Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats

Detalhes bibliográficos
Autor(a) principal: Hoexter, Marcelo Queiroz [UNIFESP]
Data de Publicação: 2005
Outros Autores: Rosa, Pedro S., Tufik, Sergio [UNIFESP], Mello, Luiz Eugenio [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1111/j.1528-1167.2005.63904.x
http://repositorio.unifesp.br/handle/11600/28433
Resumo: Purpose: To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy. We hypothesized that prolonged caffeine consumption or its withdrawal would alter adenosine levels and hence alter seizure susceptibility.Methods: We administered a 0.1% caffeine solution in the drinking water of adult male Wistar rats over a 2-week period. We challenged another group of animals with the same doses of pilocarpine or kainate 12 h after the withdrawal of the same caffeine-administration protocol.Results: This did not alter the threshold for the induction of seizures by a subconvulsant dose of pilocarpine (200 mg/kg, i.p.) or kainic acid (8 mg/kg, i.p.). Similarly, challenging another group of animals with the same doses of pilocarpine or kainate 12 h after the withdrawal of the same caffeine-administration protocol did not lead to any significant changes in seizures.Conclusions: With the pilocarpine model of epilepsy, we were not able to find any significant difference in seizure profile that could stem from either caffeine administration or its withdrawal. Despite the extensive laboratory evidence on the convulsant properties of xanthine derivatives in animal models of epilepsy, such strong evidence is lacking in clinical settings. Our current findings with the administration of caffeine at doses similar to those of daily life both support and confirm the clinical experience.
id UFSP_2b91dd00340a076f6d03bc5b48f2224d
oai_identifier_str oai:repositorio.unifesp.br/:11600/28433
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in ratsstatus epilepticusxanthinesadenosineanticonvulsantspontaneous seizurescoffeePurpose: To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy. We hypothesized that prolonged caffeine consumption or its withdrawal would alter adenosine levels and hence alter seizure susceptibility.Methods: We administered a 0.1% caffeine solution in the drinking water of adult male Wistar rats over a 2-week period. We challenged another group of animals with the same doses of pilocarpine or kainate 12 h after the withdrawal of the same caffeine-administration protocol.Results: This did not alter the threshold for the induction of seizures by a subconvulsant dose of pilocarpine (200 mg/kg, i.p.) or kainic acid (8 mg/kg, i.p.). Similarly, challenging another group of animals with the same doses of pilocarpine or kainate 12 h after the withdrawal of the same caffeine-administration protocol did not lead to any significant changes in seizures.Conclusions: With the pilocarpine model of epilepsy, we were not able to find any significant difference in seizure profile that could stem from either caffeine administration or its withdrawal. Despite the extensive laboratory evidence on the convulsant properties of xanthine derivatives in animal models of epilepsy, such strong evidence is lacking in clinical settings. Our current findings with the administration of caffeine at doses similar to those of daily life both support and confirm the clinical experience.UNIFESP, Dept Physiol, BR-04023062 São Paulo, BrazilUNIFESP, Dept Psychobiol, BR-04023062 São Paulo, BrazilUNIFESP, Dept Physiol, BR-04023062 São Paulo, BrazilUNIFESP, Dept Psychobiol, BR-04023062 São Paulo, BrazilWeb of ScienceBlackwell PublishingUniversidade Federal de São Paulo (UNIFESP)Hoexter, Marcelo Queiroz [UNIFESP]Rosa, Pedro S.Tufik, Sergio [UNIFESP]Mello, Luiz Eugenio [UNIFESP]2016-01-24T12:38:01Z2016-01-24T12:38:01Z2005-09-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1401-1406http://dx.doi.org/10.1111/j.1528-1167.2005.63904.xEpilepsia. Oxford: Blackwell Publishing, v. 46, n. 9, p. 1401-1406, 2005.10.1111/j.1528-1167.2005.63904.x0013-9580http://repositorio.unifesp.br/handle/11600/28433WOS:000231507100006engEpilepsiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-09-30T17:25:19Zoai:repositorio.unifesp.br/:11600/28433Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-09-30T17:25:19Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats
title Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats
spellingShingle Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats
Hoexter, Marcelo Queiroz [UNIFESP]
status epilepticus
xanthines
adenosine
anticonvulsant
spontaneous seizures
coffee
title_short Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats
title_full Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats
title_fullStr Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats
title_full_unstemmed Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats
title_sort Consequences of prolonged caffeine administration and its withdrawal on pilocarpine- and kainate-induced seizures in rats
author Hoexter, Marcelo Queiroz [UNIFESP]
author_facet Hoexter, Marcelo Queiroz [UNIFESP]
Rosa, Pedro S.
Tufik, Sergio [UNIFESP]
Mello, Luiz Eugenio [UNIFESP]
author_role author
author2 Rosa, Pedro S.
Tufik, Sergio [UNIFESP]
Mello, Luiz Eugenio [UNIFESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Hoexter, Marcelo Queiroz [UNIFESP]
Rosa, Pedro S.
Tufik, Sergio [UNIFESP]
Mello, Luiz Eugenio [UNIFESP]
dc.subject.por.fl_str_mv status epilepticus
xanthines
adenosine
anticonvulsant
spontaneous seizures
coffee
topic status epilepticus
xanthines
adenosine
anticonvulsant
spontaneous seizures
coffee
description Purpose: To investigate the consequences of caffeine consumption on epileptic seizures, we used the pilocarpine and the kainate models of epilepsy. We hypothesized that prolonged caffeine consumption or its withdrawal would alter adenosine levels and hence alter seizure susceptibility.Methods: We administered a 0.1% caffeine solution in the drinking water of adult male Wistar rats over a 2-week period. We challenged another group of animals with the same doses of pilocarpine or kainate 12 h after the withdrawal of the same caffeine-administration protocol.Results: This did not alter the threshold for the induction of seizures by a subconvulsant dose of pilocarpine (200 mg/kg, i.p.) or kainic acid (8 mg/kg, i.p.). Similarly, challenging another group of animals with the same doses of pilocarpine or kainate 12 h after the withdrawal of the same caffeine-administration protocol did not lead to any significant changes in seizures.Conclusions: With the pilocarpine model of epilepsy, we were not able to find any significant difference in seizure profile that could stem from either caffeine administration or its withdrawal. Despite the extensive laboratory evidence on the convulsant properties of xanthine derivatives in animal models of epilepsy, such strong evidence is lacking in clinical settings. Our current findings with the administration of caffeine at doses similar to those of daily life both support and confirm the clinical experience.
publishDate 2005
dc.date.none.fl_str_mv 2005-09-01
2016-01-24T12:38:01Z
2016-01-24T12:38:01Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1111/j.1528-1167.2005.63904.x
Epilepsia. Oxford: Blackwell Publishing, v. 46, n. 9, p. 1401-1406, 2005.
10.1111/j.1528-1167.2005.63904.x
0013-9580
http://repositorio.unifesp.br/handle/11600/28433
WOS:000231507100006
url http://dx.doi.org/10.1111/j.1528-1167.2005.63904.x
http://repositorio.unifesp.br/handle/11600/28433
identifier_str_mv Epilepsia. Oxford: Blackwell Publishing, v. 46, n. 9, p. 1401-1406, 2005.
10.1111/j.1528-1167.2005.63904.x
0013-9580
WOS:000231507100006
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Epilepsia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1401-1406
dc.publisher.none.fl_str_mv Blackwell Publishing
publisher.none.fl_str_mv Blackwell Publishing
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268445941825536