Reação transfusional hiper-hemolítica em pacientes portadores de anemia falciforme: relato de dois casos

• Autor(a) principal: Terzian, Cláudia Cristina Naufel [UNIFESP]
• Data de Publicação: 2002
• Outros Autores: Braga, Josefina Aparecida Pellegrini [UNIFESP], Cançado, Rodolfo Delfini, Langhi Junior., Dante Mário, Bordin, Jose Orlando [UNIFESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S1516-84842002000400007; http://repositorio.unifesp.br/handle/11600/1569
• topic: sickle cell anemia; blood transfusion; transfusional reactions; Anemia falciforme; transfusão de sangue; reações transfusionais

The chronic character of sickle cell anemia associated with the greater capacity to liberate oxygen by the Hb S, results in patients exhibiting few symptoms in relation to the anemia and they do not require regular hemacias transfusions. Nevertheless, in the face of acute complications, the additional drop in hemoglobin can precipitate an imbalance in the cardio-respiratory function and put the life of the patient at risk, making blood transfusion therapy of utmost importance. In the light of the increased frequency of transfusions to which these patients are submitted, knowledge of the main risks and an adequate diagnosis of the complications caused by transfusional therapy are of fundamental importance. An atypical form of transfusional reaction, denominated hyperhemolytic transfusional reaction was recently described in sickle cell anemia patients after the transfusion of apparently compatible hemacias. In this case, previous conditions can exacerbate the hemolytic condition and put the life of the patient at risk. The pathophysiological conditions of this disease are not yet understood well and the treatment consists of suspending transfusions, corticoid therapy and / or administration of immunoglobulin. The aim of this work is o present two case reports of hyperhemolytic transfusional reaction in sickle cell anemia patients.