Cardiovascular mechanisms activated by microinjection of baclofen into NTS of conscious rats
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/27158 http://dx.doi.org/10.1152/ajpheart.00447.2002 |
Resumo: | The peripheral mechanisms responsible for pressor response produced by microinjections of baclofen (GABA(B) agonist) into the nucleus tractus solitarii (NTS) of conscious rats were studied. Bilateral microinjections of baclofen (10-1,000 pmol/100 nl) produced a dose-related increase in mean arterial pressure (MAP) and heart rate. the maximal response was observed after 15 min. Intravenous injection of prazosin decreased MAP to control levels. Subsequent treatment with Manning compound (vasopressin receptor antagonist; iv) produced an additional decrease in MAP. in a different group of rats, vasopressin antagonist was injected first and MAP was significantly decreased; however, it remained elevated compared with prebaclofen injection levels. Subsequent treatment with prazosin abolished the baclofen-induced pressor response. Reductions in baclofen-induced pressor response with prazosin treatment were followed by a reflex tachycardia in animals that received a 100 pmol/100 nl dose of baclofen. the tachycardia was not observed with a dose of 1,000 pmol/100 nl. the pressor response induced by microinjection of baclofen into the NTS of conscious rats may be produced by both increases in sympathetic tonus and vasopressin release. |
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Landulpho, Carlos Daniel Almeida PitangaDias, Ana Carolina RodriguesColombari, Eduardo [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2016-01-24T12:33:44Z2016-01-24T12:33:44Z2003-03-01American Journal of Physiology-heart and Circulatory Physiology. Bethesda: Amer Physiological Soc, v. 284, n. 3, p. H987-H993, 2003.0363-6135http://repositorio.unifesp.br/handle/11600/27158http://dx.doi.org/10.1152/ajpheart.00447.200210.1152/ajpheart.00447.2002WOS:000180885200029The peripheral mechanisms responsible for pressor response produced by microinjections of baclofen (GABA(B) agonist) into the nucleus tractus solitarii (NTS) of conscious rats were studied. Bilateral microinjections of baclofen (10-1,000 pmol/100 nl) produced a dose-related increase in mean arterial pressure (MAP) and heart rate. the maximal response was observed after 15 min. Intravenous injection of prazosin decreased MAP to control levels. Subsequent treatment with Manning compound (vasopressin receptor antagonist; iv) produced an additional decrease in MAP. in a different group of rats, vasopressin antagonist was injected first and MAP was significantly decreased; however, it remained elevated compared with prebaclofen injection levels. Subsequent treatment with prazosin abolished the baclofen-induced pressor response. Reductions in baclofen-induced pressor response with prazosin treatment were followed by a reflex tachycardia in animals that received a 100 pmol/100 nl dose of baclofen. the tachycardia was not observed with a dose of 1,000 pmol/100 nl. the pressor response induced by microinjection of baclofen into the NTS of conscious rats may be produced by both increases in sympathetic tonus and vasopressin release.Universidade Federal de São Paulo, Escola Paulista Med, Dept Physiol, BR-04023060 São Paulo, BrazilUniversidade Federal de São Paulo, Escola Paulista Med, Dept Physiol, BR-04023060 São Paulo, BrazilWeb of ScienceH987-H993engAmer Physiological SocAmerican Journal of Physiology-heart and Circulatory PhysiologyGABA(B) agonistprazosinblood pressurevasopressincardiovascular controlbaroreflexCardiovascular mechanisms activated by microinjection of baclofen into NTS of conscious ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/271582023-01-30 22:17:46.486metadata only accessoai:repositorio.unifesp.br:11600/27158Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:44:41.373310Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Cardiovascular mechanisms activated by microinjection of baclofen into NTS of conscious rats |
title |
Cardiovascular mechanisms activated by microinjection of baclofen into NTS of conscious rats |
spellingShingle |
Cardiovascular mechanisms activated by microinjection of baclofen into NTS of conscious rats Landulpho, Carlos Daniel Almeida Pitanga GABA(B) agonist prazosin blood pressure vasopressin cardiovascular control baroreflex |
title_short |
Cardiovascular mechanisms activated by microinjection of baclofen into NTS of conscious rats |
title_full |
Cardiovascular mechanisms activated by microinjection of baclofen into NTS of conscious rats |
title_fullStr |
Cardiovascular mechanisms activated by microinjection of baclofen into NTS of conscious rats |
title_full_unstemmed |
Cardiovascular mechanisms activated by microinjection of baclofen into NTS of conscious rats |
title_sort |
Cardiovascular mechanisms activated by microinjection of baclofen into NTS of conscious rats |
author |
Landulpho, Carlos Daniel Almeida Pitanga |
author_facet |
Landulpho, Carlos Daniel Almeida Pitanga Dias, Ana Carolina Rodrigues Colombari, Eduardo [UNIFESP] |
author_role |
author |
author2 |
Dias, Ana Carolina Rodrigues Colombari, Eduardo [UNIFESP] |
author2_role |
author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Landulpho, Carlos Daniel Almeida Pitanga Dias, Ana Carolina Rodrigues Colombari, Eduardo [UNIFESP] |
dc.subject.eng.fl_str_mv |
GABA(B) agonist prazosin blood pressure vasopressin cardiovascular control baroreflex |
topic |
GABA(B) agonist prazosin blood pressure vasopressin cardiovascular control baroreflex |
description |
The peripheral mechanisms responsible for pressor response produced by microinjections of baclofen (GABA(B) agonist) into the nucleus tractus solitarii (NTS) of conscious rats were studied. Bilateral microinjections of baclofen (10-1,000 pmol/100 nl) produced a dose-related increase in mean arterial pressure (MAP) and heart rate. the maximal response was observed after 15 min. Intravenous injection of prazosin decreased MAP to control levels. Subsequent treatment with Manning compound (vasopressin receptor antagonist; iv) produced an additional decrease in MAP. in a different group of rats, vasopressin antagonist was injected first and MAP was significantly decreased; however, it remained elevated compared with prebaclofen injection levels. Subsequent treatment with prazosin abolished the baclofen-induced pressor response. Reductions in baclofen-induced pressor response with prazosin treatment were followed by a reflex tachycardia in animals that received a 100 pmol/100 nl dose of baclofen. the tachycardia was not observed with a dose of 1,000 pmol/100 nl. the pressor response induced by microinjection of baclofen into the NTS of conscious rats may be produced by both increases in sympathetic tonus and vasopressin release. |
publishDate |
2003 |
dc.date.issued.fl_str_mv |
2003-03-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T12:33:44Z |
dc.date.available.fl_str_mv |
2016-01-24T12:33:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
American Journal of Physiology-heart and Circulatory Physiology. Bethesda: Amer Physiological Soc, v. 284, n. 3, p. H987-H993, 2003. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/27158 http://dx.doi.org/10.1152/ajpheart.00447.2002 |
dc.identifier.issn.none.fl_str_mv |
0363-6135 |
dc.identifier.doi.none.fl_str_mv |
10.1152/ajpheart.00447.2002 |
dc.identifier.wos.none.fl_str_mv |
WOS:000180885200029 |
identifier_str_mv |
American Journal of Physiology-heart and Circulatory Physiology. Bethesda: Amer Physiological Soc, v. 284, n. 3, p. H987-H993, 2003. 0363-6135 10.1152/ajpheart.00447.2002 WOS:000180885200029 |
url |
http://repositorio.unifesp.br/handle/11600/27158 http://dx.doi.org/10.1152/ajpheart.00447.2002 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
American Journal of Physiology-heart and Circulatory Physiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
H987-H993 |
dc.publisher.none.fl_str_mv |
Amer Physiological Soc |
publisher.none.fl_str_mv |
Amer Physiological Soc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460334720253952 |