep is hypothesized to play a restorative role on immune system. in addition, disturbed sleep is thought to impair host defense mechanisms. Chronic sleep deprivation is a common occurrence in modern society and has been observed in a number of chronic inflammatory conditions, such as systemic lupus erythematosus (SLE). New Zealand Black/New Zealand White (NZB/NZW) F-1 mice develop an autoimmune disease that strongly resembles SLE in humans, exhibiting high titers of antinuclear antibodies associated with the development of rapidly progressive and lethal glomerulonephritis. On the basis of this evidence, the present study examined the onset and progress of lupus in as-yet healthy female mice submitted to sleep deprivation. Sleep deprivation was accomplished by two 96-h periods in the multiple-platform method when mice were 10 wk old, and they were observed until 28 wk of age. Blood samples were collected from the orbital plexus fortnightly to evaluate serum antinuclear antibodies and anti-double-stranded DNA. Proteinuria and longevity as well as body weight were also assessed. the results indicated that mice submitted to sleep deprivation exhibited an earlier onset of the disease, as reflected by the increased number of antinuclear antibodies. However, no statistical difference was found in the other parameters analyzed. According to these results, sleep deprivation could be considered as a risk factor for the onset but not for the evolution of the disease. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006-11-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:41:33Z |
dc.date.available.fl_str_mv |
2016-01-24T12:41:33Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 291, n. 5, p. R1527-R1532, 2006. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/29221 http://dx.doi.org/10.1152/ajpregu.00186.2006 |
dc.identifier.issn.none.fl_str_mv |
0363-6119 |
dc.identifier.doi.none.fl_str_mv |
10.1152/ajpregu.00186.2006 |
dc.identifier.wos.none.fl_str_mv |
WOS:000241106400040 |
identifier_str_mv |
American Journal of Physiology-regulatory Integrative and Comparative Physiology. Bethesda: Amer Physiological Soc, v. 291, n. 5, p. R1527-R1532, 2006. 0363-6119 10.1152/ajpregu.00186.2006 WOS:000241106400040 |
url |
http://repositorio.unifesp.br/handle/11600/29221 http://dx.doi.org/10.1152/ajpregu.00186.2006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
American Journal of Physiology-regulatory Integrative and Comparative Physiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
R1527-R1532 |
dc.publisher.none.fl_str_mv |
Amer Physiological Soc |
publisher.none.fl_str_mv |
Amer Physiological Soc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1783460237106216960 |