More stories on Th17 cells

Detalhes bibliográficos
Autor(a) principal: Basso, Alexandre Salgado [UNIFESP]
Data de Publicação: 2009
Outros Autores: Cheroutre, Hilde, Mucida, Daniel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1038/cr.2009.26
http://repositorio.unifesp.br/handle/11600/31393
Resumo: For more than two decades, immunologists have been using the so-called Th1/Th2 paradigm to explain most of the phenomena related to adaptive immunity. the Th1/Th2 paradigm implied the existence of two different, mutually regulated, CD4(+) T helper subsets: Th1 cells, driving cell-mediated immune responses involved in tissue damage and fighting infection against intracellular parasites; and Th2 cells that mediate IgE production and are particularly involved in eosinophilic inflammation, allergy and clearance of helminthic infections. A third member of the T helper set, IL-17-producing CD4(+) T cells, now called Th17 cells, was recently described as a distinct lineage that does not share developmental pathways with either Th1 or Th2 cells. the Th17 subset has been linked to autoimmune disorders, being able to produce IL-17, IL-17F and IL-21 among other inflammatory cytokines. Interestingly, it has been reported that there is not only a cross-regulation among Th1, Th2 and Th17 effector cells but there is also a dichotomy in the generation of Th17 and T regulatory cells. Therefore, Treg and Th17 effector cells arise in a mutually exclusive fashion, depending on whether they are activated in the presence of TGF-beta or TGF-beta plus inflammatory cytokines such as IL-6. This review will address the discovery of the Th17 cells, and recent progress on their development and regulation.
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spelling More stories on Th17 cellsadaptive immunitytoleranceIFN-gammaIL-4IL-23TGF-betaFor more than two decades, immunologists have been using the so-called Th1/Th2 paradigm to explain most of the phenomena related to adaptive immunity. the Th1/Th2 paradigm implied the existence of two different, mutually regulated, CD4(+) T helper subsets: Th1 cells, driving cell-mediated immune responses involved in tissue damage and fighting infection against intracellular parasites; and Th2 cells that mediate IgE production and are particularly involved in eosinophilic inflammation, allergy and clearance of helminthic infections. A third member of the T helper set, IL-17-producing CD4(+) T cells, now called Th17 cells, was recently described as a distinct lineage that does not share developmental pathways with either Th1 or Th2 cells. the Th17 subset has been linked to autoimmune disorders, being able to produce IL-17, IL-17F and IL-21 among other inflammatory cytokines. Interestingly, it has been reported that there is not only a cross-regulation among Th1, Th2 and Th17 effector cells but there is also a dichotomy in the generation of Th17 and T regulatory cells. Therefore, Treg and Th17 effector cells arise in a mutually exclusive fashion, depending on whether they are activated in the presence of TGF-beta or TGF-beta plus inflammatory cytokines such as IL-6. This review will address the discovery of the Th17 cells, and recent progress on their development and regulation.La Jolla Inst Allergy & Immunol, La Jolla, CA 92037 USAUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Microbiol Immunol & Parasitol, São Paulo, BrazilWeb of ScienceCrohn's and Colitis Foundation of AmericaNIHNIH: RO1 AI050265-06Nature Publishing GroupLa Jolla Inst Allergy & ImmunolUniversidade Federal de São Paulo (UNIFESP)Basso, Alexandre Salgado [UNIFESP]Cheroutre, HildeMucida, Daniel2016-01-24T13:52:22Z2016-01-24T13:52:22Z2009-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion399-411http://dx.doi.org/10.1038/cr.2009.26Cell Research. New York: Nature Publishing Group, v. 19, n. 4, p. 399-411, 2009.10.1038/cr.2009.261001-0602http://repositorio.unifesp.br/handle/11600/31393WOS:000265700100003engCell Researchinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2023-03-27T16:28:15Zoai:repositorio.unifesp.br/:11600/31393Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652023-03-27T16:28:15Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv More stories on Th17 cells
title More stories on Th17 cells
spellingShingle More stories on Th17 cells
Basso, Alexandre Salgado [UNIFESP]
adaptive immunity
tolerance
IFN-gamma
IL-4
IL-23
TGF-beta
title_short More stories on Th17 cells
title_full More stories on Th17 cells
title_fullStr More stories on Th17 cells
title_full_unstemmed More stories on Th17 cells
title_sort More stories on Th17 cells
author Basso, Alexandre Salgado [UNIFESP]
author_facet Basso, Alexandre Salgado [UNIFESP]
Cheroutre, Hilde
Mucida, Daniel
author_role author
author2 Cheroutre, Hilde
Mucida, Daniel
author2_role author
author
dc.contributor.none.fl_str_mv La Jolla Inst Allergy & Immunol
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Basso, Alexandre Salgado [UNIFESP]
Cheroutre, Hilde
Mucida, Daniel
dc.subject.por.fl_str_mv adaptive immunity
tolerance
IFN-gamma
IL-4
IL-23
TGF-beta
topic adaptive immunity
tolerance
IFN-gamma
IL-4
IL-23
TGF-beta
description For more than two decades, immunologists have been using the so-called Th1/Th2 paradigm to explain most of the phenomena related to adaptive immunity. the Th1/Th2 paradigm implied the existence of two different, mutually regulated, CD4(+) T helper subsets: Th1 cells, driving cell-mediated immune responses involved in tissue damage and fighting infection against intracellular parasites; and Th2 cells that mediate IgE production and are particularly involved in eosinophilic inflammation, allergy and clearance of helminthic infections. A third member of the T helper set, IL-17-producing CD4(+) T cells, now called Th17 cells, was recently described as a distinct lineage that does not share developmental pathways with either Th1 or Th2 cells. the Th17 subset has been linked to autoimmune disorders, being able to produce IL-17, IL-17F and IL-21 among other inflammatory cytokines. Interestingly, it has been reported that there is not only a cross-regulation among Th1, Th2 and Th17 effector cells but there is also a dichotomy in the generation of Th17 and T regulatory cells. Therefore, Treg and Th17 effector cells arise in a mutually exclusive fashion, depending on whether they are activated in the presence of TGF-beta or TGF-beta plus inflammatory cytokines such as IL-6. This review will address the discovery of the Th17 cells, and recent progress on their development and regulation.
publishDate 2009
dc.date.none.fl_str_mv 2009-04-01
2016-01-24T13:52:22Z
2016-01-24T13:52:22Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1038/cr.2009.26
Cell Research. New York: Nature Publishing Group, v. 19, n. 4, p. 399-411, 2009.
10.1038/cr.2009.26
1001-0602
http://repositorio.unifesp.br/handle/11600/31393
WOS:000265700100003
url http://dx.doi.org/10.1038/cr.2009.26
http://repositorio.unifesp.br/handle/11600/31393
identifier_str_mv Cell Research. New York: Nature Publishing Group, v. 19, n. 4, p. 399-411, 2009.
10.1038/cr.2009.26
1001-0602
WOS:000265700100003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Cell Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 399-411
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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