More stories on Th17 cells
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1038/cr.2009.26 http://repositorio.unifesp.br/handle/11600/31393 |
Resumo: | For more than two decades, immunologists have been using the so-called Th1/Th2 paradigm to explain most of the phenomena related to adaptive immunity. the Th1/Th2 paradigm implied the existence of two different, mutually regulated, CD4(+) T helper subsets: Th1 cells, driving cell-mediated immune responses involved in tissue damage and fighting infection against intracellular parasites; and Th2 cells that mediate IgE production and are particularly involved in eosinophilic inflammation, allergy and clearance of helminthic infections. A third member of the T helper set, IL-17-producing CD4(+) T cells, now called Th17 cells, was recently described as a distinct lineage that does not share developmental pathways with either Th1 or Th2 cells. the Th17 subset has been linked to autoimmune disorders, being able to produce IL-17, IL-17F and IL-21 among other inflammatory cytokines. Interestingly, it has been reported that there is not only a cross-regulation among Th1, Th2 and Th17 effector cells but there is also a dichotomy in the generation of Th17 and T regulatory cells. Therefore, Treg and Th17 effector cells arise in a mutually exclusive fashion, depending on whether they are activated in the presence of TGF-beta or TGF-beta plus inflammatory cytokines such as IL-6. This review will address the discovery of the Th17 cells, and recent progress on their development and regulation. |
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More stories on Th17 cellsadaptive immunitytoleranceIFN-gammaIL-4IL-23TGF-betaFor more than two decades, immunologists have been using the so-called Th1/Th2 paradigm to explain most of the phenomena related to adaptive immunity. the Th1/Th2 paradigm implied the existence of two different, mutually regulated, CD4(+) T helper subsets: Th1 cells, driving cell-mediated immune responses involved in tissue damage and fighting infection against intracellular parasites; and Th2 cells that mediate IgE production and are particularly involved in eosinophilic inflammation, allergy and clearance of helminthic infections. A third member of the T helper set, IL-17-producing CD4(+) T cells, now called Th17 cells, was recently described as a distinct lineage that does not share developmental pathways with either Th1 or Th2 cells. the Th17 subset has been linked to autoimmune disorders, being able to produce IL-17, IL-17F and IL-21 among other inflammatory cytokines. Interestingly, it has been reported that there is not only a cross-regulation among Th1, Th2 and Th17 effector cells but there is also a dichotomy in the generation of Th17 and T regulatory cells. Therefore, Treg and Th17 effector cells arise in a mutually exclusive fashion, depending on whether they are activated in the presence of TGF-beta or TGF-beta plus inflammatory cytokines such as IL-6. This review will address the discovery of the Th17 cells, and recent progress on their development and regulation.La Jolla Inst Allergy & Immunol, La Jolla, CA 92037 USAUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, BrazilWeb of ScienceCrohn's and Colitis Foundation of AmericaNIHNIH: RO1 AI050265-06Nature Publishing GroupLa Jolla Inst Allergy & ImmunolUniversidade Federal de São Paulo (UNIFESP)Basso, Alexandre Salgado [UNIFESP]Cheroutre, HildeMucida, Daniel2016-01-24T13:52:22Z2016-01-24T13:52:22Z2009-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion399-411http://dx.doi.org/10.1038/cr.2009.26Cell Research. New York: Nature Publishing Group, v. 19, n. 4, p. 399-411, 2009.10.1038/cr.2009.261001-0602http://repositorio.unifesp.br/handle/11600/31393WOS:000265700100003engCell Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2023-03-27T16:28:15Zoai:repositorio.unifesp.br/:11600/31393Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652023-03-27T16:28:15Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
More stories on Th17 cells |
title |
More stories on Th17 cells |
spellingShingle |
More stories on Th17 cells Basso, Alexandre Salgado [UNIFESP] adaptive immunity tolerance IFN-gamma IL-4 IL-23 TGF-beta |
title_short |
More stories on Th17 cells |
title_full |
More stories on Th17 cells |
title_fullStr |
More stories on Th17 cells |
title_full_unstemmed |
More stories on Th17 cells |
title_sort |
More stories on Th17 cells |
author |
Basso, Alexandre Salgado [UNIFESP] |
author_facet |
Basso, Alexandre Salgado [UNIFESP] Cheroutre, Hilde Mucida, Daniel |
author_role |
author |
author2 |
Cheroutre, Hilde Mucida, Daniel |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
La Jolla Inst Allergy & Immunol Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Basso, Alexandre Salgado [UNIFESP] Cheroutre, Hilde Mucida, Daniel |
dc.subject.por.fl_str_mv |
adaptive immunity tolerance IFN-gamma IL-4 IL-23 TGF-beta |
topic |
adaptive immunity tolerance IFN-gamma IL-4 IL-23 TGF-beta |
description |
For more than two decades, immunologists have been using the so-called Th1/Th2 paradigm to explain most of the phenomena related to adaptive immunity. the Th1/Th2 paradigm implied the existence of two different, mutually regulated, CD4(+) T helper subsets: Th1 cells, driving cell-mediated immune responses involved in tissue damage and fighting infection against intracellular parasites; and Th2 cells that mediate IgE production and are particularly involved in eosinophilic inflammation, allergy and clearance of helminthic infections. A third member of the T helper set, IL-17-producing CD4(+) T cells, now called Th17 cells, was recently described as a distinct lineage that does not share developmental pathways with either Th1 or Th2 cells. the Th17 subset has been linked to autoimmune disorders, being able to produce IL-17, IL-17F and IL-21 among other inflammatory cytokines. Interestingly, it has been reported that there is not only a cross-regulation among Th1, Th2 and Th17 effector cells but there is also a dichotomy in the generation of Th17 and T regulatory cells. Therefore, Treg and Th17 effector cells arise in a mutually exclusive fashion, depending on whether they are activated in the presence of TGF-beta or TGF-beta plus inflammatory cytokines such as IL-6. This review will address the discovery of the Th17 cells, and recent progress on their development and regulation. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-04-01 2016-01-24T13:52:22Z 2016-01-24T13:52:22Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1038/cr.2009.26 Cell Research. New York: Nature Publishing Group, v. 19, n. 4, p. 399-411, 2009. 10.1038/cr.2009.26 1001-0602 http://repositorio.unifesp.br/handle/11600/31393 WOS:000265700100003 |
url |
http://dx.doi.org/10.1038/cr.2009.26 http://repositorio.unifesp.br/handle/11600/31393 |
identifier_str_mv |
Cell Research. New York: Nature Publishing Group, v. 19, n. 4, p. 399-411, 2009. 10.1038/cr.2009.26 1001-0602 WOS:000265700100003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Cell Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
399-411 |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
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1824718346340270080 |