Linfonodo sentinela em melanoma de criança: relato de caso

• Autor(a) principal: Oliveira Filho, Renato Santos de [UNIFESP]
• Data de Publicação: 2002
• Outros Autores: Paiva, Geruza Rezende, Ferreira, Lydia Masako [UNIFESP], Alves, Marcos Chaves de Arruda [UNIFESP], Santos, Ivan Dunshee de Abranches Oliveira [UNIFESP], Enokihara, Mílvia Maria Simões e Silva [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S0021-75572002000500015; http://repositorio.unifesp.br/handle/11600/1538
• topic: sentinel lymph node; melanoma; Children; linfonodo sentinela; melanoma; criança

Objective: to present a case of a child who was subjected to sentinel lymph node biopsy for cutaneous melanoma. Description: a 12 year-old child with Dysplastic Nevus Syndrome developed melanoma on the lumbar region. The excision biopsy revealed a melanoma with depth of 1.5 mm. The patient was submitted to amplification of the margins 2 cm in all directions and the sentinel node was also excised. The histopathological exam did not show residual disease. Sentinel on exam did not show metastases either under hematoxylin-eosin stain or immunohistochemistry (S-100 and HMB45). Therefore, RT-PCR for tyrosinase mRNA was positive. The patient has been followed for twelve months without evidence of recurrence. Comments: childhood melanoma is rare, corresponding to less than 1% of malignant tumors in children. Data point to a worldwide increase in its incidence. Melanoma occurs in melanocytic lesions in 70% and in the remaining 30% it occurs de novo. Melanoma is very aggressive, so the survival depends on an early diagnosis. Sentinel lymph node biopsy has selected patients to complete lymphadenectomy. Some authors have been using this technique in childhood melanoma.