Immunoexpression of hpv 16/18 e6 and e7 oncoproteins in high-grade cervical squamous intraepithelial lesions in hiv-positive women

Detalhes bibliográficos
Autor(a) principal: Rodrigues, L. C. [UNIFESP]
Data de Publicação: 2016
Outros Autores: de Gois Speck, N. M. [UNIFESP], de Azevedo Focchi, G. R. [UNIFESP], Schimidt, M. A. [UNIFESP], Marques, R. M. [UNIFESP], Lascasas Ribalta, J. C. [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.4238/gmr.15017220
http://repositorio.unifesp.br/handle/11600/49554
Resumo: The aim of this study was to assess the immunoexpression of human papillomavirus genotypes 16 and 18 (E6 and E7) oncoproteins in cervical high-grade squamous intraepithelial lesions (HSIL) of human immunodeficiency virus (HIV)-positive women. These results were also compared to the persistence and/or recurrence of lesions after loop electrosurgical excision procedure. Cervical samples from 158 patients were divided into three groups according to the presence or absence of HSIL in women who were or were not HIV-positive. By using the tissue microarray technique, immunohistochemistry was performed to analyze the expression of HPV 16/18 E6 and E7 oncoproteins. Cervical samples from 95 HIV-positive women and 63 HIV-negative women were studied. A statistically significant difference was found in the immunoexpression of E6 and E7 oncoproteins in samples from HIV-positive women with HSIL and that of women with non-neoplastic tissue (P < 0.001). There was also a statistically significant correlation between the immunoexpression of E6 (P = 0.012) and E7 (P < 0.001) oncoproteins in lesion persistence among HIV-positive women. Within the limitations of this study, the immunoexpression of HPV 16/18 E6 and E7 oncoproteins may have prognostic value regarding lesion persistence in HIV-positive women.
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spelling Immunoexpression of hpv 16/18 e6 and e7 oncoproteins in high-grade cervical squamous intraepithelial lesions in hiv-positive womenHuman Immunodeficiency VirusE6 OncoproteinE7 OncoproteinHuman Papillomavirus 16/18High-Grade Squamous Intraepithelial LesionsHuman-PapillomavirusTissue MicroarraysInfectionDysplasiaNeoplasiaRiskThe aim of this study was to assess the immunoexpression of human papillomavirus genotypes 16 and 18 (E6 and E7) oncoproteins in cervical high-grade squamous intraepithelial lesions (HSIL) of human immunodeficiency virus (HIV)-positive women. These results were also compared to the persistence and/or recurrence of lesions after loop electrosurgical excision procedure. Cervical samples from 158 patients were divided into three groups according to the presence or absence of HSIL in women who were or were not HIV-positive. By using the tissue microarray technique, immunohistochemistry was performed to analyze the expression of HPV 16/18 E6 and E7 oncoproteins. Cervical samples from 95 HIV-positive women and 63 HIV-negative women were studied. A statistically significant difference was found in the immunoexpression of E6 and E7 oncoproteins in samples from HIV-positive women with HSIL and that of women with non-neoplastic tissue (P < 0.001). There was also a statistically significant correlation between the immunoexpression of E6 (P = 0.012) and E7 (P < 0.001) oncoproteins in lesion persistence among HIV-positive women. Within the limitations of this study, the immunoexpression of HPV 16/18 E6 and E7 oncoproteins may have prognostic value regarding lesion persistence in HIV-positive women.Núcleo de Prevenção de Doenças Ginecológicas, Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, SP, BrasilDepartamento de Patologia, Universidade Federal de São Paulo, São Paulo, SP, BrasilDisciplina de Oncologia Ginecológica, Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, SP, BrasilNúcleo de Prevenção de Doenças Ginecológicas, Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, SP, BrasilDepartamento de Patologia, Universidade Federal de São Paulo, São Paulo, SP, BrasilDisciplina de Oncologia Ginecológica, Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, SP, BrasilWeb of ScienceFunpec-editora2019-01-21T10:30:04Z2019-01-21T10:30:04Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionUNSP gmr.15017220http://dx.doi.org/10.4238/gmr.15017220Genetics And Molecular Research. Ribeirao preto, v. 15, n. 1, p. UNSP gmr.15017220, 2016.10.4238/gmr.150172201676-5680http://repositorio.unifesp.br/handle/11600/49554WOS:000373880200024engGenetics And Molecular Researchinfo:eu-repo/semantics/openAccessRodrigues, L. C. [UNIFESP]de Gois Speck, N. M. [UNIFESP]de Azevedo Focchi, G. R. [UNIFESP]Schimidt, M. A. [UNIFESP]Marques, R. M. [UNIFESP]Lascasas Ribalta, J. C. [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-10-05T15:45:57Zoai:repositorio.unifesp.br/:11600/49554Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-10-05T15:45:57Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Immunoexpression of hpv 16/18 e6 and e7 oncoproteins in high-grade cervical squamous intraepithelial lesions in hiv-positive women
title Immunoexpression of hpv 16/18 e6 and e7 oncoproteins in high-grade cervical squamous intraepithelial lesions in hiv-positive women
spellingShingle Immunoexpression of hpv 16/18 e6 and e7 oncoproteins in high-grade cervical squamous intraepithelial lesions in hiv-positive women
Rodrigues, L. C. [UNIFESP]
Human Immunodeficiency Virus
E6 Oncoprotein
E7 Oncoprotein
Human Papillomavirus 16/18
High-Grade Squamous Intraepithelial LesionsHuman-Papillomavirus
Tissue Microarrays
Infection
Dysplasia
Neoplasia
Risk
title_short Immunoexpression of hpv 16/18 e6 and e7 oncoproteins in high-grade cervical squamous intraepithelial lesions in hiv-positive women
title_full Immunoexpression of hpv 16/18 e6 and e7 oncoproteins in high-grade cervical squamous intraepithelial lesions in hiv-positive women
title_fullStr Immunoexpression of hpv 16/18 e6 and e7 oncoproteins in high-grade cervical squamous intraepithelial lesions in hiv-positive women
title_full_unstemmed Immunoexpression of hpv 16/18 e6 and e7 oncoproteins in high-grade cervical squamous intraepithelial lesions in hiv-positive women
title_sort Immunoexpression of hpv 16/18 e6 and e7 oncoproteins in high-grade cervical squamous intraepithelial lesions in hiv-positive women
author Rodrigues, L. C. [UNIFESP]
author_facet Rodrigues, L. C. [UNIFESP]
de Gois Speck, N. M. [UNIFESP]
de Azevedo Focchi, G. R. [UNIFESP]
Schimidt, M. A. [UNIFESP]
Marques, R. M. [UNIFESP]
Lascasas Ribalta, J. C. [UNIFESP]
author_role author
author2 de Gois Speck, N. M. [UNIFESP]
de Azevedo Focchi, G. R. [UNIFESP]
Schimidt, M. A. [UNIFESP]
Marques, R. M. [UNIFESP]
Lascasas Ribalta, J. C. [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, L. C. [UNIFESP]
de Gois Speck, N. M. [UNIFESP]
de Azevedo Focchi, G. R. [UNIFESP]
Schimidt, M. A. [UNIFESP]
Marques, R. M. [UNIFESP]
Lascasas Ribalta, J. C. [UNIFESP]
dc.subject.por.fl_str_mv Human Immunodeficiency Virus
E6 Oncoprotein
E7 Oncoprotein
Human Papillomavirus 16/18
High-Grade Squamous Intraepithelial LesionsHuman-Papillomavirus
Tissue Microarrays
Infection
Dysplasia
Neoplasia
Risk
topic Human Immunodeficiency Virus
E6 Oncoprotein
E7 Oncoprotein
Human Papillomavirus 16/18
High-Grade Squamous Intraepithelial LesionsHuman-Papillomavirus
Tissue Microarrays
Infection
Dysplasia
Neoplasia
Risk
description The aim of this study was to assess the immunoexpression of human papillomavirus genotypes 16 and 18 (E6 and E7) oncoproteins in cervical high-grade squamous intraepithelial lesions (HSIL) of human immunodeficiency virus (HIV)-positive women. These results were also compared to the persistence and/or recurrence of lesions after loop electrosurgical excision procedure. Cervical samples from 158 patients were divided into three groups according to the presence or absence of HSIL in women who were or were not HIV-positive. By using the tissue microarray technique, immunohistochemistry was performed to analyze the expression of HPV 16/18 E6 and E7 oncoproteins. Cervical samples from 95 HIV-positive women and 63 HIV-negative women were studied. A statistically significant difference was found in the immunoexpression of E6 and E7 oncoproteins in samples from HIV-positive women with HSIL and that of women with non-neoplastic tissue (P < 0.001). There was also a statistically significant correlation between the immunoexpression of E6 (P = 0.012) and E7 (P < 0.001) oncoproteins in lesion persistence among HIV-positive women. Within the limitations of this study, the immunoexpression of HPV 16/18 E6 and E7 oncoproteins may have prognostic value regarding lesion persistence in HIV-positive women.
publishDate 2016
dc.date.none.fl_str_mv 2016
2019-01-21T10:30:04Z
2019-01-21T10:30:04Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.4238/gmr.15017220
Genetics And Molecular Research. Ribeirao preto, v. 15, n. 1, p. UNSP gmr.15017220, 2016.
10.4238/gmr.15017220
1676-5680
http://repositorio.unifesp.br/handle/11600/49554
WOS:000373880200024
url http://dx.doi.org/10.4238/gmr.15017220
http://repositorio.unifesp.br/handle/11600/49554
identifier_str_mv Genetics And Molecular Research. Ribeirao preto, v. 15, n. 1, p. UNSP gmr.15017220, 2016.
10.4238/gmr.15017220
1676-5680
WOS:000373880200024
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Genetics And Molecular Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv UNSP gmr.15017220
dc.publisher.none.fl_str_mv Funpec-editora
publisher.none.fl_str_mv Funpec-editora
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268448798146560

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