Artrite enteropática no Brasil: dados do registro brasileiro de espondiloartrites

• Autor(a) principal: Resende, Gustavo Gomes
• Data de Publicação: 2013
• Outros Autores: Lanna, Cristina Costa Duarte, Bortoluzzo, Adriana Bruscato, Gonçalves, Célio Roberto, Silva, José Antonio Braga da, Ximenes, Antônio Carlos, Bertolo, Manoel Barros, Ribeiro, Sandra Lúcia Euzébio [UNIFESP], Keiserman, Mauro Waldemar, Menin, Rita, Skare, Thelma Larocca, Carneiro, Sueli Coelho da Silva, Azevedo, Valderílio Feijó, Vieira, Walber Pinto, Albuquerque, Elisa Martins das Neves de, Bianchi, Washington Alves, Bonfiglioli, Rubens, Campanholo, Cristiano, Carvalho, Hellen Mary da Silveira de, Costa, Izaias Pereira da, Duarte, Angela Luzia Branco Pinto [UNIFESP], Kohem, Charles Lubianca, Leite, Nocy Honorato, Lima, Sonia Anti Loduca, Meirelles, Eduardo de Souza, Pereira, Ivânio Alves, Pinheiro, Marcelo de Medeiros [UNIFESP], Polito, Elizandra, Rocha, Francisco Airton Castro da, Santiago, Mittermayer Barreto, Sauma, Maria de Fátima Lobato da Cunha, Valim, Valeria [UNIFESP], Sampaio-Barros, Percival Degrava
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1016/j.rbr.2013.04.001; http://repositorio.unifesp.br/handle/11600/8097
• topic: Enteropathic arthritis; Crohn's Disease; Ulcerative rectocolitis; Registry studies; Artrite enteropática; Doença de Crohn; Retocolite ulcerativa; Estudos de registro

Inflammatory bowel diseases (Crohn's disease and ulcerative rectocolitis) have extraintestinal manifestations 25% of the patients, with the most common one being the enteropathic arthritis. METHODS: Prospective, observational, multicenter study with patients from 29 reference centers participating in the Brazilian Registry of Spondyloarthritis (RBE), which incorporates the RESPONDIA (Ibero-American Registry of Spondyloarthritis) group. Demographic and clinical data were collected from 1472 patients and standardized questionnaires for the assessment of axial mobility, quality of life, enthesitic involvement, disease activity and functional capacity were applied. Laboratory and radiographic examinations were performed. The aim of this study is to compare the clinical, epidemiological, genetic, imaging, treatment and prognosis characteristics of patients with enteropathic arthritis with other types of spondyloarthritis in a large Brazilian cohort. RESULTS: A total of 3.2% of patients were classified as having enteroarthritis, 2.5% had spondylitis and 0.7%, arthritis (peripheral predominance). The subgroup of individuals with enteroarthritis had a higher prevalence in women (P < 0.001), lower incidence of inflammatory axial pain (P < 0.001) and enthesitis (P = 0.004). HLA-B27 was less frequent in the group with enteroarthritis (P = 0.001), even when considering only those with the pure axial form. There was a lower prevalence of radiographic sacroiliitis (P = 0.009) and lower radiographic score (BASRI) (P = 0.006) when compared to patients with other types of spondyloarthritis. They also used more corticosteroids (P < 0.001) and sulfasalazine (P < 0.001) and less non-steroidal anti-inflammatory drugs (P < 0.001) and methotrexate (P = 0.001). CONCLUSION: There were differences between patients with enteroarthritis and other types of spondyloarthritis, especially higher prevalence of females, lower frequency of HLA-B27, associated with less severe axial involvement.