Quality of oxytocin available in low- and middle-income countries: a systematic review of the literature

Detalhes bibliográficos
Autor(a) principal: Torloni, Maria Regina [UNIFESP]
Data de Publicação: 2016
Outros Autores: Freitas, Carolina Gomes [UNIFESP], Kartoglu, U. H., Gulmezoglu, A. Metin, Widmer, M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/0013000007kkt
DOI: 10.1111/1471-0528.13998
Texto Completo: http://dx.doi.org/10.1111/1471-0528.13998
https://repositorio.unifesp.br/handle/11600/56633
Resumo: BackgroundOxytocin is the drug of choice for preventing and treating postpartum haemorrhage, an important cause of maternal death. Oxytocin is widely available in low and middle-income countries (LMIC) but there are concerns about its quality. ObjectiveTo identify, critically appraise and synthesise the findings of studies on the quality of oxytocin available in LMIC. Search strategyWe searched seven electronic databases, without language restriction. Selection criteriaStudies reporting results of tests to assess quality of oxytocin samples from LMIC. Data collection and analysisStudy selection, data extraction and quality assessment were performed in duplicate. Results are presented descriptively. Main resultsThe search identified 2611 unique citations
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spelling Quality of oxytocin available in low- and middle-income countries: a systematic review of the literatureLow and middle-income countriesoxytocinpostpartum haemorrhagequalitysterilityBackgroundOxytocin is the drug of choice for preventing and treating postpartum haemorrhage, an important cause of maternal death. Oxytocin is widely available in low and middle-income countries (LMIC) but there are concerns about its quality. ObjectiveTo identify, critically appraise and synthesise the findings of studies on the quality of oxytocin available in LMIC. Search strategyWe searched seven electronic databases, without language restriction. Selection criteriaStudies reporting results of tests to assess quality of oxytocin samples from LMIC. Data collection and analysisStudy selection, data extraction and quality assessment were performed in duplicate. Results are presented descriptively. Main resultsThe search identified 2611 unique citationseight studies, assessing 559 samples from 15 different countries were included. Most samples were collected from facility level settings (n = 509) and from the private sector (n = 321). The median prevalence of oxytocin samples that failed quality tests was 45.6% (range 0-80%), mostly due to insufficient amounts of active pharmacological ingredient. Over one-third of the samples (n = 204) had low (<90%) oxytocin content indicating substandard medicinetwo samples had no active ingredient, suggesting possible counterfeit drugs. The proportion of low fails was higher in samples collected in Africa than in Asia or Latin America (57.5% versus 22.3% versus 0%, respectively, P < 0.0001), in private than in public sectors (34.0% versus 25.3%, P = 0.032) and in facilities than in central distributors (37.9% versus 22.0%, P = 0.030). ConclusionThere is a high prevalence of poor-quality oxytocin samples in LMIC countries, mainly due to inadequate amounts of active ingredient. Tweetable abstractSystematic review points to problems with quality of oxytocin samples from low- and middle-income countries. Tweetable abstract Systematic review points to problems with quality of oxytocin samples from low- and middle-income countries. This article includes Author Insights, a video abstract available atUniv Fed Sao Paulo, Dept Internal Med, Evidence Based Healthcare Postgrad Programme, Sao Paulo, BrazilWorld Hlth Org, Dept Essential Med & Hlth Prod, Geneva, SwitzerlandWorld Hlth Org, Dept Reprod Hlth & Res, Geneva, SwitzerlandEvidence Based Healthcare Post‐Graduate Programme, Department of Internal Medicine, Universidade Federal de São Paulo (UNIFESP), São Paulo, BrazilWeb of ScienceMerck Sharp and Dohme Corp.Merck and Co., Inc. (Kenilworth, NJ, USA)Wiley-Blackwell2020-07-31T12:47:10Z2020-07-31T12:47:10Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion2076-2086http://dx.doi.org/10.1111/1471-0528.13998Bjog-An International Journal Of Obstetrics And Gynaecology. Hoboken, v. 123, n. 13, p. 2076-2086, 2016.10.1111/1471-0528.139981470-0328https://repositorio.unifesp.br/handle/11600/56633WOS:000389147400033ark:/48912/0013000007kktengBjog-An International Journal Of Obstetrics And GynaecologyHobokeninfo:eu-repo/semantics/openAccessTorloni, Maria Regina [UNIFESP]Freitas, Carolina Gomes [UNIFESP]Kartoglu, U. H.Gulmezoglu, A. MetinWidmer, M.reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2022-02-10T21:23:38Zoai:repositorio.unifesp.br/:11600/56633Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T20:03:03.606173Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Quality of oxytocin available in low- and middle-income countries: a systematic review of the literature
title Quality of oxytocin available in low- and middle-income countries: a systematic review of the literature
spellingShingle Quality of oxytocin available in low- and middle-income countries: a systematic review of the literature
Quality of oxytocin available in low- and middle-income countries: a systematic review of the literature
Torloni, Maria Regina [UNIFESP]
Low and middle-income countries
oxytocin
postpartum haemorrhage
quality
sterility
Torloni, Maria Regina [UNIFESP]
Low and middle-income countries
oxytocin
postpartum haemorrhage
quality
sterility
title_short Quality of oxytocin available in low- and middle-income countries: a systematic review of the literature
title_full Quality of oxytocin available in low- and middle-income countries: a systematic review of the literature
title_fullStr Quality of oxytocin available in low- and middle-income countries: a systematic review of the literature
Quality of oxytocin available in low- and middle-income countries: a systematic review of the literature
title_full_unstemmed Quality of oxytocin available in low- and middle-income countries: a systematic review of the literature
Quality of oxytocin available in low- and middle-income countries: a systematic review of the literature
title_sort Quality of oxytocin available in low- and middle-income countries: a systematic review of the literature
author Torloni, Maria Regina [UNIFESP]
author_facet Torloni, Maria Regina [UNIFESP]
Torloni, Maria Regina [UNIFESP]
Freitas, Carolina Gomes [UNIFESP]
Kartoglu, U. H.
Gulmezoglu, A. Metin
Widmer, M.
Freitas, Carolina Gomes [UNIFESP]
Kartoglu, U. H.
Gulmezoglu, A. Metin
Widmer, M.
author_role author
author2 Freitas, Carolina Gomes [UNIFESP]
Kartoglu, U. H.
Gulmezoglu, A. Metin
Widmer, M.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Torloni, Maria Regina [UNIFESP]
Freitas, Carolina Gomes [UNIFESP]
Kartoglu, U. H.
Gulmezoglu, A. Metin
Widmer, M.
dc.subject.por.fl_str_mv Low and middle-income countries
oxytocin
postpartum haemorrhage
quality
sterility
topic Low and middle-income countries
oxytocin
postpartum haemorrhage
quality
sterility
description BackgroundOxytocin is the drug of choice for preventing and treating postpartum haemorrhage, an important cause of maternal death. Oxytocin is widely available in low and middle-income countries (LMIC) but there are concerns about its quality. ObjectiveTo identify, critically appraise and synthesise the findings of studies on the quality of oxytocin available in LMIC. Search strategyWe searched seven electronic databases, without language restriction. Selection criteriaStudies reporting results of tests to assess quality of oxytocin samples from LMIC. Data collection and analysisStudy selection, data extraction and quality assessment were performed in duplicate. Results are presented descriptively. Main resultsThe search identified 2611 unique citations
publishDate 2016
dc.date.none.fl_str_mv 2016
2020-07-31T12:47:10Z
2020-07-31T12:47:10Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/1471-0528.13998
Bjog-An International Journal Of Obstetrics And Gynaecology. Hoboken, v. 123, n. 13, p. 2076-2086, 2016.
10.1111/1471-0528.13998
1470-0328
https://repositorio.unifesp.br/handle/11600/56633
WOS:000389147400033
dc.identifier.dark.fl_str_mv ark:/48912/0013000007kkt
url http://dx.doi.org/10.1111/1471-0528.13998
https://repositorio.unifesp.br/handle/11600/56633
identifier_str_mv Bjog-An International Journal Of Obstetrics And Gynaecology. Hoboken, v. 123, n. 13, p. 2076-2086, 2016.
10.1111/1471-0528.13998
1470-0328
WOS:000389147400033
ark:/48912/0013000007kkt
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Bjog-An International Journal Of Obstetrics And Gynaecology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2076-2086
dc.coverage.none.fl_str_mv Hoboken
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1822183946760224768
dc.identifier.doi.none.fl_str_mv 10.1111/1471-0528.13998

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