Invasive Candida Infections in Liver Transplant Recipients: Clinical Features and Risk Factors for Mortality

• Autor(a) principal: Bassetti, Matteo
• Data de Publicação: 2017
• Outros Autores: Peghin, Maddalena, Carnelutti, Alessia, Righi, Elda, Merelli, Maria, Ansaldi, Filippo, Trucchi, Cecilia, Alicino, Cristiano, Sartor, Assunta, Wauters, Joost, Lagrou, Katrien, Tascini, Carlo, Menichetti, Francesco, Mesini, Alessio, De Rosa, Francesco G., Lagunes, Leonel, Rello, Jordi [UNIFESP], Colombo, Arnaldo L. [UNIFESP], Vena, Antonio, Munoz, Patricia, Tumbarello, Mario, Sganga, Gabriele, Martin-Loeches, Ignacio, Viscoli, Claudio
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• dARK ID: ark:/48912/001300000g2fd
• Texto Completo: http://dx.doi.org/10.1097/TXD.0000000000000673; https://repositorio.unifesp.br/handle/11600/54559

Background. Invasive fungal infections remain a leading cause of morbidity and mortality among liver transplant recipients (LTRs). In this patient population, invasive Candida infections (ICIs) account for the largemajority of cases. To date, only small studies and case-series analysing clinical presentation and risk factors formortality in LTRs with ICIs are available. Methods. We performed a retrospective multicenter multinational study in 10 centers in Europe and Brazil. All consecutive LTRs developing ICIs during the period January 2011 to December 2013 were included in the study. Results. A total of 42 LTRs were included. Median age was 52.5 years, and 78.6% of patients weremen. Viral hepatitis was the most common cause for liver transplantation (42.9%). Candidemia represented the majority of cases (24, 57.1%), followed by intra-abdominal candidiasis (18, 42.9%). Overall 30-day mortality was 23.8%, with higher mortality in patients with candidemia compared with intra-abdominal candidiasis (37.5% vs 5.6%, P = 0.02). Multivariate analysis showed candidemia to be a risk factor associated with mortality among LTRs presenting ICIs (odds ratio, 11.86