Safflower oil: an integrated assessment of phytochemistry, antiulcerogenic activity, and rodent and environmental toxicity
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/8644 http://dx.doi.org/10.1016/j.bjp.2014.09.004 |
Resumo: | Gastric ulcers are a significant medical problem and the development of complications lead to significant mortality rates worldwide. In Brazil, Carthamus tinctorius L., Asteraceae, seeds essential oil, the safflower oil, is currently used as a thermogenic compound and as treatment for problems related to the cardiovascular system. In this study, by Raman spectroscopy, it was shown that oleic and linoleic acids are the compounds present in higher concentrations in the safflower oil. We demonstrated that safflower oil (750 mg/kg, p.o.) decrease the ulcerogenic lesions in mice after the administration of hydrochloric acid-ethanol. The gastric ulcers induced by non-steroidal anti-inflammatory drug (NSAID) in mice treated with cholinomimetics were treated with four different doses of safflower oil, of which, the dose of 187.5 mg/kg (p.o.) showed significant antiulcerogenic properties (**p < 0.01). Moreover, the safflower oil at doses of 187.5 mg/kg (i.d.) increased the pH levels, gastric volume (**p < 0.01) and gastric mucus production (***p < 0.001), and decreased the total gastric acid secretion (***p < 0.001). The acute toxicity tests showed that safflower oil (5.000 mg/kg, p.o.) had no effect on mortality or any other physiological parameter. Ecotoxicological tests performed using Daphnia similis showed an EC50 at 223.17 mg/l, and therefore safflower oil can be considered “non-toxic” based on the directive 93/67/EEC on risk assessment for new notified substances by European legislation. These results indicate that the antiulcer activity of Safflower oil may be due to cytoprotective effects, which serve as support for new scientific studies related to this pathology. |
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Toma, WalberGuimarães, Luciana Lopes [UNIFESP]Brito, Alba R.m.s.Santos, Aldo R.Cortez, Fernando S.Pusceddu, Fábio H.Cesar, Augusto [UNIFESP]Silveira Junior, LandulfoPacheco, Marcos T.t.Pereira, Camilo Dias Seabra [UNIFESP]Universidade Santa Cecília Programa de Pós-graduação em Sustentabilidade de Ecossistemas Costeiros e Marinhos Laboratório de Pesquisa em Produtos NaturaisUniversidade Estadual de Campinas (UNICAMP)Universidade Santa Cecília Laboratório de EcotoxicologiaUniversidade Federal de São Paulo (UNIFESP)Universidade Camilo Castelo Branco Instituto de Engenharia Biomédica2015-06-14T13:47:21Z2015-06-14T13:47:21Z2014-10-01Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 24, n. 5, p. 538-544, 2014.0102-695Xhttp://repositorio.unifesp.br/handle/11600/8644http://dx.doi.org/10.1016/j.bjp.2014.09.004S0102-695X2014000500538.pdfS0102-695X201400050053810.1016/j.bjp.2014.09.004WOS:000346075000006Gastric ulcers are a significant medical problem and the development of complications lead to significant mortality rates worldwide. In Brazil, Carthamus tinctorius L., Asteraceae, seeds essential oil, the safflower oil, is currently used as a thermogenic compound and as treatment for problems related to the cardiovascular system. In this study, by Raman spectroscopy, it was shown that oleic and linoleic acids are the compounds present in higher concentrations in the safflower oil. We demonstrated that safflower oil (750 mg/kg, p.o.) decrease the ulcerogenic lesions in mice after the administration of hydrochloric acid-ethanol. The gastric ulcers induced by non-steroidal anti-inflammatory drug (NSAID) in mice treated with cholinomimetics were treated with four different doses of safflower oil, of which, the dose of 187.5 mg/kg (p.o.) showed significant antiulcerogenic properties (**p < 0.01). Moreover, the safflower oil at doses of 187.5 mg/kg (i.d.) increased the pH levels, gastric volume (**p < 0.01) and gastric mucus production (***p < 0.001), and decreased the total gastric acid secretion (***p < 0.001). The acute toxicity tests showed that safflower oil (5.000 mg/kg, p.o.) had no effect on mortality or any other physiological parameter. Ecotoxicological tests performed using Daphnia similis showed an EC50 at 223.17 mg/l, and therefore safflower oil can be considered “non-toxic” based on the directive 93/67/EEC on risk assessment for new notified substances by European legislation. These results indicate that the antiulcer activity of Safflower oil may be due to cytoprotective effects, which serve as support for new scientific studies related to this pathology.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Universidade Santa Cecília Programa de Pós-graduação em Sustentabilidade de Ecossistemas Costeiros e Marinhos Laboratório de Pesquisa em Produtos NaturaisUniversidade Estadual de Campinas Departamento de Fisiologia e Biofísica Laboratório de Produtos NaturaisUniversidade Santa Cecília Laboratório de EcotoxicologiaUniversidade Federal de São Paulo (UNIFESP) Instituto do MarUniversidade Camilo Castelo Branco Instituto de Engenharia BiomédicaUNIFESP, Instituto do MarFAPESP: 2009/01788-5SciELO538-544engSociedade Brasileira de FarmacognosiaRevista Brasileira de FarmacognosiaAntiulcerogenic activityEcotoxicologyRaman spectroscopySafflower oilToxicologySafflower oil: an integrated assessment of phytochemistry, antiulcerogenic activity, and rodent and environmental toxicityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0102-695X2014000500538.pdfapplication/pdf913044${dspace.ui.url}/bitstream/11600/8644/1/S0102-695X2014000500538.pdfdd5ef3c603a75a1709ed2e9fd5c9ccc9MD51open accessTEXTS0102-695X2014000500538.pdf.txtS0102-695X2014000500538.pdf.txtExtracted texttext/plain37783${dspace.ui.url}/bitstream/11600/8644/6/S0102-695X2014000500538.pdf.txt6472fe406dbce6dbe36fcce2a1302c7bMD56open accessTHUMBNAILS0102-695X2014000500538.pdf.jpgS0102-695X2014000500538.pdf.jpgIM Thumbnailimage/jpeg7369${dspace.ui.url}/bitstream/11600/8644/8/S0102-695X2014000500538.pdf.jpge3553e895541e30270e6b95bc7efda2cMD58open access11600/86442023-06-05 19:40:20.495open accessoai:repositorio.unifesp.br:11600/8644Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:40:20Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Safflower oil: an integrated assessment of phytochemistry, antiulcerogenic activity, and rodent and environmental toxicity |
title |
Safflower oil: an integrated assessment of phytochemistry, antiulcerogenic activity, and rodent and environmental toxicity |
spellingShingle |
Safflower oil: an integrated assessment of phytochemistry, antiulcerogenic activity, and rodent and environmental toxicity Toma, Walber Antiulcerogenic activity Ecotoxicology Raman spectroscopy Safflower oil Toxicology |
title_short |
Safflower oil: an integrated assessment of phytochemistry, antiulcerogenic activity, and rodent and environmental toxicity |
title_full |
Safflower oil: an integrated assessment of phytochemistry, antiulcerogenic activity, and rodent and environmental toxicity |
title_fullStr |
Safflower oil: an integrated assessment of phytochemistry, antiulcerogenic activity, and rodent and environmental toxicity |
title_full_unstemmed |
Safflower oil: an integrated assessment of phytochemistry, antiulcerogenic activity, and rodent and environmental toxicity |
title_sort |
Safflower oil: an integrated assessment of phytochemistry, antiulcerogenic activity, and rodent and environmental toxicity |
author |
Toma, Walber |
author_facet |
Toma, Walber Guimarães, Luciana Lopes [UNIFESP] Brito, Alba R.m.s. Santos, Aldo R. Cortez, Fernando S. Pusceddu, Fábio H. Cesar, Augusto [UNIFESP] Silveira Junior, Landulfo Pacheco, Marcos T.t. Pereira, Camilo Dias Seabra [UNIFESP] |
author_role |
author |
author2 |
Guimarães, Luciana Lopes [UNIFESP] Brito, Alba R.m.s. Santos, Aldo R. Cortez, Fernando S. Pusceddu, Fábio H. Cesar, Augusto [UNIFESP] Silveira Junior, Landulfo Pacheco, Marcos T.t. Pereira, Camilo Dias Seabra [UNIFESP] |
author2_role |
author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Santa Cecília Programa de Pós-graduação em Sustentabilidade de Ecossistemas Costeiros e Marinhos Laboratório de Pesquisa em Produtos Naturais Universidade Estadual de Campinas (UNICAMP) Universidade Santa Cecília Laboratório de Ecotoxicologia Universidade Federal de São Paulo (UNIFESP) Universidade Camilo Castelo Branco Instituto de Engenharia Biomédica |
dc.contributor.author.fl_str_mv |
Toma, Walber Guimarães, Luciana Lopes [UNIFESP] Brito, Alba R.m.s. Santos, Aldo R. Cortez, Fernando S. Pusceddu, Fábio H. Cesar, Augusto [UNIFESP] Silveira Junior, Landulfo Pacheco, Marcos T.t. Pereira, Camilo Dias Seabra [UNIFESP] |
dc.subject.eng.fl_str_mv |
Antiulcerogenic activity Ecotoxicology Raman spectroscopy Safflower oil Toxicology |
topic |
Antiulcerogenic activity Ecotoxicology Raman spectroscopy Safflower oil Toxicology |
description |
Gastric ulcers are a significant medical problem and the development of complications lead to significant mortality rates worldwide. In Brazil, Carthamus tinctorius L., Asteraceae, seeds essential oil, the safflower oil, is currently used as a thermogenic compound and as treatment for problems related to the cardiovascular system. In this study, by Raman spectroscopy, it was shown that oleic and linoleic acids are the compounds present in higher concentrations in the safflower oil. We demonstrated that safflower oil (750 mg/kg, p.o.) decrease the ulcerogenic lesions in mice after the administration of hydrochloric acid-ethanol. The gastric ulcers induced by non-steroidal anti-inflammatory drug (NSAID) in mice treated with cholinomimetics were treated with four different doses of safflower oil, of which, the dose of 187.5 mg/kg (p.o.) showed significant antiulcerogenic properties (**p < 0.01). Moreover, the safflower oil at doses of 187.5 mg/kg (i.d.) increased the pH levels, gastric volume (**p < 0.01) and gastric mucus production (***p < 0.001), and decreased the total gastric acid secretion (***p < 0.001). The acute toxicity tests showed that safflower oil (5.000 mg/kg, p.o.) had no effect on mortality or any other physiological parameter. Ecotoxicological tests performed using Daphnia similis showed an EC50 at 223.17 mg/l, and therefore safflower oil can be considered “non-toxic” based on the directive 93/67/EEC on risk assessment for new notified substances by European legislation. These results indicate that the antiulcer activity of Safflower oil may be due to cytoprotective effects, which serve as support for new scientific studies related to this pathology. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-10-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:47:21Z |
dc.date.available.fl_str_mv |
2015-06-14T13:47:21Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 24, n. 5, p. 538-544, 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/8644 http://dx.doi.org/10.1016/j.bjp.2014.09.004 |
dc.identifier.issn.none.fl_str_mv |
0102-695X |
dc.identifier.file.none.fl_str_mv |
S0102-695X2014000500538.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0102-695X2014000500538 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.bjp.2014.09.004 |
dc.identifier.wos.none.fl_str_mv |
WOS:000346075000006 |
identifier_str_mv |
Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 24, n. 5, p. 538-544, 2014. 0102-695X S0102-695X2014000500538.pdf S0102-695X2014000500538 10.1016/j.bjp.2014.09.004 WOS:000346075000006 |
url |
http://repositorio.unifesp.br/handle/11600/8644 http://dx.doi.org/10.1016/j.bjp.2014.09.004 |
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eng |
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eng |
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Revista Brasileira de Farmacognosia |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
538-544 |
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Sociedade Brasileira de Farmacognosia |
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Sociedade Brasileira de Farmacognosia |
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Repositório Institucional da UNIFESP |
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