O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos
Autor(a) principal: | |
---|---|
Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S0101-60832011000100008 http://repositorio.unifesp.br/handle/11600/6207 |
Resumo: | INTRODUCTION: A functional variable number of tandem repeats (VNTR) polymorphism of the promoter region of the monoamine oxidase A (MAOA) gene has been described and many studies have investigated the association of this polymorphism with human behaviors, as well as with several psychiatric disorders. OBJECTIVE: This study aimed to review the literature on the role of the VNTR functional polymorphism of the promoter region of the MAOA gene on the modulation of human behavior for the development of psychiatric disorders. METHOD: Searches on the Medline, Embase, Web of Science and PsycInfo databases were performed including works from January 1998 to June 2009. The words used were: MAOA and human behavior and MAOA and psychiatry. RESULTS: Several studies were found (N = 3,873). After the selection process, 109 papers were included in the review. There was found an association of MAOA low activity alleles with antisocial personality disorder, conduct disorder, ADHD, pathological gambling, and substance abuse. High activity alleles were associated with neuroticism, anorexia nervosa and depression and anxiety disorders. There was no association between the MAOA polymorphisms and bipolar disorder and schizophrenia. DISCUSSION: The main findings, summarized in this paper, support a role of MAOA VNTR polymorphism in some psychiatric disorders although some divergences were found due to methodological difficulties in genetic studies. In general, the studies associated the low activity alleles with impulsivity and aggressive behavior (hyperactive behaviors), and the high activity alleles of the gene with hypoactive behaviors, such as depression and anxiety, which demonstrates a modulation of the MAOA enzyme in hyperactive and hypoactive disorders. |
id |
UFSP_25f2a5688235cc5f7f1be9d27288297f |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br/:11600/6207 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricosThe role of the VNTR functional polymorphism of the promoter region of the MAOA gene on psychiatric disordersMonoamine oxidaseMAOAfunctional polymorphismVNTRbehaviorpsychiatric disordersInibidores da monoamina oxidaseMAOApolimorfismo funcionalVNTRcomportamentotranstornos psiquiátricosINTRODUCTION: A functional variable number of tandem repeats (VNTR) polymorphism of the promoter region of the monoamine oxidase A (MAOA) gene has been described and many studies have investigated the association of this polymorphism with human behaviors, as well as with several psychiatric disorders. OBJECTIVE: This study aimed to review the literature on the role of the VNTR functional polymorphism of the promoter region of the MAOA gene on the modulation of human behavior for the development of psychiatric disorders. METHOD: Searches on the Medline, Embase, Web of Science and PsycInfo databases were performed including works from January 1998 to June 2009. The words used were: MAOA and human behavior and MAOA and psychiatry. RESULTS: Several studies were found (N = 3,873). After the selection process, 109 papers were included in the review. There was found an association of MAOA low activity alleles with antisocial personality disorder, conduct disorder, ADHD, pathological gambling, and substance abuse. High activity alleles were associated with neuroticism, anorexia nervosa and depression and anxiety disorders. There was no association between the MAOA polymorphisms and bipolar disorder and schizophrenia. DISCUSSION: The main findings, summarized in this paper, support a role of MAOA VNTR polymorphism in some psychiatric disorders although some divergences were found due to methodological difficulties in genetic studies. In general, the studies associated the low activity alleles with impulsivity and aggressive behavior (hyperactive behaviors), and the high activity alleles of the gene with hypoactive behaviors, such as depression and anxiety, which demonstrates a modulation of the MAOA enzyme in hyperactive and hypoactive disorders.INTRODUÇÃO: Muitos estudos têm investigado a associação do polimorfismo VNTR (número variável de repetições em série) localizado na região promotora do gene da enzima monoamina oxidase A (MAOA) com alterações no comportamento humano e em diversos transtornos psiquiátricos. OBJETIVO: O objetivo do presente trabalho foi revisar a literatura sobre a participação desse polimorfismo funcional na modulação do comportamento humano para o desenvolvimento dos transtornos psiquiátricos. MÉTODO: A pesquisa foi realizada na literatura em inglês, de janeiro de 1998 a junho de 2009, disponível no Medline, Embase, Web of Science e na base de dados PsycInfo, utilizando os seguintes termos: MAOA e comportamento humano e MAOA e psiquiatria. RESULTADOS: Foram encontrados 3.873 estudos. Desses, 109 foram selecionados e incluídos na revisão. Encontrou-se associação de alelos de baixa atividade do VNTR com transtorno de personalidade antissocial, transtorno de conduta, transtorno de déficit de atenção e hiperatividade, jogo patológico e dependência de substâncias. Alelos da alta atividade da MAOA foram associados a depressão, ansiedade, neuroticismo e anorexia nervosa. Não se encontrou associação entre polimorfismos da MAOA e esquizofrenia e transtorno bipolar. CONCLUSÃO: Os principais achados dão suporte ao papel do polimorfismo VNTR da região promotora do gene da MAOA em alguns transtornos psiquiátricos, apesar das divergências encontradas devidas às dificuldades metodológicas de estudos em genética. De modo geral, os estudos associam os alelos de baixa atividade da MAOA com comportamentos impulsivos e agressivos (comportamentos hiperativos), enquanto os alelos de alta atividade do gene são mais associados a comportamentos hipoativos.Universidade de São Paulo Faculdade de Medicina Departamento e Instituto de PsiquiatriaUniversidade Federal de São Paulo (UNIFESP) Faculdade de Medicina Departamento de PsiquiatriaUNIFESP, Faculdade de Medicina Depto. de PsiquiatriaSciELOFaculdade de Medicina da Universidade de São PauloUniversidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Nishioka, Sílvia A.Perin, Eduardo Aliende [UNIFESP]Sampaio, Aline SantosCordeiro, QuirinoCappi, CarolinaMastrorosa, Rosana Savio [UNIFESP]Morais, Ivanil A.Reis, Viviane Neri De SouzaRosario-Campos, Maria Conceicao do [UNIFESP]Hounie, Ana Gabriela2015-06-14T13:42:49Z2015-06-14T13:42:49Z2011-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion34-42application/pdfhttp://dx.doi.org/10.1590/S0101-60832011000100008Archives of Clinical Psychiatry. Faculdade de Medicina da Universidade de São Paulo, v. 38, n. 1, p. 34-42, 2011.10.1590/S0101-60832011000100008S0101-60832011000100008.pdf0101-6083S0101-60832011000100008http://repositorio.unifesp.br/handle/11600/6207porArchives of Clinical Psychiatryinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T04:23:46Zoai:repositorio.unifesp.br/:11600/6207Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-30T04:23:46Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos The role of the VNTR functional polymorphism of the promoter region of the MAOA gene on psychiatric disorders |
title |
O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos |
spellingShingle |
O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos Nishioka, Sílvia A. Monoamine oxidase MAOA functional polymorphism VNTR behavior psychiatric disorders Inibidores da monoamina oxidase MAOA polimorfismo funcional VNTR comportamento transtornos psiquiátricos |
title_short |
O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos |
title_full |
O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos |
title_fullStr |
O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos |
title_full_unstemmed |
O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos |
title_sort |
O papel do polimorfismo funcional VNTR da região promotora do gene MAOA nos transtornos psiquiátricos |
author |
Nishioka, Sílvia A. |
author_facet |
Nishioka, Sílvia A. Perin, Eduardo Aliende [UNIFESP] Sampaio, Aline Santos Cordeiro, Quirino Cappi, Carolina Mastrorosa, Rosana Savio [UNIFESP] Morais, Ivanil A. Reis, Viviane Neri De Souza Rosario-Campos, Maria Conceicao do [UNIFESP] Hounie, Ana Gabriela |
author_role |
author |
author2 |
Perin, Eduardo Aliende [UNIFESP] Sampaio, Aline Santos Cordeiro, Quirino Cappi, Carolina Mastrorosa, Rosana Savio [UNIFESP] Morais, Ivanil A. Reis, Viviane Neri De Souza Rosario-Campos, Maria Conceicao do [UNIFESP] Hounie, Ana Gabriela |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Nishioka, Sílvia A. Perin, Eduardo Aliende [UNIFESP] Sampaio, Aline Santos Cordeiro, Quirino Cappi, Carolina Mastrorosa, Rosana Savio [UNIFESP] Morais, Ivanil A. Reis, Viviane Neri De Souza Rosario-Campos, Maria Conceicao do [UNIFESP] Hounie, Ana Gabriela |
dc.subject.por.fl_str_mv |
Monoamine oxidase MAOA functional polymorphism VNTR behavior psychiatric disorders Inibidores da monoamina oxidase MAOA polimorfismo funcional VNTR comportamento transtornos psiquiátricos |
topic |
Monoamine oxidase MAOA functional polymorphism VNTR behavior psychiatric disorders Inibidores da monoamina oxidase MAOA polimorfismo funcional VNTR comportamento transtornos psiquiátricos |
description |
INTRODUCTION: A functional variable number of tandem repeats (VNTR) polymorphism of the promoter region of the monoamine oxidase A (MAOA) gene has been described and many studies have investigated the association of this polymorphism with human behaviors, as well as with several psychiatric disorders. OBJECTIVE: This study aimed to review the literature on the role of the VNTR functional polymorphism of the promoter region of the MAOA gene on the modulation of human behavior for the development of psychiatric disorders. METHOD: Searches on the Medline, Embase, Web of Science and PsycInfo databases were performed including works from January 1998 to June 2009. The words used were: MAOA and human behavior and MAOA and psychiatry. RESULTS: Several studies were found (N = 3,873). After the selection process, 109 papers were included in the review. There was found an association of MAOA low activity alleles with antisocial personality disorder, conduct disorder, ADHD, pathological gambling, and substance abuse. High activity alleles were associated with neuroticism, anorexia nervosa and depression and anxiety disorders. There was no association between the MAOA polymorphisms and bipolar disorder and schizophrenia. DISCUSSION: The main findings, summarized in this paper, support a role of MAOA VNTR polymorphism in some psychiatric disorders although some divergences were found due to methodological difficulties in genetic studies. In general, the studies associated the low activity alleles with impulsivity and aggressive behavior (hyperactive behaviors), and the high activity alleles of the gene with hypoactive behaviors, such as depression and anxiety, which demonstrates a modulation of the MAOA enzyme in hyperactive and hypoactive disorders. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-01-01 2015-06-14T13:42:49Z 2015-06-14T13:42:49Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S0101-60832011000100008 Archives of Clinical Psychiatry. Faculdade de Medicina da Universidade de São Paulo, v. 38, n. 1, p. 34-42, 2011. 10.1590/S0101-60832011000100008 S0101-60832011000100008.pdf 0101-6083 S0101-60832011000100008 http://repositorio.unifesp.br/handle/11600/6207 |
url |
http://dx.doi.org/10.1590/S0101-60832011000100008 http://repositorio.unifesp.br/handle/11600/6207 |
identifier_str_mv |
Archives of Clinical Psychiatry. Faculdade de Medicina da Universidade de São Paulo, v. 38, n. 1, p. 34-42, 2011. 10.1590/S0101-60832011000100008 S0101-60832011000100008.pdf 0101-6083 S0101-60832011000100008 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Archives of Clinical Psychiatry |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
34-42 application/pdf |
dc.publisher.none.fl_str_mv |
Faculdade de Medicina da Universidade de São Paulo |
publisher.none.fl_str_mv |
Faculdade de Medicina da Universidade de São Paulo |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268420801167360 |