Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1111/j.1528-1167.2005.63904.x http://repositorio.unifesp.br/handle/11600/28433 |
Resumo: | Purpose: To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy. We hypothesized that prolonged caffeine consumption or its withdrawal would alter adenosine levels and hence alter seizure susceptibility.Methods: We administered a 0.1% caffeine solution in the drinking water of adult male Wistar rats over a 2-week period. We challenged another group of animals with the same doses of pilocarpine or kainate 12 h after the withdrawal of the same caffeine-administration protocol.Results: This did not alter the threshold for the induction of seizures by a subconvulsant dose of pilocarpine (200 mg/kg, i.p.) or kainic acid (8 mg/kg, i.p.). Similarly, challenging another group of animals with the same doses of pilocarpine or kainate 12 h after the withdrawal of the same caffeine-administration protocol did not lead to any significant changes in seizures.Conclusions: With the pilocarpine model of epilepsy, we were not able to find any significant difference in seizure profile that could stem from either caffeine administration or its withdrawal. Despite the extensive laboratory evidence on the convulsant properties of xanthine derivatives in animal models of epilepsy, such strong evidence is lacking in clinical settings. Our current findings with the administration of caffeine at doses similar to those of daily life both support and confirm the clinical experience. |
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Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in ratsstatus epilepticusxanthinesadenosineanticonvulsantspontaneous seizurescoffeePurpose: To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy. We hypothesized that prolonged caffeine consumption or its withdrawal would alter adenosine levels and hence alter seizure susceptibility.Methods: We administered a 0.1% caffeine solution in the drinking water of adult male Wistar rats over a 2-week period. We challenged another group of animals with the same doses of pilocarpine or kainate 12 h after the withdrawal of the same caffeine-administration protocol.Results: This did not alter the threshold for the induction of seizures by a subconvulsant dose of pilocarpine (200 mg/kg, i.p.) or kainic acid (8 mg/kg, i.p.). Similarly, challenging another group of animals with the same doses of pilocarpine or kainate 12 h after the withdrawal of the same caffeine-administration protocol did not lead to any significant changes in seizures.Conclusions: With the pilocarpine model of epilepsy, we were not able to find any significant difference in seizure profile that could stem from either caffeine administration or its withdrawal. Despite the extensive laboratory evidence on the convulsant properties of xanthine derivatives in animal models of epilepsy, such strong evidence is lacking in clinical settings. Our current findings with the administration of caffeine at doses similar to those of daily life both support and confirm the clinical experience.UNIFESP, Dept Physiol, BR-04023062 São Paulo, BrazilUNIFESP, Dept Psychobiol, BR-04023062 São Paulo, BrazilUNIFESP, Dept Physiol, BR-04023062 São Paulo, BrazilUNIFESP, Dept Psychobiol, BR-04023062 São Paulo, BrazilWeb of ScienceBlackwell PublishingUniversidade Federal de São Paulo (UNIFESP)Hoexter, Marcelo Queiroz [UNIFESP]Rosa, Pedro S.Tufik, Sergio [UNIFESP]Mello, Luiz Eugenio [UNIFESP]2016-01-24T12:38:01Z2016-01-24T12:38:01Z2005-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1401-1406http://dx.doi.org/10.1111/j.1528-1167.2005.63904.xEpilepsia. Oxford: Blackwell Publishing, v. 46, n. 9, p. 1401-1406, 2005.10.1111/j.1528-1167.2005.63904.x0013-9580http://repositorio.unifesp.br/handle/11600/28433WOS:000231507100006engEpilepsiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-09-30T17:25:19Zoai:repositorio.unifesp.br/:11600/28433Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-09-30T17:25:19Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats |
title |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats |
spellingShingle |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats Hoexter, Marcelo Queiroz [UNIFESP] status epilepticus xanthines adenosine anticonvulsant spontaneous seizures coffee |
title_short |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats |
title_full |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats |
title_fullStr |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats |
title_full_unstemmed |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats |
title_sort |
Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats |
author |
Hoexter, Marcelo Queiroz [UNIFESP] |
author_facet |
Hoexter, Marcelo Queiroz [UNIFESP] Rosa, Pedro S. Tufik, Sergio [UNIFESP] Mello, Luiz Eugenio [UNIFESP] |
author_role |
author |
author2 |
Rosa, Pedro S. Tufik, Sergio [UNIFESP] Mello, Luiz Eugenio [UNIFESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Hoexter, Marcelo Queiroz [UNIFESP] Rosa, Pedro S. Tufik, Sergio [UNIFESP] Mello, Luiz Eugenio [UNIFESP] |
dc.subject.por.fl_str_mv |
status epilepticus xanthines adenosine anticonvulsant spontaneous seizures coffee |
topic |
status epilepticus xanthines adenosine anticonvulsant spontaneous seizures coffee |
description |
Purpose: To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy. We hypothesized that prolonged caffeine consumption or its withdrawal would alter adenosine levels and hence alter seizure susceptibility.Methods: We administered a 0.1% caffeine solution in the drinking water of adult male Wistar rats over a 2-week period. We challenged another group of animals with the same doses of pilocarpine or kainate 12 h after the withdrawal of the same caffeine-administration protocol.Results: This did not alter the threshold for the induction of seizures by a subconvulsant dose of pilocarpine (200 mg/kg, i.p.) or kainic acid (8 mg/kg, i.p.). Similarly, challenging another group of animals with the same doses of pilocarpine or kainate 12 h after the withdrawal of the same caffeine-administration protocol did not lead to any significant changes in seizures.Conclusions: With the pilocarpine model of epilepsy, we were not able to find any significant difference in seizure profile that could stem from either caffeine administration or its withdrawal. Despite the extensive laboratory evidence on the convulsant properties of xanthine derivatives in animal models of epilepsy, such strong evidence is lacking in clinical settings. Our current findings with the administration of caffeine at doses similar to those of daily life both support and confirm the clinical experience. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005-09-01 2016-01-24T12:38:01Z 2016-01-24T12:38:01Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1111/j.1528-1167.2005.63904.x Epilepsia. Oxford: Blackwell Publishing, v. 46, n. 9, p. 1401-1406, 2005. 10.1111/j.1528-1167.2005.63904.x 0013-9580 http://repositorio.unifesp.br/handle/11600/28433 WOS:000231507100006 |
url |
http://dx.doi.org/10.1111/j.1528-1167.2005.63904.x http://repositorio.unifesp.br/handle/11600/28433 |
identifier_str_mv |
Epilepsia. Oxford: Blackwell Publishing, v. 46, n. 9, p. 1401-1406, 2005. 10.1111/j.1528-1167.2005.63904.x 0013-9580 WOS:000231507100006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Epilepsia |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1401-1406 |
dc.publisher.none.fl_str_mv |
Blackwell Publishing |
publisher.none.fl_str_mv |
Blackwell Publishing |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268445941825536 |