Multicomponent complex formation between pyrimethamine, cyclodextrins and water-soluble polymers
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/6659 http://dx.doi.org/10.1590/S1516-89132011000500014 |
Resumo: | The combined effect of hydroxypropyl-β-cyclodextrin (HPβCD) and polyvinylpyrrolidone (PVP) or sodium carboxymethylcellulose (CMC) on the solubility of pyrimethamine (PYR) was studied. Equimolar PYR-HPβCD solid systems, in the presence or the absence of 0.25% (w/v) PVP or 0.10% (w/v) CMC were prepared by coevaporation or freeze-drying, and characterized by differential scanning calorimetry, X-ray diffraction analysis and dissolution profile. Phase-solubility analysis was used to investigate the interactions in aqueous solution between PYR and HPβCD, in the absence or presence of polymers, which showed a linear increase of PYR solubility depending on the concentration of HPβCD. The presence of polymer did not alter the stoichiometry of the complexes. DSC results were indicative of complexation, due to the loss of the characteristic endothermic peak of PYR. X-ray diffraction analysis confirmed the DSC results. Binary and ternary complexes showed higher dissolution rate when compared with the pure drug. |
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Rodrigues, Leticia Norma Carpentieri [UNIFESP]Issa, Michelle GeorgesAsbahr, Ana Carolina CavassinSilva, Marco Aurélio CarvalhoFerraz, Humberto GomesUniversidade Federal de São Paulo (UNIFESP)Universidade Federal do ParanáUniversidade PositivoUniversidade de São Paulo (USP)2015-06-14T13:43:18Z2015-06-14T13:43:18Z2011-10-01Brazilian Archives of Biology and Technology. Instituto de Tecnologia do Paraná - Tecpar, v. 54, n. 5, p. 965-972, 2011.1516-8913http://repositorio.unifesp.br/handle/11600/6659http://dx.doi.org/10.1590/S1516-89132011000500014S1516-89132011000500014.pdfS1516-8913201100050001410.1590/S1516-89132011000500014WOS:000297761500014The combined effect of hydroxypropyl-β-cyclodextrin (HPβCD) and polyvinylpyrrolidone (PVP) or sodium carboxymethylcellulose (CMC) on the solubility of pyrimethamine (PYR) was studied. Equimolar PYR-HPβCD solid systems, in the presence or the absence of 0.25% (w/v) PVP or 0.10% (w/v) CMC were prepared by coevaporation or freeze-drying, and characterized by differential scanning calorimetry, X-ray diffraction analysis and dissolution profile. Phase-solubility analysis was used to investigate the interactions in aqueous solution between PYR and HPβCD, in the absence or presence of polymers, which showed a linear increase of PYR solubility depending on the concentration of HPβCD. The presence of polymer did not alter the stoichiometry of the complexes. DSC results were indicative of complexation, due to the loss of the characteristic endothermic peak of PYR. X-ray diffraction analysis confirmed the DSC results. Binary and ternary complexes showed higher dissolution rate when compared with the pure drug.Universidade Federal de São Paulo (UNIFESP) Departamento de Ciências Exatas e da TerraUniversidade Federal do ParanáUniversidade PositivoUniversidade de São Paulo Faculdade de Ciências FarmacêuticasUNIFESP, Depto. de Ciências Exatas e da TerraSciELO965-972engInstituto de Tecnologia do Paraná - TecparBrazilian Archives of Biology and TechnologyPyrimethamineHPβCDinclusion complexesMulticomponent complex formation between pyrimethamine, cyclodextrins and water-soluble polymersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS1516-89132011000500014.pdfapplication/pdf237323${dspace.ui.url}/bitstream/11600/6659/1/S1516-89132011000500014.pdf29fd6b51db885f2495030dee3d73c053MD51open accessTEXTS1516-89132011000500014.pdf.txtS1516-89132011000500014.pdf.txtExtracted texttext/plain25241${dspace.ui.url}/bitstream/11600/6659/9/S1516-89132011000500014.pdf.txtaaa7e88f3da51830d3ff17c25f0a28f4MD59open accessTHUMBNAILS1516-89132011000500014.pdf.jpgS1516-89132011000500014.pdf.jpgIM Thumbnailimage/jpeg5870${dspace.ui.url}/bitstream/11600/6659/11/S1516-89132011000500014.pdf.jpge091799c9892a7211e5dc7c7e47b7d82MD511open access11600/66592023-06-05 19:23:29.808open accessoai:repositorio.unifesp.br:11600/6659Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:23:29Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Multicomponent complex formation between pyrimethamine, cyclodextrins and water-soluble polymers |
title |
Multicomponent complex formation between pyrimethamine, cyclodextrins and water-soluble polymers |
spellingShingle |
Multicomponent complex formation between pyrimethamine, cyclodextrins and water-soluble polymers Rodrigues, Leticia Norma Carpentieri [UNIFESP] Pyrimethamine HPβCD inclusion complexes |
title_short |
Multicomponent complex formation between pyrimethamine, cyclodextrins and water-soluble polymers |
title_full |
Multicomponent complex formation between pyrimethamine, cyclodextrins and water-soluble polymers |
title_fullStr |
Multicomponent complex formation between pyrimethamine, cyclodextrins and water-soluble polymers |
title_full_unstemmed |
Multicomponent complex formation between pyrimethamine, cyclodextrins and water-soluble polymers |
title_sort |
Multicomponent complex formation between pyrimethamine, cyclodextrins and water-soluble polymers |
author |
Rodrigues, Leticia Norma Carpentieri [UNIFESP] |
author_facet |
Rodrigues, Leticia Norma Carpentieri [UNIFESP] Issa, Michelle Georges Asbahr, Ana Carolina Cavassin Silva, Marco Aurélio Carvalho Ferraz, Humberto Gomes |
author_role |
author |
author2 |
Issa, Michelle Georges Asbahr, Ana Carolina Cavassin Silva, Marco Aurélio Carvalho Ferraz, Humberto Gomes |
author2_role |
author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade Federal do Paraná Universidade Positivo Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Rodrigues, Leticia Norma Carpentieri [UNIFESP] Issa, Michelle Georges Asbahr, Ana Carolina Cavassin Silva, Marco Aurélio Carvalho Ferraz, Humberto Gomes |
dc.subject.eng.fl_str_mv |
Pyrimethamine HPβCD inclusion complexes |
topic |
Pyrimethamine HPβCD inclusion complexes |
description |
The combined effect of hydroxypropyl-β-cyclodextrin (HPβCD) and polyvinylpyrrolidone (PVP) or sodium carboxymethylcellulose (CMC) on the solubility of pyrimethamine (PYR) was studied. Equimolar PYR-HPβCD solid systems, in the presence or the absence of 0.25% (w/v) PVP or 0.10% (w/v) CMC were prepared by coevaporation or freeze-drying, and characterized by differential scanning calorimetry, X-ray diffraction analysis and dissolution profile. Phase-solubility analysis was used to investigate the interactions in aqueous solution between PYR and HPβCD, in the absence or presence of polymers, which showed a linear increase of PYR solubility depending on the concentration of HPβCD. The presence of polymer did not alter the stoichiometry of the complexes. DSC results were indicative of complexation, due to the loss of the characteristic endothermic peak of PYR. X-ray diffraction analysis confirmed the DSC results. Binary and ternary complexes showed higher dissolution rate when compared with the pure drug. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-10-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:43:18Z |
dc.date.available.fl_str_mv |
2015-06-14T13:43:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Archives of Biology and Technology. Instituto de Tecnologia do Paraná - Tecpar, v. 54, n. 5, p. 965-972, 2011. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/6659 http://dx.doi.org/10.1590/S1516-89132011000500014 |
dc.identifier.issn.none.fl_str_mv |
1516-8913 |
dc.identifier.file.none.fl_str_mv |
S1516-89132011000500014.pdf |
dc.identifier.scielo.none.fl_str_mv |
S1516-89132011000500014 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S1516-89132011000500014 |
dc.identifier.wos.none.fl_str_mv |
WOS:000297761500014 |
identifier_str_mv |
Brazilian Archives of Biology and Technology. Instituto de Tecnologia do Paraná - Tecpar, v. 54, n. 5, p. 965-972, 2011. 1516-8913 S1516-89132011000500014.pdf S1516-89132011000500014 10.1590/S1516-89132011000500014 WOS:000297761500014 |
url |
http://repositorio.unifesp.br/handle/11600/6659 http://dx.doi.org/10.1590/S1516-89132011000500014 |
dc.language.iso.fl_str_mv |
eng |
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Brazilian Archives of Biology and Technology |
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openAccess |
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965-972 |
dc.publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
publisher.none.fl_str_mv |
Instituto de Tecnologia do Paraná - Tecpar |
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