Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa

Detalhes bibliográficos
Autor(a) principal: Turano, Helena
Data de Publicação: 2017
Outros Autores: Gomes, Fernando, Barros-Carvalho, Gesiele A., Lopes, Ralf, Cerdeira, Louise, Netto, Luis E. S., Gales, Ana C. [UNIFESP, Lincopan, Nilton
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/0013000012cg6
DOI: 10.1128/AAC.00100-17
Texto Completo: http://dx.doi.org/10.1128/AAC.00100-17
https://repositorio.unifesp.br/handle/11600/54542
Resumo: A novel transposon belonging to the Tn3-like family was identified on the chromosome of a commensal strain of Pseudomonas aeruginosa sequence type 2343 (ET02). Tn6350 is 7,367 bp long and harbors eight open reading frames (ORFs), an ATPase (IS481 family), a transposase (DDE catalytic type), a Tn3 resolvase, three hypothetical proteins, and genes encoding the new pyocin S8 with its immunity protein. We show that pyocin S8 displays activity against carbapenemase-producing P. aeruginosa, including IMP-1, SPM-1, VIM-1, GES-5, and KPC-2 producers.
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spelling Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosatransposonS-type pyocinsbacteriocinPseudomonas aeruginosametallo-beta-lactamasesA novel transposon belonging to the Tn3-like family was identified on the chromosome of a commensal strain of Pseudomonas aeruginosa sequence type 2343 (ET02). Tn6350 is 7,367 bp long and harbors eight open reading frames (ORFs), an ATPase (IS481 family), a transposase (DDE catalytic type), a Tn3 resolvase, three hypothetical proteins, and genes encoding the new pyocin S8 with its immunity protein. We show that pyocin S8 displays activity against carbapenemase-producing P. aeruginosa, including IMP-1, SPM-1, VIM-1, GES-5, and KPC-2 producers.Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, BrazilUniv Sao Paulo, Inst Biosci, Dept Genet & Evolutionary Biol, Sao Paulo, BrazilUniv Sao Paulo, Inst Biosci, Dept Bot, Sao Paulo, BrazilUniv Sao Paulo, Fac Pharmaceut Sci, Dept Clin Anal, Sao Paulo, BrazilUniv Fed Sao Paulo, Lab Alerta, Sao Paulo, BrazilUniv Fed Sao Paulo, Lab Alerta, Sao Paulo, BrazilWeb of ScienceCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)FAPESP: 2016/08593-9CNPq: 462042/2014-6Amer Soc Microbiology2020-07-13T11:53:20Z2020-07-13T11:53:20Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-http://dx.doi.org/10.1128/AAC.00100-17Antimicrobial Agents And Chemotherapy. Washington, v. 61, n. 5, p. -, 2017.10.1128/AAC.00100-17WOS000403532100011.pdf0066-4804https://repositorio.unifesp.br/handle/11600/54542WOS:000403532100011ark:/48912/0013000012cg6engAntimicrobial Agents And ChemotherapyWashingtoninfo:eu-repo/semantics/openAccessTurano, HelenaGomes, FernandoBarros-Carvalho, Gesiele A.Lopes, RalfCerdeira, LouiseNetto, Luis E. S.Gales, Ana C. [UNIFESPLincopan, Niltonreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-10-05T21:59:10Zoai:repositorio.unifesp.br/:11600/54542Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:51:21.943208Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa
title Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa
spellingShingle Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa
Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa
Turano, Helena
transposon
S-type pyocins
bacteriocin
Pseudomonas aeruginosa
metallo-beta-lactamases
Turano, Helena
transposon
S-type pyocins
bacteriocin
Pseudomonas aeruginosa
metallo-beta-lactamases
title_short Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa
title_full Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa
title_fullStr Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa
Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa
title_full_unstemmed Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa
Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa
title_sort Tn6350, a Novel Transposon Carrying Pyocin S8 Genes Encoding a Bacteriocin with Activity against Carbapenemase-Producing Pseudomonas aeruginosa
author Turano, Helena
author_facet Turano, Helena
Turano, Helena
Gomes, Fernando
Barros-Carvalho, Gesiele A.
Lopes, Ralf
Cerdeira, Louise
Netto, Luis E. S.
Gales, Ana C. [UNIFESP
Lincopan, Nilton
Gomes, Fernando
Barros-Carvalho, Gesiele A.
Lopes, Ralf
Cerdeira, Louise
Netto, Luis E. S.
Gales, Ana C. [UNIFESP
Lincopan, Nilton
author_role author
author2 Gomes, Fernando
Barros-Carvalho, Gesiele A.
Lopes, Ralf
Cerdeira, Louise
Netto, Luis E. S.
Gales, Ana C. [UNIFESP
Lincopan, Nilton
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Turano, Helena
Gomes, Fernando
Barros-Carvalho, Gesiele A.
Lopes, Ralf
Cerdeira, Louise
Netto, Luis E. S.
Gales, Ana C. [UNIFESP
Lincopan, Nilton
dc.subject.por.fl_str_mv transposon
S-type pyocins
bacteriocin
Pseudomonas aeruginosa
metallo-beta-lactamases
topic transposon
S-type pyocins
bacteriocin
Pseudomonas aeruginosa
metallo-beta-lactamases
description A novel transposon belonging to the Tn3-like family was identified on the chromosome of a commensal strain of Pseudomonas aeruginosa sequence type 2343 (ET02). Tn6350 is 7,367 bp long and harbors eight open reading frames (ORFs), an ATPase (IS481 family), a transposase (DDE catalytic type), a Tn3 resolvase, three hypothetical proteins, and genes encoding the new pyocin S8 with its immunity protein. We show that pyocin S8 displays activity against carbapenemase-producing P. aeruginosa, including IMP-1, SPM-1, VIM-1, GES-5, and KPC-2 producers.
publishDate 2017
dc.date.none.fl_str_mv 2017
2020-07-13T11:53:20Z
2020-07-13T11:53:20Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1128/AAC.00100-17
Antimicrobial Agents And Chemotherapy. Washington, v. 61, n. 5, p. -, 2017.
10.1128/AAC.00100-17
WOS000403532100011.pdf
0066-4804
https://repositorio.unifesp.br/handle/11600/54542
WOS:000403532100011
dc.identifier.dark.fl_str_mv ark:/48912/0013000012cg6
url http://dx.doi.org/10.1128/AAC.00100-17
https://repositorio.unifesp.br/handle/11600/54542
identifier_str_mv Antimicrobial Agents And Chemotherapy. Washington, v. 61, n. 5, p. -, 2017.
10.1128/AAC.00100-17
WOS000403532100011.pdf
0066-4804
WOS:000403532100011
ark:/48912/0013000012cg6
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Antimicrobial Agents And Chemotherapy
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv -
dc.coverage.none.fl_str_mv Washington
dc.publisher.none.fl_str_mv Amer Soc Microbiology
publisher.none.fl_str_mv Amer Soc Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1822251414120824832
dc.identifier.doi.none.fl_str_mv 10.1128/AAC.00100-17

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