Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection

Detalhes bibliográficos
Autor(a) principal: Peribanez-Gonzalez, Mario
Data de Publicação: 2013
Outros Autores: Silva, Mariliza Henrique da, Vilar, Fernando Crivelenti, Nastri, Ana Catharina Seixas Santos, Ferreira, Paulo Roberto Abrão [UNIFESP], Focaccia, Roberto, Correa, Maria Cassia Mendes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://www.annalsofhepatology.com/vista?accion=viewArticle&idart=871
http://repositorio.unifesp.br/handle/11600/42569
Resumo: Background. Hepatitis C is a leading cause of mortality among HIV-infected individuals. Therefore, eradication of HCV in this population is a priority. There are scarce data regarding retreatment efficacy of HIV/HCV coinfected patients. The aim of our study was to evaluate efficacy, predictors of response, and long term clinical benefits of sustained virological response (SVR) after hepatitis C retreatment in a population of HIV/HCV coinfected patients. Material and methods. We evaluated efficacy, safety, and clinical benefits of peginterferon(alfa-2a or alfa-2b) and ribavirin in a restrospective, observational, multicentric study, including 47 HIV/HCV coinfected patients, non-responders to previous treatment with conventional interferon alfa-2a and ribavirin. The primary endpoint of efficacy was SVR, defined as undetectable viral toad 24 weeks after end of treatment. Death, liver disease progression, CD4 counts, and AIDS defining illness were the endpoints to access clinical benefits of treatment response. Results. In our analysis, 31.9% patients reached SVR. Genotypes 2/3 had a significant better SVR (66.7%) compared to genotypes 1/4 (33.3%) (p = 0.022). During follow-up, deaths (6.89%) and hepatic decompensation (28.6%) occurred only in the nonresponder group, while there were no cases of death or hepatic deconnpensation among the responder group(p = 0.037). Conclusion. Nearly one third of patients (mainly those with genotypes 2/3) reached SVR after hepatitis C retreatment in this group of HIV/HCV coinfected patients. SVR was protective against hepatic decompensation and death in a two-year follow-up period. Retreatment may be an effective and safe way to eradicate HCV until new anti-HCV drugs become available to this group of patients.
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spelling Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfectionNon-respondersHIV-HCV coinfectedAIDSEfficacyTreatmentBackground. Hepatitis C is a leading cause of mortality among HIV-infected individuals. Therefore, eradication of HCV in this population is a priority. There are scarce data regarding retreatment efficacy of HIV/HCV coinfected patients. The aim of our study was to evaluate efficacy, predictors of response, and long term clinical benefits of sustained virological response (SVR) after hepatitis C retreatment in a population of HIV/HCV coinfected patients. Material and methods. We evaluated efficacy, safety, and clinical benefits of peginterferon(alfa-2a or alfa-2b) and ribavirin in a restrospective, observational, multicentric study, including 47 HIV/HCV coinfected patients, non-responders to previous treatment with conventional interferon alfa-2a and ribavirin. The primary endpoint of efficacy was SVR, defined as undetectable viral toad 24 weeks after end of treatment. Death, liver disease progression, CD4 counts, and AIDS defining illness were the endpoints to access clinical benefits of treatment response. Results. In our analysis, 31.9% patients reached SVR. Genotypes 2/3 had a significant better SVR (66.7%) compared to genotypes 1/4 (33.3%) (p = 0.022). During follow-up, deaths (6.89%) and hepatic decompensation (28.6%) occurred only in the nonresponder group, while there were no cases of death or hepatic deconnpensation among the responder group(p = 0.037). Conclusion. Nearly one third of patients (mainly those with genotypes 2/3) reached SVR after hepatitis C retreatment in this group of HIV/HCV coinfected patients. SVR was protective against hepatic decompensation and death in a two-year follow-up period. Retreatment may be an effective and safe way to eradicate HCV until new anti-HCV drugs become available to this group of patients.Inst Infectol Emilio Ribas, BR-05436010 Sao Paulo, BrazilSecretaria Estado Saude Sao Paulo, Ctr Referencia & Treinamento DST Aids CRT A, Sao Paulo, BrazilUniv Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Dept Med Interna, Div Doencas Infecciosas, Sao Paulo, BrazilUniv Fed Sao Paulo, Div Doencas Infecciosas & Parasitarias, Sao Paulo, BrazilUniv Sao Paulo, Fac Med, Hosp Clin, BR-09500900 Sao Paulo, BrazilFac Med ABC, Unidade Referencia Doencas Infecciosas, Sao Paulo, BrazilUniv Fed Sao Paulo, Div Doencas Infecciosas & Parasitarias, Sao Paulo, BrazilWeb of ScienceMexican Assoc HepatologyInst Infectol Emilio RibasSecretaria Estado Saude Sao PauloUniversidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)Fac Med ABCPeribanez-Gonzalez, MarioSilva, Mariliza Henrique daVilar, Fernando CrivelentiNastri, Ana Catharina Seixas SantosFerreira, Paulo Roberto Abrão [UNIFESP]Focaccia, RobertoCorrea, Maria Cassia Mendes2018-06-15T13:50:12Z2018-06-15T13:50:12Z2013-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion228-235http://www.annalsofhepatology.com/vista?accion=viewArticle&idart=871Annals Of Hepatology. Mexico: Mexican Assoc Hepatology, v. 12, n. 2, p. 228-235, 2013.1665-2681http://repositorio.unifesp.br/handle/11600/42569WOS:000319231300008engAnnals Of Hepatologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T15:51:36Zoai:repositorio.unifesp.br/:11600/42569Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T15:51:36Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection
title Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection
spellingShingle Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection
Peribanez-Gonzalez, Mario
Non-responders
HIV-HCV coinfected
AIDS
Efficacy
Treatment
title_short Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection
title_full Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection
title_fullStr Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection
title_full_unstemmed Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection
title_sort Response predictors and clinical benefits of hepatitis C retreatment with pegylated interferon and ribavirin in HIV/HCV coinfection
author Peribanez-Gonzalez, Mario
author_facet Peribanez-Gonzalez, Mario
Silva, Mariliza Henrique da
Vilar, Fernando Crivelenti
Nastri, Ana Catharina Seixas Santos
Ferreira, Paulo Roberto Abrão [UNIFESP]
Focaccia, Roberto
Correa, Maria Cassia Mendes
author_role author
author2 Silva, Mariliza Henrique da
Vilar, Fernando Crivelenti
Nastri, Ana Catharina Seixas Santos
Ferreira, Paulo Roberto Abrão [UNIFESP]
Focaccia, Roberto
Correa, Maria Cassia Mendes
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Inst Infectol Emilio Ribas
Secretaria Estado Saude Sao Paulo
Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Fac Med ABC
dc.contributor.author.fl_str_mv Peribanez-Gonzalez, Mario
Silva, Mariliza Henrique da
Vilar, Fernando Crivelenti
Nastri, Ana Catharina Seixas Santos
Ferreira, Paulo Roberto Abrão [UNIFESP]
Focaccia, Roberto
Correa, Maria Cassia Mendes
dc.subject.por.fl_str_mv Non-responders
HIV-HCV coinfected
AIDS
Efficacy
Treatment
topic Non-responders
HIV-HCV coinfected
AIDS
Efficacy
Treatment
description Background. Hepatitis C is a leading cause of mortality among HIV-infected individuals. Therefore, eradication of HCV in this population is a priority. There are scarce data regarding retreatment efficacy of HIV/HCV coinfected patients. The aim of our study was to evaluate efficacy, predictors of response, and long term clinical benefits of sustained virological response (SVR) after hepatitis C retreatment in a population of HIV/HCV coinfected patients. Material and methods. We evaluated efficacy, safety, and clinical benefits of peginterferon(alfa-2a or alfa-2b) and ribavirin in a restrospective, observational, multicentric study, including 47 HIV/HCV coinfected patients, non-responders to previous treatment with conventional interferon alfa-2a and ribavirin. The primary endpoint of efficacy was SVR, defined as undetectable viral toad 24 weeks after end of treatment. Death, liver disease progression, CD4 counts, and AIDS defining illness were the endpoints to access clinical benefits of treatment response. Results. In our analysis, 31.9% patients reached SVR. Genotypes 2/3 had a significant better SVR (66.7%) compared to genotypes 1/4 (33.3%) (p = 0.022). During follow-up, deaths (6.89%) and hepatic decompensation (28.6%) occurred only in the nonresponder group, while there were no cases of death or hepatic deconnpensation among the responder group(p = 0.037). Conclusion. Nearly one third of patients (mainly those with genotypes 2/3) reached SVR after hepatitis C retreatment in this group of HIV/HCV coinfected patients. SVR was protective against hepatic decompensation and death in a two-year follow-up period. Retreatment may be an effective and safe way to eradicate HCV until new anti-HCV drugs become available to this group of patients.
publishDate 2013
dc.date.none.fl_str_mv 2013-03-01
2018-06-15T13:50:12Z
2018-06-15T13:50:12Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.annalsofhepatology.com/vista?accion=viewArticle&idart=871
Annals Of Hepatology. Mexico: Mexican Assoc Hepatology, v. 12, n. 2, p. 228-235, 2013.
1665-2681
http://repositorio.unifesp.br/handle/11600/42569
WOS:000319231300008
url http://www.annalsofhepatology.com/vista?accion=viewArticle&idart=871
http://repositorio.unifesp.br/handle/11600/42569
identifier_str_mv Annals Of Hepatology. Mexico: Mexican Assoc Hepatology, v. 12, n. 2, p. 228-235, 2013.
1665-2681
WOS:000319231300008
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Annals Of Hepatology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 228-235
dc.publisher.none.fl_str_mv Mexican Assoc Hepatology
publisher.none.fl_str_mv Mexican Assoc Hepatology
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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