Analysis of polymorphisms in codons 11, 72 and 248 of tp53 in brazilian women with breast cancer
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.4238/gmr.15017055 http://repositorio.unifesp.br/handle/11600/49551 |
Resumo: | The association between TP53 gene polymorphisms and breast cancer (BC) in Brazilian women is a controversial topic. In this cross-sectional study, we evaluated the association between clinical pathological variables and three polymorphisms (TP53(star)11, TP53(star)72, and TP53(star)248) in BC patients and controls. Genomic DNA was extracted from the blood cells of 393 participants |
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Analysis of polymorphisms in codons 11, 72 and 248 of tp53 in brazilian women with breast cancerBreast CancerRestriction EnzymesTp53P53 ProteinSnpBrazilian WomenGene PolymorphismsP53 PolymorphismsAssociationMutationsPopulationRiskEndometriosisVariantsThe association between TP53 gene polymorphisms and breast cancer (BC) in Brazilian women is a controversial topic. In this cross-sectional study, we evaluated the association between clinical pathological variables and three polymorphisms (TP53(star)11, TP53(star)72, and TP53(star)248) in BC patients and controls. Genomic DNA was extracted from the blood cells of 393 participantsthe cancer-free control subjects were 26-72 years old (41 +/- 11.03) and the BC patients were 28-80 years old (51 +/- 10.70). We used standard polymerase chain reaction-restriction fragment length polymorphism and confirmed the results by genetic sequencing. In TP53(star)11, there was 100% homozygous Glu distribution in both groups. TP53(star)72 showed genotypic distribution: in the control group, there was 16.10% homozygous Pro, and 42.44% heterozygous and 41.46% homozygous Argin the BC group, there was 15.43% homozygous Pro, and 42.55% heterozygous and 42.02% homozygous Arg. The relative frequency of each allele was 0.37% for Pro and 0.63% for Arg in the control group, and 0.37% for Pro and 0.63% for Arg in the BC group. The nuclear grade (P = 0.0084) and adapted histological grade (P = 0.0265) were associated with TP53(star)72. The distribution of the codon 72 genotypes did not deviate from Hardy-Weinberg equilibrium in either group. In TP53(star)248, there was 100% homozygous Arg distribution in both groups. In codon 72, the Arg allele is the most prevalent in Brazilian women. TP53(star)72 may be associated with susceptibility to BC, although more studies are required to evaluate the profile of Brazilian women with BC.Laboratório de Ginecologia Molecular e Proteômica, Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, SP, BrasilCentro de Pesquisa Translacional, Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Universidade Federal de São Paulo, São Paulo, SP, BrasilDepartamento de Lípides, Aterosclerose e Biologia Vascular, Universidade Federal de São Paulo, São Paulo, SP, BrasilLaboratório de Biofísica Celular e Molecular, Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, BA, BrasilLaboratório de Ginecologia Molecular e Proteômica, Departamento de Ginecologia, Universidade Federal de São Paulo, São Paulo, SP, BrasilCentro de Pesquisa Translacional, Departamento de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço, Universidade Federal de São Paulo, São Paulo, SP, BrasilDepartamento de Lípides, Aterosclerose e Biologia Vascular, Universidade Federal de São Paulo, São Paulo, SP, BrasilWeb of ScienceCNPqFunpec-editora2019-01-21T10:30:03Z2019-01-21T10:30:03Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionUNSP gmr.15017055http://dx.doi.org/10.4238/gmr.15017055Genetics And Molecular Research. Ribeirao preto, v. 15, n. 1, p. UNSP gmr.15017055, 2016.10.4238/gmr.150170551676-5680http://repositorio.unifesp.br/handle/11600/49551WOS:000373880200012engGenetics And Molecular Researchinfo:eu-repo/semantics/openAccessAlmeida, B. C. [UNIFESP]Kleine, J. P. F. O. [UNIFESP]Camargo-Kosugi, C. M. [UNIFESP]Lisboa, M. R. [UNIFESP]Franca, C. N. [UNIFESP]Franca, J. P.Silva, I. D. C. G. [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-10-05T15:45:57Zoai:repositorio.unifesp.br/:11600/49551Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-10-05T15:45:57Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Analysis of polymorphisms in codons 11, 72 and 248 of tp53 in brazilian women with breast cancer |
| title |
Analysis of polymorphisms in codons 11, 72 and 248 of tp53 in brazilian women with breast cancer |
| spellingShingle |
Analysis of polymorphisms in codons 11, 72 and 248 of tp53 in brazilian women with breast cancer Almeida, B. C. [UNIFESP] Breast Cancer Restriction Enzymes Tp53 P53 Protein Snp Brazilian WomenGene Polymorphisms P53 Polymorphisms Association Mutations Population Risk Endometriosis Variants |
| title_short |
Analysis of polymorphisms in codons 11, 72 and 248 of tp53 in brazilian women with breast cancer |
| title_full |
Analysis of polymorphisms in codons 11, 72 and 248 of tp53 in brazilian women with breast cancer |
| title_fullStr |
Analysis of polymorphisms in codons 11, 72 and 248 of tp53 in brazilian women with breast cancer |
| title_full_unstemmed |
Analysis of polymorphisms in codons 11, 72 and 248 of tp53 in brazilian women with breast cancer |
| title_sort |
Analysis of polymorphisms in codons 11, 72 and 248 of tp53 in brazilian women with breast cancer |
| author |
Almeida, B. C. [UNIFESP] |
| author_facet |
Almeida, B. C. [UNIFESP] Kleine, J. P. F. O. [UNIFESP] Camargo-Kosugi, C. M. [UNIFESP] Lisboa, M. R. [UNIFESP] Franca, C. N. [UNIFESP] Franca, J. P. Silva, I. D. C. G. [UNIFESP] |
| author_role |
author |
| author2 |
Kleine, J. P. F. O. [UNIFESP] Camargo-Kosugi, C. M. [UNIFESP] Lisboa, M. R. [UNIFESP] Franca, C. N. [UNIFESP] Franca, J. P. Silva, I. D. C. G. [UNIFESP] |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Almeida, B. C. [UNIFESP] Kleine, J. P. F. O. [UNIFESP] Camargo-Kosugi, C. M. [UNIFESP] Lisboa, M. R. [UNIFESP] Franca, C. N. [UNIFESP] Franca, J. P. Silva, I. D. C. G. [UNIFESP] |
| dc.subject.por.fl_str_mv |
Breast Cancer Restriction Enzymes Tp53 P53 Protein Snp Brazilian WomenGene Polymorphisms P53 Polymorphisms Association Mutations Population Risk Endometriosis Variants |
| topic |
Breast Cancer Restriction Enzymes Tp53 P53 Protein Snp Brazilian WomenGene Polymorphisms P53 Polymorphisms Association Mutations Population Risk Endometriosis Variants |
| description |
The association between TP53 gene polymorphisms and breast cancer (BC) in Brazilian women is a controversial topic. In this cross-sectional study, we evaluated the association between clinical pathological variables and three polymorphisms (TP53(star)11, TP53(star)72, and TP53(star)248) in BC patients and controls. Genomic DNA was extracted from the blood cells of 393 participants |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 2019-01-21T10:30:03Z 2019-01-21T10:30:03Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4238/gmr.15017055 Genetics And Molecular Research. Ribeirao preto, v. 15, n. 1, p. UNSP gmr.15017055, 2016. 10.4238/gmr.15017055 1676-5680 http://repositorio.unifesp.br/handle/11600/49551 WOS:000373880200012 |
| url |
http://dx.doi.org/10.4238/gmr.15017055 http://repositorio.unifesp.br/handle/11600/49551 |
| identifier_str_mv |
Genetics And Molecular Research. Ribeirao preto, v. 15, n. 1, p. UNSP gmr.15017055, 2016. 10.4238/gmr.15017055 1676-5680 WOS:000373880200012 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Genetics And Molecular Research |
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info:eu-repo/semantics/openAccess |
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openAccess |
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UNSP gmr.15017055 |
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Funpec-editora |
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Funpec-editora |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1814268324535599104 |