Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Marcio L.
Data de Publicação: 2007
Outros Autores: Shi, Li, Barreto-Bergter, Eliana, Nimrichter, Leonardo, Farias, Sandra E., Rodrigues, Elaine G., Travassos, Luiz R. [UNIFESP], Nosanchuk, Joshua D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1128/CVI.00202-07
http://repositorio.unifesp.br/handle/11600/30055
Resumo: Glucosylceramides (GIcCer) are involved in the regulation of Cryptococcus neoformans virulence. in the present study, we demonstrate that passive immunization with a monoclonal antibody to GlcCer significantly reduces host inflammation and prolongs the survival of mice lethally infected with C. neoformans, revealing a potential therapeutic strategy to control cryptococcosis.
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spelling Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infectionGlucosylceramides (GIcCer) are involved in the regulation of Cryptococcus neoformans virulence. in the present study, we demonstrate that passive immunization with a monoclonal antibody to GlcCer significantly reduces host inflammation and prolongs the survival of mice lethally infected with C. neoformans, revealing a potential therapeutic strategy to control cryptococcosis.Univ Fed Rio de Janeiro, Inst Microbiol Professor Paulo Goes, BR-21941590 Rio de Janeiro, BrazilYeshiva Univ Albert Einstein Coll Med, Div Infect Dis, Dept Med, Bronx, NY 10461 USAYeshiva Univ Albert Einstein Coll Med, Dept Immunol Microbiol, Bronx, NY 10461 USAUniv Fed Rio Grande do Sul, Inst Ciencias Basicas Saude, Dept Fisiol, Porto Alegre, RS, BrazilUniversidade Federal de São Paulo, Disciplina Biol Celular, BR-04023062 São Paulo, BrazilUniversidade Federal de São Paulo, Disciplina Biol Celular, BR-04023062 São Paulo, BrazilWeb of ScienceAmer Soc MicrobiologyUniversidade Federal do Rio de Janeiro (UFRJ)Yeshiva Univ Albert Einstein Coll MedUniv Fed Rio Grande do SulUniversidade Federal de São Paulo (UNIFESP)Rodrigues, Marcio L.Shi, LiBarreto-Bergter, ElianaNimrichter, LeonardoFarias, Sandra E.Rodrigues, Elaine G.Travassos, Luiz R. [UNIFESP]Nosanchuk, Joshua D.2016-01-24T13:49:06Z2016-01-24T13:49:06Z2007-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1372-1376application/pdfhttp://dx.doi.org/10.1128/CVI.00202-07Clinical and Vaccine Immunology. Washington: Amer Soc Microbiology, v. 14, n. 10, p. 1372-1376, 2007.10.1128/CVI.00202-07WOS000250164800019.pdf1556-6811http://repositorio.unifesp.br/handle/11600/30055WOS:000250164800019engClinical and Vaccine Immunologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-31T06:55:46Zoai:repositorio.unifesp.br/:11600/30055Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-31T06:55:46Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection
title Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection
spellingShingle Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection
Rodrigues, Marcio L.
title_short Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection
title_full Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection
title_fullStr Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection
title_full_unstemmed Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection
title_sort Monoclonal antibody to fungal glucosylceramide protects mice against lethal Cryptococcus neoformans infection
author Rodrigues, Marcio L.
author_facet Rodrigues, Marcio L.
Shi, Li
Barreto-Bergter, Eliana
Nimrichter, Leonardo
Farias, Sandra E.
Rodrigues, Elaine G.
Travassos, Luiz R. [UNIFESP]
Nosanchuk, Joshua D.
author_role author
author2 Shi, Li
Barreto-Bergter, Eliana
Nimrichter, Leonardo
Farias, Sandra E.
Rodrigues, Elaine G.
Travassos, Luiz R. [UNIFESP]
Nosanchuk, Joshua D.
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal do Rio de Janeiro (UFRJ)
Yeshiva Univ Albert Einstein Coll Med
Univ Fed Rio Grande do Sul
Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Rodrigues, Marcio L.
Shi, Li
Barreto-Bergter, Eliana
Nimrichter, Leonardo
Farias, Sandra E.
Rodrigues, Elaine G.
Travassos, Luiz R. [UNIFESP]
Nosanchuk, Joshua D.
description Glucosylceramides (GIcCer) are involved in the regulation of Cryptococcus neoformans virulence. in the present study, we demonstrate that passive immunization with a monoclonal antibody to GlcCer significantly reduces host inflammation and prolongs the survival of mice lethally infected with C. neoformans, revealing a potential therapeutic strategy to control cryptococcosis.
publishDate 2007
dc.date.none.fl_str_mv 2007-10-01
2016-01-24T13:49:06Z
2016-01-24T13:49:06Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1128/CVI.00202-07
Clinical and Vaccine Immunology. Washington: Amer Soc Microbiology, v. 14, n. 10, p. 1372-1376, 2007.
10.1128/CVI.00202-07
WOS000250164800019.pdf
1556-6811
http://repositorio.unifesp.br/handle/11600/30055
WOS:000250164800019
url http://dx.doi.org/10.1128/CVI.00202-07
http://repositorio.unifesp.br/handle/11600/30055
identifier_str_mv Clinical and Vaccine Immunology. Washington: Amer Soc Microbiology, v. 14, n. 10, p. 1372-1376, 2007.
10.1128/CVI.00202-07
WOS000250164800019.pdf
1556-6811
WOS:000250164800019
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clinical and Vaccine Immunology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1372-1376
application/pdf
dc.publisher.none.fl_str_mv Amer Soc Microbiology
publisher.none.fl_str_mv Amer Soc Microbiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268389892292609

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