Porque usamos imunoglobulina anti-D em excesso no abortamento precoce?

• Autor(a) principal: Baiochi, Eduardo [UNIFESP]
• Data de Publicação: 2004
• Outros Autores: Camano, Luiz [UNIFESP], Bordin, Jose Orlando [UNIFESP], Avritscher, Ana Paula [UNIFESP], Andrade, Carla Maria De Araújo [UNIFESP], Traina, Evelyn [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0100-72032004000500004; http://repositorio.unifesp.br/handle/11600/2095
• topic: Fetomaternal hemorrhage; Anti-D immunoglobulin; Early miscarriage; Hemorragia feto-materna; Imunoglobulina anti-D; Aborto precoce; Rh negativo

OBJECTIVE: evaluation of fetomaternal hemorrhage (FMH) in patients who would need Rh alloimmunization with anti-D immunoglobulin (300 mug) prophylaxis after early miscarriage. METHOD: we included in the study Rh (D) negative blood group patients with positive or unknown Rh (D) partners, who had had a miscarriage up to 12 weeks of gestation, and had been admitted to hospital for uterine curettage. After this procedure 5 ml of venous blood was collected from the patients and the rosette test was applied to screen which patients would need quantitative determination of fetal blood transferred to the maternal circulation, by the Kleihauer-Betke test (K-B). RESULTS: out of 26 patients evaluated the rosette test was positive in one , who showed an FMH of 1.5 ml in the K-B test. CONCLUSIONS: the dose of anti-D immunoglobulin used in cases of miscarriage up to 12 weeks of gestation should be substantially reduced. The availability of preparations of 50 mug is recommended, for a more inexpensive and rational treatment.