Monocyte transplantation for neural and cardiovascular ischemia repair

• Autor(a) principal: Sanberg, Paul R.
• Data de Publicação: 2010
• Outros Autores: Park, Dong-Hyuk, Kuzmin-Nichols, Nicole, Cruz, Eduardo, Hossne, Nelson Americo [UNIFESP], Buffolo, Enio [UNIFESP], Willing, Alison E.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1111/j.1582-4934.2009.00903.x; http://repositorio.unifesp.br/handle/11600/32294
• topic: ischemia; inflammation; angiogenesis/arteriogenesis; monocyte/macrophage; umbilical cord blood; bone marrow; peripheral blood; transplantation; stem cells

Neovascularization is an integral process of inflammatory reactions and subsequent repair cascades in tissue injury. Monocytes/macrophages play a key role in the inflammatory process including angiogenesis as well as the defence mechanisms by exerting microbicidal and immunomodulatory activity. Current studies have demonstrated that recruited monocytes/macrophages aid in regulating angiogenesis in ischemic tissue, tumours and chronic inflammation. in terms of neovascularization followed by tissue regeneration, monocytes/macrophages should be highly attractive for cell-based therapy compared to any other stem cells due to their considerable advantages: non-oncogenic, non-teratogenic, multiple secretary functions including pro-angiogenic and growth factors, straightforward cell harvesting procedure and non-existent ethical controversy. in addition to adult origins such as bone marrow or peripheral blood, umbilical cord blood (UCB) can be a potential source for autologous or allogeneic monocytes/macrophages. Especially, UCB monocytes should be considered as the first candidate owing to their feasibility, low immune rejection and multiple characteristic advantages such as their anti-inflammatory properties by virtue of their unique immune and inflammatory immaturity, and their proangiogenic ability. in this review, we present general characteristics and potential of monocytes/macrophages for cell-based therapy, especially focusing on neovascularization and UCB-derived monocytes.