Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://www.annalsofhepatology.com/vista?accion=viewArticle&idart=871 http://repositorio.unifesp.br/handle/11600/42569 |
Resumo: | Background. Hepatitis C is a leading cause of mortality among HIV-infected individuals. Therefore, eradication of HCV in this population is a priority. There are scarce data regarding retreatment efficacy of HIV/HCV coinfected patients. The aim of our study was to evaluate efficacy, predictors of response, and long term clinical benefits of sustained virological response (SVR) after hepatitis C retreatment in a population of HIV/HCV coinfected patients. Material and methods. We evaluated efficacy, safety, and clinical benefits of peginterferon(alfa-2a or alfa-2b) and ribavirin in a restrospective, observational, multicentric study, including 47 HIV/HCV coinfected patients, non-responders to previous treatment with conventional interferon alfa-2a and ribavirin. The primary endpoint of efficacy was SVR, defined as undetectable viral toad 24 weeks after end of treatment. Death, liver disease progression, CD4 counts, and AIDS defining illness were the endpoints to access clinical benefits of treatment response. Results. In our analysis, 31.9% patients reached SVR. Genotypes 2/3 had a significant better SVR (66.7%) compared to genotypes 1/4 (33.3%) (p = 0.022). During follow-up, deaths (6.89%) and hepatic decompensation (28.6%) occurred only in the nonresponder group, while there were no cases of death or hepatic deconnpensation among the responder group(p = 0.037). Conclusion. Nearly one third of patients (mainly those with genotypes 2/3) reached SVR after hepatitis C retreatment in this group of HIV/HCV coinfected patients. SVR was protective against hepatic decompensation and death in a two-year follow-up period. Retreatment may be an effective and safe way to eradicate HCV until new anti-HCV drugs become available to this group of patients. |
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Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfectionNon-respondersHIV-HCV coinfectedAIDSEfficacyTreatmentBackground. Hepatitis C is a leading cause of mortality among HIV-infected individuals. Therefore, eradication of HCV in this population is a priority. There are scarce data regarding retreatment efficacy of HIV/HCV coinfected patients. The aim of our study was to evaluate efficacy, predictors of response, and long term clinical benefits of sustained virological response (SVR) after hepatitis C retreatment in a population of HIV/HCV coinfected patients. Material and methods. We evaluated efficacy, safety, and clinical benefits of peginterferon(alfa-2a or alfa-2b) and ribavirin in a restrospective, observational, multicentric study, including 47 HIV/HCV coinfected patients, non-responders to previous treatment with conventional interferon alfa-2a and ribavirin. The primary endpoint of efficacy was SVR, defined as undetectable viral toad 24 weeks after end of treatment. Death, liver disease progression, CD4 counts, and AIDS defining illness were the endpoints to access clinical benefits of treatment response. Results. In our analysis, 31.9% patients reached SVR. Genotypes 2/3 had a significant better SVR (66.7%) compared to genotypes 1/4 (33.3%) (p = 0.022). During follow-up, deaths (6.89%) and hepatic decompensation (28.6%) occurred only in the nonresponder group, while there were no cases of death or hepatic deconnpensation among the responder group(p = 0.037). Conclusion. Nearly one third of patients (mainly those with genotypes 2/3) reached SVR after hepatitis C retreatment in this group of HIV/HCV coinfected patients. SVR was protective against hepatic decompensation and death in a two-year follow-up period. Retreatment may be an effective and safe way to eradicate HCV until new anti-HCV drugs become available to this group of patients.Inst Infectol Emilio Ribas, BR-05436010 Sao Paulo, BrazilSecretaria Estado Saude Sao Paulo, Ctr Referencia & Treinamento DST Aids CRT A, Sao Paulo, BrazilUniv Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Dept Med Interna, Div Doencas Infecciosas, Sao Paulo, BrazilUniv Fed Sao Paulo, Div Doencas Infecciosas & Parasitarias, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Hosp Clin, BR-09500900 Sao Paulo, BrazilFac Med ABC, Unidade Referencia Doencas Infecciosas, Sao Paulo, BrazilUniv Fed Sao Paulo, Div Doencas Infecciosas & Parasitarias, Sao Paulo, BrazilWeb of ScienceMexican Assoc HepatologyInst Infectol Emilio RibasSecretaria Estado Saude Sao PauloUniversidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Fac Med ABCPeribanez-Gonzalez, MarioSilva, Mariliza Henrique daVilar, Fernando CrivelentiNastri, Ana Catharina Seixas SantosFerreira, Paulo Roberto Abrão [UNIFESP]Focaccia, RobertoCorrea, Maria Cassia Mendes2018-06-15T13:50:12Z2018-06-15T13:50:12Z2013-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion228-235http://www.annalsofhepatology.com/vista?accion=viewArticle&idart=871Annals Of Hepatology. Mexico: Mexican Assoc Hepatology, v. 12, n. 2, p. 228-235, 2013.1665-2681http://repositorio.unifesp.br/handle/11600/42569WOS:000319231300008engAnnals Of Hepatologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T15:51:36Zoai:repositorio.unifesp.br/:11600/42569Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T15:51:36Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection |
title |
Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection |
spellingShingle |
Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection Peribanez-Gonzalez, Mario Non-responders HIV-HCV coinfected AIDS Efficacy Treatment |
title_short |
Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection |
title_full |
Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection |
title_fullStr |
Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection |
title_full_unstemmed |
Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection |
title_sort |
Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection |
author |
Peribanez-Gonzalez, Mario |
author_facet |
Peribanez-Gonzalez, Mario Silva, Mariliza Henrique da Vilar, Fernando Crivelenti Nastri, Ana Catharina Seixas Santos Ferreira, Paulo Roberto Abrão [UNIFESP] Focaccia, Roberto Correa, Maria Cassia Mendes |
author_role |
author |
author2 |
Silva, Mariliza Henrique da Vilar, Fernando Crivelenti Nastri, Ana Catharina Seixas Santos Ferreira, Paulo Roberto Abrão [UNIFESP] Focaccia, Roberto Correa, Maria Cassia Mendes |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Inst Infectol Emilio Ribas Secretaria Estado Saude Sao Paulo Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) Fac Med ABC |
dc.contributor.author.fl_str_mv |
Peribanez-Gonzalez, Mario Silva, Mariliza Henrique da Vilar, Fernando Crivelenti Nastri, Ana Catharina Seixas Santos Ferreira, Paulo Roberto Abrão [UNIFESP] Focaccia, Roberto Correa, Maria Cassia Mendes |
dc.subject.por.fl_str_mv |
Non-responders HIV-HCV coinfected AIDS Efficacy Treatment |
topic |
Non-responders HIV-HCV coinfected AIDS Efficacy Treatment |
description |
Background. Hepatitis C is a leading cause of mortality among HIV-infected individuals. Therefore, eradication of HCV in this population is a priority. There are scarce data regarding retreatment efficacy of HIV/HCV coinfected patients. The aim of our study was to evaluate efficacy, predictors of response, and long term clinical benefits of sustained virological response (SVR) after hepatitis C retreatment in a population of HIV/HCV coinfected patients. Material and methods. We evaluated efficacy, safety, and clinical benefits of peginterferon(alfa-2a or alfa-2b) and ribavirin in a restrospective, observational, multicentric study, including 47 HIV/HCV coinfected patients, non-responders to previous treatment with conventional interferon alfa-2a and ribavirin. The primary endpoint of efficacy was SVR, defined as undetectable viral toad 24 weeks after end of treatment. Death, liver disease progression, CD4 counts, and AIDS defining illness were the endpoints to access clinical benefits of treatment response. Results. In our analysis, 31.9% patients reached SVR. Genotypes 2/3 had a significant better SVR (66.7%) compared to genotypes 1/4 (33.3%) (p = 0.022). During follow-up, deaths (6.89%) and hepatic decompensation (28.6%) occurred only in the nonresponder group, while there were no cases of death or hepatic deconnpensation among the responder group(p = 0.037). Conclusion. Nearly one third of patients (mainly those with genotypes 2/3) reached SVR after hepatitis C retreatment in this group of HIV/HCV coinfected patients. SVR was protective against hepatic decompensation and death in a two-year follow-up period. Retreatment may be an effective and safe way to eradicate HCV until new anti-HCV drugs become available to this group of patients. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-03-01 2018-06-15T13:50:12Z 2018-06-15T13:50:12Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.annalsofhepatology.com/vista?accion=viewArticle&idart=871 Annals Of Hepatology. Mexico: Mexican Assoc Hepatology, v. 12, n. 2, p. 228-235, 2013. 1665-2681 http://repositorio.unifesp.br/handle/11600/42569 WOS:000319231300008 |
url |
http://www.annalsofhepatology.com/vista?accion=viewArticle&idart=871 http://repositorio.unifesp.br/handle/11600/42569 |
identifier_str_mv |
Annals Of Hepatology. Mexico: Mexican Assoc Hepatology, v. 12, n. 2, p. 228-235, 2013. 1665-2681 WOS:000319231300008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Annals Of Hepatology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
228-235 |
dc.publisher.none.fl_str_mv |
Mexican Assoc Hepatology |
publisher.none.fl_str_mv |
Mexican Assoc Hepatology |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268424335917056 |