Furazolidone-based triple therapy for H pylori gastritis in children
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/11600/45741 http://dx.doi.org/10.3748/WJG.v12.i34.5544 |
Resumo: | AIM: To evaluate the furazolidone-based triple therapy in children with symptomatic H pylori gastritis.METHODS: A prospective and consecutive open trial was carried out. The study included 38 patients with upper digestive symptoms sufficiently severe to warrant endoscopic investigation. H pylori status was defined based both on histology and on positive C-13-urea breath test. Drug regimen was a seven-day course of omeprazole, clarithromycin and furazolidone (100 mg, 200 mg if over 30 kg) twice daily. Eradication of H pylori was assessed two months after treatment by histology and C-13-urea breath test. Further clinical evaluation was performed 7 cl, 2 and 6 mo after the treatment.RESULTS: Thirty-eight patients (24 females, 14 males) were included. Their age ranged from 4 to 17.8 (mean 10.9 +/- 3.7) years. On intent-to-treat analysis (n = 38), the eradication rate of H pylori was 73.7% (95% CI, 65.2%-82%) whereas in per-protocol analysis (n = 33) it was 84.8% (95% CI,. 78.5%-91%)., All the patients with duodenal ulcer (n = 7) were successfully treated (100% vs 56.2% with antral nodularity). Side effects were reported in 26 patients (68.4%), mainly vomiting (14/26) and abdominal pain (n = 13). Successfully treated dyspeptic patients showed improvement in 78.9% of H pylori-negative patients after six months and in 50% of H pylori-positive patients after six months of treatment.CONCLUSION: Triple therapy with furazolidone achieves moderate efficacy in H pylori treatment. The eradication rate seems to be higher in patients with duodenal ulcer. (C) 2006 The WJG Press. All rights reserved. |
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Kawakami, Elisabete [UNIFESP]Machado, Rodrigo Strehl [UNIFESP]Ogata, Silvio Kazuo [UNIFESP]Langner, Marini [UNIFESP]Fukushima, Erika [UNIFESP]Carelli, Anna Paula [UNIFESP]Bonucci, Vania Claudia Guimaraes [UNIFESP]Patricio, Francy Reis Silva [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2018-06-18T12:15:15Z2018-06-18T12:15:15Z2006-09-14World Journal Of Gastroenterology. Beijing: W J G Press, v. 12, n. 34, p. 5544-5549, 2006.1007-9327http://repositorio.unifesp.br/11600/45741http://dx.doi.org/10.3748/WJG.v12.i34.5544WOS000240647100020.pdf10.3748/WJG.v12.i24.3891WOS:000240647100020AIM: To evaluate the furazolidone-based triple therapy in children with symptomatic H pylori gastritis.METHODS: A prospective and consecutive open trial was carried out. The study included 38 patients with upper digestive symptoms sufficiently severe to warrant endoscopic investigation. H pylori status was defined based both on histology and on positive C-13-urea breath test. Drug regimen was a seven-day course of omeprazole, clarithromycin and furazolidone (100 mg, 200 mg if over 30 kg) twice daily. Eradication of H pylori was assessed two months after treatment by histology and C-13-urea breath test. Further clinical evaluation was performed 7 cl, 2 and 6 mo after the treatment.RESULTS: Thirty-eight patients (24 females, 14 males) were included. Their age ranged from 4 to 17.8 (mean 10.9 +/- 3.7) years. On intent-to-treat analysis (n = 38), the eradication rate of H pylori was 73.7% (95% CI, 65.2%-82%) whereas in per-protocol analysis (n = 33) it was 84.8% (95% CI,. 78.5%-91%)., All the patients with duodenal ulcer (n = 7) were successfully treated (100% vs 56.2% with antral nodularity). Side effects were reported in 26 patients (68.4%), mainly vomiting (14/26) and abdominal pain (n = 13). Successfully treated dyspeptic patients showed improvement in 78.9% of H pylori-negative patients after six months and in 50% of H pylori-positive patients after six months of treatment.CONCLUSION: Triple therapy with furazolidone achieves moderate efficacy in H pylori treatment. The eradication rate seems to be higher in patients with duodenal ulcer. (C) 2006 The WJG Press. All rights reserved.Univ Fed Sao Paulo, Escola Paulista Med, Dept Pediat,Pediat Gastroenterol Div, Pept Dis Outpatient Clin, Sao Paulo, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Pathol, Sao Paulo, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Pediat,Pediat Gastroenterol Div, Pept Dis Outpatient Clin, Sao Paulo, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Pathol, Sao Paulo, BrazilWeb of Science5544-5549engW J G PressWorld Journal Of GastroenterologyFurazolidoneH pylori treatmentgastritisChildrenFurazolidone-based triple therapy for H pylori gastritis in childreninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/457412022-09-19 22:26:18.41metadata only accessoai:repositorio.unifesp.br:11600/45741Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:38:05.465172Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Furazolidone-based triple therapy for H pylori gastritis in children |
title |
Furazolidone-based triple therapy for H pylori gastritis in children |
spellingShingle |
Furazolidone-based triple therapy for H pylori gastritis in children Kawakami, Elisabete [UNIFESP] Furazolidone H pylori treatment gastritis Children |
title_short |
Furazolidone-based triple therapy for H pylori gastritis in children |
title_full |
Furazolidone-based triple therapy for H pylori gastritis in children |
title_fullStr |
Furazolidone-based triple therapy for H pylori gastritis in children |
title_full_unstemmed |
Furazolidone-based triple therapy for H pylori gastritis in children |
title_sort |
Furazolidone-based triple therapy for H pylori gastritis in children |
author |
Kawakami, Elisabete [UNIFESP] |
author_facet |
Kawakami, Elisabete [UNIFESP] Machado, Rodrigo Strehl [UNIFESP] Ogata, Silvio Kazuo [UNIFESP] Langner, Marini [UNIFESP] Fukushima, Erika [UNIFESP] Carelli, Anna Paula [UNIFESP] Bonucci, Vania Claudia Guimaraes [UNIFESP] Patricio, Francy Reis Silva [UNIFESP] |
author_role |
author |
author2 |
Machado, Rodrigo Strehl [UNIFESP] Ogata, Silvio Kazuo [UNIFESP] Langner, Marini [UNIFESP] Fukushima, Erika [UNIFESP] Carelli, Anna Paula [UNIFESP] Bonucci, Vania Claudia Guimaraes [UNIFESP] Patricio, Francy Reis Silva [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Kawakami, Elisabete [UNIFESP] Machado, Rodrigo Strehl [UNIFESP] Ogata, Silvio Kazuo [UNIFESP] Langner, Marini [UNIFESP] Fukushima, Erika [UNIFESP] Carelli, Anna Paula [UNIFESP] Bonucci, Vania Claudia Guimaraes [UNIFESP] Patricio, Francy Reis Silva [UNIFESP] |
dc.subject.eng.fl_str_mv |
Furazolidone H pylori treatment gastritis Children |
topic |
Furazolidone H pylori treatment gastritis Children |
description |
AIM: To evaluate the furazolidone-based triple therapy in children with symptomatic H pylori gastritis.METHODS: A prospective and consecutive open trial was carried out. The study included 38 patients with upper digestive symptoms sufficiently severe to warrant endoscopic investigation. H pylori status was defined based both on histology and on positive C-13-urea breath test. Drug regimen was a seven-day course of omeprazole, clarithromycin and furazolidone (100 mg, 200 mg if over 30 kg) twice daily. Eradication of H pylori was assessed two months after treatment by histology and C-13-urea breath test. Further clinical evaluation was performed 7 cl, 2 and 6 mo after the treatment.RESULTS: Thirty-eight patients (24 females, 14 males) were included. Their age ranged from 4 to 17.8 (mean 10.9 +/- 3.7) years. On intent-to-treat analysis (n = 38), the eradication rate of H pylori was 73.7% (95% CI, 65.2%-82%) whereas in per-protocol analysis (n = 33) it was 84.8% (95% CI,. 78.5%-91%)., All the patients with duodenal ulcer (n = 7) were successfully treated (100% vs 56.2% with antral nodularity). Side effects were reported in 26 patients (68.4%), mainly vomiting (14/26) and abdominal pain (n = 13). Successfully treated dyspeptic patients showed improvement in 78.9% of H pylori-negative patients after six months and in 50% of H pylori-positive patients after six months of treatment.CONCLUSION: Triple therapy with furazolidone achieves moderate efficacy in H pylori treatment. The eradication rate seems to be higher in patients with duodenal ulcer. (C) 2006 The WJG Press. All rights reserved. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006-09-14 |
dc.date.accessioned.fl_str_mv |
2018-06-18T12:15:15Z |
dc.date.available.fl_str_mv |
2018-06-18T12:15:15Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
World Journal Of Gastroenterology. Beijing: W J G Press, v. 12, n. 34, p. 5544-5549, 2006. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/11600/45741 http://dx.doi.org/10.3748/WJG.v12.i34.5544 |
dc.identifier.issn.none.fl_str_mv |
1007-9327 |
dc.identifier.file.none.fl_str_mv |
WOS000240647100020.pdf |
dc.identifier.doi.none.fl_str_mv |
10.3748/WJG.v12.i24.3891 |
dc.identifier.wos.none.fl_str_mv |
WOS:000240647100020 |
identifier_str_mv |
World Journal Of Gastroenterology. Beijing: W J G Press, v. 12, n. 34, p. 5544-5549, 2006. 1007-9327 WOS000240647100020.pdf 10.3748/WJG.v12.i24.3891 WOS:000240647100020 |
url |
http://repositorio.unifesp.br/11600/45741 http://dx.doi.org/10.3748/WJG.v12.i34.5544 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
World Journal Of Gastroenterology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
5544-5549 |
dc.publisher.none.fl_str_mv |
W J G Press |
publisher.none.fl_str_mv |
W J G Press |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
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1783460318748344320 |